• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.271-272
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• 1998

Contrast-enhanced CT has an important role in the assessment of liver lesions. However, the optimal protocol to get most effective result is not clear. The main principle for deciding injection protocol is to optimize lesion detectability by rapid scanning when lesion-to-liver contrast is maximum. For this purpose, we developed a physiological model of contrast medium enhancement based on the compartment modeling and pharmacokinetics. Blood supply to liver was modeled in two paths. This dual supply character distinguishes the CT enhancement of liver from that of the other organs. The first path is by hepatic artery and the second is by portal vein. It is assumed that only hepatic artery can supply blood to hepatocellular carcinoma (HCC) compartment. It is known that this causes the difference of contrast enhancement between normal liver tissue and hepatic tumor. By solving differential equations for each compartment simultaneously using computer program Matlab, CT contrast-enhancement curves were simulated. Simulated enhancement curves for aortic, hepatic, portal vein, and HCC compartments were compared with mean enhancement curves from 24 patients exposed to the same protocols as simulation. These enhancement curves were in a good agreement. Furthermore, we simulated lesion-to-liver curves for various injection protocols, and analyzed the effects. These may help to optimize the scanning protocols for good diagnosis.

• 동의생리병리학회지
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• 제24권1호
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• pp.124-133
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• 2010

The object of this study was to obtain acute information single oral dose toxicity of Mahwangbujaseshin-tang extracts, with mouse bone marrow cell micronucleus test for detecting possible genotoxicity. In order to observe the 50% lethal dose, approximate lethal dosage, maximum tolerance dosage and target organs, test articles were once orally administered to ICR mice at dose levels of 2000, 1000, 50 mg/kg according to the recommendation of KFDA Guidelines. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing according to KFDA Guidelines with organ weights of 12 types of principle organs. In addition, after twice oral treatment of Mahwangbujaseshin-tang extracts 2000, 1000 and 500 mg/kg, we checked the changes on the number of MNPCE. We could not find any mortality, clinical signs, changes in the body weight and gross findings upto 2000 mg/kg treated group. The limited dosages in rodents except for increases of lymphoid organ weights and hypertrophy encounted as results from pharmacological effects of Mahwangbujaseshin-tang extracts, immune modulator effects with some sporadic accidental findings not toxicological signs. No evidence of increases of MNPCE numbers were also detected in all three different dosages of Mahwangbujaseshin-tang extracts treated mice. The results obtained in this study suggest that the LD50 and ALD of Mahwangbujaseshin-tang extracts in mice were considered as over 2000 mg/kg because no mortalities were detected upto 2000 mg/kg that was the highest dose recommended by KFDA and OECD. And the results of mouse bone marrow micronucleus test of Mahwangbujaseshin-tang extracts is negative results.

• Steel and Composite Structures
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• 제25권1호
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• pp.105-116
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• 2017

This paper presents the dynamic stability study of laminated composite plates with different force combinations and aspect ratios. Optimum non-diverging stacking is obtained for certain loading combination and aspect ratio. In addition, the stability force is maximized for a definite operating frequency. A dynamic version of the principle of virtual work for laminated composites is used to obtain force-frequency relation. Since dynamic stiffness governs the divergence or flutter, an efficient optimization method is necessary for the response functional and the relevant constraints. In this way, a model based on the ant colony optimization (ACO) algorithm is proposed to search for the proper stacking. The ACO algorithm is used since it treats with large number of dynamic stability parameters. Governing equations are formulated using classic laminate theory (CLT) and von-Karman plate technique. Load-frequency relations are explicitly obtained for fundamental and secondary flutter modes of simply supported composite plate with arbitrary aspect ratio, stacking and boundary load, which are used in optimization process. Obtained results are compared with the finite element method results for validity and accuracy convince. Results revealed that the optimum stacking with stable dynamic response and maximum critical load is in angle-ply mode with almost near-unidirectional fiber orientations for fundamental flutter mode. In addition, short plates behave better than long plates in combined axial-shear load case regarding stable oscillation. The interaction of uniaxial and shear forces intensifies the instability in long plates than short ones which needs low-angle layup orientations to provide required dynamic stiffness. However, a combination of angle-ply and cross-ply stacking with a near-square aspect ratio is appropriate for the composite plate regarding secondary flutter mode.

