• Title/Summary/Keyword: taking drug information

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Adverse Drug Reactions with Oseltamivir Treatment in the South Korea Outbreak of 2009 Pandemic Influenza A(H1N1) (2009년 국내 신종플루 유행시기의 Oseltamivir 부작용 평가)

  • Do, Youn-A;Lee, Suk-Hyang
    • Korean Journal of Clinical Pharmacy
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    • v.21 no.4
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    • pp.353-363
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    • 2011
  • The World Health Organization (WHO) declared the outbreak of H1N1 pandemic in 2009. South Korea also had outbreaks of H1N1 virus and used oseltamivir in large volume with increased reports of adverse drug reaction(ADR). The present study was aimed to investigate the ADR frequency, the factors related to ADR, and characteristics of oseltamivir's ADR. Participants for the study were patients randomly drawn from those who were prescribed oseltamivir for treatment from CHA Bundang Medical Center during October 1 and October 30. The information examined as factors related to ADR were collected by a subsequent cross-sectional telephone survey. The factors are the following; a) age; b) gender; c) patient medical history; d) diagnosis of H1N1 virus; e) adherence; f) whether taking other medication with oseltamivir or not; and g) the number of combined medications. We also asked ADR after taking oseltamivir. Total subjects were 86 patients. The average age is $22.6{\pm}18.48$ years old. The gender was 45.3% women and 54.7% men. Half (50%) of all respondents showed one or more ADR, 67.4% were positively diagnosed for H1N1 virus, and 54.7% were completed the full course of oseltamivir (i.e. twice daily x 5days). The most frequently reported ADR symptoms were: dizziness (15.1%), nausea (11.6%), lethargy (10.4%), diarrhea (10.4%), abdominal pain (8.1%), headache and vomiting (6.9%). ADR classifications by categories are gastro intestinal (44.2%), neuropsychiatric events (22.1%), systemic symptom (20.9%), skin events (5.8%), eye events (4.7%), and other cases (2.3%). The onset of ADR 'after taking 1~3 doses' was 69.7%. No increase in neuropsychiatric events was detected in children and adolescents. No factors examined for the study do have significant influence on the presence of ADR. This study showed that ADR of oseltamivir have occurred in half of the patients. The use of oseltamivir is essential for treatment and prophylaxis of influenza A(H1N1). But mass treatment should be properly monitored for ADR.

Necessity of revision of the mandatory medication guidance regulation under the Pharmaceutical Affairs Act (약사법상 복약지도의무 규정의 개정 필요성)

  • Dawoon Jung
    • The Korean Society of Law and Medicine
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    • v.24 no.2
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    • pp.119-145
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    • 2023
  • The Pharmaceutical Affairs Act stipulates medication counseling as an obligatory requirement in the case of preparation of medicine. In fact, there are many cases where pharmacists only tell patients the dose and time and do not properly guide them on taking medications. However, in light of the current situation where non-face-to-face treatment is being attempted, there is a high possibility of drug-taking accidents due to insufficient medication guidance. In addition, as an aging society progresses, the need for explanations on pharmaceuticals is increasing. If a pharmacist causes damage to a patient by failing to give appropriate medication guidance, the patient can claim compensation for damages. In addition, if a drug accident occurs due to a conflict between the pharmacist's duty to guide medication and the doctor's duty to explain, a joint tort is established between the pharmacist and the doctor. Nevertheless, there are cases in which only doctors are judged to bear the tort liability. However, the Pharmaceutical Affairs Act includes providing information for the selection of over-the-counter drugs in the medication guidance as part of the medication guidance obligation. Therefore, in order to reconsider the importance of the medication-taking guidance duty, it is necessary to define the medicationaking information provision method and the medication-taking guidance duty as separate concepts. In addition, it is necessary to amend related regulations centered on patients so that medication guidance, such as side effects of medicines and interactions with concomitant medications, can be made in detail.

