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Immune response and antioxidant status of broilers as influenced by oxidized vegetable oil and pomegranate peel

  • Ghasemi-Sadabadi, Mohammad;Ebrahimnezhad, Yahya;Maheri-Sis, Naser;Ghalehkandi, Jamshid Ghiasi;Shaddel-Teli, Abdolahad
    • Journal of Animal Science and Technology
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    • v.63 no.5
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    • pp.1034-1063
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    • 2021
  • The experiment was designed as a 3 × 3 × 2 factorial arrangement of treatments, including (i) pomegranate peel (zero, 4%, and 8 percent), (ii) oxidized soybean oil (zero, 2%, and 4 percent), and (iii) alpha-tocopherol (zero and 200 mg/kg). Supplementation of 8% pomegranate peel in diets significantly decreased the growth performance of broiler chickens. The supplementation of 4% oxidized oil in diets significantly reduced body weight gain and Feed intake whole experimental period (p < 0.05). The results showed that supplementation of 4% pomegranate peel in the diet was associated with low aspartate transaminase (AST), alanine transaminase, and malondialdehyde (MDA). However, 4% pomegranate peel increased the total antioxidant capacity (TAC) and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. The supplemental 4% oxidized oil increased the serum AST, alanine aminotransferase (ALT), and MDA concentrations. TAC, SOD, and Catalase (CAT) activities were affected by 4% oxidized oil and alpha-tocopherol. The use of oxidized oil and vitamin E decreased MDA concentration. The serum glucose and globulin concentrations were significantly lower in the 8% pomegranate peel. The results showed that supplementation with 4% pomegranate peel in diets reduced serum low-density lipoprotein (LDL). The inclusion of 4% oxidized oil in diets reduced serum glucose and increased the blood lipid concentration such as triglyceride, cholesterol and LDL. Vitamin E supplementation reduced the serum cholesterol and LDL concentrations. The use of 8% pomegranate peel reduced red blood cell (RBC), hemoglobin, and packed cell value (PCV). The results indicated that supplementation with 8% pomegranate peel and 4% oxidized oil in diets decreased the immunoglobulin concentration in broilers. In addition, it was found that the inclusion of 4% pomegranate peel in diets resulted in higher IgG, IgM and total immunoglobulin. Pomegranate peel supplementation significantly decreased meat MDA concentration. Supplementation of 4% oxidized oil increased MDA of meat (p < 0.05). Vitamin E supplementation (200 mg/kg) significantly decreased MDA of meat (p < 0.05). Consequently, the results of this experiment showed that supplementation with 4% pomegranate peel had beneficial effects on broiler chickens. It was also found that feeding 2% oxidized oil in diets had no adverse effect on broilers.

Model for Price Formation of Fish and Its Demand Structure (어류의 가격형성과 수요구조분석)

  • Park, Hoan-Jae
    • The Journal of Fisheries Business Administration
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    • v.40 no.1
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    • pp.133-152
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    • 2009
  • The purpose of this paper is to model price formation and analyze demand structures for fishes under the restriction of Korean fisheries regulations. This study suggests the model that the price of fish is formed by its quantity, expenditure, and habit persistence. In economic literature, such a fishery market demand is called the inverse demand with dynamic habit persistence. Based upon a static differential price formation model, the paper has generalized it dynamically incorporating habit persistence effects. The empirical results show that all the species have values less than one and (-) sign of price flexibilities, thus being price inflexible. The estimated habit adjustment coefficients are significant at the level of 1%. Especially, TAC species have the smaller values of them than those of other main fish species. The contribution and results are summarized as follows. First, the fishery market demand has a strong dynamic effects from habit persistence. Second, the fishery market demand structure could be analyzed in a way different from the ordinary demand analysis, which is based upon price flexibility, scale flexibility, and cross adjustment flexibility. Third, the limitation of this paper is that it ignores the increasing stock effects by catching restrictions, thus raising consumers' benefit in the future.

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Trends of Deep UV-LED Technology for the Pathogen and Biotoxin Aerosol Detection System (병원균 및 생물독소 탐지시스템을 위한 원자외선 LED 기술동향)

  • Chong, Eugene;Jeong, Young-Su;Choi, Kibong
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.28 no.5
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    • pp.277-284
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    • 2015
  • The humans are under attack involving the hazardous environment and pathogen/biotoxin aerosol that is realistic concerned. A portable, fast, reliable, and cheap Pathogen and Biotoxin Aerosol threat Detection(PBAD) trigger is an important technology for detect-to-protect and detect-to-treat system because the man-made biological terror is a fast and lethal infection. The ultraviolet C(UVC) wavelengths light source is key issue for PBAD that is sensitive because of strong fluorescence cross section from fluorescent amino acids in proteins such as tryptophan and tyrosine. The UVC-light emitting diode(LED) is emerging light source technology as alternative to laser or lamps as they offer several advantages. This paper discussed about the design consideration of UVC-LED for the PBAD system. The UVC-LED and PBAD technology, currently available or in development, are also discussed.

