• Korean Journal of Cognitive Science
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• v.21 no.1
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• pp.199-231
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• 2010

This study tried to contrast the relation-based and the dimension-based explanations and to suggest its implications on the noun-noun conceptual combination. In experiment 1, we investigated whether the dimension-based approach and intra-conceptual explanation can explain both thematic relational and property interpretations of conceptual combinations based upon the intrinsic and extrinsic features of constituent concepts. We defined intrinsic(or extrinsic) concepts according to the degree of dependency on intrinsic(or extrinsic) features. Property interpretation was facilitated when modifiers were the intrinsic concepts. This result implies that processing of conceptual combination can be influenced by the structures and information of constituent concepts. In experiment 2, exocentricity of the concepts used in Gagne(2000) was examined to reanalyze her data according to the dimension-based approach. The exocentricity was higher when the concepts were combined by their relational connections. Results of experiment 1 and 2 suggest the possibility that both approaches can be integrated through the diversities of information involved during interpreting conceptual combination. Implications and future directions of this study were discussed.

• Journal of Embryo Transfer
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• v.28 no.4
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• pp.361-371
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• 2013

The present study assessed the effect of FSH and LH on oocyte meiotic, cytoplasmic maturation and on the expression level and polyadenylation status of several maternal genes. Cumulus-oocyte complexes were cultured in the presence of FSH, LH, or the combination of FSH and LH. Significant cumulus expansion and nuclear maturation was observed upon exposure to FSH alone and to the combination of FSH and LH. The combination of FSH and LH during entire IVM increased the mRNA level of four maternal genes, C-mos, Cyclin B1, Gdf9 and Bmp15, at 28 h. Supplemented with FSH or LH significantly enhanced the polyadenylation of Gdf9 and Bmp15; and altered the expression level of Gdf9 and Bmp15. Following parthenogenesis, the exposure of oocytes to combination of FSH and LH during IVM significantly increased cleavage rate, blastocyst formation rate and total cell number, and decreased apoptosis. In addition, FSH and LH down-regulated the autophagy gene Atg6 and upregulated the apoptosis gene Bcl-xL at the mRNA level in blastocysts. These data suggest that the FSH and LH enhance meiotic and cytoplasmic maturation, possibly through the regulation of maternal gene expression and polyadenylation. Overall, we show here that FSH and LH inhibit apoptosis and autophagy and improve parthenogenetic embryo competence and development.

• Journal of Fashion Business
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• v.12 no.4
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• pp.73-87
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• 2008

The main objective of this research was to investigate the characteristics of achromatic & chromatic color coordination of contemporary female fashion by reviewing 'pre-a-porter Collections' of four collections (i. e. cities) - Paris, Milan, New York, London - from the periods of 2002 S/S to 2006/7 A/W. The data was collected by reviewing 'pre-a-porter Collections' magazine and total 677 observations were made. Statistical analysis of frequency and also qualitative interpretation of achromatic & chromatic color coordination characteristics were completed. The main findings were; (1) The achromatic & chromatic color coordination was identified as one of most used color coordination in contmeporary women's fashion collections. (2) Black and white mainly used for achromatic color, and brown used the most often, then followed by blue, red, yellow, green and the others for chromatic color in achromatic & chromatic coordination of contmeporary women's fashion collections. (3) The characteristics of achromatic & chromatic color coordination of modern women's fashion collections from 2002 S/S to 2006/07 A/W showed various images according to chromatic colors and tone variation. The combination of achromaticand brown color variations produced an intelligent and sophisticated image. The soft or light chromatic color and chromatic color combination projected soft, feminine and subtle feeling, while the combination of vivid or strong chromatic color and achromatic color projected a clean and strong feeling through contrasting tones of clear and bright colors. The chromatic color of deep or dark tone and black combination demonstrated supernatural and gloomy image. (4)In all four collections, Paris showed most use of two color coordination and then followed by Milan, N.Y, and London. N.Y showed higher rate of using achromatic & chromatic color coordination, and then followed by Paris, London and Milan.

• BMB Reports
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• v.53 no.10
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• pp.545-550
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• 2020

Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral activity against SARS-CoV-2. However, clinical trials have revealed that the co-administration of CQ and AZM resulted in severe side effects, including cardiac arrhythmia, in patients with COVID-19. To elucidate the cardiotoxicity induced by CQ and AZM, we examined the effects of these drugs based on the electrophysiological properties of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) using multi-electrode arrays. CQ treatment significantly increased the field potential duration, which corresponds to prolongation of the QT interval, and decreased the spike amplitude, spike slope, and conduction velocity of hESC-CMs. AZM had no significant effect on the field potentials of hESC-CMs. However, CQ in combination with AZM greatly increased the field potential duration and decreased the beat period and spike slope of hESC-CMs when compared with CQ monotherapy. In support of the clinical data suggesting the cardiovascular side effects of the combination therapy of CQ and AZM, our results suggest that AZM reinforces the cardiotoxicity induced by CQ in hESC-CMs.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.25 no.1
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• pp.39-45
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• 2007

In this paper, a research has been conducted to find out the optimal combination of central meridian and scale factor of UTM-K to apply for the whole area of Korean peninsula. For this research, various combinations of central meridian and stale factor are set up and the cumulated level or distortion for each combination has been computed and compared to each other. In the case of using the central meridian and scale factor defined in the present UTM-K, the level of distortion shows about $47.0837{\times}10^{-2}$. On the other hand, the minimum distortion which is about $21.0495{\times}10^{-2}$ can be obtained when the $127^{\circ}26'$ for the central meridian and 0.99991 for scale factor are used for computation. Consequently, we can conclude that later result is the optimum combination of central meridian and scale factor for the Korean peninsula.