Co-occurrence Based Drug-disease Relationship Inference with Genes as Mediators (유전자를 중간 매개로 고려한 동시발생 기반의 약물-질병 관계 추론)

  • Shin, Sangwon;Sin, Yeeun;Jang, Giup;Yoo, Youngmi
    • The Journal of Korean Institute of Information Technology
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    • v.16 no.11
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    • pp.1-9
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    • 2018
  • Drug repositioning is to discover new uses of drugs. Text mining derives knowledge from unstructured text. We propose a method to predict new drug-disease relationships by taking into account the rate of frequency of genes simultaneously measured in disease-gene and gene-drug. Co-occurrence of drug-gene and gene-disease in the biological literature is counted and calculate the rate of the gene for each drug and disease. Weights of drug-disease relationships are calculated using the average of the rates of genes that are measured and used to measure the accuracy for each disease. In measuring drug-disease relationships, a more accurate identification of relationships was shown by measuring the frequency on a sentence and considering multiple relationships than existing method.

A Study on Self-medication Beharior of Four Cautious Drugs. (특정의약품의 자가투약행위에 관한 연구)

  • 황미숙
    • Korean Journal of Health Education and Promotion
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    • v.4 no.2
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    • pp.46-70
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    • 1987
  • The survey with questionnaire were conducted to grasp the actual condition of four cautious drugs-antibiotics, sedative hypnctics, mincr tranquilizer, analeptics-self -medication behavior through drugstore use and to analyze the primary factors connected with it. The following six objectives were established. 1) To catch the reason why the man who medicate himself buy four cautious drugs at a drugstore, and to know the choice motive of each drug purchased. 2) To grasp the distribution of four cautious drug taken by the man who medicate himself and to analyse the reason of taking the drug. 3) To find out whether the buyer has taken the same drug past and to know the duration and the frequency. 4) To grasp the degree of recognition about four cautious drugs and the attitude toward continuous taking them. 5) To analyze the degree of recognition about the influence on human body and the attitude of medication behavior. 6) To know "the experience of side-effects" and to grasp the kind of the side-effects. The data were collected from 15 drugstores with 677 respondents in seoul from August 17 to september 21, 1987. The following results were obtained. 1) The reasons for drugstore use were first, "for easy access and convenience" (53.7%) second, "for the slightness of illness" (19.9%) third "for the cheap price" (13.2%). According to that result, the factor of "the easy access of drugstore" was most influential. In case of the poor, the factor "for the cheap price "was revealed second (37.3%). And "for the slightness of illness" was second reason in the medically insured (22. 9%), "for the cheap price" was second reason in the others (29%). 2) The kind of drugs purchased were antibiotics (62.8%), analeptics(17.2%), minor tranquilizer(13.3%) and sedative hypnotics (6.7%) on the whole. In teenagers, besides antibiotics the percentage of taking analepits came second (42.4%) and it was revealed that the percentage of sedative hypnotics, minor tranquilizer increase with age. But in proportion to the increase of age, the taking of analeptis decreased. 3) The choice motives of each drug purchased were all different. In case of antibiotics "recommendation of pharmacist" was 39.6%, sedative hypnotics "recommendation of pharmacist" and "my own judgement", 28.9%, respectively, minor tranquilizer "my own judgement", 35.2%. and in case of analeptics "my oun judgement" was most common with 53.5%. 4) The reasons for taking drugs were as follows. antibiotics was taken for the inflammation mitigation of a wound and a swelling (38.5%), sedative hypnotics for the removal of insomnia (97.5%), minor tranquilizer because of restlessness and qloominess(39.3%), and analeptics for the shortening of sleeping hours (35.1%). 5) Those experienced in taking four cautious drugs were 78.2% on the average. It was revealed that antibiotics use duration was "from one week to one month" (38.9%), the frequency was "rarely" (62.1%), sedative hypnotics and minor tranquilizer; "More than three years", (35.7%, 30.4%), respectively, "Somtimes", (43.8%, 35%), respectively. analeptics ; "from one year to three years", (27.6%), "Sometimes", (42.7%). 6) In regard to the source of information in taking drugs, 35.3 percent of male were relied on "recommendation of pharmacist", 32.6 percent of female "my own judgement", There was a difference between below the middle school graduates and over the high school graduates Thease were relied on "recommendation of pharmacist" first, those "my own judgement" first. And "my own judgement" was the first source of specialist(40%), labours(41.4%), salesman(43.5%), and jobless men(36.8%), "recommendation of ralatives on friends" was the first source of students (30.4%), "recommendation of pharmacist" was the first soure of teachers, administrative office workers (39%) and housewives (40.7%). 7) The degree of recognition about four cautious drugs was as follows. "know a little" was (43.0%), "don't know" (30.2%), "know" (26.8%), respectively. In regard to the attitude toward continuous taking them, it was revealed that "I will take it according to circumstamces" was first (56.2%), " I will not take it as possible" was first(56.2%), "I dont know well" (12.9%), "I will take it continuously" (8.3%). 8) About the influence on human body, "if proper, it is effect" was common attitude toward antibiotics (43.6%), "Probably bad influence on the health" was first toward the other drugs (46.2%), In terms of the degree of observance to taking-time and dose of drugs, "suitably" was first (37.3%), "relatively correctly" second (27%), "correctly" (17%). 9) The percentage of four cautious drugs side-effects was 27.5 on the average. The kind of side-effects were eruption and urticaria (28.5%), heart acceleration and so forth. (25.4%), headache and Giddiness, dyspepsia (23%), respectively.

