• 한국지역사회생활과학회지
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• 제25권2호
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• pp.131-145
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• 2014

This study examines the effects of maternal behaviors and children's self-control ability on their subjective well-being. Data were collected from 416 fifth- and sixth-graders residing in Kwangju, Korea. Cronbach's ${\alpha}$ and the hierarchical regression analysis method were employed for a statistical analysis. According to the results of the hierarchical multiple regression analysis, children's self-control ability best explained their subjective well-being. For individual factors, motivational self-control had the greatest effect on subjective well-being, followed by behavioral self-control, cognitive self-control, the level of income, gender, and the employment status, in that order. The results for effects of maternal behaviors and children's self-control ability on children's subjective well-being highlight. The important roles played by the mother and the child's self-control ability in improving the child's subjective well-being. The study contributes to the literature by providing fundamental insights into children's higher quality of life.

• Human Ecology Research
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• 제57권3호
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• pp.419-430
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• 2019

This study examined the influences of middle school students' affective empathy and guilt-proneness on defending behavior against bullying and investigated if class climate (teacher support and student support) had moderating effects. The participants consisted of 163 second to third grade students (77 boys and 86 girls) in Seoul and Gyeonggi-do. The data were analyzed with descriptive statistics, Pearson's correlation, and hierarchical regression. Moderating effects were examined using multiple regression analysis. The results of this study indicated that guilt-proneness, teacher support, and student support had significant effects on the defending behavior of middle school students. The higher the level of guilt-proneness, the higher the level of defending behavior. Defending behavior was also higher when students perceived a belongingness to a classroom where their teacher and students provided support. However, affective empathy had no effect on defending behavior. Second, teacher support moderated the relation between guilt-proneness and defending behavior. The effects of guilt-proneness on defending behavior against bullying were greater when teacher support was high compared to low. The results suggested that guilt-proneness and classroom climate play important roles in increasing defending behavior in middle school students. Some implications for future research were also discussed.

• 셀메드
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• 제5권4호
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• pp.27.1-27.6
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• 2015

Literatures and experimental studies have shown that Prunella has an effect on anti-hypertension, however, its components are complicated, so that it is still difficult to clear the specific roles of its various components in blood pressure regulation in. So we decide to systematically study the anti-hypertension mechanism of Prunella. We integrated multiple databases and constructed molecular interaction network between the chemical constituents of Prunella Vulgaris and hypertension based on entity grammar systems model. The network has 262 nodes and 802 edges. Then we infer the interactions between chemical compositions and disease targets to clarify the anti-hypertension mechanism. Finally, we found Prunella could influence hypertension by regulating apoptosis, cell proliferation, blood vessel development and vasoconstriction, etc. Thus this study provides reference for drug development and compatibility, and also gives guidance for health care at a certain extent.

• Child Health Nursing Research
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• 제29권2호
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• pp.149-160
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• 2023

Purpose: Based on the health belief model and theory of planned behavior, this study investigated how age group (adolescence and emerging adulthood) moderated the relative effects of perceived susceptibility, perceived severity, and subjective norms on preventive behavior against coronavirus disease 2019 (COVID-19). Methods: This secondary data analysis utilized data from adolescents (n=272) and emerging adults (n=239). Hierarchical multiple regression analysis was performed to test the moderating effect of age group on the relationships among variables. Results: Higher perceived susceptibility (β=.21, p<.001), perceived severity (β=.14, p=.002), subjective norms (friends) (β=.26, p<.001), subjective norms (parents) (β=.44, p<.001), and subjective norms (schools) (β=.28, p<.001) enhanced COVID-19 preventive behaviors. Moderated regression analysis showed that subjective norms (friends and school) impacted preventive behavior in adolescents more than in emerging adults. Conclusion: Given the need to increase perceived susceptibility and severity among adolescents and emerging adults, these findings provide baseline data for designing effective COVID-19 prevention interventions that consider the developmental characteristics of different age groups. Interventions by health centers at universities can strengthen COVID-19 preventive behavior among emerging adults. As adolescents are influenced by friends, their peer roles must be strengthened to enhance adherence to COVID-19 preventive guidelines.

• IMMUNE NETWORK
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• 제9권4호
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• pp.122-126
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• 2009

Transforming growth factor-$\beta$ (TGF-$\beta$) is a highly pleiotropic cytokine playing pivotal roles in immune regulation. TGF-$\beta$ facilitates tumor cell survival and metastasis by targeting multiple cellular components. Focusing on its immunosuppressive functions, TGF-$\beta$ antagonists have been employed for cancer treatment to enhance tumor immunity. TGF-$\beta$ antagonists exert anti-tumor effects through #1 activating effector cells such as NK cells and cytotoxic $CD8^+$ Tcells (CTLs), #2 inhibiting regulatory/suppressor cell populations, #3 making tumor cells visible to immune cells, #4 inhibiting the production of tumor growth factors. This review focuses on the effect of TGF-$\beta$ on T cells, which are differentiated into effector T cells or newly identified tumor-supporting T cells.

• 대한가정학회지
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• 제49권10호
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• pp.15-27
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• 2011

The predominant concern of the study consists in:(1)the positive direct effects of both individual's intimacy toward parents and individual's self-efficacy of care-giving roles on individual's care-giving commitment; (2)the positive mediating effect of individual's self-efficacy of care-giving on individual's care-giving commitment; (3)the moderating effect of the degree of unhealthy condition of individual's elderly parents on each causal relationship. For conducting this study, a survey method was used on 318 males with parents at the aged of 45-60, residing in Daegu and KyungPook. In order for subjects to verify research questions, structural equation models were explored. The findings of the study supported the direct, indirect effect and moderating effects, which suggested in research questions. Participants with unhealthy parents showed greater tendency in terms of influencing their intimacy toward parents on care giving commitment than participants with healthy parents did. The above findings claimed our attention in that provided a range of practical implication.

