• 한국지반공학회논문집
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• 제19권6호
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• pp.261-271
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• 2003

본 연구에서는 다단계 하중 Falling Weight Deflectometer를 사용하여 도로기초의 상태를 평가하는 방법을 제시하였다. 응력의존 재료모델을 포함한 동적 유한요소법을 활용하여 가상의 처짐과 응력/변형률 데이터베이스를 구축하였다. 이러한 가상의 데이터베이스를 바탕으로 표면처짐 및 보조기층 또는 노상의 중요한 위치에서 발생하는 응력/변형률과의 관계를 제시하였다. 미국의 LTPP와 노스캐롤라이나 주도로국에서 실시한 FWD 처짐값, 동적관입시험 결과, 그리고 반복하중 탄성계수시험을 활용하여 평가방법을 개발하였다. 특히 본 연구는 FWD 하중크기가 상태평가 방법에 미치는 영향에 대하여 연구의 초점을 맞추었다. 연구결과, 구조적으로 수정된 보조기층 손상지수와 보조기층 곡률지수가 각각 보조기층과 노상토의 강성도 특성을 예측할 수 있는 좋은 인자들로 판단되었다. 66.7kN 또는 그 보다 작은 하중은 예측의 정밀도를 높이는데 부족하였다. 도로기초의 비선형 거동에 대한 연구결과, 다단계 하중으로부터 발생하는 처짐비는 도로기초 재료의 종류와 상태를 판단할 수 있었다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권2호
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• pp.143-149
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• 2004

Background: Some clinical trials have reported that a new analgesic combination of tramadol and acetaminophen provides good efficacy in various pain models. For the more clinical uses of this agent, comparisons about the onset of analgesia and analgesic efficacy in the acute state of pain with the other drugs known as strong analgesics were needed. Purpose: The goal of this study was to compare the times to onset of analgesia and the other analgesic efficacy of 75 mg tramadol/650 mg acetaminophen and 20 mg codeine/500 mg acetaminophen/400 mg ibuprofen in the treatment of acute pain after oral surgery. Patients and Methods: Using a randomized, single-dose, parallel-group, single-center, and active-controlled test design, this clinical study compared the times to onset of analgesia using a two-stopwatch technique and the other analgesic efficacy of the single-dose tramadol/acetaminophen and codeine/acetaminophen/ibuprofen. These were assessed in 128 healthy subjects with pain from oral surgical procedures involving extraction of one or more impacted third molars requiring bone removal. From the time of pain development, the times to onset of perceptible and meaningful pain relief, pain intensity, pain relief, an overall assessment, and adverse events of the study medications were recorded for 6 hours. Results: The demographic distribution and baseline pain data in the two groups were statistically similar. The median times to onset of perceptible pain relief were 21.0 and 24.4 minutes in the tramadol/acetaminophen and codeine/acetaminophen/ibuprofen groups respectively and those to onset of meaningful pain relief were 56.4 and 57.3 minutes, which were statistically similar. The other efficacy variables such as mean total pain relief (TOTPAR) and the sum of pain intensity differences (SPID) were also similar in the early period after pain development and drug dosing. The safety of tramadol/acetaminophen was well tolerated and very comparable to that of codeine/acetaminophen/ibuprofen. Conclusions: In this acute dental pain model, the onset of analgesia and analgesic efficacy of tramadol/acetaminophen was comparable to that of codeine/acetaminophen/ibuprofen. These results showed that tramadol/acetaminophen was recommendable for fast and effective treatment in the management of postoperative acute pain.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권6호
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• pp.464-469
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• 2011

