• Korean Educational Research Journal
• /
• v.43 no.1
• /
• pp.1-27
• /
• 2022

As the COVID-19 virus became prevalent worldwide, non-face-to-face contact was implemented in various ways, and the education system also began to draw much attention due to rapid non-face-to-face contact. The purpose of this study is to analyze the direction of non-face-to-face education in line with the continuously changing educational environment to date. In this study, data were visualized using Textom and Ucinet6 analysis tool programs to collect social network big data with various opinions. As a result of the study, keywords related to "COVID-19" were dominant, and keywords with high frequency such as "article" and "news" existed. As a result of the analysis, various issues related to non-face-to-face education, such as network failures and security issues, were identified. After the analysis, the direction of the non-face-to-face education system was studied according to the growth of the education market and changes in the educational environment. In addition, there is a need to strengthen security and feedback on teaching methods in non-face-to-face education analyzed using big data.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.27 no.1
• /
• pp.107-115
• /
• 2024

Various vaccines were rapidly developed during the COVID-19 pandemic to prevent and treat infections but global infections continue, and concerns about new mutations and infectious diseases persist. Thus, active research focuses on developing, producing, and supplying vaccines and treatments for various infectious diseases and potential pandemics. Natural killer(NK) cells, as innate immune cells, can recognize and eliminate abnormal cells like virus-infected and cancer cells. Hence, their development as anticancer and antiviral treatments is rapidly advancing. In this study, optimal short-term culture conditions were identified for allogeneic NK cells by simplifying the culture process through the isolation of NK cells(referred to as NKi cells) and eliminating CD3+ cells(referred to as CD3- cells). NK cells demonstrated reduced viral titer in injection of NK cells into SARS-CoV-2 infected ACE-tg mice increased survival. The study's findings could form the basis for an antiviral treatment platform that swiftly responds to new viral disease pandemics.

• Proceedings of the Korean Society of Computer Information Conference
• /
• 2022.01a
• /
• pp.383-386
• /
• 2022

본 논문에서는 COVID-19와 같은 위급한 상황에서 바이러스 검사를 빠르게 진행하기 위한 K-d 트리 기반의 그래프 구축과 환자 이동 경로 시스템을 제안한다. 가상환경에서 활용되는 대표적인 길 찾기 알고리즘은 A^*나 NavMesh 자료구조는 정해진 정적 이동 경로만을 안내하려는 방법이기 때문에 가상환경에서 NPC를 제어할 때는 효율적이지만, 실제 환경에 적용하여 문제를 풀기에는 충분하지 않다. 특히, 빠른 바이러스 검사를 받기 위해서는 짧은 거리만을 이용하는 게 아닌, 실제 도로 교통상황, 병원의 크기, 환자 이동 수, 환자 처리 시간 등 고려해야 할 상황들이 많다. 본 논문에서는 위에서 언급한 다양한 속성들과 이를 이용한 최적화 함수를 모델링하여, 실제 도시 맵에서 바이러스 검사를 빠르고 효율적으로 제어할 수 있는 프레임워크를 제안한다.

• Journal of the Korea Convergence Society
• /
• v.12 no.6
• /
• pp.233-239
• /
• 2021

Recently, the COVID-19 virus has caused people to stay indoors longer without going out. As a result of this, people's activity decreased sharply, and their weight gained. So people became more interested in health. Home training can be an alternative method to solve this problem. Accordingly, To find out the trends of home training, we collected articles from December 1, 2019, to November 30, 2020, using the news provided by BIG KINDS, a news analysis system. We analyzed frequency analysis, relational analysis according to weighting, and related word analysis with the program using the algorithm developed by BIG KINDS. In conclusion, first, it was found that home training is led by technology and the emergence of artificial intelligence. Second, it can be assumed that people mainly do home training using content and video services related to mobile carriers. Third, people had a high preference for Pilates in the sports category. It can be seen that the number of patent applications increased as the demand for exercise products related to Pilates increased. In the next study, we expect that this study will be used as primary data for various big data studies by supplementing the research methodology and conducting various analyses.

• Biomolecules & Therapeutics
• /
• v.31 no.4
• /
• pp.370-387
• /
• 2023

The COVID-19 pandemic has increased demand for safe and effective vaccines. Research to develop vaccines against diseases including Middle East respiratory syndrome, Ebolavirus, human immunodeficiency virus, and various cancers would also contribute to global well-being. For successful vaccine development, the advancement of technologies such as antigen (Ag) screening, Ag delivery systems and adjuvants, and manufacturing processes is essential. Ag delivery systems are required not only to deliver a sufficient amount of Ag for vaccination, but also to enhance immune response. In addition, Ag types and their delivery systems determine the manufacturing processes of the vaccine product. Here, we analyze the characteristics of various Ag delivery systems: plasmids, viral vectors, bacterial vectors, nanoparticles, self-assembled particles, natural and artificial cells, and extracellular vesicles. This review provides insight into the current vaccine landscape and highlights promising avenues of research for the development and improvement of Ag delivery systems.

• Journal of Korea Multimedia Society
• /
• v.24 no.2
• /
• pp.208-214
• /
• 2021

Since face masks in public were mandated during COVID-19, more people have taken temperature checks, with their masks on. The study has developed a contactless thermal camera that accurately measures temperatures of people wearing different kinds of masks, detect people wearing masks wrong, and record the temperature data. The built-in system that identifies people wearing masks wrong is what masks our contactless thermal camera differentiated from other thermal cameras. Also our contactless thermal camera can keep track of the number of mask wearers in different regions and their temperatures. Thus, the analysis of such regional data can significantly contribute to stemming the spread of the virus.