• 한국콘텐츠학회논문지
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• 제13권11호
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• pp.277-287
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• 2013

본 연구에서는 혈액투석환자의 삶의 질과 사회적 지지와의 관계에서 공적 서비스가 수행할 수 있는 보완적 역할 가능성을 살펴보고자 하였다. 이를 위해 서울과 경기지역에 거주하고 있는 156명의 혈액투석환자를 대상으로 설문 조사를 실시하고 이 자료를 기초로 혈액투석환자의 삶의 질에 사회적 지지가 미치는 영향에서 공적 서비스의 조절효과를 분석하였다. 연구 결과 혈액투석환자의 삶의 질에 사회적 지지, 결혼형태, 직업유무가 유의미한 영향을 미치는 것으로 드러났고, 공적 서비스는 혈액투석환자의 삶의 질에 사회적 지지가 낮을 때 미치는 부적 영향을 완충해주는 조절효과를 가지고 있는 것으로 확인되었다. 이러한 결과를 근거로 혈액투석환자의 삶의 질을 높이는데 있어 공적 서비스 역할의 중요성과 효과적인 서비스 제공 방안을 제언하였다.

• 한국융합학회논문지
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• 제8권3호
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• pp.265-273
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• 2017

본 연구의 목적은 골프전공 대학생의 사회적 지지, 진로결정 자기효능감, 진로결정수준 간의 관계를 검증하는데 있다. 이런 목적을 위해 편의표집방법을 이용하여 서울과 수도권에 소재한 215명의 골프전공 대학생을 표본으로 추출하였고 기술통계, 상관관계 분석, 그리고 다중회귀분석을 실시하였다. 연구결과를 요약하면 다음과 같다. 첫째, 골프전공 대학생의 사회적 지지는 진로결정 자기효능감에 유의한 영향을 미치는 것으로 나타났다. 둘째, 골프전공 대학생의 사회적 지지는 진로결정수준에 유의한 영향을 미치는 것으로 나타났다. 셋째, 골프전공 대학생의 진로결정 자기효능감은 진로결정수준에 유의한 영향을 미치는 것으로 나타났다. 본 연구는 골프전공 학생들의 진로결정에 필요한 사회적 지지와 진로결정 자기효능감의 역할에 대한 실증적 자료를 제공했다는데 그 의의가 있다.

• 아동학회지
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• 제31권3호
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• pp.255-272
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• 2010

This study explored pathways from mothers' beliefs to children's subjective well-being through children's private after-school activities and stress levels. A sample of 230 6th grade elementary school students (125 boys and 105 girls) in Seoul completed questionnaires on children's stress and subjective well-being. Their mothers responded to questionnaires on mothers' beliefs and children's private after-school activities. Data were analyzed by means of Pearson's correlation coefficients and multiple regression analyses. Our results demonstrated that mothers' beliefs indirectly influenced children's subjective well-being through both children's private after-school activities and stress levels. Neither children's private after-school activities nor children's stress mediated between mothers' beliefs and children's subjective well-being. Mothers' beliefs also had a direct effect on children's subjective well-being. Significantly, both mothers' beliefs and children's stress played crucial roles in improving children's subjective well-being.

• 대한약침학회지
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• 제20권3호
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• pp.158-172
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• 2017

Nigella sativa (N. sativa, family Ranunculaceae) is a medicinal plant that has been widely used for centuries throughout the world as a natural remedy. A wide range of chemical compounds found in N. sativa expresses its vast therapeutic effects. Thymoquinone (TQ) is the main component (up to 50%) in the essential oil of N. sativa. Also, pinene (up to 15%), p-cymene (40%), thymohydroquinone (THQ), thymol (THY), and dithymoquinone (DTQ) are other pharmacologically active compounds of its oil. Other terpenoid compounds, such as carvacrol, carvone, 4-terpineol, limonenes, and citronellol, are also found in small quantities in its oil. The main pharmacological characteristics of this plant are immune system stimulatory, anti-inflammatory, hypotensive, hepatoprotective, antioxidant, anti-cancer, hypoglycemic, anti-tussive, milk production, uricosuric, choleretic, anti-fertility, and spasmolytic properties. In this regard, we have searched the scientific databases PubMed, Web of Science, and Google Scholar with keywords of N. sativa, anti-cancer, apoptotic effect, antitumor, antioxidant, and malignancy over the period from 2000 to 2017. The effectiveness of N. sativa against cancer in the blood system, kidneys, lungs, prostate, liver, and breast and on many malignant cell lines has been shown in many studies, but the molecular mechanisms behind that anti-cancer role are still not clearly understood. From among the many effects of N. sativa, including its anti-proliferative effect, cell cycle arrest, apoptosis induction, ROS generation, anti-metastasis/anti-angiogenesis effects, Akt pathway control, modulation of multiple molecular targets, including p53, p73, STAT-3, PTEN, and $PPAR-{\gamma}$, and activation of caspases, the main suggestive anti-cancer mechanisms of N. sativa are its free radical scavenger activity and the preservation of various anti-oxidant enzyme activities, such as glutathione peroxidase, catalase, and glutathione-S-transferase. In this review, we highlight the molecular mechanisms of apoptosis and the anti-cancer effects of N. sativa, with a focus on its molecular targets in apoptosis pathways.