• The Research Journal of the Costume Culture
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• v.20 no.2
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• pp.154-168
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• 2012

This study examined size combination suitability of the underwear sets in home shopping and discussed the degree of consumer satisfaction as well as purchase criteria and evaluation after purchase of women's underwear. The survey was conducted from 1st to 15th September 2010 on a total of 300 women aged between 20 to 50, living in Seoul and Gyeonggi-do region who had bought women's underwear through home shopping. The completed data, 245 out of 300, was used for the final analysis. The analysis conducted in the study with SPSS statistics package includes frequency analysis, reliability analysis, factor analysis, chi-square analysis, $t$-test, ANOVA and Duncan's Multiple Range test. Evaluation items on purchase criteria and evaluation after purchase were processed with factor analysis. The results of the present study showed that product differentiation strategies are required based on age in order to improve consumer satisfaction and repurchase intention in home shopping underwear. Moreover, most of underwear products sold in sets in home shopping are provided based on the brassiere size. As a result, women who do not fit into the home shopping underwear size combination may be less satisfied. When consumers choose their own brassier and briefs size or combinations of various brassier and briefs sizes, it would increase consumer satisfaction.

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.4
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• pp.115-119
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• 2008

Purpose: To compare the tentative and final addition, a combination chart of cross-grid and red green with the final addition prescribed in presbyopia were used in this study. Methods: The study subjects were 60 persons with presbyopia who were 41 to 60 years (mean: 51.7 years). Tentative addition were determined using red green chart (RG), cross-grid chart (CG) and the combination chart (red green cross-grid chart, RGCG) of the above two. And the final addition for a 40 cm working distance was determined for each subject by adjusting the tentative addition. Results: It was found that there were statistically significant differences of the final addition and the tentative addition between the each different test method. This result indicated that using the red-green cross-grid chart is the higher repeatability. Conclusions: This study shows that red green cross-grid chart (RGCG) seems to be get proper data for determining addition in presbyopes, and this method would be helpful in the diagnostic evaluation of addition in binocular vision testing.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.3
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• pp.88-103
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• 2023

With the recent advancement of 4th Industrial Revolution technology, transportation systems are generating large amounts of mobility data related to the individual movement trajectories of vehicles and people. There are many constraints on utilizing mobility data containing personal information. Thus, in South Korea, the processing and generation of pseudonymized information and the analysis and utilization of this information have been managed in a dual manner by applying separate agencies and technologies through the revision of the Data 3 Act and the enactment of the Data Basic Act. However, this dual approach fails to securely support the entire data lifecycle and suffers from inefficiencies in terms of processing time and cost. Therefore, to compensate for the problems of the existing Expert Data Combination System and Data Safety Zone, this study proposes an Integrated Data Safety Zone Framework that integrates and unifies the process of generating, processing, analyzing, and utilizing mobility data. The integrated process for data processing was redesigned, and common requirements and core technologies were derived. The result is an architecture for a next-generation Integrated Data Safety Zone system that can manage and utilize the entire life cycle of mobility data at one stop.

• Biomolecules & Therapeutics
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• v.30 no.1
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• pp.80-89
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• 2022

The targeting of DNA methylation in cancer using DNA hypomethylating drugs has been well known to sensitize cancer cells to chemotherapy and immunotherapy by affecting multiple pathways. Herein, we investigated the combinational effects of DNA hypomethylating drugs and ionizing radiation (IR) in human sarcoma cell lines both in vitro and in vivo. Clonogenic assays were performed to determine the radiosensitizing properties of two DNA hypomethylating drugs on sarcoma cell lines we tested in this study with multiple doses of IR. We analyzed the effects of 5-aza-dC or SGI-110, as DNA hypomethylating drugs, in combination with IR in vitro on the proliferation, apoptosis, caspase-3/7 activity, migration/invasion, and Western blotting using apoptosis- or autophagy-related factors. To confirm the combined effect of DNA hypomethylating drugs and IR in our in vitro experiment, we generated the sarcoma cells in nude mouse xenograft models. Here, we found that the combination of DNA hypomethylating drugs and IR improved anticancer effects by inhibiting cell proliferation and by promoting synergistic cell death that is associated with both apoptosis and autophagy in vitro and in vivo. Our data demonstrated that the combination effects of DNA hypomethylating drugs with radiation exhibited greater cellular effects than the use of a single agent treatment, thus suggesting that the combination of DNA hypomethylating drugs and radiation may become a new radiotherapy to improve therapeutic efficacy for cancer treatment.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.12
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• pp.2259-2264
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• 2008

Significant genes are defined as genes in which the expression level characterizes a specific experimental condition. Such genes in which the expression levels differ significantly between different groups are highly informative relevant to the studied phenomenon. In this paper, first the system can detect informative genes by similarity scale combination method being proposed in this paper after normalizing data with methods that are the most widely used among several normalization methods proposed the while. And it compare and analyze a performance of each of normalization methods with multi-perceptron neural network layer. The Result classifying in Multi-Perceptron neural network classifier for selected 200 genes using combination of PC(Pearson correlation coefficient) and ED(Euclidean distance coefficient) after Lowess normalization represented the improved classification performance of 98.84%.