• Toxicological Research
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• v.17
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• pp.167-171
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• 2001

The introduction of genetically modified crops has raised concerns regarding safety issues over the insertion of foreign genes into plant genomes using recombinant DNA technology. Since 1991 in Japan, 29 foods and 6 food additives have been evaluated, based on the "Guideline for Safety Assessment", before these foods were marketed. The MHW, however, decided that safety assessment of such foods and food additives should be legally imposed. because soon such foods and food additives are expected to circulate globally and a new system for assessing safety of such foods and food additives at a pre-market stage is necessary, in order to avoid the distribution of any genetically modified foods that have had no safety assessment. The MHW published relevant announcements to amend existing regulations on 1 May 2000. "Standards for safety assessment of seed plant" is established based on a concept of substantial equivalence, and applicable to the products which are regarded as equivalent to the existing products used as foods and food additives. The characterization of the food products entails consideration of the molecular characterization. phenotypic and compositional characteristics, key nutrients and toxicants, and toxicity and allergenicity of the introduced proteins, and if there are indications of unintended effects of the modification, whether further safety testing (animal studies etc.) is needed should be considered. Safety and wholesomeness studies with whole foods should be care fully designed in order to avoid nutritional imbalances causing artifacts and uninterpretable results as was the case of Dr. Pusztaiis report. A case study of genetically modified soybeans (glyphosate-tolerant soybeans) on the immune system of rats and mice is shown. Chemical compositions were also compared with those of the non-GM soybeans. The studies failed to detect any differences in immuno-toxic activity.muno-toxic activity.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1211-1217
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• 2014

Background: Cancer in infants younger than one year of age represents a unique problem with distinct epidemiological, clinical and genetic characteristics compared with older age groups. No report is yet available from Iran regarding epidemiological and survival rate of cancers diagnosed in this age group. Materials and Methods: The population under study comprised of patients which were diagnosed and admitted to Ali-Asghar hospital between years 1996-2005. In total, 287 infants were included in the retrospective descriptive survey. Patient files were evaluated for age of patient at the time of diagnosis, sex, geographical residence, consanguinity of parents, histological diagnosis, site of cancer involvement, type of therapy, date of last follow-up and cause of death (if applicable). Results: The average age at the time of diagnosis was 7.2 months old. The most frequent malignancy was retinoblastoma (44%), followed by leukemia (19%) and neuroblastoma (10%), with five-year overall survival rates of 77.7%, 41% and 90%, respectively Parents of 40 infants (13.9%) had consanguinity relationships. Conclusions: Although we cannot make any conclusions regarding the incidence of infant cancer subtypes based on this study, survival rates for major types were similar to the developed countries, which signifies strict adherence to standards of care in Ali-Asghar hospital, the main infant cancer care centre in Iran. A Childhood Cancer Registry with high-resolution data collection and also advanced genetic testing is advocated for in-depth analysis of variation in incidence and survival.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.6
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• pp.2472-2478
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• 2012

This research is aiming to develop Semiconductor equipment maintenance certification course to train qualified maintenance experts more effectively requested in related semiconductor industry. In the course of research, we adopted diverse research technique such as interview, on-spot investigation, documentary references to analyze current status of related training facilities, and forecast the population of test applicants. We analyzed similar certification course(Craftsman SMT, Industrial Engineer SMT, Craftsman Mechatronics, Industrial Enginee Mechatronics, et) as reference to set up job objectives and curriculum of semiconductor equipment maintenance certification. We conducted survey on expectations on newly created certificate, presented evaluation standard and objective of test, and preliminary writing test and demonstration test. Based on the result of various research, we were able to present training program for semiconductor equipment maintenance certification and set the assessment standard of qualification exam.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.53 no.3
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• pp.443-450
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• 2020

No established method can be used to select effective antibiotics in antibiotic susceptibility tests for fish bacterial pathogens quickly and accurately. Here, we established the optimal conditions for determining the minimal inhibitory concentration (MIC) of major fish bacterial pathogens (Streptococcus spp., Edwardsiella tarda, Vibrio spp., Aeromonas spp., and Pseudomonas spp.) using the KRAQ1 and CAMPY2 panels. The MIC panel used 18 antibiotics of two types and we conducted experiments to establish the optimal culture medium and temperature for each species. The optimal conditions for incubating Streptococcus spp. were in cation-adjusted Mueller-Hinton broth with TES buffer (CAMHBT) at 28℃, using 5% lysed horse blood (LHB) as recommended by the Clinical Laboratory Standards Institute. For Vibrio spp., the optimal culture conditions were 28℃ in CAMHBT supplemented with 1% NaCl. The optimal conditions for culturing E. tarda, Aeromonas spp., and Pseudomonas spp. were in CAMHBT at 28℃.

