• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.74-79
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• 1996

• Proceedings of the Korean Vacuum Society Conference
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• 1994.02a
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• pp.16-16
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• 1994

• BMB Reports
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• v.46 no.1
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• pp.47-52
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• 2013

Intestinal epithelial cell (IEC) apoptosis induced by hypoxia compromise intestinal epithelium barrier function. Both Akt and Hsp90 have cytoprotective function. However, the specific role of Akt and $Hsp90{\beta}$ in IEC apoptosis induced by hypoxia has not been explored. We confirmed that hypoxia-induced apoptosis was reduced by $Hsp90{\beta}$ overexpression but enhanced by decreasing $Hsp90{\beta}$ expression. $Hsp90{\beta}$ overexpression enhanced BAD phosphorylation and thus reduced mitochondrial release of cytochrome C. Reducing $Hsp90{\beta}$ expression had opposite effects. The protective effect of $Hsp90{\beta}$ against apoptosis was negated by LY294002, an Akt inhibitor. Further study showed that Akt phosphorylation was enhanced by $Hsp90{\beta}$, which was not due to the activation of upstream PI3K and PDK1 but because of stabilization of pAkt via direct interaction between $Hsp90{\beta}$ and pAkt. These results demonstrate that $Hsp90{\beta}$ may play a significant role in protecting IECs from hypoxia-induced apoptosis via stabilizing pAkt to phosphorylate BAD and reduce cytochrome C release.

• 아동간호학회:학술대회논문집
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• 1996.06a
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• pp.54-55
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• 1996

• The Bulletin of The Korean Astronomical Society
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• v.41 no.1
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• pp.44.2-44.2
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• 2016

The solar wind electrons are made of three or four distinct components, which are core Maxwellian background, isotropic halo, and super-halo (and sometimes, highly field-aligned strahl component which can be considered as a fourth element). We put forth a steady-state model for the solar wind electrons by considering both the steady-state particle and wave kinetic equations. Since the steady-state solar wind electron VDFs and the steady-state wave fluctuation spectrum are related to each other, we also investigate the complete fluctuation spectra in the whistler and Langmuir frequency ranges by considering halo- and superhalo-like model electron VDFs. It is found that the energetic electrons make important contributions to the total emission spectrum. Based on this, we complete the steady-state model by considering both the whistler and Langmuir fluctuations. In particular, the Langmuir fluctuation plays an important role in the formation and maintenance of nonthermal electrons.

• Journal of Families and Better Life
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• v.11 no.1
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• pp.134-148
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• 1993

The study was designed to examine the present state of the provider-role consciousness of married working women in Korea and to identify five variable-clusters which were drawn from the theoretical perspectives. The subjects of this study were 573 married working women whose husbands also had their work. The statistical methods adopted for data analyses were frequencies. oneway ANOVA. Scheffe-test t-test, and multiple regression analysis. The major findings of this study can be summarized as follows; 1) The level of the provider-role consciousness of married working women was slightly high. 2) As for the aspects of the individual attribute variables. educational level job income age native area motive of work. and sex-role identity significantly influenced the provider-role consciousness of married working women. 3) Concerning the family background variables marriage duration number of children mother's experience of employment father's educational level and husbands's income were significantly related to the provider-role consciousness of married working women, 4) As for the social relationship variables. degree of participation in social associations significant others' attitudes toward housewife's work degree of domestic role sharing with husband and wife/husband income ration significantly affected the provider-role conscious-ness of married working women. Based on these findings it came to be revealed that multidirectional perspecitves were useful to identify variables which could predict the provider-role consciousness of married working women, Also it was revealed that the significant others' approvals for women's work were necessary to the establishment of the provider-role consciousness of married working women.