Analysis of South Korea Outdoor Design Temperature with respect to Assigned Period of the Weather Data (기상 데이터 산정 기간에 따른 국내의 설계용 외기온도 분석)

  • Nam, A Young;Kim, Young Il;Chung, Kwang Seop
    • Journal of the Korean Society for Geothermal and Hydrothermal Energy
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    • v.13 no.2
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    • pp.1-8
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    • 2017
  • Outdoor design temperature is important for selecting proper capacity of heating and cooling systems of a building to implement indoor thermal comfort and save energy consumption. The purpose of this study is to investigate the change of South Korea outdoor design temperature according to the assigned period. When outdoor design temperature of 8 locations calculated with the latest weather data during 2008~2015 years using ASHRAE Bin method are compared to the standard temperature of Ministry of Land, Infrastructure and Transport which is widely used for designing South Korea air-conditioning system at present, the maximum temperature difference becomes $0.97^{\circ}C$ for cooling, and $1.94^{\circ}C$ for heating. Due to wide outdoor temperature variation, update of outdoor design temperature based on recent weather data is recommended.

Dynamic Forecasting of Market Growth according to Portable Internet Carrier Licensing Policy (휴대인터넷 사업자 선정 정책에 따른 동태적 시장 예측과 함의)

  • Kim, Jong-Tac;Park, Sang-Hyun;Oh, Myung-Ryoon;Kim, Sang-Uk
    • Korean System Dynamics Review
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    • v.5 no.2
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    • pp.67-88
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    • 2004
  • This paper attempts to explore the generic pitfalls of the traditional number-crunching methods adopted thus far for the forecast of newly emerging market trends, and present an alternative by introducingsystems thinking to the portable Internet service market as an example, followed by its rationale as a new tool for forecasting and some reasoning about why traditional methods are no longer appropriate. Most adoption models in general to forecast market trends have several limitations due to theirbasic assumptions and prospective. First, they fail to capture dynamic interactions among the factors involved over time, with implicit assumptions of 'unilateral causality' in that each factor contributes as a cause to the effect, i.e., causality runs one way; each factor acts independently the weighting factor of each is fixed, etc. Second, the number-crunching models have no way of taking into account the impact of delayed feedback often caused by introducing new policies and legislative changes on the whole system under investigation. Third, there is not a way to reflect the effect of competition by players.

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Lipid-lowering and Antioxidant Effects of Curcuma Radix in Poloxamer 407-induced Hyperlipidemia Model Rat Models

  • Park, So-Ae;Jo, Hyun-Kyung;Yoo, Ho-Ryong;Kim, Yoon-Sik;Seol, In-Chon;An, Joung-Jo
    • The Journal of Internal Korean Medicine
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    • v.32 no.2
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    • pp.243-258
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    • 2011
  • Objectives : This study investigated the hypolipidemic and antioxidant effects of Curcuma radix using a rat model induced by poloxamer 407 injection. Methods : Serum lipid parameters and oxidative stress-associated biomarkers were determined. Additionally, hepatic cholesterol and triglyceride as well as lipid metabolism-associated gene expressions were observed in hepatic tissue. Results : 1. Curcuma radix ameliorated elevation of serum cholesterol, triglyceride, LDL-cholesterol, MDA, hepatic cholesterol level, and reduction of serum TAC, SOD, GSH, GSH-reductase level. 2. Curcuma radix augmented up-regulated ACAT gene expression. 3. Curcuma radix almost completely ameliorated down-regulated CYP-7A1 but up-regulated HMG-CoA gene expression. Conclusions : The hypolipidemic and antioxidant properties of Curcuma radix were evidenced. This study provides a scientific basis for the clinical application of Curcuma radix and development of hypolipidemics using this herb in the future.

