• Journal of Preventive Medicine and Public Health
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• 제45권4호
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• pp.235-243
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• 2012

Objectives: Nail has been a substitute DNA source for genotyping. To investigate the integrity and consistency of nail DNA amplification for biomarker study, nail clippings from 12 subjects were collected at monthly intervals. The possibility of longer amplification and existence of GAPDH RNA/protein, were also investigated with three nail samples. Methods: Three primer sets were designed for quantitative amplification of nuclear and mitochondrial genes and analysis of their consistency. The mean threshold cycles in amplification of the target genes were compared to test the consistency of polymerase chain reaction (PCR) performance among individual factors including age groups, sex, family, the nail source, and by the size of the amplification segments. Results: The amplification of the target genes from nail DNA showed similar integrity and consistency between the nail sources, and among the serial collections. However, nail DNA from those in their forties showed earlier threshold cycles in amplification than those in their teens or seventies. Mitochondrial DNA (mtDNA) showed better DNA integrity and consistency in amplification of all three targets than did nuclear DNA (nucDNA). Over 9 kb of mtDNA was successfully amplified, and nested quantitative PCR showed reliable copy numbers (%) between the two loci. Reverse transcription PCR for mRNA and immunoblotting for GAPDH protein successfully reflected their corresponding amounts. Regarding the existence of RNA and protein in nails, more effective extraction and detection methods need to be set up to validate the feasibility in biomarker study. Conclusions: Nail DNA might be a feasible intra-individual monitoring biomarker. Considering integrity and consistency in target amplification, mtDNA would be a better target for biomarker research than nucDNA.

• 천문학회보
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• 제39권2호
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• pp.46-46
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• 2014

Interactions such as mergers and flybys play a fundamental role in shaping galaxy morphology. We used the Horizon Run 4 cosmological N-body simulations to study the frequency and the type of halo interactions as a function of the environment, the separation p, the mass ratio q, and the target halo mass. We defined targets as haloes more massive than 10^11 Msun/h, and a target is interacting if it is located within the virial radius of a neighbour halo more massive than 0.4 times the target mass. We find that the interaction rate as a function of time has a universal shape for different halo mass and large-scale density, with an increase and saturation. Larger density yield steeper slopes and larger final interaction rates, while larger masses saturate later. Most interactions happen at large-scale density contrast ${\delta}$ about 10^3, regardless of the redshift. We also report the existence of two modes of interactions in the (p,q) plane, reflecting the nature (satellite or main halo) of the target halo. These two trends strongly evolve with redshift, target mass, and large-scale density. Interacting pairs have similar spins parameters and aligned spins, with radial trajectories, and prograde encounters for non-radial trajectories. The satellite trajectories become less and less radial as time proceed. This effect is stronger for higher-mass target, but independent of the large-scale density.

• 한국산학기술학회논문지
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• 제18권5호
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• pp.99-110
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• 2017

레이다를 이용한 다수 표적의 상태 추정을 통해 추적 성능을 향상시키는 문제는 중요하다. 클러터 환경에서 추적 필터를 이용하여 다수 표적 추적 시 트랙과 측정치 간의 결합사건이 발생하며 개수가 증가함에 따라 결합사건은 기하급수적으로 증가한다. 이러한 환경에서 다수 표적 추적 필터 설계 시 고려해야할 문제는 첫째, 신속한 거짓트랙 제거 및 표적트랙 확정을 통하여 오경보율 최소화하고, 이를 통해 FTD(False Track Discrimination) 성능을 높인다. 둘째, 다수의 트랙이 측정치를 공유하는 결합사건 발생시 효율적으로 각각의 측정치를 트랙에 할당함으로써 트랙 유지성능을 향상시키는 것이다. 두 가지 고려사항을 통해 단일 표적 추적 자료결합 기법을 다수 표적 추적 필터로 확장하여 사용하며, 대표적인 알고리듬으로 JIPDAF(Joint Integrated Probabilistic Data Association Filter)와 LM-IPDAF(Linear Multi-target IPDAF)가 있다. 본 논문에서는 측정치 할당 시 생기는 수 많은 가설들에 대한 확률적 평가를 하지 않음으로써 측정치와 트랙의 개수에 따라 비선형으로 연산량이 증가하지 않으며, 클러터밀도 추정을 통해 트랙을 쇄신하는 트랙존재확률 기반의 LM-IPDAF 알고리듬을 소개한다. 그리고 LM-IPDAF의 트랙존재확률 산출 시 필요한 클러터밀도 추정 방법을 개선함으로써 연산량을 효과적으로 감소시킬 수 있는 방법을 제안하고 시뮬레이션을 통해 기존의 알고리듬과 비교, 분석하여 성능을 검증하였다. 그 결과, 위치 RMSE, Confirmed True Track 측면에서는 동일한 성능을 내면서 시뮬레이션 처리 시간을 약 20% 감소시킬 수 있었다.

• 한국군사과학기술학회지
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• 제21권2호
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• pp.225-234
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• 2018

In this paper, we consider a problem of partitioning a search area into smaller rectangular regions, so that multiple platforms can conduct search operations independently without requiring unnecessary coordination among themselves. The search area consists of cells where each cell has some prior information regarding the probability of target existence. The detection probability in particular cell is evaluated by multiplying the observation probability of the platform and the target existence probability in that cell. The total detection probability within the search area is defined as the cumulative detection probability for each cell. However, since this search area partitioning problem is NP-Hard, we decompose the problem into three sequential phases to solve this computationally intractable problem. Additionally, we discuss a special case of this problem, which can provide an optimal analytic solution. We also examine the performance of the proposed approach by comparing our results with the optimal analytic solution.

