• Proceeding of EDISON Challenge
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• 2015.03a
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• pp.177-183
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• 2015

$\text\tiny{D}$-Psicose 3-Epimerase (DPE)는 $\text\tiny{D}$-Fructose의 C3 Epimerase로써 $\text\tiny{D}$-Fructose를 $\text\tiny{D}$-Psicose로 전환해 주는 효소이다. $\text\tiny{D}$-Psicose는 설탕 대신 사용하는 감미료로 몸에 흡수되지 않아 칼로리가 없다고 알려져 있고 자연에서는 오로지 DPE에 의해서만 생산되는 희귀당이다. 이에 따라 DPE를 통한 $\text\tiny{D}$-Psicose 대량생산의 필요성이 대두되고 있는 등 이 분야에 대한 관심이 뜨거운 실정이다. 본 연구팀은 이 당과 관련된 작용기작 연구를 수행하기 위하여 아직 단백질 3차구조가 알려지지 않은 Clostridium hylemonae DPE (chDPE) 단백질의 3차 구조예측 연구를 수행 하였다. 우리는 HHsearch를 이용하여 agrobacterium tumefaciens의 DPE 외 2개의 구조를 호몰로지 모델링 연구를 위한 주형으로 선정하였다. 다음으로 PROMALS3D를 이용하여 주형들과 chDPE의 multiple sequence alignment를 수행하였고 이를 바탕으로 3차구조 예측 연구를 수행 하였다. 예측된 구조를 검증하기 위하여 ProSA와 Ramachandran plot분석을 이용하였고 Ramachandran plot에서 단백질의 94.8%에 해당하는 잔기들이 favoured regions에 위치하였다. ProSA에서는 Z-score값이 -9.3으로 X-선 결정학이나 핵자기 공명법으로 밝혀진 구조들에서 관측되는 범위 내에 위치하였다. 나아가 예측된 구조에 $\text\tiny{D}$-Psicose와 $\text\tiny{D}$-Fructose의 결합모드를 규명하기 위하여 도킹을 시도하였다. 이번 연구를 통하여 chDPE의 구조를 예측 할 수 있었고 이를 바탕으로 이 단백질의 기능을 이해하는데 도움을 줄 것으로 기대된다.

• Journal of the Korea Society for Simulation
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• v.29 no.2
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• pp.49-61
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• 2020

It is important to operate a limited number of interceptors effectively to counter ballistic missile threats. The existing interceptor operating method determines the number of interceptors according to the level of TBM (Theater Ballistic Missile) engagement effectiveness applied to a defended asset. It can cause either excessive interceptor waste compared to the intercept probability or the intercept probability decrease. Thus, interceptor operating method must be decided considering the number of ballistic missiles, intercept probability and cost. This study proposes a mathematical model to improve the existing interceptor operating method. In addition, the efficiency indicator is proposed for trade-off between intercept probability and cost. As a result of the simulations, the mathematical model-based interceptor operating method can achieve better results than the existing interceptor operating method.

• Proceedings of the KSR Conference
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• 2004.10a
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• pp.308-327
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• 2004

As use of tunnels and subways increase there also are accidents proportionate to it. Daegu Subway Station fire, Hongjimoon tunnel fire led people to be conscious of disaster protection and as a result, there is a trend to adopt standards for fire protection. Accordingly, this thesis is focused on investigating various fire and water protection related issues for subaqueous tunnel under Ran river. The thesis developed evacuation and disaster prevention plan as fire level increases and have identified the suitability of disaster prevention through evacuation and fire simulation, countermeasure of a water leakage during construction and operation considering the subaqueous tunnel. And we selected EPB shield TBM equipment considering the ground condition and effect of boring hole, and accomplished reasonable water protection design through setting goals using event-tree method, as well as examining model test of boring hole and flooding in heavy rain. Also included structured total system consist of water leakage sensing system, water protection gate, pumping system and fire protection system to respond systematically in emergency.