• Clinical and Experimental Vaccine Research
• /
• v.12 no.4
• /
• pp.337-345
• /
• 2023

Purpose: The global fight against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has led to widespread vaccination efforts, yet the optimal dosing schedule for SARS-CoV-2 vaccines remains a subject of ongoing research. This study aims to investigate the effectiveness of administering two booster doses as the third and fourth doses at different intervals to enhance vaccine protection. Materials and Methods: This study was conducted at a military regional hospital operated by the Ministry of National Defense in Taiwan. A cohort of vaccinated individuals was selected, and their vaccine potency was assessed at various time intervals following their initial vaccine administration. The study participants received booster doses as the third and fourth doses, with differing time intervals between them. The study monitored neutralizing antibody titers and other relevant parameters to assess vaccine efficacy. Results: Our findings revealed that the potency of the SARS-CoV-2 vaccine exhibited a significant decline 80 days after the initial vaccine administration. However, a longer interval of 175 days between booster injections resulted in significantly higher neutralizing antibody titers. The individuals who received the extended interval boosters exhibited a more robust immune response, suggesting that a vaccine schedule with a 175-day interval between injections may provide superior protection against SARS-CoV-2. Conclusion: This study underscores the importance of optimizing vaccine booster dosing schedules to maximize protection against SARS-CoV-2. The results indicate that a longer interval of 175 days between the third and fourth doses of the vaccine can significantly enhance the neutralizing antibody response, potentially offering improved protection against the virus. These findings have important implications for vaccine distribution and administration strategies in the ongoing battle against the SARS-CoV-2 pandemic. Further research and largescale trials are needed to confirm and extend these findings for broader public health implications.

• Genomics & Informatics
• /
• v.18 no.4
• /
• pp.43.1-43.13
• /
• 2020

The coronavirus disease 2019 is a contagious disease and had caused havoc throughout the world by creating widespread mortality and morbidity. The unavailability of vaccines and proper antiviral drugs encourages the researchers to identify potential antiviral drugs to be used against the virus. The presence of RNA binding domain in the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be a potential drug target, which serves multiple critical functions during the viral life cycle, especially the viral replication. Since vaccine development might take some time, the identification of a drug compound targeting viral replication might offer a solution for treatment. The study analyzed the phylogenetic relationship of N protein sequence divergence with other 49 coronavirus species and also identified the conserved regions according to protein families through conserved domain search. Good structural binding affinities of a few natural and/or synthetic phytocompounds or drugs against N protein were determined using the molecular docking approaches. The analyzed compounds presented the higher numbers of hydrogen bonds of selected chemicals supporting the drug-ability of these compounds. Among them, the established antiviral drug glycyrrhizic acid and the phytochemical theaflavin can be considered as possible drug compounds against target N protein of SARS-CoV-2 as they showed lower binding affinities. The findings of this study might lead to the development of a drug for the SARS-CoV-2 mediated disease and offer solution to treatment of SARS-CoV-2 infection.

• Journal of Plant Biotechnology
• /
• v.48 no.4
• /
• pp.289-303
• /
• 2021

Covid-19 is an ongoing pandemic as we speak in 2022. This infectious disease is caused by the SARS-CoV-2 virus, which infects cells by binding to the angiotensin-converting enzyme 2 (ACE2) receptor on the cell surface. Thus, strategies that inhibit the binding of SARS-CoV-2 to the ACE2 receptor can stop this contagion. Hanjeli (Coix lacryma-jobi) essential oil contains many bioactive compounds, including dodecanoic acid; tetradecanoic acid; 7-Amino-8-imino-2-(2-imino-2H-chromen-3-yl); and 1,5,7,10-tetraaza-phen-9-one. These compounds suppress viral replication and may prevent Covid-19. Accordingly, this study assessed whether, these four limonoid compounds can block the ACE2 receptor. To this end, their physicochemical properties were predicted using Lipinski's "rule of five" on the SwissADME website, and their toxicity was assessed using the online tools ProTox and pkCSM. Additionally, their interactions with the ACE2 receptor were predicted via molecular docking using Autodock Vina. All the four compounds satisfied the "rule of five" and tetradecanoic acid was predicted to have a higher affinity than the comparison compound remdesivir and the original ligand of ACE2. Molecular docking results suggested that the compounds from hanjeli essential oil interact with the active site of the ACE2 receptor similarly as the original ligand and remdesivir. In conclusion, hanjeli essential oil contains compounds predicted hinder the interaction of SARS-CoV-2 with the ACE2 receptor. Accordingly, our data may facilitate the development of a phytomedical strategy against SARS-CoV-2 infection.

• Clinical and Experimental Reproductive Medicine
• /
• v.49 no.1
• /
• pp.9-15
• /
• 2022

The angiotensin-converting enzyme 2 receptor (ACE2) appears to be widely expressed in cells in the testes, predominantly in spermatogonia, Sertoli cells, and Leydig cells, and its co-expression with transmembrane protease serine 2 (TMPRSS2) is essential for the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For this reason, the male reproductive system could be considered a potential target for SARS-CoV-2, as well as a possible reservoir of infection. However, to date, there is very little evidence about the presence of SARS-CoV-2 in semen and testicular samples. The aim of this paper was to review the current evidence regarding the impact of SARS-CoV-2 on male fertility and sexual health, with a particular focus on reproductive hormones, the presence of the virus in seminal fluid and testis, and its impact on fertility parameters. We found very limited evidence reporting the presence of SARS-CoV-2 in semen and testicular samples, and the impact of SARS-CoV-2 on reproductive hormones and fertility parameters is unclear. The quality of the examined studies was poor due to the small sample size and several selection biases, precluding definitive conclusions. Hence, future well-designed prospective studies are needed to assess the real impact of SARS-CoV-2 on male reproductive function.