• The Korean Journal of Pharmacology
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• v.19 no.1
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• pp.61-69
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• 1983

Hypothermia is an essential preparatory procedure for cardiac surgery, which lows the metabolic rate and myocardial oxygen demand. However, hypothermia itself is a stress enough to change the tonus of sympathoadrenal system, especially the cardiovascular responses to the catecholamines. It is reported that the positive chronotropic and inotropic response of catecholamines is exaggerated during hypothermia because of decreased norepinephrine uptake at the junctional cleft or decreased catecholamine metabolism. On the other hand, there are evidences of diminished catecholamines responses in low temperature ana further, interconversion of adrenergic receptors is also suggested. Present investigation was planned to observe the cardiovascular changes and its responses to catecholamines during surface hypothermia in cat. Healthy mongrel cats, weighing $2{\sim}3\;kg$, anesthetized with secobarbital(30 mg/kg), were permitted to hypothermia by external cooling technic. Esophageal temperature, ECG (lead II), heart rate, left ventricular pressure with dP/dt, carotid artery pressure and left ventricular contractile force were monitored with Polygragh (Model 7, Grass), and the respiration was maintained with artificial respirator (V 5 KG, Narco). Followings are summarized results. 1) Surface cooling caused progressive decrease of body temperature and reached $l8.8{\pm}0.8^{\circ}C$ and $16.9{\pm}0.6^{\circ}C$ in 120 and 150 min respectively, after immersion into ice water, and ventricular fibrillation was developed at $20.4{\pm}0.65^{\circ}C$. 2) Heart rate, blood pressure and myocardial contractility were decreased after initial increase as the body temperature falls. 3) Systolic and diastolicdd P/dt of left ventricular pressure were decreased and that the decrement of diastolic dP/dt was more marked. 4) On ECG, ST depression, Twave inversion and prolongation of PR interval were prominent in hypothermia, and moreover, the prolongation of PR interval was marked just prior to the development of ventricular fibrillation. 5) The cardiovascular responses to catecholamines, especially to isoproterenol, were suppressed under hypothermia.

• Quality Improvement in Health Care
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• v.6 no.1_2
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• pp.48-79
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• 1999

Background : The clothing is considered as second skin. The patient clothing needs basic clothing demands which are comfortable, functional and aesthetical and special demeands which are associated with medical examination, treatment and management of daily-life inconveniences. The patient is weak and labile to psychic trauma and has limitation of movement. So the help of others is needed. But recent patient clothing does not satisfy above demands. So the design, making and management of patient clothing to satisfy those demands are very important. The purpose of this study' is to develop multipurpose clothing which is comfortable, functional, aesthetical and satisfying patients and medical personnels. Method : The questionnaires of existing patient clothing were tested by patients, medical doctors, and nurses. After analyzing two types of questionnaires, eight types of experimental patient clothing were made. After preference test, shortcomings were removed and merits were adapted. One type of multipurpose patient clothing mixing eight above experimental clothing was made. The state of wearing and moving were videotaped. The videotape-recoding was watched by patient, caregivers(medical doctors, nurses) and clothing specialists. Result : The general reaction for experimental clothing were positive by the group of patients, medical personnels and clothing specialist, there were significant differences among three groups. Conclusion : It was thought that to develop one type of multipurpose clothing is possible. If the studys for patient clothing which are free-size and economic matters that are type of clothes and method of washing are made in depth, the desirable patient clothing will appear.

• KIISE Transactions on Computing Practices
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• v.22 no.6
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• pp.296-301
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• 2016

Object-based storage is an efficient storage solution that can handle unstructured data and shows better security and scalability than traditional block-based storage. However, in terms of power management, Object-based storage writes multiple copies in storage cluster, hence many servers consume unnecessary power in idle state. In order to resolve this problem, it is necessary to apply power management strategy by adjusting power mode of servers in idle state according to their workloads. In this paper, we proposed a new dynamic power management (DPM) method to transform power mode of storage servers dynamically according to workload information sent from proxy server. The experimental result shows that the proposed power management technic reduces total power consumption by 12% in the OpenStack based Swift object storage.

