• Title/Summary/Keyword: template synthesis

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Preparation of Molecularly Imprinted Poly(methacrylic acid) and Its HPLC Separation Characteristics of Retinoids (분자각인 Poly(methacrylic acid)의 제조 및 레티노이드 화합물의 HPLC 분리 특성)

  • 남기훈;권영돈;김덕준
    • Polymer(Korea)
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    • v.26 no.6
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    • pp.710-717
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    • 2002

  • Molecularly imprinted polymers were prepared in particle forms by crosslinking methacrylic acid (MAA)) using all trans-retinoic acid as a template. The HPLC column packed with the prepared molecular imprinted polymers showed high capability in separation of retinoid derivatives. The column capacity factor and selectivity increased with increasing MAA to template ratio when the incorporated template amount was fixed, as it statistically generated more binding sites between host molecules and template. Molecularly imprinted polymer particles prepared via an emulsion polymerization method were round-shaped and their sizes were more uniformly distributed, but their separation capability was inferior to those obtained by solution polymerization method. It was presumably because the loss of interaction strength between MAA and the template due to hydrogen bonding either between MAA and water or between template and water during the synthesis of molecularly imprinted polymers.

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Synthesis of 2'-Methyl and 4'-Hydroxy Branched Novel Carbocyclic Nucleosides (2'-메칠 및 4'-하이드록시 측쇄를 가진 새로운 카보사이클릭 뉴크레오사이드의 합성)

  • 홍준희;고옥현
    • YAKHAK HOEJI
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    • v.47 no.6
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    • pp.417-421
    • /
    • 2003

  • This paper describes a synthetic route to novel 2'-methyl and 4'-hydroxy carbocyclic nucleosides. The methyl group was successfully installed by carbonyl addition reaction of isopropenyl magnesium bromide followed by ring-closing metathesis and the hydroxy group was directly introduced from carbohydrate chiral template "D-lactose".ose".uot;.

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