• Journal of TMJ Balancing Medicine
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• v.5 no.1
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• pp.20-26
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• 2015

Four cases of functional cerebrospinal therapy (FCST) were reviewed to see whether any improvement is observed in the X-ray images of open-mouth view and cephalocervical views. Intraoral appliances of TMJ balancing appliance (TBA) and cervical balancing appliance (CBA) and active movement of within range-of-movement of the jaw and the neck were applied to each patient. Improved balance of $2^{nd}$ cervical vertebra position and cervical alignment were observed in all the four cases.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.08a
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• pp.324-324
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• 2010

핵융합의 고체형 증식(Helium Cooled Solid Breeder : HCSB) 블랑켓(Blanket Module)은 삼중수소 증식을 위해서 Li4SiO4, Li2TiO3, Li2O 및 Li2ZrO3 등의 페블이 고려되고 있다. 이러한 페블을 제조하기 위해서는 먼저 각각의 분말 제조가 선행되어야 한다. 한국의 Test Blanket Module(TBM)은 Li4SiO4 페블을 개발을 개발하여 사용할 예정이고 옵션으로 Li2TiO3 페블을 개발하는 것으로 되어 있다. Li4SiO4 페블을 개발하기 위해서 먼저 분말합성이 필수적이다. Li4SiO4 분말을 합성에 하기 위해서는 Lithium 금속염과 실리카 졸을 용매 및 폴리머 캐리어로서의 두 가지 기능을 하는 에틸렌글리콜에 첨가한 후 가열하여 완전히 용해시킨 후 혼합 용액을 건조시켜 겔형의 전구체를 제조한다. 이를 하소한 후 결정화시켜 Silicate 분말을 얻는데 이때의 건조, 하소 및 결정화 온도의 조건에 따른 분말의 크기 및 특성이 각각 다르다. 즉, 바인더 물질의 비율과 합성온도에 따라 특성이 약간씩 다른 분말을 얻을 수 있었다. 이렇게 얻어진 Silicate 분말은 지르코니아 볼을 이용하여 약 24 시간 동안 볼 밀링 과정을 통해 입도가 작은 미세한 Silicate 분말로 만들었다. 합성된 분말은 여러 가지 시험 및 분석을 통해서 검증되었으며, 불순물 등은 관찰되지 않았다.

• Magazine of korean Tunnelling and Underground Space Association
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• v.21 no.1
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• pp.101-112
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• 2019

This case study presented a simplified failure mechanism approach used as a preliminary deformation prediction for the Mexico City's metro system expansion. Because of the Mexico City's difficult subsoils, Line 12 project was considered one of the most challenging projects in Mexico. Mexico City's subsurface conditions can be described as a multilayered stratigraphy changing from soft high plastic clays to dense to very dense cemented sands. The Line 12 trajectory crossed all three main geotechnical Zones in Mexico City. Starting from to west of the City, Line 12 was projected to pass through very dense cemented sands corresponding to the Foothills zone changing to the Transition zone and finalizing in the Lake zone. Due to the change in the subsurface conditions, different constructions methods were implemented including the use of TBM (Tunnel Boring Machine), the NATM (New Austrian Tunneling Method), and cut-and-cover using braced Diaphragm walls for the underground section of the project. Preliminary crown and excavation front deformations were determined using a simplified failure mechanism prior to performing finite element modeling and analysis. Results showed corresponding deformations for the crown and the excavation front to be 3.5cm (1.4in) and 6cm (2.4in), respectively. Considering the complexity of Mexico City's difficult subsoil formation, construction method selection becomes a challenge to overcome. The use of a preliminary results in order to have a notion of possible deformations prior to advanced modeling and analysis could be beneficial and helpful to select possible construction procedures.

