• Journal of Microbiology and Biotechnology
• /
• v.31 no.7
• /
• pp.933-941
• /
• 2021

Ginsenoside Rg4 is a rare ginsenoside that is naturally found in ginseng, and exhibits a wide range of biological activities including antioxidant and anti-inflammatory properties in several cell types. The purpose of this study was to use an in vivo model of hair follicle (HF)-mimic based on a human dermal papilla (DP) spheroid system prepared by three-dimensional (3D) culture and to investigate the effect of Rg4 on the hair-inductive properties of DP cells. Treatment of the DP spheroids with Rg4 (20 to 50 ㎍/ml) significantly increased the viability and size of the DP spheres in a dose-dependent manner. Rg4 also increased the mRNA and protein expression of DP signature genes that are related to hair growth including ALP, BMP2, and VCAN in the DP spheres. Analysis of the signaling molecules and luciferase reporter assays further revealed that Rg4 induces the activation of phosphoinositide 3-kinase (PI3K)/AKT and the inhibitory phosphorylation of GSK3β, which activates the WNT/β-catenin signaling pathway. These results correlated with not only the increased nuclear translocation of β-catenin following the treatment of the DP spheres with Rg4 but also the significant elevation of mRNA expression of the downstream target genes of the WNT/β-catenin pathway including WNT5A, β-catenin, and LEF1. In conclusion, these results demonstrated that ginsenoside Rg4 promotes the hair-inductive properties of DP cells by activating the AKT/GSK3β/β-catenin signaling pathway in DP spheres, suggesting that Rg4 could be a potential natural therapy for hair growth.

• Mass Spectrometry Letters
• /
• v.3 no.1
• /
• pp.4-9
• /
• 2012

• Proceedings of the KIEE Conference
• /
• 2007.11c
• /
• pp.97-100
• /
• 2007

There are regulations on each building for its classification and It is corresponding determined contract demand. For transformer's capability calculation algorithm, cumulated power information of each customer is used to analysis the correlation between power usage and Demand Rate. By modeling this using Least Square Method, it can be targeted to recognize the pattern of transformer use in the past and make a prediction on it in the future.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
• /
• 2008.10a
• /
• pp.98-101
• /
• 2008

The goal of this paper is to select and analyze the sound for robot which can help and serve the big retail market, as the part of research for design foundation development of Human Robot Interface. The sounds which are related with activity, such as thanks, reject, agony,absurdity, gladness, approval, were selected among targeted sounds with 2 step SD method. The result for using Quantitative analysis model-3 with psychological similar degree of selected sound was argued with 'the brightness of sound' and 'violent of sound'.

• Journal of Distribution Science
• /
• v.10 no.12
• /
• pp.5-11
• /
• 2012

Purpose - This paper proposes measurement models to evaluate the management performance of small and medium-sized retail businesses on the basis of a trading area analysis that compares their proposed revenue to actual revenue in the trading area. Research design, data, methodology - The study proposes measurement models consisting of five stages, namely: (1) district background survey, (2) customer survey, (3) competitor survey, (4) business district survey, and (5) business performance analysis. Results - To identify business districts easily, this study preferred a minor-adjusted method based on the Euclidean distance, as it is simple to employ for the small and medium-sized businesses. This model was applied to select coffee shops in Daejeon. Results indicated that although the targeted shop was not located in an appropriate location, actual sales were higher than expected. Conclusions - Small- or medium-sized retail businesses face difficulties regarding the economies of scale and brand recognition and must choose an appropriate location to ensure management stability. However, such businesses will find it difficult to evaluate their competitive edge accurately using a trading area analysis.

• 한국신재생에너지학회:학술대회논문집
• /
• 2006.11a
• /
• pp.265-268
• /
• 2006

Performed fatigue strength analysis for Hub to get the targeted service life of 20 years. ANSYS is used to analysis. The major structure of bearing which connect the hub and blades is modeled using the element of LINK10. To represent the stiffness of LINK10 element, initial strain and diameter of LINK10 element is applied. Prior to calculating the fatigue damages, the influence matrix is extracted from the unit loads. The target service life of 20 years is achieved from the Analysis results.

• Proceedings of the Korean Society of Agricultural Engineers Conference
• /
• 2003.10a
• /
• pp.507-510
• /
• 2003

The development of a basin-wide runoff analysis model is to analysis monthly and daily hydrologic runoff components including surface runoff, subsurface runoff, return flow, etc. at key operation station in the targeted basin. A short-term water demand forecasting technology will be developed taking into account the patterns of municipal, industrial and agricultural water uses. For the development and utilization of runoff analysis model, relevant basin information including historical precipitation and river water stage data, geophysical basin characteristics, and water intake and consumptions needs to be collected and stored into the hydrologic database of Integrated Real-time Water Information System. The well-known SSARR model was selected for the basis of continuous daily runoff model for forecasting short and long-term natural flows.

• Journal of the Korean Society of Costume
• /
• v.50 no.6
• /
• pp.21-31
• /
• 2000

The purpose of this study was to characterize the attitudes of Net generation customers toward purchasing fashion products or apparels through Cyber communication media. This study targeted 333 individuals aged from 14 to 24 purchasing fashion apparels through the Interned or PC communication. The data were analyzed by using frequency analysis, factor analysis, t-test, ANOVA by SASS package. The results of this study are as follows : 1. Fashion life-style of Net generation is classified into four groups - Fashion attached type, Web entertainment type, Web information type, Web media purchasing type. Net-Generation shows a little preference for brand. 2. As a result of the statistical analysis of each group's demographic variables, price is not so important when purchasing and according to the analysis of age, it proves that twenties are trendier than teenagers. 3. The most significant factor of information search is watching others' clothes and the most popular place for purchase is wholesale mall. Net-Generation has a little intention to purchase through Cyber communication media.

• 한국신재생에너지학회:학술대회논문집
• /
• 2007.11a
• /
• pp.525-528
• /
• 2007

Geothermal Energy is related part of important the technology, and getting Patent statistics and analysis are targeted to Koran, Japan and America. Accoding to patent statistics, checking the analysis, developing speed of technology in korean and technology level and compared with America between Japan of technology. In this paper, Give help to national level can be achieved by reinforcing companies R&D, putting more concern and effort on getting straegical patents, activation of jog invention, expanding the quality Intellectual property(IP) & licensing Personnel, building a system responsive to international patent dispute. and national level can be archived by encouraging &supporting R&D of core technology, overseas applications of IP rights

• Journal of Korea Multimedia Society
• /
• v.19 no.7
• /
• pp.1216-1224
• /
• 2016

This study analyzed the montage pattern of e-book in a bid to include e-book in the film language system. To this end, this study targeted three pieces of e-books which reproduced the animation for theater use of Disney Company. This study did research on characteristics of montage in films, and kinds of film vectors, and defined it as 'Montage of Experience' according to media characteristics of e-book. This study deducted the montage pattern of 3 sorts of classification, and 10 sorts of detailed classification by doing research on the analysis object. This study has a significance in that it pioneers a new perspective in e-book research which has been biased towards a functional perspective. Analysis of the point of contact where the existing visual media, and new media meet with each other could be a driving force promoting the growth of the relevant industry, and this study thinks that the analysis of the point of contact is the research which is helpful to working out qualitative improvement of e-book contents.