• 제어로봇시스템학회논문지
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• 제14권8호
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• pp.733-739
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• 2008

This article proposes algorithms for the automatic initiation of the tracks of maneuvering targets in cluttered environments. These track initiation algorithms consist of IPDA-AI(Integrated Probabilistic Data Association-Amplitude Information) and MPDA(Most Probable Data Association) in an Interacting Multiple Model(IMM) configuration, and they are referred to as the IMM-IPDAF-AI and IMM-MPDA respectively. The IMM portion consists of several filters based on different dynamical models to handle target maneuvers. Each of the filters utilizes an IPDA-AI(or MPDA) algorithm to deal with the problem of track existence in the presence of clutter. Although the primary purpose of this study is to deal with the track initiation problem, the IMM-IPDAF-AI and IMM-MPDA can also be used for the maintenance of existing tracks and the termination of tracks for targets when they disappear. For illustrative purposes, simulation is used to compare the performance of the algorithms proposed to other track formation algorithms.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2008년도 하계종합학술대회
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• pp.813-814
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• 2008

In this paper, we propose a new tracking algorithm which uses weighted sum of color bin's centroids to find the main centroid of the target. The weights are determined by the proportion of colors of the target and by the colors of background. That is, A color which has high occupation in forming the target is highly weighted and a color which has low occupation is lowly weighted. Moreover, the proposed algorithm prevent track failure by lowering the weight of the colors which forms the background. Therefore, the proposed algorithm performs stable tracking inspite of occlusion and existence of confusing backgrounds.

• BMB Reports
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• 제43권6호
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• pp.407-412
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• 2010

Homeodomain (HD) is a highly conserved DNA-binding domain composed of helix-turn-helix motif. Drosophila Vnd (Ventral nervous system defective) containing HD acts as a regulator to either enhance or suppress gene expression upon binding to its target sequence. In this study, kinetic analysis of Vnd binding to DNA was performed. The result demonstrates that DNA-binding affinity of the recombinant protein containing HD and NK2-specific domain (NK2-SD) was higher than that of the full-length Vnd. To access whether phosphorylation sites within HD and NK2-SD affect the interaction of the protein with the target sequence, alanine substitutions were introduced. The result shows that S631A mutation within NK2-SD does not contribute significantly to the DNA-binding affinity. However, S571A and T600A mutations within HD showed lower affinity for DNA binding. In addition, DNA-binding analysis using embryonic nuclear protein also demonstrates that Vnd interacts with other nuclear proteins, suggesting the existence of Vnd as a complex.

• 경영과학
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• 제24권2호
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• pp.81-93
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• 2007

Achieving a target operational availability is more economical and efficient than having many quantities of the weapon system, since the cost of weapon system becomes expensive. The intent of this study is twofold; first, we develop the simulation model to determine the optimal inventory level of the maintenance float while achieving a target operational availability of the Korean-made helicopter. The quantity decision model considers following factors such as a reliability. a turn around time(TAT). a protection level for inventory, and so on. Second, we analyze whether the existence of a lateral transshipment among bases and the reduction of TAT relate to an inventory level and the operational availability. The research result shows that both TAT and lateral transshipment have an effect on reducing the inventory level of the maintenance float and improving an operational availability.

• 한국음향학회지
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• 제38권4호
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• pp.415-426
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• 2019

본 논문은 연안 군사시설 및 주요 기반시설에 대한 침투세력을 감시하는 수영자 탐지 소나에서의 자동 표적추적 알고리즘을 다루었다. 이를 위해 수영자 탐지 소나에서의 해상실험 데이터를 분석하였고, 클러터 환경에서 자동표적 추적을 위한 트랙평가수단으로서 트랙존재확률 기반의 알고리즘을 적용하여 시스템을 구성하였다. 특히 트랙초기화, 확정, 제거, 합병 등의 트랙관리 알고리즘과 단일표적추적 IPDAF(Integrated Probabilistic Data Association Filter), 다중표적추적 LMIPDAF(Linear Multi-target Integrated Probabilistic Data Association Filter) 등의 표적추적 알고리즘을 제시하였으며, 해상실험 데이터 및 몬테카를로 모의실험 데이터를 이용하여 성능을 분석하였다.

• 대한수학회보
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• 제34권2호
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• pp.273-285
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• 1997

The aim of this paper is to present theorems on the exitence of zeros for mappings defined on convex subsets of topological vector spaces with values in a vector space. In addition to natural assumptions of continuity, convexity, and compactness, the mappings are subject to some geometric conditions. In the first theorem, the mapping satisfies a "Darboux-type" property expressed in terms of an auxiliary numerical function. Typically, this functions is, in this case, related to an order structure on the target space. We derive an existence theorem for "obtuse" quasiconvex mappings with values in an ordered vector space. In the second theorem, we prove the existence of a "common zero" for an arbitrary (not necessarily countable) family of mappings satisfying a general "inwardness" condition againg expressed in terms of numerical functions (these numerical functions could be duality pairings (more generally, bilinear forms)). Our inwardness condition encompasses classical inwardness conditions of Leray-Schauder, Altman, or Bergman-Halpern types.