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Survey of Correlations on the Drug Use Patterns between Children and Their Parents (영·유아와 부모의 약물사용 상관관계에 대한 조사연구)

  • Hwang, Mi-Young;Bang, Joon Seok;Sohn, Uy Dong
    • Korean Journal of Clinical Pharmacy
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    • v.25 no.2
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    • pp.111-119
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    • 2015
  • Background: It is thought that drug use of parents is related to that of young children. The status of drug among young children's parents and a correlation of with parents and their children on drug use was surveyed by questionnaire. Method: The questionnaire is composed of 34 items, and the data was collected by 108 parents of young children from March to April of 2012. Results: On the basis of the analysis results, the following conclusions were drawn. About half of parents thought the minimum use of drug was better for health, and 44% parents thought drug is essential for cure. When parents had queries on prescription, they mostly consult with doctors and pharmacists. Most parents had a household medicine. A fever reducer was the most common household medicine (92.5%). They pick the household medicine by consulting with pharmacist. Parents usually checked the expiration date of drug before they use and they dumped the drugs when the expiration date was due (82.4%). Over half of young children and their parents took a dietary supplements. They got an information about a dietary supplement by associates (30.5%) and internet (19.4%). Most parents tried to follow the directions as prescribed. However, more than half of the parents stopped taking the drug when the symptoms disappeared. Conclusion: Drug use of parents and that of young children had a very strong positive correlation, suggesting that correct drug use of parents have an impact on their young children's drug use.

Design and Implementation of the Prevention System for Side Effects of Polypharmacy Components Utilizing Data Queuing Algorithm

  • Choi, Jiwon;Kim, Chanjoo;Ko, Yunhee;Im, Hyeji;Moon, Yoo-Jin;McLain, Reid
    • Journal of the Korea Society of Computer and Information
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    • v.26 no.11
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    • pp.217-225
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    • 2021
  • In this paper, we designed and implemented the integrated system to prevent adverse drug reactions of polypharmacy components in medicine by supporting component-component information and disease-component information, through data queuing algorithm and vast amounts of pharmaceutical big data. In addition, by providing information for drugs, drug components, prohibited drugs, as well as suppliers and distributors, it could help ease anxiety about taking drugs not only for health-care professionals but also for general users. The representative information provided were side effects between two drugs, main components and effectiveness of particular drugs, drugs manufactured by the same pharmaceutical company, and drug component information for patients with chronic diseases. The future work is to update the database by collecting information on rare & new diseases and new drugs.

