• Membrane and Water Treatment
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• 제4권3호
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• pp.175-189
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• 2013

A membrane bioreactor (MBR) with sludge retention time (SRT) of 300 days was maintained for over 2 years. Polypropylene microfiltration (MF) membrane with pore size of 0.2 ${\mu}m$ was used in the MBR system. The fouling behaviors of various sludge fractions from the MBR were studied and sub-divided resistances were analyzed. It was observed that $R_{cp}$ was a dominant resistance during the filtration of activated sludge, contributing 63.0% and 59.6% to the total resistance for MBR and sequential batch reactor (SBR) respectively. On the other hand, $R_c$ played the significant role during the filtration of supernatant and solutes, varying between 54.54% and 67.18%. Compared with $R_{cp}$ and $R_c$, $R_{if}$ was negligible, and $R_m$ values remained constant at $0.20{\times}10^{12}m^{-1}$. Furthermore, resistances of all sludge fractions increased linearly with rising mixed liquor suspended solids (MLSS) concentration and growing trans-membrane pressure (TMP), while the relationship was inversed between fraction resistances and cross flow velocity (CFV). Among all fractions of activated sludge, suspended solid was the main contributor to the total resistance. A compact cake layer was clearly observed according to the field emission scanning electro microscopy (FE-SEM) images.

• 식품보건융합연구
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• 제5권4호
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• pp.13-17
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• 2019

Amiodarone hydrochloride is an antiarrhythmic agent which has low aqueous solubility and presents bioavailability problem. These properties are a challenge for the pharmaceutical industry. Inclusion of lipophilic compound in the hydrophobic core of micelles, i.e. self-assembled structures based on surfactants in aqueous solution, is one way of increasing the solubility. Intravenous formulation of amiodarone hydrochloride with polysorbate 80 as a detergent and benzyl alcohol as a co-solvent is used in medical practice. This paper aimed to study the effect of polysorbate 80 and benzyl alcohol on the water solubility of amiodarone hydrochloride. Formation of mixed micelles consisting of nonionic surfactant polysorbate 80 and cationic amiodarone with chloride counterion was investigated by fluorescence spectroscopy. Benzyl alcohol was found to decrease the stability of the mixed micelles and lead to crystallization of amiodarone hydrochloride. The greatest amounts of crystals formed at 4℃ for 30 days in the model drug solutions with polysorbate 80 concentrations of 100.1 mg/mL and 97.9 mg/mL. A change of the polysorbate 80 concentration and avoidance the use of benzyl alcohol are recommended to improve the stability of the parenteral dosage form. These results can open new perspectives in the optimization of amiodarone intravenous formulations.

• Membrane and Water Treatment
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• 제3권4호
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• pp.221-230
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• 2012

This study employed the modified fouling index (MFI) to determine the performance of a two-step recycling system - a membrane filtration integrated laminar flow water storage (LFWS) tank followed by an ion exchange process to reclaim ultrapure water (UPW) from the wastewater generated from semiconductor wafer backgrinding and sawing processes. The first step consisted of the utilization of either ultrafiltration (UF) or nanofiltration (NF) membranes to remove solids in the wastewater where the second step consisted of an ion exchanger to further purify the filtrate. The system was able to produce high purity water in a continuous operating mode. However, higher recycling cost could be incurred due to membrane fouling. The feed wastewater used for this study contained high concentration of fine particles with low organic and ionic contents, hence membrane fouling was mainly attributed to particulate deposition and cake formation. Based on the MFI results, a LFWS tank that was equipped with a turbulence reducer with a pair of auto-valves was developed and found effective in minimizing fouling by discharging concentrated wastewater prior to any membrane filtration. By comparing flux behaviors of the improved system with the conventional system, the former maintained a high flux than the latter at the end of the experiment.

