• 제목/요약/키워드: tcdd

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디젤동차의 동력장치 관련 설계 고려 사항 (Considerations on Design with related to Propulsion System of Diesel Multiple Unit)

  • 고동우;염규학;유현규
    • 한국철도학회:학술대회논문집
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    • 한국철도학회 2007년도 춘계학술대회 논문집
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    • pp.1639-1645
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    • 2007
  • The Diesel Multiple Units (DMU) can be classified into three types by the type of the transmission. One of those is a Diesel Hydraulic Multiple Unit which is operated with a hydraulic transmission and its propulsion system consists of a diesel engine, transmission, cooling unit, fuel system, intake air and exhaust system, etc. In designing and integrating the propulsion system components, the operation and environment conditions should be considered as well as related standards. This paper describes points to be considered on design with related to propulsion system of Diesel Hydraulic Multiple Unit that is now being developed for Turkish Republic State Railway -TCDD.

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우리나라 성인에 대한 다이옥신의 일일 노출량 예측 (Assessment of human daily intake/uptake for dioxins in Korea)

  • 양지연;신동천;임영욱;김명현;김영수
    • 한국대기환경학회:학술대회논문집
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    • 한국대기환경학회 2002년도 춘계학술대회 논문집
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    • pp.119-120
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    • 2002
  • 소각로, 산업공정 등 다양한 배출원을 가지고 있는 다이옥신은 식품, 피부접촉, 대기 및 토양 통의 매체를 통하여 인간의 건강과 자연 생태계에 유해 영향을 미치고 있다. 환경 중 다이옥신의 배출량은 극미량이기는 하나 높은 지용성 물질로써 환경 매체간 이동 및 먹이사슬을 통해 생체농축현상을 일으키는 것이 밝혀지면서 그로 인한 유해성 야기되기 시작하였으며, 특히, 2001년 미국 환경보호청에서 다이옥신에 대한 재평가를 통해 2,3,7,8-TCDD는 인체 발암물질로, 다이옥신은 인체 발암 유발 가능 물질로 분류하고 있어, 선진국에서는 다이옥신에 대한 적극적인 연구가 진행되고 있다. (중략)

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Neurotoxicity of Halogenated Aromatic Hydrocarbons; Structure-Activity Relationship

  • Yang, Jae-Ho;Kim, Sun-Young;Lee, Ji-Hye;Lee, Hyun-Gyo;Kim, Mi-Young
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2003년도 추계학술대회
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    • pp.64-67
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    • 2003
  • Halogenated aromatic hydrocarbons (HAHs) including TCDD and PCBs are known to cause neurotoxic effects in both man and animals such as cognitive impairment and motor dysfunctions. While theses chemicals may lead to neurodevelopmental and neurobehavioral deficit, structural activity relationship and molecular targets for these chemicals are not elucidated.(omitted)

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Regulation of Cyp 1A1 Gene Expression by Retinoic Acid Receptor, Retinoid X Receptor and Constitutive Androstane Receptor in Rainbow Trout Hepatoma Cells(Rth 149)

  • Kim, Ji-Sun;Yang, So-Yeun;Seo, Mi-Jung;Sheen, Yhun-Yhong
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2003년도 추계학술대회
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    • pp.136-136
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    • 2003
  • Exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a variety of biological and toxicology effects, most of which are mediated by aryl hydrocarbon receptor (AhR). The ligand-bound AhR as a heterodimer with AhR nuclear translocator (ARNT) binds to its specific DNA recognition site, the dioxin-responsive element (DRE), and it results in increased transcription of CVP1A1 gene.(omitted)

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Resveratrol, an Antioxidant in Red Wine, Inhibits Metabolic Formation of Catechol Estrogens and Their Induction of Oxidative Dna Damage and Cell Death

  • Chen, Zhi-Hua;Hurh, Yeon-Jin;Na, Hye-Kyung;Kim, Do-Hee;Chun, Young-Jin;Kim, Dong-Hyun;Surh, Young-Joon
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2003년도 추계학술대회
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    • pp.182-182
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    • 2003
  • cResveratrol (3,5,4'-trihydroxystilbene), a naturally occurring phytoalexin present in grapes and other foods, has been well documented for chemopreventive effects in different systems based on its striking inhibition of diverse cellular events associated with tumor initiation, promotion and progression.(omitted)

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Modulation of Cytochrome P450 1B1 Expression by A Stilbene Analog and its Effect on the Sensitivity to Anticancer Agents in Human Cancer Cells.

  • Lee, Sang-Kwang;Park, Sung-Sik;Kim, Mie-Young;Chun, Young-Jin
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.209.1-209.1
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    • 2003
  • We have previously shown that 2, 3', 4, 5' -tetramethoxystilbene(TMS) from synthetic trans-stilbene analogues, is one of the most potently selective inhibitor of recombinant human cytochrome P450 1B1 in vitro. In the present studies. the effects of TMS on the expression of cytochrome P450 1B1 were investigated in human cancer cell lines such as MCF-7 and HL -60. TCDD-stimulated P450 1B1 protein and mRNA expression was significantly suppressed by TMS in a dose-dependent manner. (omitted)

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Regulation of CYP 1A1 gene expression by retinoic acid receptor, retinoid X receptor and constitutive androstane receptor in rainbow trout hepatoma cells(RTH 149)

