• IMMUNE NETWORK
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• v.22 no.1
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• pp.3.1-3.21
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• 2022

Cancer is one of the leading causes of death worldwide and the number of cancer patients is expected to continuously increase in the future. Traditional cancer therapies focus on inhibiting cancer growth while largely ignoring the contribution of the immune system in eliminating cancer cells. Recently, better understanding of immunological mechanisms pertaining to cancer progress has led to development of several immunotherapies, which revolutionized cancer treatment. Nonetheless, only a small proportion of cancer patients respond to immunotherapy and maintain a durable response. Among multiple factors contributing to the variability of immunotherapy response rates, commensal microbiota inhabiting patients have been identified as one of the most critical factors determining the success of immunotherapy. The functional diversity of microbiota differentially affects the host immune system and controls the efficacy of immunotherapy in individual cancer patients. Moreover, clinical studies have demonstrated that changing the gut microbiota composition by fecal microbiota transplantation in patients who failed a previous immunotherapy converts them to responders of the same therapy. Consequently, both academic and industrial researchers are putting extensive efforts to identify and develop specific bacteria or bacteria mixtures for cancer immunotherapy. In this review, we will summarize the immunological roles of commensal microbiota in cancer treatment and give specific examples of bacteria that show anticancer effect when administered as a monotherapy or as an adjuvant agent for immunotherapy. We will also list ongoing clinical trials testing the anticancer effect of commensal bacteria.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.24 no.3
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• pp.134-145
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• 1998

Facial hyperpigmentation in women, which is considered to be a serious cosmetic disability and a cause of mental distress, requires proper management. Melanocyte dendricity is a crucial factor affecting epidermal pigmentation. We found that BQ-788, the endothelin-B (ETB) receptor antagonist, blocks the formation of multi-dendricity which is induced by cocultured keratinocytes. Melanocytes in vivo show numerous dendrites which are in close contact with multiple keratinocytes, forming the epidermal-melanin unit. While melanocytes transfer their melanosomes into the neighboring keratinocytes via dendrites, keratinocytes secrete many growth factors and cytokines that influence viability, morphology, and melanin formation of melanocytes. Endothelin-1 (ET-1), prostaglandin E2(PGE2), and leukotriene-C4 (LT-C4) have been suggested as the candidates for increasing dendricity. Other reports suggested that ET-1 has stimulatory effects on proliferation and melanin formation of melanocytes in vitro. In the present study, using type-specific ET receptor antagonists, we observed how the morphology of melanocytes could be modulated in a coculture system. In addition, the roles of ET-1 for morphology and proliferation on melanocytes were evaluated in different culture media. We suggest that ET-1 increases dendricity and proliferation of melanocytes, and that its dendrite-inducing effect and mitogenic effect are regulated independently.

• Journal of the Korean Applied Science and Technology
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• v.40 no.6
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• pp.1350-1362
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• 2023

This study aims to identify the influence of the image of Chinese Taekwondo leaders at university on the athlete's grit, psychological state, and performance. The analysis is expected to contribute to the quality development of Chinese universities' Taekwondo program in the future. For this study, a population was selected from athletes at a university in Henan Province, China. The samples were taken by convenience sampling method. Of the 380 questionnaires retrieved, a total of 365 were used to process the results, excluding 15 insincere responses or missing values. The collected data were conducted by frequency analysis, correlation analysis, reliability analysis, exploratory factor analysis and multiple regression analysis using SPSS 23.0 program. The results of this study are as follows. First, the sub-factors of the leader image, the leader's social activities and vocational awareness, qualities, tasks and roles, were found to have a significant impact on the grit of taekwondo athletes. Second, the sub-factors of the leader image, the leader's social activities and vocational awareness, qualities, attitudes, tasks and roles had significant impact on the phychological state of taekwondo athletes. Third, social activities, vocational awareness, quality, and attitude of the leader, which are the sub-factors of the leader image, have a significant impact on the performance of taekwondo athletes.

