• Herbal Formula Science
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• v.12 no.1
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• pp.93-104
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• 2004

Recently, more and more natural herbal products are investigated and used popularly. Pharmaceutical companies of Korea are very interested in developing herbal new drugs. And oriental doctors also need popular, modernized form of oriental drugs. The objective of this article is, first, to examine current situations of drug development in Korea, second, to know general concepts of patent and third, to think about new drug development and patent in oriental medicine's point of view. With consideration of oriental medicine's characteristics, concepts of new drug and patent should be improved. Therefore, the oriental pharmaceutical industry and developments of oriental new drugs could be inspired to further efforts.

• The Korea Journal of Herbology
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• v.26 no.4
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• pp.9-14
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• 2011

Objective : Present study was carried out to investigate the effect of Gyungohkgo-gamibang extract on hair growth and protein expression in an alopecia model of C57BL/6 mice. Methods : Mice were divided into 3 experimental groups including normal (vehicle), Gyungohkgo-gamibang extract (YNS-10) and 5% minoxidil-treated group. The test materials were daily applied with 0.1 ml per mouse on shaved dorsal skin for 3 weeks. The hair growth was monitored by photograph at 5, 10, 15, 21 days after topical application. Then the changes of hair density and hair thickness in the hair-removed area were evaluated by phototrichogram using folliscope. Also the expression level of growth factors related to hair growth was measured by western blotting. Results : Application of minoxidil or YNS-10 stimulated the hair growth compared to vehicle treatment. Therefore hair density of minoxidil or YNS-10 application was increased about 200% and 210% more than in vehicle application on 14 day, respectively. And hair thickness of both minoxidil group and YNS-10 group was increased about 220% and 210 % more than in vehicle spreading on 14 day, respectively. Futhermore the protein expression of IGF-1 and VEGF were significantly up-regulated on 7 day in YNS-10 and minoxidil-spreaded group compared to vehicle-applied group. Conclusion : These data suggest that YNS-10 has potent stimulating activity on hair growth in C57BL/6 mice and potential usefulness as ingredients of hair tonic and hairrestore.

• Journal of Evidence-Based Herbal Medicine
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• v.1 no.2
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• pp.17-26
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• 2008

Nowadays the flow of international trade is that there seems to appear economic block significantly because most countries contract FTAs, so our market condition is changing to a severe competitive situation. Korea which has 70% of foreign dependence of trade must get involved in regionalism, and also actively promote FTA more than any other countries. FTA on February in 2006, the pharmaceutical industry are anxious. The pharmaceutical industry in Korea has recently come to a crisis that it is hard to expect a growth due to structure of profit and a change for the worse of management. If Korea-U.S. FTA are contracted in this kind of situation, domestic pharmaceutical companies will be at stake. We can anticipate that FTA with the country that has a strong competitive power like U.S. affect negatively on pharmaceutical industry, because the industry doesn't have enough self-competitiveness. Considering this kind of surroundings, we need to present the policy to enhance competitiveness for damage limitation on pharmaceutical industry by Korea-U.S. FTA. Under this background, this research has groped for a direction to strengthen the competitiveness to develop pharmaceutical industry in quality. The competitive enhancement plan is presented which is divided into the government policy part, the R&D part, and the management part. Although Korea-U.S. FTA is analyzed to wither the pharmaceutical industry, it would be thought that it is a good chance to upgrade domestic pharmaceutical industry if we make the best use of it, and also to make in roads into foreign market.

