• Macromolecular Research
• /
• v.15 no.6
• /
• pp.547-552
• /
• 2007

Water soluble polymer, poly(vinyl pyrrolidone) was chosen to conjugate with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (N-succinyl DPPE) to make a new drug delivery system. PVP with an amine group (amino-PVP) was polymerized by free radical polymerization. The amine group of amino-PVP was conjugated with the carboxylic group of N-succinyl DPPE. The resultant conjugate could form nanoparticles in the aqueous solution; these nanoparticles were termed a lipid-polymer system. The critical aggregation concentration was measured with pyrene to give a value of $1{\times}10^{-3}g/L$. The particle size of the lipid-polymer system, as measured by DLS, AFM and TEM, was about 70 nm. Lipophilic component in the inner part of the lipid-polymer system could derive the physical interaction with hydrophobic drugs. Griseofulvin was used as a model drug in this study. The loading efficiency and release profile of the drug were measured by HPLC. The loading efficiency was about 54%. The release behavior was sustained for a prolonged time of 12 days. The proposed lipid-polymer system with biodegradable and biocompatible properties has promising potential as a passive-targeting drug delivery carrier because of its small particle size.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.22 no.2
• /
• pp.86-94
• /
• 1989

Yellowfin and bigeye tunas have been targeting and the most important species for the Korean tuna longline fishery in the Indian Ocean. This study is aimed to analyse the fishing efficiency of the regular and the deep longlines and the vortical distribution of tunas, and the weight composition by fishing depth based on the data from Korean tuna longline fishery from 1973 to 1980 and from 1984 to 1986 in the Indian Ocean. It was found that the deep longline gear on bigeye tuna was significantly different from the regular longline gear on yellowfin tuna in the whole Indian Ocean. Yellowfin tuna and billfishes were chiefly distributed at the shallow layer and bigeye at the deep layer. The weight composition of yellowfin and bigeye tunas by depth showed that the deeper the depth, the larger the bigeye distributed.

• Journal of Pharmaceutical Investigation
• /
• v.30 no.1
• /
• pp.1-12
• /
• 2000

Gene therapy is a method for the treatment of diseases with introducing the gene-engineered materials into a patient with gene-deficiency disease (e.g. cystic fibrosis) or cancer to produce a therapeutic protein in a patient's cells. Successful gene therapy requires establishing both gene expression systems and delivery systems. Viral and non-viral vectors have been used for gene delivery. Viral vectors have a high transfection efficiency, but are limited in relations to issues of safety, toxicity and immunogenecity. Non-viral vectors are easy to prepare and relatively safe. However, non-viral vectors have a low transfection efficiency. Cationic liposomes are the most available among non-viral vectors. Cationic liposomes have been used to transfect cells both in vitro and in vivo experiments. Besides, several formulations containing cationic lipid are being used in clinical trials in cases of cystic fibrosis or cancer. A crucial subject to the further development of gene delivery vectors will be a long-term gene expression with following characteristics; protecting and deliverying DNA efficiently, non-toxic and non-immunogenic, and easy to produce in large scale.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.34 no.2
• /
• pp.212-225
• /
• 2010

This study investigates the dimensionality of perceived web site quality for fashion e-retailers to compare the differences in perceived web site quality between Korean and Chinese college students in the identification of the decisive web site quality dimensions for customer satisfaction and repurchase intentions. Data were collected from 300 Korean and 300 Chinese online apparel shoppers. The survey was statistically analyzed by factor analysis, T-test, and regression analysis. The perceived service quality dimensions were identified as product quality, economic efficiency, information quality, site design, and trust. The Chinese college students had significantly higher evaluations than Korean college students on information quality and trust. For Korean college students, product quality, economic efficiency, and trust were the most decisive predictors of customer satisfaction and they have indirect effects on repurchase intentions. For Chinese college students, product quality and information quality were identified as the most decisive predictors of customer satisfaction and they have indirect effects on repurchase intentions. Strategic directions for e-commerce business targeting Korean or Chinese college students are suggested in the conclusion.

• Journal of the Korea Society for Simulation
• /
• v.22 no.3
• /
• pp.81-87
• /
• 2013

This paper is about study how to decrese surge pressure that is occurred in excavator driving motor. We used computer simulation program SimulationX. It is also about the way finding design problem and approaching a solution through interpreting shape design sensitivity analysis. Programmes are below. First of all, finding shape fault by analyzing dynamic behavior of valves installed in hydraulic driving motor which is designed now. And drawing variable which is considered sensitive to improve dynamic efficiency among a lot of shape variables. Then, targeting that variable and examining dynamic efficiency stabilization tendency with controlling it. Finally, suggesting the most effective tuning method through variable combination as there are a lot of sensitive variables.

• The Journal of Fisheries Business Administration
• /
• v.47 no.3
• /
• pp.15-33
• /
• 2016

This study aims to analyze effectiveness of the resource use under the total allowable catch system (TACs) of Comb pen shell, a species among TAC targeting ones through its stock assessment based on the surplus production model such as the Clark Yoshimoto Pooley (CYP) model. Particularly, this study is separated into five analysis periods in order to understand changes in Comb pen shell resource and its efficient use after TAC system implemented in 2001. The results of this study are as follows. First, five sustainable yield curves (SYCs) and exponential growth functions (EGFs) produced by the surplus production model based on Gompertz growth function to compare before and after implementation of the Korean TAC system show that the TAC system has generated a positive stock rebuilding effect for Comb pen shell caught by the diver fishery since 2001. Secondly, five profits based on differences between the sustainable total revenue (STR) and the total cost (TC) with respect to fishing efforts present that the TAC system has increased efficiency of resource use of Comb pen shell caught by the diver fishery after implementation of the Korean TAC system. In conclusion, the Korean TAC system has increased efficiency of resource use as well as has led a positive stock rebuilding effect for Comb pen shell.