• Journal of the Korean Society of Marine Environment & Safety
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• v.22 no.2
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• pp.174-180
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• 2016

This study suggests a navigation route for maritime tourism cruise sail yacht that sails off from Yeosu, and passes by Baekdo and Geomundo with their live island culture, to Kimnyeonghang of the Jeju islands. Recently, there are increasing number of accidents in proportion to vitalizing marine leisure. That's why it should be examined by region and sea when developing safe sea route considering characteristics of the sailing yacht. Thus, it is needed to introduce marine culture, hold international sailing yacht race and develop multi-functional sea port according to the case of Geomundo. Also additional analysis for navigation ruote patterns and density of the fairway is required. This information will improve safe sailing level of sailing yacht that will help the local tourism industry.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.2
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• pp.349-359
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• 2020

Objective: Orchastric changes in the mammary glands are vital, especially during lactation. The secretary epithelial cells together with the supporting myoepithelial and stromal cells function cordially to secrete milk. Increase in the number of luminal epithelial cells and a decrease in adipocytes are visible during lactation, whereas the reverse happens in the involution. However, an early involution occurs if the epithelial cells transdifferentiate towards adipocytes during the lactation period. We aimed to inhibit the adipocyte transdifferentiation of luminal cells by restraining the peroxisomal proliferator-activated receptor γ (PPARγ) pathway. Methods: Linolenic acid (LA) and thiazolidinediones (TZDs) induced adipogenesis in mammary epithelial cells were conducted in monolayer, mixed culture as well as in transwell plate co-culture with mammary myoepithelial cells. Results: Co-culture with myoepithelial cells showed higher adipogenic gene expression in epithelial cells under LA+TZDs treatment. Increase in the expressions of PPARγ, CCAAT/enhancer-binding protein α and vimentin in both mRNA as well as protein levels were observed. Whereas, bisphenol A diglycidyl ether treatment blocked LA+TZDs induced adipogenesis, as it could not show a significant rise in adipose related markers. Although comparative results were found in both mixed culture and monolayer conditions, co-culture technic was found to work better than the others. Conclusion: Antagonizing PPARγ pathway in the presence of myoepithelial cells can significantly reduce the adipogenisis in epithelial cells, suggesting therapeutic inhibition of PPARγ can be considered to counter early involution or excessive adipogenesis in mammary epithelium in animals.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.8
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• pp.2835-2839
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• 2010

This paper estimated the technical specialization of UAV system by analyzing related patents. For that, variable indicators such as patent numbers regarding country, subsystem technic, periods and revealed number of patents are used in this paper. RPA and PII index are also used to estimate technical specialization of the coutry. Positive RPA value means superior competitiveness, and vice versa. PII means the quality of the patent. PII value more than 1 means that the quality of the patent is better than others, Otherwise the quality of the patent is worse. This paper estimated the specialization of technologies among countries using above two index.

• Journal of Korea Foundry Society
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• v.32 no.2
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• pp.104-108
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• 2012

The effect of heat treatment on mechanical properties of 0.4C-2.3Si(wt%) steel with bainitic ferrite matrix were investigated. This steel has been synthesized intergrating concepts from TRIP(Transformation Induced Plasticity) steel & Austempered Ductile Cast Iron(ADI) technology. The low alloy medium carbon (0.4 %C) steel with high silicon (2.3 %Si) was initially annealed for 60 min at $800^{\circ}C$, $820^{\circ}C$ and $840^{\circ}C$ respectively in the intercritical region and then subsequently austempered at various temperatures at $260^{\circ}C$, $320^{\circ}C$ and $380^{\circ}C$ for 30 min in a salt bath. The mechanical properties were measured by using a tensile test. A detailed study of the microstructure of this steel after heat treatment was carried out by means of electron back scattering diffraction (EBSD) technic. In this study, a new low alloy steel with high strength (780~1,050MPa) and exceptionally high ductility (20~40%) was obtained.

