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Clinical Application of Serum Tumor Abnormal Protein from Patients with Gastric Cancer

  • Liu, Jin;Huang, Xin-En
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.9
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    • pp.4041-4044
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    • 2015
  • Background: To verify whether serum tumor abnormal protein (TAP) would correlate with the responsiveness of palliative chemotherapy in patients with advanced gastric cancer, and the variation of conventional serum tumor markers e.g., carcinoembryonic antigen (CEA), antigen 125 (CA125),carbohydrate antigen19-9 (CA19-9) of adjuvant chemotherapy in patients with early gastric cancer. Materials and Methods: Patients with histologically confirmed gastric cancer and treated with chemotherapy were enrolled into this study. TAP values of these patients were determined by detecting abnormal sugar chain glycoprotein in serum, combined with the area of agglomerated particles. For patients with advanced gastric cancer, responsiveness of palliative chemotherapy was compared with variation of TAP and the relation between variation of TAP and tumor markers in patients with early gastric cancer was analyzed. Results: Totally 82 gastric cancer patients were enrolled into this study. The value of TAP is more closely related to responsiveness of palliative chemotherapy for patients with advanced gastric cancer. The correlation between TAP and responsiveness to palliative chemotherapy is stronger than the correlation between several conventional serum tumor markers (CEA, CA125 and CA199). The variation of TAP was also positively correlated with the trend of CA125 in adjuvant chemotherapy. Conclusions: TAP is sensitive in monitoring the responsiveness to palliative chemotherapy in patients with advanced gastric cancer. But this result should be confirmed by randomized clinical trials for patients with gastric cancer.

DISTRIBUTION OF VIRUSES IN WATER ENVIRONMENT

  • Lee Seung-Hoon;Cho Hong Baek;Kim Sang-Jong
    • Proceedings of the Microbiological Society of Korea Conference
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    • 2000.05a
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    • pp.94-101
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    • 2000
  • We investigated the viral contamination of water environment including tap water in Korea. River water used for source water was analyzed about monthly between 1997 and 1999 over a period 26 months. A total of 22 tap water samples were collected in 10 sites in 2 urban areas between 1997 and 1998 over a 11 months. All samples were examined for infectious enteroviruses and adenoviruses by a cell culture technique followed by PCR amplification. To identify the recovered viruses from tap water, sequence analysis of PCR products was performed. Infectious viral particles were detected in river water all year round, ranging from 0.93 to 17.3 Most Probable Number of Infectious Unit (MPNIU) /100L. Tap water samples also contained infectious viral particles. The frequency of enteroviruses and adenoviruses in tap water were $50.0\%$ (11/22) and $36.7\%$ (8/22), respectively. Both enteroviruses and adenoviruses were detected in five tap water samples $(22.7\%)$. The level of viral contamination in tap water was quite high, ranging from 0.2 to 2.9 MPNIU/100L, far above the recommended virus level in drinking water set by the U.S. EPA. Poliovirus type 1 derived from vaccine was frequently detected and the remainder comprised coxsackievirus B type or echovirus type 6, which were causative agents of aseptic meningitis in Korea in 1997 and 1998, respectively. Several types of adenovirus were detected in tap water samples and some water samples were found to contain adenoviruses which were closely related to enteric adenovirus type 40 and 41. This stusy shows that surface water and tap water in Korea may be exposed to the risk of viral contamination, especially from recently recognized viruses and this constitutes a potential public health hazard.

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Chemical Compositions and Lead Isotope Ratios of Some Glass Beads from Seokga-tap, Gyeongju

  • Kang, Hyung-Tae;Yun, Eun-Young
    • Conservation and Restoration of Cultural Heritage
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    • v.1 no.1
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    • pp.3-8
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    • 2012
  • Chemical compositions and lead isotope ratios for four glass bead samples of Seokga-tap were analyzed and the results were organized. Among 4 glass beads found in the Seokga-tap, 3 pieces were lead glass. Manufacturing method was to firstly grind pebbles finely and mix lead ore to be melt at $740{\sim}760^{\circ}C$. The mixed ratio of silica and lead was 3:7. Moreover, The evaluation on the lead isotope ratio indicated that two lead glass pieces used lead ore from northern Korea. One piece has the direction of southern Korea lead ore, but it requires a further review. One glass bead of Seokga-tap was brown and it was potash lead glass ($K_2O-PbO-SiO_2$) System. The mixed ratio was approximately 50:10:40 for silica, natural saltpeter, and lead, respectively. Lead isotope ratio data fell within the lead ore from northern China. Therefore, it was concluded that potash lead glass found in the Seokga-tap was produced in northern area of China at the end of $10^{th}$ century and transferred to the Seokga-tap.

