• 제목/요약/키워드: the East

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Forsythiae Fructus and Its Active Component, Arctigenin, Provide Neuroprotection by Inhibiting Neuroinflammation

  • Park, Ji-Ho;Hong, Ye-Ji;Moon, Eun-Jung;Kim, Seul-A;Kim, Sun-Yeou
    • Biomolecules & Therapeutics
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    • 제19권4호
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    • pp.425-430
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    • 2011
  • In this study, we found that Forsythiae fructus (FF) and one of its main compounds, arctigenin, significantly inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Arctigenin also suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2, and inhibited the activation of extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38. Moreover, it also reduced levels of proinflammatory cytokines, interleukin $1{\beta}$, tumor necrosis factor ${\alpha}$ and prostaglandin E2, and inhibited neuronal death in LPS-treated organotypic hippocampal cultures. Therefore, we suggest that arctigenin may confer a neuroprotective effect via the inhibition of neuroinflammation.

암 환자의 한약-양약 상호작용에 대한 고찰 (Study about Herb-Drug Interaction for Cancer Patients)

  • 방선휘;한성수;조정효;이연월;조종관;유화승
    • 대한한방내과학회지
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    • 제29권4호
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    • pp.887-903
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    • 2008
  • Objectives : We present some opinions to reduce the risk of herb-drug interactions through scanning "About Herbs" of the Memorial Sloan Kettering Cancer Center Website. Methods : We searched the Memorial Sloan Kettering Cancer Center Website of About Herbs and investigated herb-drug interactions. Results : There are 237 herbs and 196 drugs on About Herbs. 81.1% of herbs have fewer than 2 interactions listed.: 86.3% of drugs fewer than 3 interactions. Especially, 13 herbs were reported to have interactions with inclusive chemoagents on About Herbs. Only L-theanine has positive interaction with inclusive chemoagents. The others have negative interactions with inclusive chemoagents. 12 single chemoagents were reported to have interactions with some herbs. Especially tamoxifen-black cohosh, methotrexate-glutamin and aldesleukin-Huang Chi have positive interactions to increase the effects of the chemoagent. Conclusions : We should urgently create a risk management system of herb-drug interactions and take note of the risk of herb-drug interactions. We should build up systemic, evidence-based informations on popular herbs used by Korean cancer patients and herb-drug interactions in oncology like About Herbs.

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한약에 의한 진행성 위선암의 퇴축에 대한 증례보고 - 8년간의 추적조사를 통한 후향적 증례연구 (A Case of Regression of Advanced Gastric Cancer by Herbal Medicine - A Retrospective Case Study with 8-years Follow-up)

  • 박정석;이연월;조정효;손창규;조종관;유화승
    • 대한한방내과학회지
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    • 제28권1호
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    • pp.193-198
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    • 2007
  • Objective : The aim is to derive further studies evaluating the effectiveness of oriental medical treatment on advanced gastric cancer (AGC) patients. We present a case of a stage IV AGC patient who has survived over 8 years. Methods : We followed up all documents related to the patient. We prescribed to the patient HangAmDan (HAD) three times a day over five years. Abdomen CT was performed to evaluate the therapeutic efficacy. Results : The patient has survived over 8 years. Abdomen CT has shown complete regression. Conclusion : This case may give us the possibility of that oriental medical treatment offers potential benefits for patients with AGC.

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암환자의 사상체질별 사초 부위와 원발암 부위의 체열 분석 연구 (Thermogram analysis of Sasang constitutional Four Burners and primary cancer organ in cancer patients)

  • 서영광;김은희;김선형;김달래;최원철;이수경
    • 대한암한의학회지
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    • 제13권1호
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    • pp.25-32
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    • 2008
  • 1. Objective This study was conducted to research a corelation between the Sasang constitutions and primary cancer organs in cancer patient with their thermography. 2. Method We Analyzed the thermography taken from cancer patients and compared it with their cancer origins and Sasang constitution. 3. Result It was found that there are some relationships between the cancer origins and abnormal skin temperature. Also according to the Sasang constitutions of each cancer patient, the lesion of abnormal skin temperature could be differentiated. 4. Conclusion Thermogram can be affected by both the constitution and the primary cancer organs of the patient. To utilize the thermography as a diagnostic or prognostic method of cancer, further studies are needed.

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