• Nuclear Engineering and Technology
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• v.53 no.7
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• pp.2151-2161
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• 2021

Nuclear data (ND) sensitivity and uncertainty (S/U) quantification in shielding applications is performed using deterministic and probabilistic approaches. In this paper the validation of the newly developed deterministic program package ASUSD (ADVANTG + SUSD3D) is presented. ASUSD was developed with the aim of automating the process of ND S/U while retaining the computational efficiency of the deterministic approach to ND S/U analysis. The paper includes a detailed description of each of the programs contained within ASUSD, the computational workflow and validation results. ASUSD was validated on two shielding benchmark experiments from the Shielding Integral Benchmark Archive and Database (SINBAD) - the fission relevant ASPIS Iron 88 experiment and the fusion relevant Frascati Neutron Generator (FNG) Helium Cooled Pebble Bed (HCPB) Test Blanket Module (TBM) mock-up experiment. The validation process was performed in two stages. Firstly, the Denovo discrete ordinates transport solver was validated as a standalone solver. Secondly, the ASUSD program package as a whole was validated as a ND S/U analysis tool. Both stages of the validation process yielded excellent results, with a maximum difference of 17% in final uncertainties due to ND between ASUSD and the stochastic ND S/U approach. Based on these results, ASUSD has proven to be a user friendly and computationally efficient tool for deterministic ND S/U analysis of shielding geometries.

• Geomechanics and Engineering
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• v.37 no.4
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• pp.323-339
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• 2024

If the pressure exerted on the face of a tunnel excavated by TBM exceeds a threshold, it leads to failure of the soil or rock masses ahead of the tunnel face, which results in heaving the ground surface. In the current research, the upper bound method of limit analysis was employed to calculate the blow-out pressure of tunnels excavated in rock masses obeying the Hoek-Brown nonlinear criterion. The results of the proposed method were compared with three-dimensional finite element models, as well as the available methods in the literature. The results show that when σ_ci, m_i, and GSI increase, the blow-out pressure increases as well. By doubling the tunnel diameter, the blow-out pressure reduces up to 54.6%. Also, by doubling the height of the tunnel cover and the surcharge pressure exerted on the ground surface above the tunnel, the blow-out pressure increased up to 74.9% and 5.4%, respectively. With 35% increase in the unit weight of the rock mass surrounding the tunnel, the blow-out pressure increases in the range of 14.8% to 19.6%. The results of the present study were provided in simple design graphs that can easily be used in practical applications in order to obtain the blow-out pressure.

• Korean Chemical Engineering Research
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• v.45 no.2
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• pp.143-148
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• 2007

In hydrogen production for fuel cell by reforming city-gas, sulfur compounds, odorant in city-gas, are detrimental to reforming catalyst and fuel cell electrodes. We prepared metal salt impregnated ${\beta}-zeolite(BEA)$ to remove sulfur compound in city-gas by adsorption. The sulfur breakthrough adsorption capacity was changed depending on the concentration and species of metal salt. $AgNO_3$ impregnated BEA showed the highest sulfur breakthrough capacity among adsorbents used in this experiment(41.1 mg/g). But metal salt impregnated BEA such as $Ni(NO_3)_2/BEA$, $Fe(NO_3_)_3/BEA$, $Co(NO_3)_2/BEA$ showed a certain amount of sulfur adsorption capacity comparable to $AgNO_3/BEA$. Adsorption temperature effect, desorption study, and x-ray photoelectron spectroscopy analysis revealed that the dominant interaction between metal impregnated adsorbent and sulfur compounds was not chemisorption but physisorption.

• Journal of Korean Tunnelling and Underground Space Association
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• v.5 no.4
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• pp.361-370
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• 2003

In this study, the performance of water tightness of water expansional sealing material and gasket was evaluated. The water tightness test was performed varying the type of inner pressure condition, for which the water expansional sealing material was inundated for 5 days to evaluate the ability of water tightness. In order to carry out this test, we made use of two types of water expansional sealing material; general type and combined type with non-expansional rubber. In the case of gasket, EPDM gasket and complex gasket sticked to the water expansional sealing material were applied. The performance of water tightness depended on the construction defect and the deformation of segment. The construction defect and segment deformation were generally expressed by gap and offset of the construction joint. The results, of tests showed that the performance of water tightness was largely influenced by the gap between segments. Management criteria of gap and offset were proposed.