• Knowledge Management Research
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• v.5 no.2
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• pp.1-23
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• 2004

Knowledge sharing, as well as knowledge creation, is the basis for an organization to maintain its competitive advantage. Organizations trying to use knowledge resources for strategic purposes or pursuing knowledge management are now paying more attention to methods to facilitate knowledge sharing. This study aims to find out the answers to the questions below. (1) Which relational or structural factors influence the intentions to share knowledge among groups? (2) Does the intension to share knowledge among groups really influence the knowledge sharing behavior? (3) What are the roles of accessibility on the relationship between intention to share knowledge and behavior of knowledge sharing? (4) Does the behavior of knowledge sharing really improve the effectiveness of knowledge sharing among groups? Findings of this study are summarized as follows. First, the positive relations of the relational and structural factors with the intention to share knowledge among groups are found. However, crisis intensity was found to have no meaningful influence on the intention to share knowledge among groups. After all we could see through additional analysis that it is in curvilinear relation, not linear relation. Second, we examined relation of the intention to share knowledge with the behavior of knowledge sharing among groups. Multiple regression analysis showed that intention to share knowledge among groups had a statistically significant influence on the behavior of knowledge sharing among groups. Third, the moderating effect of accessibility on the relation between the intention to share knowledge and the behavior of knowledge sharing was found to be statistically significant. Fourth, the relation between behavior of knowledge sharing and the effectiveness among groups was found to be statistically significant, but in a negative direction. The findings imply that the quantity of knowledge sharing does not always lead to the effectiveness of knowledge sharing.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39C no.3
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• pp.291-297
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• 2014

Due to the rapid increase in demand for transportation of human and freight in modern railway systems, the CBTC system has been proposed, which is the solution for improvement of the line capacity that has been limited by the conventional track circuit based train control system. In the CBTC system, higher reliability of the communication system should be guaranteed for the safety of passengers and trains. However, due to the inherent characteristics of the wireless channel environment, performance degradations are inevitable. The diversity techniques can increase the reliability of data transmission using multiple antennas. In this paper, we investigate the performance of the STBC in the railway channel environment. Rician fading model is used for the viaduct scenarios which take important roles in the railway system. Also, considered is the Doppler effect which is an important factor in the mobile communication system. Simulations are performed to analyze the performance of the STBC in various channel environments. Results show that the performance degradation due to the phase error in viaduct scenarios is independent of the diversity order but is affected by the constellation of the modulation.

• Journal of Families and Better Life
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• v.35 no.1
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• pp.31-44
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• 2017

The purpose of this study was to examine the relationship between toddler's negative emotionality, parenting behavior, and the moderating roles of mother's personality. The participants in this study consisted of 221 mothers of toddlers (aged from 18 to 35months) in Seoul. The participants completed questionnaires on toddler's negative emotionality, their personality and parenting behavior. The collected data were mainly analyzed by descriptive statistics, t-test, one-way ANOVA, Duncan test, Pearson's correlation and the multiple regression analysis. The main findings of this study were as follows. First, there was a significant difference in the negative parenting behavior according to the mother's educational level. Second, relations between individual variables and parenting behavior were analyzed. As a result, number of children, mother's age, toddler's negative emotionality, and mother's personality were significantly correlated with parenting behavior. Third, through the analysis of the moderating effect of the mother's personality on the relationship between the toddler's negative emotionality and parenting behavior, it was found that interactions between the mother's neuroticism and the toddlers' negative emotionality affected the mother's warm parenting behavior. And interactions between the mother's extraversion and the toddlers's negative emotionality affected the mother's rejection parenting behavior. The results of this study provide basic data to support mothers' positive parenting behavior.

• The Korean Journal of Franchise Management
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• v.9 no.4
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• pp.33-43
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• 2018

Purpose - In hotel industry, quality of leader-member exchange(LMX) relationship is very critical, because it impacts on the employee's work attitude and behaviors. Thus, this research examines the effect of LMX on employee loyalty in the context of hotel business and identifies mediating roles of work stressors, work role performance in the relationship between LMX and employee loyalty. This research suggests the guidelines for how hotel leaders should manage their employees and build employee loyalty that improve management and business performance. Research design, data, and methodology - This study tests the structural relationship between LMX, work stressors, work role performance, and employee loyalty. Work role performance divide into three sub-dimensions such as individual task proficiency, individual task adaptivity, and individual task proactivity. In order to examine the purposes of this research, research model and hypotheses were developed. All constructs were measured with multiple items developed and tested in the previous studies. The data were collected from 113 franchise hotel employees and were analyzed using SPSS 22.0 and SmartPLS 3 program. Result - The findings of this research are as follows. First, leader-member exchange(LMX) have significant positive impacts on work stressors, work role performance, and employee loyalty. Second, work stressors have significant negative impacts on work role performance and employee loyalty. Third, work role performance has significant positive impact on employee loyalty. Conclusions - The outcomes of this research indicate that hotel leaders should focus on the dyadic relationship with their employees how to improve employee productivity through LMX relationship. In turn, the quality of this relationship influences employees's work attitudes and behaviors. As a result of increasing job demands in hotel business which relies heavily on human resources, the hotel leader must find ways to prevent or reduce stressors and associated strains. If hotel employees perceive the high quality of LMX relationship, they improve their work role performance which influences loyalty. Therefore, the hotel leaders should develop monetary or non-monetary reward system for the employees and, make an efforts to have unique social exchange relationships with employees.