• Korea Journal of Hospital Management
• /
• v.26 no.3
• /
• pp.56-67
• /
• 2021

There are few domestic studies on medical services in medically vulnerable areas where medical use is not met due to a lack of medical resources. The past studies on smart medicine targeting medically vulnerable areas grasp only the overall satisfaction level, or the sub-dimensions of satisfaction are not classified clearly. Also, it lacks consideration of the patient's needs. This study aims to analyze the effect of users' experience of the smart medicine pilot project conducted in medically vulnerable areas on satisfaction and demand. The user's experience was measured by variables in the dimensions of structure, process, and outcome. Among the pilot project participants, 282 subjects responded to the 2019 survey. Using the hierarchical regression method, we tried to find out the determinants of satisfaction and service demands. Experience factors affecting satisfaction were found to be accessibility, certainty, effectiveness, and efficiency. In addition, it was found that the demand in their 60s was high and that accessibility, certainty, effectiveness, and efficiency had a statistically significant effect on the demand. It is expected that the smart medicine pilot project will be effectively operated by well utilizing the factors influencing satisfaction and demand revealed in this study.

• The Journal of Sustainable Design and Educational Environment Research
• /
• v.6 no.2
• /
• pp.25-52
• /
• 2007

This paper is focused on the economical efficiency of the geothermal heat pump system in school. As the importance of problems of environment and energy becomes larger, the development and distribution of energy-saving technology in the whole nation has become influential. This paper is intended, targeting on school buildings scattered all over the country, to evaluate the introduction and possibility of a terrestrial heat system which is in the first stage of introduction in the country, through energy consumption and efficiency in case where a terrestrial heat system is introduced. To do that, the author performed a qualitative analysis of the heat pump system using various terrestrial heat energy and the system introduced to existing school buildings and, through the analysis, made tentative evaluation on the most environment-friendly and energy saving type system. Also, the author performed simulation analysis using a currently typical school building standard and, on the basis of this result, conducted efficiency analysis of various heat pump systems. The conclusion according to synthetical analysis & evaluation can be summarized as follows. In case a heat pump system is introduced to a school building, it was deemed the investment in the early stage would increase, but the investment could be collected within 5~6 years through reduction of large operation expenses. Also, it was analyzed in case of terrestrial heat contracted heat mode using midnight electric power among heat pump systems, not only early investment but also operation expenses could be reduced to a great extent. Accordingly in case the system using terrestrial heat energy is applied to the school buildings that are to be newly built or repaired in the future, it will provide an object-lesson to students as well as contributing to energy saving.

• Korean Journal of Environmental Agriculture
• /
• v.40 no.3
• /
• pp.179-185
• /
• 2021

BACKGROUND: Tomato genome editing using CRISPR-Cas9 is being actively conducted in recent days, and lots of plant researches have been aiming to develop high valued crops by editing target genes without inserting foreign genes. Many researchers have been involved in the manipulation of the crop ripening process because fruit ripening is an important fruit phenotype for increasing fruit shelf life, taste, and texture of crops. This paper intends to evaluate target sgRNA to edit the two ripening-related genes encoding pectate lyase (PL) and phytoene synthase (Psy) with the CRISPR-Cas9 system. METHODS AND RESULTS: The CRISPR-Cas9 expression vector was cloned to target the PL (Solyc03g111690), Psy1 (Solyc03g031860), and Psy2 (Solyc02g081330) genes, which are the ripening genes of tomatoes. Tomatoes injected with Agrobacterium containing the CRISPR-Cas9 expression vector were further cultured for 5 days and used to check gene editing efficiency. As a result of the target gene sequence analysis by the next generation sequencing method, gene editing efficiency was calculated, and the efficient target location was selected for the PL and Psy genes. CONCLUSION: Therefore, this study was aimed to establish target sgRNA data that could have higher efficiency of the CRISPR-Cas9 system to obtain the delayed ripening phenotype of tomato. The developed method and sgRNA information is expected to be utilized in the development of various crops to manage its ripening processes.

• Journal of the Semiconductor & Display Technology
• /
• v.21 no.4
• /
• pp.18-22
• /
• 2022

Photovoltaics (PV) power generation efficiency is affected by meteorological factors such as temperature and wind speed. In general, it is known that the power generation amount decreases because photovoltaics panel temperature rises and the power generation efficiency decreases in summer. Photovoltaics Thermal (PVT) power generation has the ad-vantage of being able to produce heat together with power, as well as preventing the reduction in power generation efficien-cy and output due to the temperature rise of the panel. In this study, the amount of heat collected by season and time was calculated for photovoltaics thermal modules using the International Weather for Energy Calculations (IWEC) data provided by the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE). Based on this, we propose a method of predicting the temperature of the photovoltaics panel using thermal analysis and then calculating the flow rate of coolant to improve power generation efficiency. As the results, the photovoltaics efficiencies versus time on January, April, July, and October in Jeju of the Republic of Korea were calculated to the range of 15.06% to 17.83%, and the maxi-mum cooling load and flow rate for the photovoltaics thermal module were calculated to 121.16 W and 45 cc/min, respec-tively. Though this study, it could be concluded that the photovoltaics thermal system can be composed of up to 53 modules with targeting the Jeju, since the maximum capacity of the coolant circulation pump of the photovoltaics thermal system applied in this study is 2,400 cc/min.