• Korean Journal of Social Welfare
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• v.35
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• pp.289-317
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• 1998

This study aims to review and evaluate the changes of the British social housing policy under the Conservative government(1979-1997), and to get some implications for the Korean case. The Conservatives tried to diminish the role of state in the realm of social welfare :in general, and to retreat the social housing policy in particular as a reaction to the' welfare state crisis' started from the early 1970s. In the realm of housing policy, privatisation and marketisation including the massive sale of council houses were driven enthusiastically. Public expenditure cut and redirection of the housing subsidy scheme were also implemented according to the changed policy orientation. The clear visible results of the policy changes can be seen as follows; radical changes of the housing tenure distribution, changing role of local authorities, and the worsening housing problems- housing shortages, residualisation, affordability problem, deepening dependency and the negative distribution of housing subsidy etc. Furthermore the goal of public expenditure cut, in fact, was not accomplished successfully. The results of this study support the argument that the Neo-liberalistic approach to the 'welfare state crisis' have resulted in reconstruction and redirection rather than total abolition of the role of state in welfare provision. This conclusion could provide important implications to Korean case, especially concerning the role of state in the social housing policy.

• Journal of Microbiology and Biotechnology
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• v.19 no.5
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• pp.431-438
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• 2009

The alkaline serine protease asp, which was shown to be a virulence factor of Vibrio alginolyticus as a purified protein, was cloned from V. alginolyticus EPGS, a strain recently isolated from moribund Epinephelus coioides in an outbreak of vibriosis in a mariculture farm of Shenzhen. The asp null mutant was constructed by homologous recombination with suicide plasmid pNQ705-1. Compared with the wild-type strain, the asp null mutant exhibited a significant decrease of total extracellular protease activity, and caused a IS-fold decrease in virulence of V. alginolyticus. In our previous study, the luxO and $luxR_{val}$ genes from V. alginolyticus MVP01 were cloned and identified, and the luxO-$luxR_{val}$ regulatory couple was shown to regulate various genes expression, suggesting that it played a central role in the quorum sensing system of V. alginolyticus. In this study, the regulation of the asp gene was analyzed by using RT-PCR and quantitative real-time PCR methods; we proved that its transcription was greatly induced at the late stage of growth and was regulated by a luxO-$luxR_{val}$ regulatory system.

• Korean Journal of Social Welfare
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• v.67 no.2
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• pp.259-284
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• 2015

This case study is to identify the role and strategies of think tanks in Britain which have shown institutional initiative in global welfare paradigm such as the establishment of welfare state, Thatcherism, and the Third Way. Fabian Society, Institute of Economic Affairs (IEA), Institute for Public Policy Research (IPPR), and Policy Exchange (PX) were selected for the research, and seven staff members from these think tanks were interviewed while their relevant publications were gathered and analyzed. As a result, the role of each think tank in welfare paradigm change were presented as well as strategic similarities were found: distinguished idea on the relationship between economy and welfare, adherence to independence based on their values, and strategic communication with diverse routs. However, there was also strategic difference between the first round and the second in the history. In the first round between Fabian Society and IEA, building a space for discussion based on new paradigm was the key, while in the second round between IPPR and PX, producing a set of alternative policies was the main task for them. This British example may provide useful implication to Korea, in which political debate on social welfare still just focus on individual pledges competition and the role of think tank is highly limited.

• Child Studies in Asia-Pacific Contexts
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• v.7 no.1
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• pp.39-55
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• 2017

This study explored the role of Korean immigrant churches as a social context for Korean American youths, with a specific focus on its role in ethnic socialization. Semistructured interviews were conducted with 23 Korean American young adults. The results show that such churches serve as a salient social context for Korean American youths in which day-to-day lives are deeply integrated. Specifically, they serve as a salient context for coethnic peer relationships and family interactions. Moreover, Korean immigrant churches play a salient role as an agent of enculturation for Korean American youths by engaging them in cultural socialization, constructing and transmitting immigrant discourse, and providing a coethnic community. Taken as whole, findings suggest a distinct and salient role of immigrant churches in the lives of Korean American youths and highlight the importance of studying the social context specific to the children of immigrants.