Prescription Drug Use Behavior and Influence Factors in Veteran Patients from the Perspective of Veterans (보훈환자 시각에서의 처방의약품 사용 행태와 영향요인)

  • Kim, Jin;Lee, Iyn-Hyang
    • Korean Journal of Clinical Pharmacy
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    • v.30 no.3
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    • pp.185-195
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    • 2020
  • Objective: This study aimed to explore a veteran patients' behavior of prescribing drug use and of which influencing factors from the veteran patients' perspective through qualitative interviews. Methods: We recruited veteran patients through purposive sampling and interviewed 30 veteran patients aged 20 and over who had been taking prescription drugs. We developed and utilized an interview guide consisting of three themes for data collection. We made verbatim transcripts and analyzed data using the framework analysis. Results: Participants were aware that they had large amounts of prescribing medicines and discarded the medicines. They often used improperly by the person himself or his family or acquaintances. The factors that influenced these inefficient prescription drug usage were grouped into 'factors procuring more drugs than necessary' and 'factors being prescribed more drugs than necessary'. Anxiety about downgrading from the upper class to the lower among reward classes for veterans, and suspicion or dissatisfaction with the veteran policy caused the participants to procure more drugs than necessary. Additionally, they received too many medicines due to long-term prescriptions and lack of communication with their doctors, and poor quality of veteran health services. Conclusion: To improve the medication use behavior of veteran patients, providing information or introducing interventions for the proper medication use is not enough. Efforts should be made to improve their negative recognition over relevant policies and health care services.

Utility of Structural Information to Predict Drug Clearance from in Vitro Data

  • Lee, So-Young;Kim, Dong-Sup
    • Interdisciplinary Bio Central
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    • v.2 no.2
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    • pp.3.1-3.4
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    • 2010
  • In the present research, we assessed the utility of the structural information of drugs for predicting human in vivo intrinsic clearance from in vitro intrinsic clearance data obtained by human hepatic microsome experiment. To compare with the observed intrinsic clearance, human intrinsic clearance values for 51 drugs were estimated by the classical methods using in vivo-in vitro scale-up and by the new methods using the in vitro experimental data and selected molecular descriptors of drugs by the forward selection technique together. The results showed that taking consideration of molecular descriptors into prediction from in vitro experimental data could improve the prediction accuracy. The in vitro experiment is very useful when the data can estimate in vivo data accurately since it can reduce the cost of drug development. Improvement of prediction accuracy in the present approach can enhance the utility of in vitro data.

A Study on Medications and Health Histories of 2,528 Dental Patients (초진시 치과환자가 복용중인 약과 병력에 관한 조사연구)

  • 고경용;정성창
    • Journal of Oral Medicine and Pain
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    • v.5 no.1
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    • pp.17-25
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    • 1980
  • The purpose of this survey is to determine what medication dental patients are taking and to compile information from medical histories on the most frequent conditions. The frequency of use of drug and positive medical findings are reported by age and sex group. 1.Use of drugs were found to increase with age. The proportion taking a medication was 1 in 5 for teenage group, 1 in 4 for young adults, 1 in 3 for patients in their 40s, and 1 in 2 for patients aged 50and older. 2. One seconds of all dental patients in the study had a positive medical history for at least one problem, and more than 35% of these patients reported multiple medical problem.

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Application Development to provide General Phrase Medication Guidance for Visually Impaired (시각장애인을 위한 일반의약품 복용 방법 제공 애플리케이션 연구)

  • Min-Seok Cho;Min-Ki Yoon;Min-Su Seo;Young-Hoon Hwang;Won-Whoi Huh
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.23 no.2
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    • pp.201-208
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    • 2023
  • Visually impaired people have difficulty accessing medical services and drug information, and it is not easy for them to take the correct drugs. A health law has been established to deal with this, but the plans are not unified and not applicable to all over-the-counter medicines. Therefore, we planned an application that provides instructions for taking general medicines using image recognition technology, bar code, and QR recognition technology for visually impaired people who are in the blind spot of taking general medicines. In this research, we will optimize the camera shooting environment standards and UI and UX screens for image recognition for the visually impaired, and improve the accessibility for the visually impaired to make it more convenient. If you can apply the results of your research to an application and provide it, it will help people with visual impairments learn the correct way to take over-the-counter medicines.