• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5343-5348
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• 2015

Promoter hypermethylation of the runt-related transcription factor 3 (RUNX3) gene is associated with increased risk of hepatocellular carcinoma (HCC). Oxidative stress plays a vital role in both carcinogenesis and progression of HCC. However, whether oxidative stress and RUNX3 hypermethylation in HCC have a cause-and-effect relationship is not known. In this study, plasma protein carbonyl and total antioxidant capacity (TAC) in patients with hepatitis B virus (HBV)-associated HCC (n=60) and age-matched healthy subjects (n=80) was determined. RUNX3 methylation in peripheral blood mononuclear cells (PBMC) of subjects was measured by methylation-specific PCR. Effect of reactive oxygen species (ROS) on induction of RUNX3 hypermethylation in HCC cells was investigated. Plasma protein carbonyl content was significantly higher, whereas plasma TAC was significantly lower, in HCC patients than healthy controls. Based on logistic regression, increased plasma protein carbonyl and decreased plasma TAC were independently associated with increased risk for HCC. PBMC RUNX3 methylation in the patient group was significantly greater than in the healthy group. RUNX3 methylation in hydrogen peroxide ($H_2O_2$)-treated HepG2 cells was significantly higher than in untreated control cells. In conclusion, increase in oxidative stress in Thai patients with HBV-associated HCC was demonstrated. This oxidative increment was independently associated with an increased risk for HCC development. RUNX3 in PBMC was found to be hypermethylated in the HCC patients. In vitro, RUNX3 hypermethylation was experimentally induced by $H_2O_2$. Our findings suggest that oxidative stress is a cause of RUNX3 promoter hypermethylation in HCC cells.

• Korean Journal of Child Studies
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• v.26 no.4
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• pp.293-302
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• 2005

This study investigated behavior characteristics for the gifted(N=210) and the high achievers(N=1l5). The participations in this study were 200 teachers who rated their 325 students' behavior characteristics in 25 public elementary schools in U.S.A rating of behavior characteristics in learning style, motivation, creativity, and leaderships by teachers indicated differences in keen observation, rapid insight into cause-effect relationship, a large storehouse of information, language fluency, absorption/task persistent, preference for own learning activities, concerns for moral/ethical issues, and a diversity of interests between groups. No differences in understanding of underlying principles, organization, curiosity, creativeness, motivation, initiating activities in areas of personal interest, directing group activities, and intellectual playfulness/imagination were found in addition to some differences between two groups.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.809-816
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• 2002

전통적 재무제표가 기업의 재무적인 성과 측정에만 초점을 맞춘다는 한계를 극복하기 위한 방법으로서 BSC(Balanced Scorecard)가 제시되었다. BSC는 KPI(Key Performance Indicator)들의 상관관계가 명확하고 논리적이라는 장점 때문에 정부 및 기업의 다양한 분야에서 적용되어왔다. 이러한 BSC는 KPI를 통해 측정된 값의 비교에 대한 고려를 하고 있지 않으므로 다수 조직의 성과를 비교하기에 어려움이 있다. 조직의 효율성을 rPfidd적으로 나타내는 여러 기법 중, 경영과학 기법을 이용한 DEA의 경우 다수의 측정 지표를 단일의 통합된 성과 측정 지표 (Aggregate Performance Measure)_로 나타낼 수 있다는 장점이 있으나, DEA에 고려되는 입력 및 출력의 개수에 제한이 있으며 다수 조직의 분석에 사용해야 한다는 단점이 있다. 본 연구에서는, 재무적인 요소와 비재무적인 요소를 포괄하여 조직간의 효율성을 비교하기 위한 벙법으로서, DEA를 이용한 효율성 평가에 조직의 성과측정 기법인 BSC가 제공하는 KPI 간의 노릴적 인과관계(cause-and-effect relationship)와 측정 지표를 이용하는 방법으로 CDB(Combined DEA and BSC methodology)를 제안한다. 이를 위하여 BSC 정보 비교 가능한 형태로 바꾸는 방법을 제시하며, 기존 DEA가 지니는 입력 및 출력 변수 개수의 증가에 따른 효율성의 구분능력의 감소와 관련된 한계를 극복할 수 있는 방법을 제시한다.

• Journal of Korea Foundry Society
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• v.13 no.1
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• pp.50-61
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• 1993

Retained austenite in matrix of austempered ductile iron has been well-known as a parameter in controlling mechanical properties, but investigation to obtain quantitative relationship with mechanical properties lack. Therefore, this study executed austempering treatment at various temperatures on ductile iron alloyed with Mo, Ni, Cu. In consequence, microstructure of retained austenite transformed coarse, and quantity increased according as austempering temperature increased. After heat-treatment, microstructure of specimen alloyed with Ni was fine, and toughness improved. At austempering temperature up to $400^{\circ}C$, carbide precipitation started in retained austenite. In consequence, afforded cause of hardness increase, a lot of increase did not arise for coarse structure.