• Journal of Korea Foundry Society
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• v.32 no.3
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• pp.138-143
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• 2012

This steel has been synthesized integrating concepts from Austempering Ductile Cast Iron (ADI) technology. While ADI has excellent mechanical and physical properties, the Young's modules of ADI is approximately 20% lower than steel. In addition, the presence of graphite nodules in ADI can be sites of crack initiation, where fracture takes place at graphite matrix interface. Because of this limitations of ADI, there has been a growing interest in austempered steels as structural materials in resent years. In this investigation, a new steel with microstructure composed of ferrite and austenite and with simultaneous high tensile strength (1,150 MPa) and high ductility (33%) was developed. The goal of this investigation is to obtain a better understanding of deformation and transformation behaviour in high carbon retained austenite(${\gamma}_{HC}$) and over-saturated ferrite(${\alpha}$) during the plastic deformation. A detailed study of the microstructure of this steel was carried out by means of X-ray diffraction (XRD) and electron back scattering diffraction (EBSD) technic. In this way it was shown that BCC phase (BCC) took up the larger part of the nominal strain whereas the a part of retained austenite responded to the mechanincal load by partial martensite transformation, and misorientation change in the retained austenite after plastic strain could be attributed to the large elongation.

• The Korean Journal of Pharmacology
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• v.8 no.1
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• pp.31-40
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• 1972

The author studied the actions of ouabain and diphenylhydantoin sodium on the ATPase activity in mitochondrial fraction isolated from rabbit heart and compared with that of quinidine. The results obtained are as follows: 1) In studying the $(Na^++K^+)-activated$ ATPase activity, the rabbit heart isolated was immediately frozen for 7-9 days (ageing of preparation) and thereafter the mitochondria1 fraction obtained by differential centrifugation technic was treated with solution A containing 0.15% deoxycholate for 24-48 hours at $-10^{\circ}C$ before using in experiment. These methods increased the activity ratio to 0.87-0.98. 2) The $(Na^++K^+)-activated$ ATPase activity in mitochondrial fraction of rabbit heart was not completely but markedly inhibited by ouabain. This inhibitory action of ouabain was moderately antagonised by $K^+$ concentration at constant Na concentration. 3) Diphenylhydantoin sodium in concentration of $5{\times}10^{-4}{\sim}10^{-3}M$ stimulated markedly not only $Mg^{++}-dependent$ ATPase activity but also $(Na^++K^+)$-activated ATPase activity and in concentration lower than $10^{-6}M$ had little effect. However, this effect of diphenylhydantoin was markedly increased in the presence of $Na^+$ alone rather than $K^+$ alone, but lesser than that effect in the presence of both $Na^+$ and $K^+$, together. The stimulating effect of diphenylhydantoin was specifically antagonized by ouabaion. 4) When the rabbits were intravenously injected with ouabain and diphenylhydantion respectively, $(Na^++K^+)-activated$ ATPase activity of rabbit heart of ouabain-treated group was much decreased and both $(Na^++K^+)-activated$ ATPase and $Mg^{++}-activated$ ATPase activity were moderately increased in diphenylhydantoin-treated rabbit group. 5) The $(Na^++K^+)-activated$ ATPase activity in mitochondrial fraction of rabbit heart was slightly inhibited by quinidine in high concentration of $10^{-4}M$, but nearly little effect was observed below the concentration of $5{\times}10^{-5}M$. 6) It might be possible to conclude that diphenylhydantoin specifically antagonised the action of ouabain on the membrane ATPase, which is different from the action of quinidine.

• Journal of Korea Water Resources Association
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• v.38 no.9 s.158
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• pp.699-711
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• 2005

In this study, the U.S. Geological Survey's DR3M-II(Distributed Routing Rainfall-Runoff Model) was applied for small urban drainage. DR3M-II is a watershed model for routing storm runoff through a branched system of pipes and natural channels using rainfall input. The model was calibrated and verified using short term rainfall-runoff data collected from Sanbon basin. Also, the parameters were optimized using Rosenbrock technic. An estimated simulation error for peak discharge was about 7.4 percent and the result was quite acceptable. Results of the sensitivity analysis indicate that the percent of effective impervious area and ${\alpha}$ defining surface slope and roughness were the most sensitive variables affecting runoff volumes and peak discharge for low and high intensity storm respectively. In most cases, soil moisture accounting and infiltration parameters are the variables that give more effects to runoff volumes than peak discharge. Parameter ${\alpha}$ showed the opposite result.