• Journal of Society of Preventive Korean Medicine
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• v.6 no.2
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• pp.86-94
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• 2002

Ligusticum Chuanxiong and its components were reviewed in terms of pharmacodynamic mechanisms. Three components of about 40 chemical components in Chuanxiong tetramethylpyrazine, ferulinolol and Butylidenephthalide have mainly been studied for its pharmacodynamic mechanisms which are focused on the increase in blood flow and anti-oxidative stress. The mechanisms for the effects of Chuanxiong on the increase in blood flow can be summarized as four ways, 1) anti-coagulation 2) blocker of ${\beta}1$ adrenergic receptor 3) cellular control of Ca++ level 4) collagen synthesis. Chuanxiong also showed the effectiveness on free radical-induced injury. It seems that its effectiveness is also related to the mechanisms for the increase in blood flow.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.1
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• pp.173-187
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• 2022

Recent studies have focused on self-management of hypertension using smart devices (cellular phones, tablets, watches). It has proven to be an effective tool for early detection and control of high Blood Pressure (BP) without affecting patients' daily routines. This systematic review surveys the existing self-monitoring systems, evaluate their effectiveness and compares the different approaches. We investigated the current systems in terms of various attributes, including methods used, sample size, type of investigation, inputs/ outputs, rate of success in controlling BP, group of users with higher response rate and beneficiaries, acceptability, and adherence to the system. We identified some limitations, shortcomings, and gaps in the research conducted recently studying the impact of mobile technology on managing hypertension. These shortcomings can generate future research opportunities and enable it to become more realistic and adaptive. We recommended including more observable factors and human behaviors that affect BP. Furthermore, we suggested that vital monitoring/logging and medication tuning are insufficient to improve hypertension control. There is also a need to observe and alter patient behavior and lifestyles.

• Journal of Software Assessment and Valuation
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• v.17 no.2
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• pp.125-142
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• 2021

Reports of rampant cross-site scripting (XSS) vulnerabilities raise growing concerns on the effectiveness of current Static Analysis Security Testing (SAST) tools as an internet security device. Attentive to these concerns, this study aims to examine seven open-source SAST tools in order to account for their capabilities in detecting XSS vulnerabilities in PHP applications and to determine their performance in terms of effectiveness and analysis runtime. The representative tools - categorized as either text-based or graph-based analysis tools - were all test-run using real-world PHP applications with known XSS vulnerabilities. The collected vulnerability detection reports of each tool were analyzed with the aid of PhpStorm's data flow analyzer. It is observed that the detection rates of the tools calculated from the total vulnerabilities in the applications can be as high as 0.968 and as low as 0.006. Furthermore, the tools took an average of less than a minute to complete an analysis. Notably, their runtime is independent of their analysis type.

• Journal of computational fluids engineering
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• v.16 no.4
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• pp.92-99
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• 2011

In order to protect the turbine blade from working fluid of high temperature, many cooling techniques such as internal convection cooling, film cooling, impinging jet cooling and thermal barrier coating have been developed. With all other things, film-cooling has been widely used as the important alternative. In the present work, numerical analysis has been performed to investigate and to compare the film-cooling performance of various film-cooling hole schemes such as cylindrical, crescent, louver, and dumbbell holes. To analyze the turbulent flow and the film-cooling mechanism, three-dimensional Reynolds-averaged Navier-Stokes analysis has been performed with shear stress transport turbulence model. The validation of numerical results has been assessed in comparison with experimental data. The characteristics of fluid flow and the film-cooling performance for each shaped hole have been investigated and evaluated in terms of centerline, laterally averaged and spatially averaged film-cooling effectivenesses. Among the film cooling holes, the dumbbell shaped hole shows better film-cooling effectiveness than the other shaped holes. And the louver and cylindrical shaped hole show the worst film cooling performance, and concentrated flows on near the centerline only.

• Journal of Korean Elementary Science Education
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• v.32 no.3
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• pp.250-259
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• 2013

This study was aimed at developing eco-STEAM educational programs based on smart learning, implementing the programs to verify their educational effectiveness, and exploring the possibilities for eco-education. The subjects of Science, Mathematics, Practical Arts, Arts, and Physical Education were analyzed to extract STEAM elements for the 5th and 6th grades at elementary school, and then 16 lessen plans were developed under 8 thematic strands. The programs were applied to classes of 5th and 6th graders, and then tested to see the effectiveness in terms of emotional experience, convergence, creative design and satisfaction. The average scores for post-test were statistically higher than those of pre-test(p<.001), showing positive effectiveness of the eco-STEAM programs developed. This study put out the following conclusions. First, the students got emotional experiences through inquiry and observation. Second, the programs helped students to learn about the environment in their contexts and provided a base for interdisciplinary approach. Third, the students in this study could have opportunities for improving their problem-solving abilities by using the creative design. Forth, the students' interests in the ecological topics were increased throughout regular curricula.