On the background levels of $CO_2$ observed at Tae-ahn Peninsula in Korea during 1990-1992 (한국의 태안반도에서 관측된 이산화탄소의 배경농도에 관한 연구)

  • 이근준;정용승
    • Journal of Korean Society for Atmospheric Environment
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    • v.9 no.1
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    • pp.61-68
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    • 1993
  • Since November 1990, the observations of carbon dioxide$(CO_2)$ levels have been carried out at Tae-ahn Peninsula(TAP) in Korea. Analysis on atmospheric data obtained in the period from November 1990 to August 1992 is carried out and the results are included in this study. It is observed that variations of monthly average level on $CO_2$ are in the range of 315.72 $\sim$ 365.37ppm(amplitude 17.65ppm). The seasonal variation is large with a maximum occurring in March-April and with a minimum in July-August. A comparison of TAP data is made with data obtained at Ryori in Japan for 1991. The annual average value of TAP is 1.79ppm higher than that of Ryori. It is also found that in summer the minimum level of $CO_2$ at TAP is almost same as the $CO_2$ level occurring at Quinghai Province in China and at Ulaan Uul in Mongolia. Albeit, a maximum concentration of $CO_2$ at TAP is slightly higher than that of the same gas observed at other sites in spring. We interpret that TAP is generally under the influence of airflows coming from China. According to analysis of trajectories and airflows, we find the high values of $CO_2$ when an air flow is originated mainly from China and when an airflow is both of local(Korea) and of China origins. In contrast, when an airflow of maritime origin arrives, a low value of the atmospheric constituent is observed at TAP.

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Study on the alternatives to trace the origin and to diminish the sediments of drinking water (수돗물의 앙금발생규명 및 저감기술방안)

  • 김갑수;임병진;권은미
    • Journal of environmental and Sanitary engineering
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    • v.9 no.1
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    • pp.17-28
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    • 1994
  • There are many possibilities that may lead to low quality of drinking water Recently, some unknown deposits in tap water raised a lot of public concern regarding the safety of drinking water in Seoul. We analyzed the quality of tap water from several areas of Seoul, including the area where public complaints about tap water were high. The results shows that the quality of tap water in Seoul was good, well below the environmental standards. Only the tap water from the area with high public complaints showed turbidity higher than that of other area. Also, result shows that component of deposit in tap water was Al, Fe, Mn, and Zn. Based on the research result we propose several measures that might help to reduce the amount of deposit in tap water as follows : 1 Using coagulant aid when coagulating or adjusting pH when filtering. 2. Replacing old water pipeline with new corrosive- resistant one. 3. Increasing water treatment efficiency by enhancing water treatment system such as automation of water treatment system adjusting production capacity, and improving operational condition of filler basin. 4. Chlorine disinfection at the distribution reservoir would help maintaining the same pH level and chlorine concentration throughout the water pipeline and reduce corrosion of pipe.

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On the Regional Background Level of CO Observed at Tae-ahn Peninsula in Korea During 1990-1992 (한국의 태안반도에서 관측된 CO의 지역적 배경농도에 관한 연구)

  • 정용승;이근준
    • Journal of Korean Society for Atmospheric Environment
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    • v.9 no.3
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    • pp.200-206
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    • 1993
  • Since November 1990, observations of carbon monoxide(CO) levels have been carried out at Tat-ahn Peninsula(TAP) in Korea. Analysis on atmospheric data, obtained in the period from November 1990 to February 1992, is carried out and the results are included in this study. It is observed that variations of monthly average level on CO are in the range of 141.61-516.06ppb(amplitude 374.45 ppb). An average level in 1991 is 308.18 ppb. CO observed at TAP has a larger seasonal variation. One of reasons appears that CO of TAP is strongly influenced by local sources and westerly airflows. When this gas of TAP is compared with data observed at Korea National University of Education(KNU) and in Seoul, we learn that CO values of KNU are higher(in average 2.15 times) than those of TAP; CO value observed in Seoul are 7 times higher than those of TAP. We interprete that air samples taken both at KNU and in Seoul are influenced strongly by local sources than those at TAP. According to analysis of trajectories and air flows, the CO value is higher with NW airflows than the value with SW airflows.