• Journal of Families and Better Life
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• v.33 no.5
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• pp.87-102
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• 2015

The purpose of this study was to examine the relationship between job stress, turnover intention, and the moderating roles of motivation for child care work. The subjects were 238 child-care teachers who were worked at child-care centers in Seoul. Questionnaires were used to rate job stress, turnover intention, and the motivation for child care work of teachers. The collected data were mainly analyzed by descriptive statistics, t-test, one-way ANOVA, Duncan test, Pearson's correlation and the multiple regression analysis. The main results of this study were as follows. First, there were differences in turnover intention according to individual characteristics such as career at the current child-care center and total career. Second, job stress was positively correlated with turnover intention, and negatively correlated with active motivation and material motivation. And turnover intention was negatively correlated with active motivation and material motivation. Third, a moderator effect of the active motivation was found in the relationship between the job stress and the turnover intention. Especially the active motivation is suggested to reduce the negative results of job stress and turnover intention. Therefore, the results indicate the importance of the active motivation which is considered as an aptitude, interest, affection for children and self realization when child-care teachers make a decision to enter the child-care work profession.

• Molecules and Cells
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• v.40 no.3
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• pp.186-194
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• 2017

A brain-enriched secreting signal peptide, NELL2, has been suggested to play multiple roles in the development, survival, and activity of neurons in mammal. We investigated here a possible involvement of central NELL2 in regulating feeding behavior and metabolism. In situ hybridization and an immunohistochemical approach were used to determine expression of NELL2 as well as its colocalization with proopiomelanocortin (POMC) and neuropeptide Y (NPY) in the rat hypothalamus. To investigate the effect of NELL2 on feeding behavior, 2 nmole of antisense NELL2 oligodeoxynucleotide was administered into the lateral ventricle of adult male rat brains for 6 consecutive days, and changes in daily body weight, food, and water intake were monitored. Metabolic state-dependent NELL2 expression in the hypothalamus was tested in vivo using a fasting model. NELL2 was noticeably expressed in the hypothalamic nuclei controlling feeding behavior. Furthermore, all arcuatic POMC and NPY positive neurons produced NELL2. The NELL2 gene expression in the hypothalamus was up-regulated by fasting. However, NELL2 did not affect POMC and NPY gene expression in the hypothalamus. A blockade of NELL2 production in the hypothalamus led to a reduction in daily food intake, followed by a loss in body weight without a change in daily water intake in normal diet condition. NELL2 did not affect short-term hunger dependent appetite behavior. Our data suggests that hypothalamic NELL2 is associated with appetite behavior, and thus central NELL2 could be a new therapeutic target for obesity.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.43 no.4
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• pp.307-313
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• 2010

Stanniocalcin 1 (STC1) is a glycoprotein hormone that is important in the maintenance of calcium and phosphate homeostasis in both fish and mammals. STC1 and its paralog STC2 are expressed in multiple tissues in fishes, although the physiological roles of piscine STCs are still unclear compared with those of mammals. In this study, we cloned olive flounder STC1 (ofSTC1) and ofSTC2 cDNAs into pET28a vector and used E. coli Rosetta (DE3) as the host strain for protein expression. Expression experiments were carried out using isopropyl-$\beta$-D-thiogalactoside (IPTG) and nickel affinity chromatography. We could identify the recombinant proteins as single 29.5 kDa (ofSTC1) and 33.2 kDa (ofSTC2) bands in the insoluble fraction on sodium dodecyl sulfate- polyacrylamide gel electrophoresis (SDS-PAGE). These results indicate that ofSTC1 and ofSTC2 were expressed as insoluble proteins in E. coli. Furthermore, the injection of ofSTC1 protein into juvenile tilapia resulted in a decrease of the serum calcium level. These results suggest that the purified fish STC1 and STC2 proteins may be used to elucidate the physiological role of STCs in fishes.