• 공업화학
• /
• 제22권4호
• /
• pp.390-394
• /
• 2011

디테트라하이드로퍼퓨릴프로판(Ditetrahydrofurfurylpropane, DTHFP, ($CH_2CH_2CH_2OCH)_2C(CH_3)_2$)과 용매인 사이클로헥산(Cyclohexane), 노말헵탄(n-Heptane), 테트라하이드로퓨란(Tetrahydrofuran), 그리고 물을 포함하는 각 이성분계의 기액상평형을 측정하였다. 기액 상평형 측정은 DTHFP의 농도가 낮은 영역에 대하여 실시하였다. NRTL 모델을 이용하여 기액 상평형을 해석하였으며 측정된 실험자료를 이용하여 NRTL 모델의 이성분계 상호작용 매개변수를 회귀분석하였다.

• 한국섬유공학회:학술대회논문집
• /
• 한국섬유공학회 1992년도 제2차 학술발표초록집
• /
• pp.103-103
• /
• 1992

• 한국섬유공학회:학술대회논문집
• /
• 한국섬유공학회 1994년도 춘계학술발표회 프로그램 및 초록
• /
• pp.102-102
• /
• 1994

• Bulletin of the Korean Chemical Society
• /
• 제21권10호
• /
• pp.973-979
• /
• 2000

• Journal of Applied Biological Chemistry
• /
• 제58권4호
• /
• pp.295-301
• /
• 2015

Five phenylpropanoids (1-5), a benzofuran neolignan (6), two 8-O-4'-neolignans (7-8), and five tetrahydrofuran lignans (9-13) were isolated from a methanol extract of Myristica fragrans seeds. The structures of 1-13 were determined by $^1H$- and $^{13}C$-NMR spectroscopic data analyses and a comparison with the literature data. Compound 3 was isolated for the first time from this plant. All the isolated compounds were evaluated for their inhibitory activity against tyrosinase. Among them, safrole (1) showed significant inhibitions against both the monophenolase ($IC_{50}=32.11{\mu}M$) and diphenolase ($IC_{50}=27.32{\mu}M$) activities of tyrosinase. The kinetic analysis shows that safrole (1) is competitive inhibitors for both monophenolase and diphenolase. The apparent inhibition constant ($K_i$) for safrole (1) binding with free enzyme was determined to be 16.05 and $13.66{\mu}M$ for monophenolase and diphenolase, respectively.

• Fibers and Polymers
• /
• 제1권1호
• /
• pp.1-5
• /
• 2000

Poly(3-methyltetrahydrofuran)(3-MTHF) and poly(tetrahydrofuran-co-3-MTHF), having very narrow molecular weight distribution were successfully synthesized via photo-induced living cationic polymerization in the presence of diphenyliodonium hexafluorophosphate. Linear relationship between % conversion and number average molecular weight of resulting poly(3-MTHF) in the polymerization of 3-MTHF, carried out at -22$^{\circ}C$, indicates that the 5-membered cyclic oxonium ion, being responsible for the cationic propagation is stabilized by ion pall formation with hexafluorophosphate anion, supplied from the salt. The linear relationship between two parameters, mentioned above was also observed in the copolymerization of 3-MTHF with THF, carried out at 0 and -22$^{\circ}C$. The molecular structures including the copolymer composition and average molecular weight and its distribution is determined by reaction parameters such as monomer feed ratio and reaction temperature.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
• /
• pp.392.2-392.2
• /
• 2014

Poly (vinylidene fluoride) thin films were deposited by a spray-coating technology. Two organic solvents with different boiling point were used to prepare the mixture solution for spray coating process: N-Methylpyrrolodone ($B.P.=202^{\circ}C$); Tetrahydrofuran ($B.P.=66^{\circ}C$). Post-deposition annealing temperature was varied for the spray-coated Poly(vinylidene fluoride) thin films. Structural characteristics of the thin films were comparatively investigated by FT-IR and XRD in relation with the organic solvent and post-deposition annealing temperature.

• Bulletin of the Korean Chemical Society
• /
• 제30권7호
• /
• pp.1588-1592
• /
• 2009

Lithium cyanoaluminum hydride (LCAH) was prepared by the metal cation exchange reaction of sodium cyanoaluminum hydride with lithium chloride in tetrahydrofuran. The reducing characteristics of LCAH were explored systematically by the reaction with selected organic compounds containing representative functional groups under the standardized conditions (tetrahydrofuran, 0 ${^{\circ}C}$). The reducing ability of LCAH was also compared with of the sodium derivative, sodium cyanoaluminum hydride (SCAH). Generally, the reducing behavior of LCAH resembles that of SCAH closely, but the reactivity of LCAH toward representative organic functional groups appeared to be stronger than that of SCAH. Thus, the regent reduces carbonyl compounds, epoxides, amides, nitriles, disulfides, carboxylic acids and their acyl derivatives to the corresponding alcohols or amines, at a relatively faster rate than that of SCAH. The cyano substitution, a strong election-withdrawing group, diminishes the reducing power of the parent metal aluminum hydrides and hence effects the alteration of their reducing characteristics.

• Archives of Pharmacal Research
• /
• 제24권4호
• /
• pp.300-306
• /
• 2001

A novel and two known bioactive mono-tetrahydrofuran (THF) annonaceous acetogenins, annomocherin (1), annonacin (2) and annomontacin (3), have been isolated from the fractionated ethanolic extracts of the seeds of Annona cherimolia, guided by the brine shrimp lethality test (BST). Their structures were elucidated on the basis of spectroscopic and chemical methods. All compounds have a relative stereochemistry of threo/trans/threo for the mono-THF ring with two flanking hydroxyls. Compound 1 has a double bond at C-23/ 24 of aliphatic chain. Compound 1 was isolated from natural sources for the first time, and was named annomocherin. Two known Compounds 2 and 3 which have never been isolated from this species before, were obtained. Compound 1 exhibited potent and selective cytotoxicities against the breast carcinoma (MCF-7) and kidney carcinoma (A-498) cell lines with 100 to 1,000 times the potency of adriamycin. In brine shrimp lethality test (BST), 1-3 exhibited cytotoxicity.

• Natural Product Sciences
• /
• 제13권4호
• /
• pp.355-358
• /
• 2007

Further bioactivity-directed fractionation of the ethanol extract of the seeds of Annona cherimolia has led to the isolation of two mono-tetrahydrofuran acetogenins, xylomaticin (1) and gonionenin (2). The structures of these compounds were characterized on the basis of chemical and spectroscopic data. Compounds 1 and 2 have a relative stereochemistry relationship of threo/trans/threo across the mono-tetrahydrofuran ring with its two flanking hydroxyls. Compounds 1 and 2 are known, but are first isolated from this plant. In brine shrimp lethality test (BST), 1 and 2 exhibited cytotoxic activity.