• 디지털융복합연구
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• 제8권3호
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• pp.1-17
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• 2010

본 연구의 목적은 적절하고 타당한 체벌 방법을 구안하여 학생들의 학교생활만족도를 향상시키기 위한 것이다. 이를 위하여 체벌상황을 게임이론를 적용하여 분석하여 어떤 경우에 체벌이 가장 최소화되면서 학교생활만족도가 증가되는지를 분석하였다. 주요한 연구 결과는 다음과 같이 정리되었다. 첫째, 교사와 학생 간에 체벌관련 정보의 공개정도가 증가함에 따라 학생은 체벌 받을 바람직하지 못한 행동을 하지 않는 경향을 보였다. 둘째 불완전 정보가 주어지는 게임상황하에서는 50% 이상의 체벌 받을 행동이 나타나는 것으로 분석되었다. 셋째, 완전정보가 주어지는 게임상황 하에서는 체벌 받을 행동이 거의 나타나지 않는다. 넷째, 완전정보가 주어지는 체벌사용지침이 규정되는 상황 하에서는 체벌의 빈도가 줄어들면서 학교생활만족도도 증가하였다. 요약컨대 체벌을 전면적으로 금지하는 정책보다는 체별사용규정안과 같은 문서를 작성하는 등 체벌가능성을 시사하고 있어야 체벌 받을 행동을 억제할 수 있다.

• Structural Engineering and Mechanics
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• 제65권5호
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• pp.573-585
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• 2018

This article presents strain gradient elasticity-based procedures for static bending, free vibration and buckling analyses of functionally graded rectangular micro-plates. The developed method allows consideration of smooth spatial variations of length scale parameters of strain gradient elasticity. Governing partial differential equations and boundary conditions are derived by following the variational approach and applying Hamilton's principle. Displacement field is expressed in a unified way to produce numerical results in accordance with Kirchhoff, Mindlin, and third order shear deformation theories. All material properties, including the length scale parameters, are assumed to be functions of the plate thickness coordinate in the derivations. Developed equations are solved numerically by means of differential quadrature method. Proposed procedures are verified through comparisons made to the results available in the literature for certain limiting cases. Further numerical results are provided to illustrate the effects of material and geometric parameters on bending, free vibrations, and buckling. The results generated by Kirchhoff and third order shear deformation theories are in very good agreement, whereas Mindlin plate theory slightly overestimates static deflection and underestimates natural frequency. A rise in the length scale parameter ratio, which identifies the degree of spatial variations, leads to a drop in dimensionless maximum deflection, and increases in dimensionless vibration frequency and buckling load. Size effect is shown to play a more significant role as the plate thickness becomes smaller compared to the length scale parameter. Numerical results indicate that consideration of length scale parameter variation is required for accurate modelling of graded rectangular micro-plates.

• 한국터널지하공간학회 논문집
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• 제16권5호
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• pp.487-495
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• 2014

본 연구에서는 주방식 지하구조물에서 지보재 설계를 위한 매개변수 연구를 수행하였다. 지보재 설계에 앞서 설계에 필요한 암주와 공간의 형상별 천단변위, 최대 주응력, 소성영역에 대한 해석을 수행하였다. 해석에 사용할 매개변수를 최적화 하기위해 주방식 지하구조물의 대상 심도와 지반 조건은 기존 지하철 정거장 건설 사례를 분석하여 결정하였으며 지하공간의 활용 목적에 따라 암주의 형상과 공간의 형상을 설정하여 총 180가지의 경우를 선택하였다. 매개변수 해석을 통해 획득한 결과는 향후 지하구조의 안정성과 공간 활용성, 시공장비의 적용성을 고려하여 지보재 설계와 설치 여부를 판단할 수 있는 근거자료로 활용될 수 있을 것으로 판단된다.

• 지구물리와물리탐사
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• 제13권3호
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• pp.198-202
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• 2010

20세기에 한반도 및 인근에서 발생한 지진 중, 그 메카니즘이 Waveform Modelling 혹은 Moment Tensor Inversion 등 정량적인 방법에 의해 밝혀진 규모 4.5 이상의 18개 지진의 발생 원인을 분석하고 이들을 한반도 주변 동아시아 지역에서 발생하는 지진들과 비교 분석하였다. 한반도 및 인접지역에서 발생한 지진의 대부분은 주향이동 단층 운동에 의한 메카니즘에 다소의 역단층 운동이 첨가된 단층운동을 보여주고 단층작용을 일으킨 주응력 방향은 거의 수평한 동북 동-서남서 방향을 나타낸다. 이는 같은 판내 지역인 북동부 중국 지역과 일본 남서부의 주응력 방향과 매우 유사하고 동해 동부와는 상당한 차이를 보인다. 이는 한반도 및 그 주변에서 지진을 일으키는 주응력은 동쪽에서 유라시아판 밑으로 침강하는 태평양판의 영향뿐만 아니라 서남쪽에서 충돌하는 인도판의 영향도 상당히 작용하는 것으로 해석된다.