• 전자통신동향분석
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• 제37권5호
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• pp.11-21
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• 2022

GaN (Gallium-Nitride) is a promising candidate material in various radio frequency applications due to its inherent properties including wide bandgap, high carrier concentration, and high electron mobility/saturation velocity. Notably, AlGaN/GaN heterostructure field effect transistor exhibits high operating voltage and high power-density/power at high frequency. In next-generation radar systems, GaN power transistors and monolithic microwave integrated circuits (MMICs) are significant components of transmitting and receiving modules. In this paper, we introduce technological trends for C-/X-/Ku-band GaN MMICs including power amplifiers, low noise amplifiers and switch MMICs, focusing on the status of GaN MMIC fabrication technology and GaN foundry service. Additionally, we review the research for the localization of C-/X-/Ku-band GaN MMICs using in-house GaN transistor and MMIC fabrication technology. We also discuss the results of C-/X-/Ku-band GaN MMICs developed at Defense Materials and Components Convergence Research Department in ETRI.

• Structural Engineering and Mechanics
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• 제32권4호
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• pp.549-561
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• 2009

As it is known, laminated composite materials are increasingly used in many technological applications, and in some instance, cutouts must be made into laminated panels for practical reasons, changing the stress distribution. The present study deals with the determination of the stress concentration factor that holes of square shape cause in an orthotropic plate subjected to distributed in - plane loading. Square holes of rounded corners in a rectangular plate are considered, and the effect of different combinations of axial and tangential forces applied to its middle plane at the external edges, is studied. The mutually perpendicular axes, which define the principal axes of orthotropy, are assumed in many different directions referred to the sides of the plate. Numerical experiments by means of a finite element code is performed, evaluating the influence of the fiber orientation with respect to the edges of the plate and the characteristics of the orthotropic materials since such structures do not exhibit easily predictable behavior.

• 대한화학회지
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• 제54권5호
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• pp.523-532
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• 2010

제안된 방법은 국제표준(IS)인 Entacapone-d10(EAD10)을 사용하여 체외에서 Entacapon(EA)의 정량화를 위한 간단하고, 감도가 좋고, 명확한 액체 크로마토그래피-직렬 질량 분석법(LC-ESI-MS/MS)이다. 크로마토그래피 분리는 Zorbax SB-C18에서 수행되었고, $2.1{\times}50\;mm$, $5\;{\mu}m$ 컬럼과 10 mM Ammonium formate (pH 3.0)로 구성된 이동상에서 수행되었다: 0.7 mL/min 유속의 아세토나이트릴(60:40 v/v)은 액체-액체 추출을 따른다. EA와 EAD10은 다중 반응 탐색법(MRM)에서 수소부가물을 가지고 상대적으로 포지티브 모드인 m/z $306.1{\rightarrow}233.1$과 $316.3{\rightarrow}233.0$에서 수소부과물을 가지고 측정되었다. 그 방법은 상관계수($r^2$) 0.993 이상을 갖는 1.00 - 2000.00 ng/mL의 선형 농도 범위 이상으로 입증되었다. 하루 중과 하루 이내에 3.60에서 7.30과 4.20에서 5.50% 이내의 정밀성과 97.30에서 104.20과 98.30에서 105.80% 이내의 정확도는 EA를 위해 입증되었다. 이러한 방법은 건강한 인도인 자원자들의 생물학적 동등성 연구에서 성공적으로 적용되었다.

• 한국콘텐츠학회논문지
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• 제21권8호
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• pp.69-78
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• 2021

디지털 기술발전과 더불어 극장이 아닌 디지털 온라인 매체에서의 영화 수요와 공급이 지속적으로 증가하고 있다. 본 연구는 극장에 비해 다양한 영화가 상영되는 디지털 온라인 영화시장의 수요 집중화 경향을 분석하고자 한다. 2013년 1월부터 2019년 12월까지 TV VOD 자료에 대한 실증분석을 통해 다음의 결과를 확인하였다. 첫째, 극장개봉작 1,137편의 영화에 대한 분석을 통해 디지털 온라인 매체인 TV VOD 관람 수요에 비해 극장 관람 수요의 집중도가 상대적으로 더 높음을 확인하였고 이러한 차이가 통계적으로도 유의하게 나타났다. 둘째, TV VOD 수요 집중도 추이를 살펴보면, 시장에 공급되는 작품편수가 증가함에 따라 절대적 롱테일 지수에 해당하는 독립·예술영화(틈새 상품) 수요도 증가하는 추이를 보이지만 상대적 롱테일 지수인 독립·예술영화 수요 비중과 상위 1% 영화의 수요 비중의 경우 증가 또는 감소 추이가 뚜렷하게 나타나지 않았다. 셋째, TV VOD 수요 집중도와 TV VOD 시장규모 간에 통계적으로 유의한 관계가 있다고 보기 어려웠다. 본 연구는 우리나라의 디지털 온라인 영화시장의 특징을 파악할 수 있는 실증적 결과들을 제시하였다는 점에서 유용성을 가질 것이다.