• Health Policy and Management
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• v.14 no.1
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• pp.65-88
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• 2004

In general, empowerment is defined as the motivational concept of autonomy and self-efficacy. Recently, the concept of empowerment is applied to improve organizational staff's job satisfaction and organizational commitment in many organizations. Empower-ment in service organizations, i.e., hospitals, has certainly generated more publicity than any other organizations. The objectives of this study are, first, to measure the degree of hospital employees' empowerment using Spreitzer(1995)'s empowerment theory, second, to analyze the causal relationship of organizational and job characteristics, a degree of empowerment, and organizational performance(job satisfaction and organizational commitment), and third, to offer the strategy for the improvement of job satisfaction and organizational commitment. Spreitzer insists that the empowerment is composed of 4 dimensions(meaning, competence, self-determination, and impact). And he argues that various work-related characteristics is a direct cause of empowerment and the indirect cause of job satisfaction and organizational commitment, mediated by the empowerment latent variable. In order to perform this study, data were collected by self-administered questionnaires from hospital employees working in administrative department of 3 university hospitals in Inchon and Kyunggi-Do region. The number of cases is 181(response rate; 86%). The Collected data were analyzed with SPSS Ver. 10.0 and AMOSV Ver. 4.0. First, to test validity of variables, the factor analysis was used. Second, to test reliability, Cronbach's alpha coefficients was calculated. Cronbach's alpha of empowerment variable is 0.8323 showing that there's no problem in regard to the internal consistency. Also the Cronbach's alpha of other variables are 0.8301 of the degree of perceived control, 0.6705 of job characteristics, O.8787 of compensation, 0.9254 of job satisfaction, and 0.8389 of organizational commitment, respectively. Among the questions of job characteristics, two survey questions are deleted due to lowering the reliability. Third, to test multicollinearity and correlation of variables, the correlation analysis was performed. There was no problem of multicollinearity. Finally structural equation modelling (SEM) analysis was conducted to find the causal relationship of organizational and job Characteristics, empowerment, job satisfaction and organizational commitment. The 16 variables are included for the SEM analysis. The major results of this study are as follows: First, in the case of model fitness, the condition of x$^2$ statistic(92.187) is not fully satisfied, but the indices of GFI(0.912), AGFI(0.863), NFI(0.917) and CFI(0.928) are partially satisfied, which needs to upper 0.90. Second, in the result of hypotheses testing, all hypotheses are accepted and have a positive effect in 95% or 99% confidence interval(P<0.05 or P<0.001) except the effect of compensation variable on empowerment(P=0.082). Third, in regard to the direct, indirect, and total effect of variables, the direct effect of perceived control, task characteristics, and compensation on job satisfaction are 0.728, 2.264, 0.328 and on organizational commitment are 0.094, 1.411, 0.418, respectively. Also the indirect effect of perceived control, task characteristics, and compensation on job satisfaction are 0.311, 0.196, 0.028 and on organizational commitment are 0.210, 0.132, 0.019, respectively. Thus, these findings imply that various work-related factors are direct effect of empowerment and indirect effect of result variables, job satisfaction and organizational commitment. Also These results showed that the workplace empowerment is significant mediating factor of employee's job satisfaction and organizational commitment.

• International journal of advanced smart convergence
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• v.12 no.4
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• pp.328-333
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• 2023

Breaking the fourth wall is a very popular concept right now, and depictions of breaking the barrier between virtuality and reality are often used in game advertising. In VR games, game manufacturers describe the experience after breaking the fourth wall as an experiencer who will be completely immersed in the virtual world, as if they are actually living in the virtual world. At the same time, research in the field of traditional drama also shows that breaking the fourth wall can also bring a sense of alienation to the player, allowing the experiencer to clearly realize that he and the character are in a completely different world, and to conduct aesthetic criticism of related works of art.So why there are two completely different feelings after breaking the fourth wall will be the content of this article. This article will focus on the theoretical analysis of the relationship between two different cognitions and two completely different cognitions after breaking the fourth wall. Finally, it will be analyzed from three directions: game perspective, game art style, and different world views of the game. Finally, it was concluded that when players break the fourth wall in the game, these three factors will cause the experiencer to have two completely different cognitions.

