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Synthesis of 2'-Methyl and 4'-Hydroxy Branched Novel Carbocyclic Nucleosides  

홍준희 (조선대학교 약학대학)
고옥현 (조선대학교 약학대학)
Publication Information
YAKHAK HOEJI / v.47, no.6, 2003 , pp. 417-421 More about this Journal
Abstract
This paper describes a synthetic route to novel 2'-methyl and 4'-hydroxy carbocyclic nucleosides. The methyl group was successfully installed by carbonyl addition reaction of isopropenyl magnesium bromide followed by ring-closing metathesis and the hydroxy group was directly introduced from carbohydrate chiral template "D-lactose".ose".uot;.
Keywords
antiviral agents; carbocyclic nucleoside; Grignard addition; ring-closing metathesis (RCM);
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