• Advances in environmental research
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• 제2권3호
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• pp.245-260
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• 2013

Biosorption represents a technological innovation as well as a cost effective excellent remediation technology for cleaning up radionuclides from aqueous environment. In the present study, a bacteria strain FB12 with high adsorption rate of uranium ion was isolated from the vicinity of the nuclear power plant. It was tentatively identified as Bacillus sp.FB12 according to the 16S rDNA sequencing. Efforts were made to further improve the adsorption rate and genetic stability by UV irradiation and UV-LiCl cooperative mutagenesis. The improved strain named Bacillus sp.UV32 obtains excellent genetic stability and a high adsorption rate of 95.9%. The adsorption of uranium U (VI) by Bacillus sp.UV32 from aqueous solution was examined as a function of metal ion concentration, cell concentration, adsorption time, pH, temperature, and the presence of some foreign ions. The adsorption process of U (VI) was found to follow the pseudo-second-order kinetic equation. The adsorption isotherm study indicated that it preferably followed the Langmuir adsorption isotherm. The thermodynamic parameters values calculated clearly indicated that the adsorption process was feasible, spontaneous and endothermic in nature. These properties show that Bacillus sp.UV32 has potential application in the removal of uranium (VI) from the radioactive wastewater.

• Advances in Traditional Medicine
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• 제8권2호
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• pp.178-186
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• 2008

In this study, ionotropic gelation method was used for the preparation of ibuprofen-loaded calcium alginate (CALG) and ethylenediamine (EDA) treated calcium alginate (EDA-CALG) microspheres. The effect of EDA-treatment on drug entrapment efficiency, particle size, morphology, swelling behavior and in vitro release characteristics of the microspheres was investigated by varying its concentration from 0.5 to 2% (v/v). The reduction in drug entrapment efficiency by a maximum of 44.60% was noted for EDA-CALG microspheres compared to untreated CALG microspheres. The particle size and swelling index of EDA-CALG microspheres were reduced with increasing EDA concentration. All the microspheres were observed to retain their spherical shapes with rough surfaces. EDA-CALG microspheres prepared using 1% and 2% v/v EDA, released almost all of its content within 7 h in pH 6.8 phosphate buffer, however, CALG microspheres were found to release the same within 3 h. The intensity of melting endothermic peak of ibuprofen reduced significantly at lower drug load as experienced from DSC thermograms. The FT-IR spectrum of pure ibuprofen, ibuprofen-loaded CALG and EDA-CALG microspheres showed the characteristic band of C = O stretching vibration of ibuprofen. Hence, this study revealed that EDA can be employed for the preparation of ibuprofen-loaded CALG microspheres to retard the drug release to some extent.

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2009년도 춘계학술발표대회 논문집
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• pp.263-268
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• 2009

The current focus of domestic car industry is moving from technological development to reducing greenhouse gas. This study investigates and measures the HVAC system and indoor air condition of highway buses, which is conducted to develop a HVAC system using natural energy in the future. The measurements show that thermal balance is not fulfilled because heating sources are randomly placed, and relative humidity is in the 20 percent range both in HVAC and non-HVAC systems, which is far below 40%, or the highest thermal comfort level. CO2 concentration was found to be an average of 1500 ppm, but not more than 2522 ppm with 15 persons on board, and with 29 persons on board, an average of 2053 ppm, but not more than 3066 ppm, both of which far exceed allowed CO2 concentration level, or 1000 ppm. Generally, highway buses drop by rest stops and open doors for 15 to 20 minutes for getting in fresh air. But its air improvement effect is temporary, and it exacerbates indoor air condition.