• Korean Journal of Oriental Medicine
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• v.13 no.1 s.19
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• pp.125-128
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• 2007

Objective : This study aims to review the current status and problems of Korean Medicine and attempts to come up with the means to present a comprehensive and effective set of statistical data. Methods : We have analyzed the current statistics and tried to show how to establish an effective system to gather and organize statistics related to Korean Medicine, including national surveys by the Ministry of Health and Welfare or other relevant insititutions. Results : The existing statistics in Korean Medicine were established not as a result of national demand based on comprehensive analysis but due to the demand of the government ministries such as the Ministry of Health and Welfare or other relevant institutions. Thus, the statistics have been revealed to possess limitations such as a lack of systemization and consistency. In addition, the statistics analyze only the current industrial status of Korean Medicine, and as a result the information in unable to show systematic data for innovation, which is indispensable for the advancement and development of the Korean Medicine industry. Conclusion : To improve the statistical data in Korean Medicine, the statistics need to get over not only the level of management or regulation in Korean Medicine, but also the production of fragmentary statistics. It has to ultimately reflect the innovative activities in Korean Medicine nationally, and show what we need to advance and develop the industry.

• The Korea Journal of Herbology
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• v.27 no.3
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• pp.67-74
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• 2012

Objectives : The present study was designed to investigate effects of Ssanghwa-tang (Shu$\bar{a}$nghu$\bar{a}$-g$\bar{e}$ng) on oxidation/reduction reaction-related and aging-related enzymes $in$ $vitro$. Methods : We performed MTT assay, collagenase inhibition assay, elastase inhibition assay, tyrosinase inhibition assay, DPPH free radical scavenging assay, SOD-like activity and xanthine oxidase (XO) inhibition assay. Results : The 50% ethanol (EtOH) extract of Ssanghwa-tang (SHT) showed 55% inhibition of collagenase activity, and 42% inhibition of elastase activity at 1 mg/ml concentration. Also it's treatment showed 18% inhibition of tyrosinase activity, to relate whitening effect, at the same dose of 50% ethanol extract of SHT. Antioxidant activities were determined by DPPH radical scavenging, XO inhibiting activity and SOD-like activity. These scavenging, XO-inhibiting and SOD-like activities were measured in 80%, 75%, and 28% inhibitions, respectively, at a 1 mg/ml treated dose, compared to those of control. The inhibitory effects of 50% EtOH extract on aging and oxidation-related enzyme activities were higher than those of water extract and 95% EtOH extract. Conclusions : Taken together, our findings suggest that the SHT has potential and applicable benefits for development of cosmetics to have anti-aging (anti-wrinkle and whitening) and anti-oxidation functions.

• Korean Journal of Oriental Medicine
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• v.14 no.1
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• pp.33-40
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• 2008

Revising 11 historical topography of Jecheon city we could notice that this territory was traditionally producing high quality medicinal plants. This view is supported as it was tributed to the King. Production of medicinal plants continue these days, Jecheon being one of the largest production of medicinal plants in Korea. Abundant production of diverse medicinal plants of high quality seems to be linked with the soil, climate and environmental characteristics unique of Jecheon. Therefore we propose to develop new type of herbal medicin drugs like Gobang(膏方) which could distinguish from other places. Gobang matchs well to the requirement of current days being convenient to carry and of good taste. Also is appropriate to treat chronic diseases. Its primordial abundant herbal medicines of high quality for the development of Gobang where Jecheon can provide.

• Journal of Sasang Constitutional Medicine
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• v.21 no.2
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• pp.137-143
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• 2009

1. Objective : This study aims to evaluate the medical tourism structures in countries with prosperous medical tourism industry such as Thailand, Malaysia, Singapore and India in order ro propose optimal strategies that can promote the medical tourism in Korea. 2. Methods : All pertinent literature concerning medical tourism directly and indirectly were assessed, and reviews of medical tourism strategies found in various countries were evaluated. 3. Results : Evaluation of related literature reveals that medical tourism is a recent burgeoning industry that has grown In market size considerably in the last five to ten years. Also, it shows that oriental medicine is a highly likely candidate amidst the various medical fields for attraction foreign patients. 4. Conclusion : The Korean government should support and install appropriate legal and administrative bodies in order to attract medical tourists; Korea-specific medical tourism programs (ie. traditional Korean medicine package tours) should be developed in order to attract medical tourists from the western world and the middle-east. In addition, low-price policy of medical tourism is not a proper strategies for the competition against advanced medical tourism destinations such as Thailand, Malaysia, Singapore and India. Differentiated medical tourism package such as oriental medical tourism program rather than provision of low-price policy seems to be more effective strategy for the medical tourism in Korea. Future studies on strategies for promoting medical tourism should focus on how foreigners recognize traditional Korean medicine, what diagnostic approach might be appealing to them and how the legal system concerning the medical procedures may be altered and modified.

