• Toxicological Research
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• v.23 no.1
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• pp.65-72
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• 2007

This study was conducted to obtain information of the oral dose acute toxicity of PGB-2, a novel polyglucosamine polymer produced from Citrobacter sp. BL-4 (a new strain) in male and female mice. Mortality, body weight changes, clinical signs were monitored during 14 days after single oral dose of test article at dose levels of 2000, 1000, 500, 250 and 125 ml/kg. Gross lesions, organ weight and histopathology of principal organs were examined after necropsy. As the results, we could not find any mortalities, clinical signs, changes in the body weight and gross findings except for white foci in the liver. In addition, no PGB-2-treatment related abnormal changes on the organ weight and histopathology of principle organs were detected except for atypical signs of liver. White liver foci were confirmed as focal infiltration of inflammatory cells. The results suggest that the PGB-2 is relatively safe in mice but the possibility of hepatotoxicity could not be excluded. The $LD_{50}$ and approximate LD in mice after single oral dose of PGB-2 were considered over 2000 mg/kg, respectively. In future, the potential hepatotoxicity of PGB-2 should be evaluated through the repeat dose toxicity test prior to develop as a new agent.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.40 no.12
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• pp.1040-1047
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• 2012

This paper presents a fault diagnosis algorithm of control surfaces of small fixed-wing aircraft to reduce maintenance cost or to improve repair efficiency by estimation of fault occurrence or part replacement periods. The proposed fault diagnosis algorithm consists of ANPSD (Averaged Normalized Power Spectral Density), PCA (Principle Component Analysis), and GC (Geometric Classifier). ANPSD is used for frequency-domain vibration testing. PCA has advantage to extract compressed information from ANPSD. GC has good properties to minimize errors of the fault detection and isolation. The algorithm was verified by the accelerometer measurements of the scaled normal and faulty ailerons and the test results show that the algorithm is suitable for the detection and isolation of the control surface faults. This paper also proposes solutions for some kind of implementation problems.

• The Korean Journal of Applied Statistics
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• v.28 no.1
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• pp.103-114
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• 2015

The role of small and medium enterprises as an economic growth factor has been accentuated; consequently, the need to develop a business forecast model and indexes that accurately examine business situation of small and medium enterprises has increased. Most current business model and indexes concerning small and medium enterprises, released by public and private institutions, are based on Business Survey Index (BSI) and depend on subjective (business model and) indexes; therefore, the business model and indexes lack a capacity to grasp an accurate business situation of these enterprises. The business forecast model and indexes suggested in the study have been newly developed with Principal Component Analysis(PCA) and weight method to accurately measure a business situation based on reference dates addressed by the National Statistical Office(NSO). Empirical studies will be presented to prove that the newly proposed business model and indexes have their basis in statistical theory and their trend that resembles the existing Composite Index.

• Journal of the Korea Computer Graphics Society
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• v.24 no.2
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• pp.11-20
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• 2018

We propose a new method particle-based method that explicitly preserves thin liquid sheets for animating liquids on CPU-GPU heterogeneous computing framework. Our primary contribution is a particle-based framework that splits at thin points and collapses at dense points to prevent the breakup of liquid on GPU. In contrast to existing surface tracking methods, the our method does not suffer from numerical diffusion or tangles, and robustly handles topology changes on CPU-GPU framework. The thin features are detected by examining stretches of distributions of neighboring particles by performing PCA(Principle component analysis), which is used to reconstruct thin surfaces with anisotropic kernels. The efficiency of the candidate position extraction process to calculate the position of the fluid particle was rapidly improved based on the CPU-GPU heterogeneous computing techniques. Proposed algorithm is intuitively implemented, easy to parallelize and capable of producing quickly detailed thin liquid animations.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.40 no.2
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• pp.11-19
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• 2003

This paper proposes an algorithm to reduce the estimation error of surface spectral-reflectance(SR) using a conventional 3-band RGB camera. In the proposed method, estimation error can be reduced by using adaptive principal components(PCs) for each color region. In order to build adaptive set of PCs, n SR populations are organized for n PC sets by using Lloyd quantizer design algorithm. Macbetch ColorCheckcer is utilized as initial representative SR values for 1485 Munsell color chips of total color population and the Munsell chips arc divided subsets and a set of corresponding adaptive PCs per each subset is organized. As a result of experiments, the proposed method showed advanced estimation performance compared to both the two 3-band PCA methods and the 5-band wiener method.

• Toxicological Research
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• v.23 no.4
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• pp.373-382
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• 2007

This study was conducted to obtain acute information of the oral dose toxicity of PGB-1, a novel polyglucosamine polymer produced from a new strain Enterobacter sp. BL-2 in male and female mice. In order to calculated 50% lethal dose ($LD_{50}$) and approximate lethal dose (LD), test material was once orally administered to male and female ICR mice at dose levels of 2000, 1000, 500, 250, 125 and 0 (vehicle control) ml/kg (body wt.). The mortality and changes on body weight, clinical signs, gross observation and organ weight and histopathology of principle organs were monitored 14 days after dosing with PGB-1. We could not find any mortalities, clinical signs, body weight changes and gross findings. In addition, significant changes in the organ weight and histopathology of principal organs were not observed except for some sporadic findings. The results obtained in this study suggest that PGB-1 may not be toxic in mice and may be therefore safe for clinical use. The $LD_{50}$ and approximate LD in mice after single oral dose of PGB-1 were considered over 2000 mg/kg in both female and male mice.