• Geomechanics and Engineering
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• 제4권4호
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• pp.281-294
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• 2012

Filtration using granular media such as quarried sand, anthracite and granular activated carbon is a well-known technique used in both water and wastewater treatment. A relatively new pre-filtration method called pebble matrix filtration (PMF) technology has been proved effective in treating high turbidity water during heavy rain periods that occur in many parts of the world. Sand and pebbles are the principal filter media used in PMF laboratory and pilot field trials conducted in the UK, Papua New Guinea and Serbia. However during first full-scale trials at a water treatment plant in Sri Lanka in 2008, problems were encountered in sourcing the required uniform size and shape of pebbles due to cost, scarcity and Government regulations on pebble dredging. As an alternative to pebbles, hand-made clay pebbles (balls) were fired in a kiln and their performance evaluated for the sustainability of the PMF system. These clay balls within a filter bed are subjected to stresses due to self-weight and overburden, therefore, it is important that clay balls should be able to withstand these stresses in water saturated conditions. In this paper, experimentally determined physical properties including compression failure load (Uniaxial Compressive Strength) and tensile strength at failure (theoretical) of hand-made clay balls are described. Hand-made clay balls fired between the kiln temperatures of $875^{\circ}C$ to $960^{\circ}C$ gave failure loads of between 3.0 kN and 7.1 kN. In another test when clay balls were fired to $1250^{\circ}C$ the failure load was 35.0 kN compared to natural Scottish cobbles with an average failure load of 29.5 kN. The uniaxial compressive strength of clay balls obtained by experiment has been presented in terms of the tensile yield stress of clay balls. Based on the effective stress principle in soil mechanics, a method for the estimation of maximum theoretical load on clay balls used as filter media is proposed and compared with experimental failure loads.

• 실천공학교육논문지
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• 제14권3호
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• pp.491-498
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• 2022

본 논문에서는 비전공자들을 위한 교양과정으로, 기초 순환신경망 과목 커리큘럼을 설계하는데 필수적으로 요구되는 순환신경망 SW 실습 사례를 개발하였다. 개발된 SW 실습 사례는 순환신경망의 동작원리를 이해시키는 데 초점을 두고, 시각화된 전체 동작 과정을 확인할 수 있도록 스프레드시트를 사용하였다. 개발된 순환신경망 실습 사례는 지도학습 방식의 텍스트완성 훈련데이터 생성, 입력층, 은닉층, 상태층(컨텍스트 노드) 그리고 출력층을 차례대로 구현하고, 텍스트 데이터에 대해 순환신경망의 성능을 테스트하는 것으로 구성되었다. 본 논문에서 개발한 순환신경망 실습사례는 다양한 문자 수를 갖는 단어를 자동 완성한다. 제안한 순환신경망 실습사례를 활용하여, 한글 또는 영어 단어를 구성하는 최대 문자 수를 다양하게 확장하여 자동 완성하는 인공지능 SW 실습 사례를 만들 수 있다. 따라서, 본 순환신경망 기초 실습 사례의 활용도가 높다고 할 수 있다.

• 산업융합연구
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• 제17권4호
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• pp.45-51
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• 2019

본 연구에서는 기후변화 고려는 한 나라 또는 한 도시의 경제, 사회, 환경의 조화와 균형을 이루는 지속가능발전의 원칙에 부합하고 그 도시의 규모나 기능, 특징을 최대한 보존할 수 있는 회복력 있는 도시를 만들기 위한 중요한 척도가 되는 것이다. 이러한 관점에서 아일랜드 더블린도시에서 구축·운영되고 있는 대중교통시스템은 녹색교통을 통한 도시의 체계를 잘 보여주고 있다. 따라서 아일랜드, 더블린이 기후변화를 고려한 선제적 대중교통지향적인 도시개발(TOD)을 실현하고 있다는 점에서 더블린이 갖추고 있는 도시기반여건을 바탕으로 연구의 방법을 SWOT분석을 통해 내부상황 요인(강점과 약점)과 외부상황 요인(기회와 위협)으로 분류하여 대중교통지향적인 도시개발 전략과 정책적 시사점을 제시하는 데 목적을 두었다.