Introduction: As dental implant surgery is becoming increasingly popular, it has become one of the causes for the hypesthesia of the inferior alveolar nerve, along with other surgical procedures, such as a third molar extraction. In addition, it tends to cause legal problems between the operator and patient. Therefore, there must be a proper method that is reliable, objective and economical to assess the nerve impairment. For this reason, an attempt was made to use an Electric Pulp Tester to assess inferior alveolar nerve block anesthesia. Materials and Methods: Thirty patients were tested. Electric pulp testing of the lower jaw skin was performed at the three different times, before anesthesia, at the onset of sensory changes and after 15 minutes waiting from the onset, and on the 10 points of the chin, which produced 10 sections on the skin area. Results: Twenty seven patients (90%) could feel the electric stimulus on the chin at all 10 points before local anesthesia and the scores represent the statistical differences between the right and left points except R4 and L4. After anesthesia, the difference between the right and left points (L3-R3, L4-R4, L5-R5) increased significantly with time but two points (L2, R2) showed no significant difference. The scores on the left chin (L3, L4, L5) increased, whereas the other points (R1-R5, L1, L2) showed no significant differences. Conclusion: This study highlights the potential clinical use of an electric pulp tester for an assessment of inferior alveolar nerve impairment.

• Journal of Periodontal and Implant Science
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• 제49권6호
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• pp.355-365
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• 2019

Purpose: The modified minimally invasive surgical technique (M-MIST) has been successfully employed to achieve periodontal regeneration. Platelet-rich fibrin (PRF) is known to enhance wound healing through the release of growth factors. This study aimed to observe the outcomes of periodontal surgery when M-MIST was used with or without PRF for the treatment of isolated intrabony defects. Methods: This randomized clinical trial was conducted on 36 systemically healthy patients, who had chronic periodontitis associated with a single-site buccal probing pocket depth (PPD) and clinical attachment level of ≥5 mm. Patients were randomly divided into 2 groups: the test group treated with M-MIST and PRF, and the control group treated with M-MIST alone. The primary periodontal parameters analyzed were PPD, relative attachment level (RAL), and relative gingival margin level. The radiographic parameters analyzed were change in alveolar crest position (C-ACP), linear bone growth (LBG), and percentage bone fill (%BF). Patients were followed up to 6 months post-surgery. Results: Intragroup comparisons at 3 and 6 months showed consistently significant improvements in PPD and RAL in both the groups. In intergroup comparisons, the improvement in PPD reduction, gain in RAL, and the level of the gingival margin was similar in both groups at 3 and 6 months of follow-up. Furthermore, an intergroup comparison of radiographic parameters also demonstrated similar improvements in C-ACP, LBG, and %BF at 6 months of follow-up. Conclusions: M-MIST with or without PRF yielded comparable periodontal tissue healing in terms of improvements in periodontal and radiographic parameters. Further investigation is required to confirm the beneficial effects of PRF with M-MIST.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6429-6438
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• 2015

Glutathione S-transferases (GSTs) play an important role in detoxification of carcinogenic electrophiles. The null genotypes in GSTM1 and GSTT1 have been implicated in carcinogenesis. Present study was planned to evaluate the influence of genetic polymorphisms of GSTM1 and GSTT1 gene loci in cervical carcinogenesis. The study was conducted in Lok Nayak hospital, New Delhi. DNA from clinical scrapes of 482 women with minor gynaecologic complaints attending Gynaecology OPD and tumor biopsies of 135 cervical cancer cases attending the cancer clinic was extracted. HPV DNA was detected by standard polymerase chain reaction (PCR) using L1 consensus primer pair. Polymorphisms of GSTM1 and GSTT1 were analysed by multiplex PCR procedures. Differences in proportions were tested using Pearson's Chi-square test with Odds ratio (OR) and 95% confidence interval (CI). The risk of cervical cancer was almost three times in women with GSTM1 homozygous null genotype (OR-2.62, 95%CI, 1.77-3.88; p<0.0001). No association of GSTM1 or GSTT1 homozygous null genotypes was observed in women with normal, precancerous and cervical cancerous lesions among ${\leq}35$ or >35 years of age groups. Smokers with null GSTT1 genotype had a higher risk of cervical cancer as compared to non-smokers (OR-3.01, 95% CI, 1.10-8.23; p=0.03). The results further showed that a significant increased risk of cervical cancer was observed in HPV positive smoker women with GSTT1 (OR-4.36, 95% CI, 1.27-15.03; p=0.02) and GSTM1T1 (OR-3.87, 95% CI, 1.05-14.23; p=0.04) homozygous null genotypes as compared to HPV positive non smokers. The results demonstrate that the GST null genotypes were alone not associated with the development of cervical cancer, but interacted with smoking and HPV to exert effects in our Delhi population.