• Journal of the Korean Wood Science and Technology
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• v.35 no.5
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• pp.24-37
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• 2007

The Korean Ministry of Environment started controlling indoor air quality (IAQ) in 2004 through the introduction of a law regulating the use of pollutant emitting building materials. The use of materials with formaldehyde emission levels above $1.25 mg/m^2{\cdot}h$ (JIS A 1901, small chamber method) has been prohibited. This level is equivalent to the $E_2$ grade ($>5.0mg/{\ell}$) of the desiccator method (JIS A 1460). However, the $20{\ell}$ small chamber method requires a 7-day test time to obtain the formaldehyde and volatile organic compound (VOC) emission results from solid building interior materials. As a approach to significantly reduce the test time, the field and laboratory emission cell (FLEC) has been proposed in Europe with a total test time less than one hour. This paper assesses the reproducibility of testing formaldehyde and TVOC emissions from wood-based composites such as medium density fiberboard (MDF), laminate flooring, and engineered flooring using three methods: desiccator, perforator and FLEC. According to the desiccator and perforator standards, the formaldehyde emission level of each flooring was ${\le}E_1$ grade. The formaldehyde emission of MDF was $3.48 mg/{\ell}$ by the desiccator method and 8.57 g/100 g by the perforator method. To determine the formaldehyde emission, the peak areas of each wood-based composite were calculated from aldehyde chromatograms obtained using the FLEC method. Formaldehyde, acetaldehyde, propionaldehyde, butyraldehyde and benzaldehyde were detected as aldehyde compounds. The experimental results indicated that MDF emitted chloroform, benzene, trichloroethylene, toluene, ethylbenzene, m,p-xy-lene, styrene, and o-xylene. MDF emitted significantly greater amounts of VOCs than the floorings did.

• The Korea Journal of Herbology
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• v.31 no.3
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• pp.59-69
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• 2016

Objectives： Presently Mume Fructus (MF) undergoes fumigation, which produces benzo[a]pyrene. As a primary analysis with the aims to minimize the production of benzo[a]pyrene and to suggest standards for processing the MF, the steaming method was chosen among the various processing methods, and reviewed through a series of experiments.Methods： Methods：Pitted and un-pitted MF were steamed and processed into samples. After testing level of benzo[a]pyrene, the samples were analyzed for amount of polyphenol and flavonoids. Scavenging activities of the samples for the DPPH and ABTS radicals were tested. In order to measure anti-inflammatory effects of the samples, cell survival rate was investigated using CCK-8 Assay. Also, water extracts of dried and steamed MF were administered to the RAW 264.7 cells to compare expressions of NO, PGE₂, IL-1β, and TNF-α. In addition, anti-diarrhea effects of the herbal medicine were tested on animal models with diarrhea induced by MgSO₄ and Castor oil.Results： Regardless of pitting, processed MF contained no benzo[a]pyrene. Anti-oxidation effect increased in relation to the frequency of steaming process. However, extracts of dried and steamed MF suppressed different kinds of inflammation factors, and extract of dried MF showed superior anti-diarrhea effect than extract of steamed MF.Conclusions： It is suggested that steaming method of MF is recommended for processing the herbal medicine without the production of benzo[a]pyrene. But regarding that dried and steamed MF showed differences in their anti-oxidative, anti-inflammatory, and anti-diarrhea effects, it is recommended to perform further researches on different efficacies of MF according to their processing methods.

• Journal of Auto-vehicle Safety Association
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• v.9 no.1
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• pp.6-12
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• 2017