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A Study About Tool Wear Characteristic on Geometry of Tap (탭 형상에 따른 공구마모 특성에 관한 연구)

  • 최만성;윤홍기
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2000.11a
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    • pp.892-897
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    • 2000
  • In this study, tap wear was analyzed not only to predict the tap life time but also to propose an improved tap design. Because rake angle and thread relief of tap are the significant factors in geometry of tap, these two factors were picked as the experiment variables. The experiment was conducted with six types of tap which have 6$^{\circ}$ , 8$^{\circ}$ and 12$^{\circ}$ of rake angles with 0,08mm and 0.14 mm of thread relief. From the measured cutting force, it could be known that cutting torque was low at the large the rake thread relief and tool life was long as rake angle became large. Eventually, tool life is longest when rake angle is 12$^{\circ}$ and the with 0.08mm thread relief. Aand the width of crater wear and that of flank wear were measured when a tapping torque was 20 [$kg_f$-mm] . Most of the measured values were above the width of tool wear[$V_B$=O.O3m], which means that tool life is over.

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Clinical Application of Serum Tumor Abnormal Protein (TAP) in Colorectal Cancer Patients

  • Wu, Xue-Yan;Huang, Xin-En
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.8
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    • pp.3425-3428
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    • 2015
  • Objective: To explore the association of serum tumor abnormal protein (TAP) with other serological biomarkers e.g. carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9) and its clinical application in colorectal cancer (CRC) patients. Methods: Patients (N=98) were enrolled into this study with histologically or cytologically confirmed CRC. Using a test kit, the level of TAP was determined, while chemiluminescence was used to measure the levels of some other common serological biomarkers e.g. CEA, CA125 and CA19-9. Results: The area of TAP condensed particulate matter decreased after chemotherapy compared with before chemotherapy when CT or MRI scans showed disease control. In contrast, it increased with disease progression (P<0.05). Furthermore, a statistically significant difference was confirmed in monitoring of TAP and common serological biomarkers e.g. CEA and CA19-9 (p<0.05). Conclusions: Detecting TAP in CRC patients has high sensitivity and specificity and can be used as a new independent indicator for clinically monitoring CRC patients in the course of chemotherapy.

Non-invasive Evaluation of the Patients after Total Correction of Tetralogy of Fallot (활로 4 징증의 완전교정술후 비관혈적 방법에 의한 추적관찰)

  • 안홍남
    • Journal of Chest Surgery
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    • v.22 no.2
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    • pp.234-245
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    • 1989
  • Between January 1984 and December 1986, sixty nine patients, aged 16 months to 25 years [mean age 10.05*6.40 years], underwent total correction of tetralogy of Fallot in Kyungpook national university hospital. In 66 hospital survivors, 30 patients were followed up for 12 to 48 months [mean 30.10*10.26 months]. These 30 patients were classified in two groups, TAP [transannular patch] and Non-TAP group. There were 9 patients in TAP group, and 21 in Non-TAP group. There were no significant differences between two groups in terms of age at operation, follow up duration, ACC time, and bypass time. All patients were evaluated by two dimensional echocardiography, Doppler echocardiography, standard 12-lead electrocardiography, and plain chest X-ray. Right ventricular systolic pressure, pulmonary arterial systolic pressure, pressure gradient between the right ventricle and the pulmonary artery, presence or absence of pulmonary regurgitation and its grading, fractional shortening of the left ventricle, and Qp/Qs in case of remnant ventricular septal defect were obtained by echocardiographic examination. Cardiothoracic ratio was measured by plain chest film, and ventricular dysrrhythmia was detected by electrocardiogram. Comparing the data between two groups, there was significant difference in incidence of postoperative pulmonary regurgitation [p< 0.05], 100%[9/9] in TAP group and 47.6 %[10/21] in Non-TAP group, but all the regurgitations were not severe. There were no significant differences in other comparisons, despite of higher incidence of cardiomegaly in TAP group [CT ratio: 59.3*5.3% VS 54.7*6, 4 %].

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