  • Kim, Ji-Sun;Yang, So-Yeun;Seo, Mi-Jung;Sheen, Yhun-Yhong
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.119.2-119.2
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    • 2003
  • Exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a variety of biological and toxicology effects, most of which are mediated by aryl hydrocarbon receptor (AhR). The ligand-bound AhR as a heterodimer with AhR nuclear translocator (ARNT) binds to its specific DNA recognition site, the dioxin-responsive element (DRE), and it results in increased transcription of CYP1A1 gene. Retinoic acid (RA) regulates the transcription of various genes for several essential functions through binding to two classes of nuclear receptors, the retinoic acid receptor (RAR) and retinoid X receptor (RXR). (omitted)

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Modulation of carcinogen-activating enzymes by synthetic trans-stilbene analogs

  • Lee, Sang-Kwang;Kim, Sang-Hee;Kim, Mie-Young;Chun, Young-Jin
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.312.1-312.1
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    • 2002
  • Previous studies have demonstrated that 2,3',4,5' -tetramethoxystilbene (TMS) and 3,3',4',5,5'-pentamethoxystilbene (PMS) showed selective inhibition of human cytochrome P450 1 Bl and 1A1 in vitro., respectively, In the present study, the effects of synthetic stilbene analogs on the expression of cytochrome P450 1Al or lBl were investigated in human tumor cell lines such as HepG2, MCF-7 and MCF-l0A, TCDD caused a dramatic increase in the amount of P450 1A1 or 1B1 proteins and mRNA levels. (omitted)

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조선 의서 『향약집성방』 중에 실린 상한(傷寒) 논의 연구 - 인용 문헌, 의론(醫論), 처방, 본초 등을 중심으로 - (A Study on Cold Damage(傷寒) in the Compendium of Prescription from the Countryside(鄕藥集成方) - Focusing on citation, medical theory, prescription, medicinal herbs -)

  • 오재근
    • 한국의사학회지
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    • 제25권2호
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    • pp.121-136
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    • 2012
  • The purpose of this paper is to derive the features of cold damage clinical medicine during the early days of the Chosun(朝鮮) period by analyzing discussions on cold damage published in the official medical book of the Chosun period, Compendium of Prescription from the Countryside(鄕藥集成方, CPC). Cold damage was one of the typical diseases in East Asia where there was constant seeking of the utilization of prescriptions, ways of preparations, and awareness regarding cold damage as shown in Zhang, Zhongjing(張仲景)'s Treatise on Cold Damage Disease(傷寒論, TCDD) below. Traditional Korean medicine which possessed the medical universality of East Asia also was no exception and through an analysis of the part on cold damage in CPC, it is expected that medical features of cold damage in Korea passed down from the Koryo(高麗) Dynasty to the early Chosun period will be revealed. For this, first there needs to be an organization of past discussions on cold damage surrounding the existence of infection and after checking the issues, exploring which of the writings related to TCDD and editions are being utilized through an analysis on citing literature of Cold Damage Disease Literature(傷寒門) and Heat Pathogen Disease Literature(熱病門) which have developed discussions on cold damage in CPC. In addition, by comparing Peaceful Holy Benevolent Prescription(太平聖惠方, PHBP) and Complete Record of Sacred Benevolence(聖濟總錄, CRSB), known to have greatly influenced CPC and Cold Damage Literature and Heat Pathogen Disease Literature, features of form and content used by CPC were analyzed. Features of form were examined through pattern of organization and number of citing literature were examined and for features of content, cold damage infection, classification, syndrome differentiation method, and utilization of materia medica among prescriptions were examined. Discussions on cold damage as being uninfectious as stated in Treatise on the Pathogenesis and Manifestations of All Diseases(諸病源候論) unlike pestilence, epidemic pathogen(時氣), warm pathogen disease(溫病), and heat pathogen disease were excluded in PHBP. PHBP opened the possibility of cold damage infection and later writings, CRSB and CPC also follow this. As a result of analyzing citing literature of the part on cold damage in CPC, it is uncertain which edition of TCDD is being utilized; however, the most distinctive feature was that Classified Emergency Materia Medica(證類本草) and not writings specializing in cold damage are in use. In general, although CPC in terms of form is similar to CRSB, content creation predominantly depended on PHBP. More specifically; first, in terms of the existence of cold damage infection, arguments of PHBP and CRSB are maintained. Second, in terms of cold damage classification, although CRSB is followed, heat pathogen disease is classified separately developing PHBP as is. Third, in terms of method, as Book of Keep Healthy(南陽活人書) and CRSB compiled in later times are cited, it is deemed that arguments were raised to a certain extent regarding six-meridian syndrome differentiation(六經辨證). Fourth, although the majority of utilized materia medica among cold damage prescriptions utilize Materia Medica from the Countryside(鄕藥本草) in CPC and materia medica from Korean Peninsula, this is due to the desire for the compilation performance of CPC to be propagated to ordinary citizens and not the ruling class. CPC as the official medical book compiled in the early days of the Chosun period was greatly influenced by the Song(宋) Dynasty's medical books, PHBP and CRSB shows that cold damage medicine in the early Chosun Period indeed possesses the medical universality of East Asia. Furthermore, the features of published medical theory and prescriptions reveal the existence of the cold damage medical tradition of the Chosun period serving as clues for cold damage research tradition among Korea's medical history.