• 한국전산구조공학회논문집
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• 제22권5호
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• pp.445-452
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• 2009

본 논문에서는 유한요소모델개선기법을 이용하여 골조구조물의 손상탐지를 실시하였다. 유한요소모델개선기법은 계측된 동특성을 모사하는 구조해석모델을 구하는 방법으로서 손상탐지 및 구조건전도감시를 위해 효과적으로 이용될 수 있다. 유한요소모델개선기법에는 다양한 종류의 동특성데이터가 사용될 수 있는데, 본 연구에서는 고유진동수와 모드형상, 주파수응답함수를 사용한 모델 개선식을 유도한 후, 고유진동수와 모드형상, 고유진동수와 주파수응답함수식을 조합한 경우에 대해 실험실 규모의 구조물의 손상위치 및 손상정도를 추정하였다. 구조물은 4층 철골조 구조물로서 진동대를 이용하여 원구조물에 백색잡음 가진실험을 실시한 후 손상의 모사를 위해 1층 부분의 보 부재를 다양한 단면의 부재로 교체하고 동일한 실험을 반복하였다. 보 부재 교체 전 후에 계측된 데이터와 두 종류의 모델개선기법을 각각 적용하여 손상탐지를 실시한 후, 손상위치 및 손상정도에 대한 정확도를 분석하였다. 분석결과 고유진동수+모드형상을 사용한 경우보다 고유진동수+주파수응답함수를 사용한 경우 더욱 정확히 손상을 탐지할 수 있었다.

• Tuberculosis and Respiratory Diseases
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• 제40권5호
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• pp.610-615
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• 1993

저자들은 colporrhaphy를 목적으로 실리콘 피하주사 후 호흡곤란을 주소로 내원한 2명의 환자에서 기관지폐포세척액 검사, 경기관지 폐생검, 고해상 컴퓨터 단층촬영, 폐동맥조영술 등을 시행하여 폐색전증으로 인한 급성호흡부전으로 진단하고 지지요법만으로 치료한 1예와 사망한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 가정과삶의질연구
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• 제20권4호
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• pp.37-52
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• 2002

This study is preliminary study of the status of school counseling and demands for service at middle and high schools from universities to provide the youth middle and high schools in Changwon with counseling and educational service. The results of this research are below, First, the excessive workload became the most difficulties for operateschool counseling systems and counseling activities. Second, school counseling activities focused mainly on the formal and narrow areas of counseling such as career guidance, personality programs and intelligence test and so on. Third, the most problems which we have counselled, were friendship problems in the personal relationship, school absences in the delinquent, lack of information of sex in the sexual field, conflicts with Parents, in the family relationship, poor academic progresses in the academical and future directional problems and. character of personality difficulties in the psychological field. Fourth, the major offers from the teachers to counsel students in the school were advices, suggestions, career guidance, Preventative activities, and providing information through school counseling. Fifth, though the middle and high schools were in need of outside institutions related to counseling, It was difficult to get help because of being Ignorant of procedures or methods for using counseling and being lacking in enough information on such organizations. Sixth, ordinary students and students in danger of maladjustment besides problem students wanted to get a lot of help. Seventh, the counseling which are the most wanted from out of school was an opposite-sex relationship in the personal relationship, a lack of information on sex in the sexual fields, conflict with parents in the family problems, a strong unwillingness of study in the academical and future directional fields, and personalty difficulties In the psychological fields. Eighth, the subjects wanted to get counseling and educational service in regard to sex, addiction to PC, smoking, and ostracism and so on in counseling and education for young people. Ninth, education designed to have an adequate understanding of children turned out to be mostly needed as educational programs for parents Based on the above results, the proposals from universities for provide youth counseling and educational services are below. 1) setting up the positive publicity strategies E) developing and execution of various counseling and educational programs 3) expanding the counseling and education from maladjusted students to general students 4) expanding youth counseling and education to parental education and family counseling 5) continuous human resources improvement and training 6) reinforcement relationships with middle and high school organizations 7) building cooperation with local counseling organizations