• Archives of design research
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• v.11 no.1
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• pp.153-160
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• 1998

User, contents exchanged between user and computer system, and media are axes among the vanous factors related to multimedia interface. The points of contact resulted by three mam factors bring many design problems. User factor is most important among and its cognitive constraints become mam design principle for multi-modality features of multimedia. Because media could be understood differently depending on the level of information delivery, it is necessary that various characteristics and representation mode of media are clarified. This thesis develops design evaluation process that tells multimedia interface as a entity integrated with contents, media, and representation elements and assesses its sub elements whether they are correspond with design principal.

• KIPS Transactions on Computer and Communication Systems
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• v.8 no.4
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• pp.93-102
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• 2019

As interest in wellness grows, There is a lot of research about monitoring individual health using wearable devices. Accordingly, a variety of methods have been studied to distinguish exercise from daily activities using wearable devices. Most of these existing studies are machine learning methods. However, there are problems with over-fitting on individual person's learning, data discontinuously recognition by independent segmenting and fake activity. This paper suggests a detection method for exercise activity based on the physiological response principle of heart rate up and down during exercise. This proposed method calculates activity intensity and heart rate from triaxial and photoplethysmography sensor to determine a heart rate recovery, then detects exercise by estimating activity intensity or detecting a heart rate rising state. Experimental results show that our proposed algorithm has 98.64% of averaged accuracy, 98.05% of averaged precision and 98.62% of averaged recall.

• Journal of Plant Biotechnology
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• v.43 no.2
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• pp.213-222
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• 2016

This study aims to establish a system for the rapid discrimination of Zoysia species using metabolite fingerprinting of FT-IR spectroscopy combined with multivariate analysis. Whole cell extracts from leaves of 19 identified Zoysia japonica, 6 identified Zoysia sinica, and 38 different unidentified Zoysia species were subjected to Fourier transform infrared spectroscopy (FT-IR). PCA (principle component analysis) and PLS-DA (partial least square discriminant analysis) from FT-IR spectral data successfully divided the 25 identified turf grasses into two groups, representing good agreement with species identification using molecular markers. PC (principal component) loading values show that the $1,100{\sim}950cm^{-1}$ region of the FT-IR spectra are important for the discrimination of Zoysia species. A dendrogram based on hierarchical clustering analysis (HCA) from the PCA and PLS-DA data of turf grasses showed that turf grass samples were divided into Zoysia japonica and Zoysia sinica in a species-dependent manner. PCA and PLS-DA from FT-IR spectral data of Zoysia species identified and unidentified by molecular markers successfully divided the 49 turf grasses into Z. japonica and Z. sinica. In particular, PLS-DA and the HCA dendrogram could mostly discriminate the 47 Z. japonica grasses into two groups depending on their origins (mountainous areas and island area). Considering these results, we suggest that FT-IR fingerprinting combined with multivariate analysis could be applied to discriminate between Zoysia species as well as their geographical origins of various Zoysia species.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.14
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• pp.103-152
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• 2000

English contract law has traditionally taken the view that it is not the duty of the parties to a contract to give information voluntarily to each other. In English law, one of the principal distinctions between insurance contract law and general contract law is the existence of the doctrine of utmost good faith in insurance law. The doctrine gives rise to a variety of duties, some of which apply before formation of the contract while others apply post-formation. This article is, therefore, designed to analyse the overall structure and problems of the doctrine of utmost good faith in English marine insurance law. The results of analysis are as following : First, the requirement of utmost good faith in marine insurance law arises from the fact that many of the relevant circumstances are within the exclusive knowledge of the assured and it is impossible for the insurer to obtain the facts to make a appropriate calculation of the risk that he is asked to assume without this information. Secondly, the duty of utmost good faith provided in MIA 1906, s. 17 has the nature as a bilateral or reciprocal, overriding and absolute duty. Thirdly, the Court of Appeal in Skandia held that breach of the pre-formation duty of utmost good faith did not sound in damages since the duty did not arise out of an implied contractual term and the breach did not constitute a tort. Instead, the Court of Appeal held that the duty was an extra-contractual duty imposed by law in the form of a contingent condition precedent to the enforceability of the contract. Fourthly, the scope of the duty of utmost good faith is closely related to the test of materiality and the assured is required to disclose only material circumstances subject to MIA 1906, s. 18(1) and 20(1). The test of materiality, which had caused a great deal of debate in English courts over 30 years, was finally settled by the House of Lords in Pan Atlantic and the House of Lords rejected the 'decisive influence' test and the 'increased risk' test, and the decision of the House of Lords is thought to accept the 'mere influence' test in subsequent case by the Court of Appeal. Fifthly, the insurer is, in order to avoid contract, required to provide proof that he is induced to enter into the contract by reason of the non-disclosure or misrepresentation of the assured. Sixthly, the duty of utmost good faith is, in principle, terminated before contract is concluded, but it is undoubtful that the provision under MIA 1906, s. 17 is wide enough to include the post-formation duty. The post-formation duty is, however, based upon the terms of marine insurance contract, and the duty lies entirely outside s. 17. Finally, MIA 1906, s. 17 provides expressly for the remedy of avoidance of the contract for breach of the duty. This means rescission or retrospective avoidance of the entire contract, and the remedy is based upon a fairly crude 'all-or-nothing' approach. What is needed in English marine insurance law is to introduce a more sophiscated or proportionate remedy.