• International Journal of Contents
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• v.7 no.4
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• pp.90-97
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• 2011

This study identifies how management theory and philosophy work in conjunction with and support one another as both are critical to understanding leadership concepts and viewing the design organization holistically in terms of organizational behavior and performance. This paper analyses data from an in-depth single-case study at management in interior design organization in Korea. Two new 'most efficient and effective way' to achieve the goals of the design organization has been launched. The first was organizational behavior and performance, and the second a needed new paradigm of management skills. Organizational culture affects organizational effectiveness in design because it can (a) provide an organization with a competitive advantage, (b) improve the way an organizational structure works, and (c) increase the motivation of designers to pursue organizational interests. Moreover, the result of research creates paradigm of thinking that how leaders in the design organization need to focus on innovative and strategic systems to gain competitive advantage and enter global markets; a key inter-organizational cooperation strategy to achieve a targeted goal.

• Proceedings of the KIEE Conference
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• 2006.10c
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• pp.220-222
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• 2006

This paper presents intelligent digital redesign method of global approach for hybrid state space fuzzy-model-based controllers. For effectiveness and stabilization of continuous-time uncertain nonlinear systems under discrete-time controller, Takagi-Sugeno(TS) fuzzy model is used to represent the complex system. And global approach design problems viewed as a convex optimization problem that we minimize the error of the norm bounds between nonlinearly interpolated lineal operators to be matched. Also, by using the bilinear and inverse bilinear approximation method, we analyzed nonlinear system's uncertain parts more precisely. When a sampling period is sufficiently small, the conversion of a continuous-time structured uncertain nonlinear system to an equivalent discrete-time system have proper reason. Sufficiently conditions for the global state-matching of the digitally controlled system are formulated in terms of linear matrix inequalities (LMIs). Finally, a T-S fuzzy model for the chaotic Lorentz system is used as an example to guarantee the stability and effectiveness of the proposed method.

• YAKHAK HOEJI
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• v.51 no.3
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• pp.186-193
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• 2007

This study was performed to analyse the economic value of abciximab which is used in PCI to prevent high-risk patients with ischemic complications. The effectiveness of abciximab was extracted from published clinical trials by search-ing CCIS, and the direct medical costs relevant to using abciximab were estimated from the NHI claims database. The results in terms of cost per life-year gained (LYG) and cost per QALY gained showed that abciximab was cost-effective enough to deserve its cost. Social net benefit resulting from abciximab in PCI was estimated to be 60-70 billion Won per year.

• KDI Journal of Economic Policy
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• v.41 no.3
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• pp.39-75
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• 2019

An emphasis on public-private partnership (PPP) in the regulatory policy process can overcome the challenges hindering regulatory effectiveness with the emergence of fast developing technologies and new industries. This study attempts to evaluate quantitatively different aspects of institutional settings of South Korean regulatory policy in terms of stakeholder engagement as PPP, using evidence-based data released by the OECD. From the results of the principal component analysis, South Korea can be evaluated as being at a very good level overall in its institutional establishment. Nevertheless, the fact that the outcome of regulatory reforms in South Korea is still insufficient compared with this well-established system suggests that the country should concentrate on improving system operation. Consequently, this study makes policy suggestions to improve regulatory effectiveness through PPP by supplementing the facets that are well-equipped but not feasible with respect to regulatory policy cycle, regulatory governance, regulatory method, and conflict resolution.

• Korea Trade Review
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• v.47 no.5
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• pp.95-113
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• 2022

Tariffs on pharmaceuticals are generally low, but the time-consuming and costly licensing procedures of importing countries may act as barriers to trade. Accordingly, in terms of improving export competitiveness through cost reduction of exporting countries and improving public health for importing countries, international regulatory collaboration is effective for both countries. However, little is known about the impact of cross-border cooperation in pharmaceutical regulation on international trade. This study empirically analyzed the effect of cross-border regulatory collaboration on pharmaceutical trade using the gravity model. It was confirmed that the regulatory collaboration measures had a trade promotion effect in all drugs(HS29+HS30), finished drugs (HS30), and vaccines (HS300220). This study is meaningful in that it empirically analyzed with the consideration of the reference pharmacopoeia, safety and effectiveness in addition to the GMP inspection used in the previous study.