• Journal of Distribution Science
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• v.17 no.8
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• pp.35-44
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• 2019

Purpose - This study examines the changes in the mobile MMORPG market in recent years and the factors affecting the performance of mobile games through flow experience according to the characteristics of game content. Research design, data, and methodology - This study focuses on the fact that the cause of game use behavior changes is the flow experience which influences the duration of mobile game continuation. The flow experience and the influencing factors are divided into the relationship between first, second-leading factors, and lagged factors. Results - The user's sense of challenge, skillfulness, concentration, and reality influenced the flow experience as a leading factor influencing the performance of MMORPG games. On the other hand, fun and preference were found to be the outcomes of the flow experience. This is because the game content is experienced not through passive enjoyment but by intentionally enjoying the game content. The flow experience has a positive effect on the intention of continuous use as in the previous study. Conclusions - This study found that the flow experience of game users is necessary for continuous use by organizing relationships of flow experience in mobile MMORPG users' gaming behavior.

• Journal of Welding and Joining
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• v.2 no.1
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• pp.30-40
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• 1984

Moisture content in the coating of an electrode is known to cause defects such as porosities, fish eyes and cracks in the weld metal, however, quantitative relationship between them is not clearly understood. In this study widely consumed and the most common type of arc welding rods such as ilmenite and low hydrogen type were chosen for the investigation, and attempts were made to correlate the relationship between the mechanical properties and gas contents when welding was carried out with electrodes of various moisture contents. As the relative humidity changed from 70% to 92%, it was determined that moisture content to reach saturation was in the range of 0.6~6.8%. As the moisture content in the electrode coating was increased, the amount of gaseous components (H, O, N) in the weld metal was accordingly increased, especially diffusible hydrogen showed prominent effect, i.e. it increased proportionally to the increase of the moisture content. The mechanical properties of the weld metal was observed to become more inferior as the diffusible hydrogen was greater. It was determined for ilmenite type of electrode that the increase of hydrogen content was approximately 1.8ml per unit weight percent increase of moisture and also tensile strength resulted lowering from $45.3kg/\textrm{mm}^2$ to $42.7kg/\textrm{mm}^2$ as moisture content increased from 0.7% to 6.8%. For low hydrogen type the increase of the hyrogen was about 2.4ml per unit percent of moisture and tensile strength decreased from $63.0kg/\textrm{mm}^2$ to $53.8kg/\textrm{mm}^2$ particularly in the region of moisture content 0.1~4.2%.

• Korean journal of food and cookery science
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• v.22 no.6 s.96
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• pp.783-791
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• 2006

The consciousness and eating habits of the housekeeper directly influence the stress level and health quality of the household occupants. In Korea, most housewives are in charge of dietary life. Accordingly, their attitudinal clusters toward dietary (eating) life were researched in relation to their stress and health. The research results showed that irregular eating habits cause stress. Therefore, it is necessary for housewives to have a regular eating habit. The results were as follows. The house wives' attitudes toward dietary life were categorized into 5 clusters: regular and speedy overeating, regular and frequent eating, regular and light eating, irregular and light eating, irregular and speedy overeating. The cluster of regular and frequent snacks was 24.3%. The cluster of irregular and speedy overeating caused the most stress. Especially the house wives' group belonging to the cluster of irregular and speedy overeating were under social and emotional stress, while the cluster of regular and light eating and the cluster of irregular and light eating were under concentration stress. The cluster of regular and frequent snacks and the cluster of irregular and light eating had negative effect on their health, while the cluster of regular and speedy overeating had negative effect on their family's health by their social stress.

• Journal of Environmental Health Sciences
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• v.36 no.1
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• pp.20-26
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• 2010

Temperature change has been shown to affect daily mortality even though different analytical methods produce different results. The effect of air pollution on the relationship between the temperature and the mortality is not large, although differences exist between temperature models. The aim of this study was to examine how the temperature change affected the daily mortality in Seoul by comparing the results from the temperature model using two study periods: one from 1994 to 2007 and the other from 1997 to 2007. Generally mean temperature, minimum temperature and Q10 temperature was derived as an optimal model, even though there are differences between age and cause of death. The analysis of threshold using total mortalities in all ages from 1994 to 2007 and from 1997 to 2007 showed that the number of the deaths increased 7.02% (95% CI: 6.06~7.98) and 2.51% (95% CI: 1.83~3.19), respectively as the mean temperature increased $1^{\circ}C$ from a threshold temperature of $27.5^{\circ}C$ and $25.7^{\circ}C$ respectively. These results indicated that the temperature has less effect on the number of death than does an extreme heat wave period.