• Genomics & Informatics
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• 제5권1호
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• pp.10-18
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• 2007

Numerous studies have reported that genes with similar expression patterns are co-regulated. From gene expression data, we have assumed that genes having similar expression pattern would share similar transcription factor binding sites (TFBSs). These function as the binding regions for transcription factors (TFs) and thereby regulate gene expression. In this context, various analysis tools have been developed. However, they have shortcomings in the combined analysis of expression patterns and significant TFBSs and in the functional analysis of target genes of significantly overrepresented putative regulators. In this study, we present a web-based A Functional Clustering Analysis Tool for Predicted Transcription Regulatory Elements and Gene Ontology Terms (FCAnalyzer). This system integrates microarray clustering data with similar expression patterns, and TFBS data in each cluster. FCAnalyzer is designed to perform two independent clustering procedures. The first process clusters gene expression profiles using the K-means clustering method, and the second process clusters predicted TFBSs in the upstream region of previously clustered genes using the hierarchical biclustering method for simultaneous grouping of genes and samples. This system offers retrieved information for predicted TFBSs in each cluster using $Match^{TM}$ in the TRANSFAC database. We used gene ontology term analysis for functional annotation of genes in the same cluster. We also provide the user with a combinatorial TFBS analysis of TFBS pairs. The enrichment of TFBS analysis and GO term analysis is statistically by the calculation of P values based on Fisher’s exact test, hypergeometric distribution and Bonferroni correction. FCAnalyzer is a web-based, user-friendly functional clustering analysis system that facilitates the transcriptional regulatory analysis of co-expressed genes. This system presents the analyses of clustered genes, significant TFBSs, significantly enriched TFBS combinations, their target genes and TFBS-TF pairs.

• 한국콘텐츠학회논문지
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• 제13권2호
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• pp.475-487
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• 2013

탈냉전의 국제정세와 세계화의 심화로 세계 각국의 국방정책은 기존에 비해 상대적으로 군비축소의 경향을 보이고 있다. 이는 세계의 군사적 성향이 다극화 체제로 구축되면서 실제적인 무력충돌의 상황에 대처하기 보다는 잠재적인 안보 위협에 대응하는 방향으로 전환되고 있는 것에 기인한다. 이 경우 국가간의 군사적 관계설정이 중요하기 때문에 본 연구에서는 ${\beta}$ 및 ${\sigma}$-수렴성 검정, 합리적기대에 의한 수렴성 검정 및 Granger 인과관계 분석을 통해 동북아 국가 상호간의 국방비 지출 및 군수물자 수입을 분석하고 이를 바탕으로 군사적 상호의존성을 파악하였다. 분석결과에 의하면 동북아 국가의 경우 국방비 지출뿐만 아니라 군수물자 수입의 ${\beta}$-수렴성, ${\sigma}$-수렴성 및 합리적기대에 의한 수렴성이 세계전체의 추이에 수렴하고, 세계전체의 추이로부터 이탈하는 요인이 발생하면 신속하게 조정하는 것으로 분석되었다. 그러나 동북아 국가 상호간의 변화에 따른 인과관계는 미약한 것으로 나타났다. 결과적으로 동북아 국가의 경우 국방비 지출이나 군수물자 수입에 있어서 세계전체의 추이에는 반응을 하지만 동북아 국가 상호간의 변화에 따른 반응은 미미한 것으로 분석되었다. 이와 같은 결과는 동북아 국가의 군사적 성향도 잠재적인 안보 위협에 대응하려는 세계전체의 추이를 따르기 때문인 것으로 볼 수 있다.