• Food Industry And Nutrition
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• v.10 no.2
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• pp.1-11
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• 2005

• Korean Journal of Pharmacognosy
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• v.43 no.4
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• pp.308-315
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• 2012

Opuntia humifusa known as the Eastern prickly pear have been used as a treatment of burns, diarrhea, asthma, rheumatism, gonorrhea, and diabetes in alternative medicine. O. humifusa is widely cultivated in the middle and southern provinces of Korea and distributed in North America. The aim of this study is to investigate anti-diabetic effect of O. humifusa stem (OHS) water or 80% MeOH extract using 3T3-L1 adipocytes and db/db mice animal models. OHS 80% MeOH extract at a dose of $250{\mu}g/ml$ significantly increased the glucose uptake and lipid accumulation compared with the control in 3T3-L1 adipocytes. Blood glucose, plasma total cholesterol and triglyceride levels were significantly reduced by oral treatment of OHS 80% MeOH extract (200 mg/kg BW) for 6 weeks in db/db mice. Also, the oral treatment of OHS 80% MeOH extract slightly changed the plasma insulin and insulin resistance levels in db/db mice, but were no significance in comparison to control. Glucose transporter(GLUT)4 expressions of adipose tissue and muscle were significantly increased more than that in the control. Therefore, these results suggest that OHS 80% MeOH extract inhibits the blood glucose level through regulation of lipid profile, insulin resistance, and GLUT4 expression in db/db mice and its diabetic effect is effective more than water extract.

• The Journal of Korean Medicine
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• v.34 no.2
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• pp.41-50
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• 2013

Objectives: As a newcomer to the medical tourism industry, Korea needs to differentiate itself from the leading competing countries to vitalize its early-stage medical tourism industry. This study aims to introduce a strategic plan to vitalize the Korean integrated medical tourism so that Korea can differentiate itself from competing countries and create high added value. Methods: The concept and actual conditions of medical tourism and Oriental medical tourism were examined. A plan to differentiate Korea from the competing countries in the medical tourism industry was studied to create high added-value through strategic vitalization of its medical tourism industry. Results: Korean integrated medical tourism must be developed differently from those of other South-East Asian countries in order to strategically promote the cash-cow medical tourism industry. In order to develop such medical tourism, Korean medical practice, which integrates Western and Oriental medicine, is to be developed through mutual understanding and fusion of other disciplines among medical doctors and Oriental medical doctors who are working in local healthcare for health promotion of local residents and disease prevention and control. This will play a key role in developing a unique medical tourism product of Korea by means of strategic alliances as an integrated medicine. Manpower specialized for integrated medicine is to be specially supplied for Oriental medicine-related business lines at city, county and borough levels, among local governments, that are enthusiastically carrying forward Oriental medical tourism with an interest to promoting more active and strategic business development and raise the effectiveness and efficiency of public health centers handling related medical tourism. Manpower specialized for Korean integrated medical tourism is to be specially supplied for the Ministry of Culture, Health and Tourism, a policy control tower to develop and vitalize high value-added fusion (theme) tourism products such as the Korean integrated medical tourism, in order to discover, promote and support Korean integrated medical tourism's differences from existing medical tourism. Conclusions: The differentiated integrated medical tourism that only Korea can offer in a variety of forms, in order to create a key area of high value-added medical tourism, should be strategically vitalized through a liaison between integrated medicine and tourism and the realization of patient-centered health care services with medical technology developed based on mutual understanding of Western and Oriental medicine.