Regulation for the testing and operation of automated vehicles on public roadways has been recently developed all over the world. For example, the licensing standards and the evaluation technology for automated vehicles have been proposed in California, Nevada and EU. But specific safety evaluation scenarios for automated vehicles have not been proposed yet. This paper presents safety evaluation scenarios for extraordinary service permission of automated vehicles on highways. A total of seven scenarios are selected in consideration of safety priority and real traffic situation. Six scenarios are relevant with lane keeping and one scenario is relevant with lane change. All scenarios are developed based on existing ADAS evaluation scenarios and repeated simulation of automated vehicle algorithm. Safety evaluation factors as well as scenarios are developed. The safety factors are based on existing ADAS ISO requirements, ADAS safety factors and current traffic regulations. For the scenarios, a hunter vehicle is needed in addition to automated vehicle evaluated. The hunter vehicle performs multiple roles like preceding vehicle, cut-in vehicle and so on. The hunter vehicle is also automated vehicle equipped with high performance GPS, radar and Lidar. All the scenarios can be implemented by driving a lap on a KATRI ITS test track. These scenarios and safety evaluation factors are investigated via both a computer simulation and an experimental vehicle test on the test track. The experimental vehicle test was conducted with two automated vehicles, which are the evaluated vehicle and the hunter vehicle.

• Journal of Auto-vehicle Safety Association
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• v.9 no.4
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• pp.38-47
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• 2017

With automobiles sharply increasing worldwide, we are faced with serious social problems such as traffic accidents, traffic jams, environmental pollution, and economic inefficiency. In response, research on ITS is promoted mainly by regions with advanced automotive industry such as the US, Europe, and Japan. While Korea is working to get ahead to take global market through developing and turning into global standards systems related to ASV(Advanced Safety Vehicle), the country is not excellently prepared for such projects. The purpose of ACC is to control the vehicle's longitudinal speed and distance and minimize driver workload. Such a system should be useful in preventing accidents, as it reduces driver workload in the 21st-century world of telematics created by the development of automobile culture industry. In this light, the thesis presents a method to test and evaluate ACC system and a mathematical method to assess distance. Furthermore, for the proposed test and evaluation, theoretical values are tested with vehicle test and a database is acquired, by using vehicles equipped with an ACC system. We proposed the scenarios suitable for the domestic environment and conducted the actual road test. Theoretical evaluation criteria for developing ACC system may be employed and scenario-specific evaluation methods may find their useful application through testing the formula proposed by comparing the database and the mathematical method. and, many companies are expected to utilize the scenario in the developing stage of ACC, and be able to employ as a verification method by harnessing theoretical formula before a road test.

• International Journal of Highway Engineering
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• v.14 no.5
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• pp.179-188
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• 2012

PURPOSES: The aim of this study is to analyze overloading control effectiveness of enforcing overweighted vehicles using HS-WIM (High-Speed Weigh-in-Motion) at main lane of expressway. METHODS: To analyze the weight distribution statistically, HS-WIM system should has an appropriate weighing accuracy. Thus, the weighing accuracy of the two HS-WIM systems was estimated by applying European specifications and ASTM (American Standards for Testing and Materials) for WIM in this study. Based on the results of accuracy test, overweight enforcement system has been operated at main lanes of two expressway routes in order to provide weight informations of overweighted vehicle in real time for enforcement squad. To evaluate the overloading control effectiveness with enforcement, traffic volume and axle loads of trucks for two months at the right after beginning of the enforcement were compared with data set for same periods before the enforcement. RESULTS: As the results of weighing accuracy test, both WIM systems were accepted to the most precise type that can be useful to applicate not only statistical purpose but enforcing on overweight vehicles directly. After the enforcement, the rate of overweighted trucks that weighed over enforcement limits had been decreased by 27% compared with the rate before the enforcement. Especially, the rate of overweighted trucks that weighed over 48 tons had been decreased by 91%. On the other hand, in counterpoint to decrease of the overweighted vehicle, the rate of trucks that weighed under enforcement limits had been increased by 7%. CONCLUSIONS: From the results, it is quite clear that overloading has been controlled since the beginning of the enforcement.

• Journal of the Korean GEO-environmental Society
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• v.4 no.2
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• pp.47-56
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• 2003

The production of industrial wastes have increased due to the growth of population and industrial development. Among these wastes, especially amount of paper ash has been increased year after year. If it is possible to reuse industrial wastes, it will be beneficial not only economically but also environmentally. In this study, the possibility of the utilization of paper ash were investigated as a construction materials through a series of laboratory testing carried out to evaluate physical properties, compaction, consolidation, permeability and compressive strength characteristics. Concrete bricks with replacement ratio of paper ash at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20%, and clayey bricks with replacement ratio of paper ash at 5, 10, 15, 20, 25, 30% were used in the test in order to evaluate its quality. As a result of tests, it were shown that the maximum replacement ratio of paper ash satisfying the quality standards of concrete bricks and clayey bricks were 11.5% and 12%, respectively.