Effect of Galhwahyejung-tang (GHT) on Alcohol-induced Oxidative Stress in Rats

  • Kim, Dong-Gyu;Kim, Tae-Hwan;Park, Sang-Eun;Kim, Hyung-Geug;Son, Chang-Gue;Hong, Sang-Hoon
    • The Journal of Korean Medicine
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    • v.31 no.6
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    • pp.1-7
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    • 2010
  • Objectives: This study was aimed to investigate the effects of Galhwahyejung-tang (GHT) on alcohol-induced oxidative stress in rat model. Methods: Twenty SD rats were orally administrated with 40% ethanol (mL/kg) combined with GHT (50, 100, 200mg/kg) or distilled water for 2 weeks. Biochemistry in blood, malondialdehyde (MDA), total reactive oxygen species (ROS), and total antioxidant capacity (TAC) in serum, liver, brain, and kidney were determined. Results: GHT treatment significantly ameliorated the alcohol-induced alteration of hepatic enzyme; especially AST and ALT. GHT treatment also ameliorated the increase of MDA in liver, ROS level in serum and brain. GHT treatment reduced the depletion of antioxidant capacity in serum and brain. Conclusion: These results that GHT has antioxidant properties explaining the relevance of clinical application and its partial mechanisms of GHT.

The Sociopolitical Economics of Marine Ranching Program in Korea

  • Park, Seong-Kwae
    • Ocean and Polar Research
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    • v.23 no.3
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    • pp.265-277
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    • 2001
  • This paper aims at overviewing Korean fisheries profile with a view on why Korean fisheries need marine ranching program as a new fisheries paradigm - a community-based co-management approach and drawing some policy implications from the advanced experience in fisheries. The aims of community-based co-management approach as a planned approach can be set out under the planning objectives of efficiency and equity. In this context Tongyeong marine ranching program is an important government-sponsored pilot enterprise. Experiences in the advanced fisheries such as Canadian Snow-Crab case suggest that in order to be successful for marine ranching be successful it is necessary that (i) there should be high-value species, (ii) property right should be established, (iii) there should be the reasonable number of participants involved, (iv) the participants and the government should be able to share resource enhancement/management/utilization responsibilities and associated fisheries management expenses. Among these, management cost sharing based on the practical partnership between fishing communities and government is of particular importance because the government must have a full responsibility for all ranching program expenditure unless revenues sufficient to guarantee reasonable income and to share management cost are generated from the ranching business.

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Field Sequential Liquid Crystal Display using Electrically Controlled Birefringence (ECB) Mode (ECB 모드를 적용한 Field Sequential LCD)

  • Lee, Ji-Youn;Ryu, Je-Woo;Oh, Sang-Min;Kim, Seung-Jae;Lee, Seung-Hee
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2006.11a
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    • pp.294-295
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    • 2006
  • Field sequential liquid crystal display (FSLCD) has advantages such as a high transmittance due to no use of color filter and high color reproductivity because of LED backlight for a luminance source. However, to realize FSLCD response time of the LCD must be below 5ms. In this paper, we have chosen electrically controlled birefringence (ECB) mode for this application and studied film compensation to improve the operating voltage and viewing angle and to achieve a fast response time optimizing the condition of the discotic film and TAC film, operating voltage decreases to 5V, and viewing angle range is $160^{\circ}$ at horizontal and vertical direction, respectively and $120^{\circ}$ in diagonal direction. (contrast ratio > 10:1) and optimized cell exhibits a fast response time of 4ms in most grey levels.

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Preparation of Highly Water Soluble Tacrolimus Derivatives: Poly(Ethylene Glycol) Esters as Potential Prod rugs

  • Chung, Yong-Seog;Cho, Hoon
    • Archives of Pharmacal Research
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    • v.27 no.8
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    • pp.878-883
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    • 2004
  • Tacrolimus (FK506), which is isolated from Streptomyces tsukubaensis, is a new potent immu-nosuppressant. Because of poor solubility in water, the conventional intravenous dosage forms of tacrolimus contain surfactants such as cremophor EL (BASF Wyandotte Co.) or hydroge-nated polyoxy 60 castor oil (HCO-60) which may cause adverse effects. This study relates to a polymer-tacrolimus conjugate, which can be dissolved in water, formed by chemically binding the sparingly soluble drug, tacrolimus, with the water soluble polymer, methoxypoly(ethylene glycol) (mPEG). Water soluble tacrolimus-mPEG conjugates have been synthesized and shown to be function in vitro as prodrugs. These conjugates are in the form of an ester wherein the 24-, 32- or 24,32-positions are esterified. The desired 24-, 32- or 24,32-esterified com-pounds were obtained by initially acylating of tacrolimus with iodoacetic acid at the 24-,32-, or 24,32-positions and then reacting the resulting acylated tacrolimus with a mPEG in the pres-ence of a base such as sodium bicarbonate. These conjugates were converted again into tac-rolimus by the action of enzymes in human liver homogenate, and the half-lives of the conjugates are approximately 10 min in the homogenate, indicating that the esterified tacroli-mus derivatives may be practically applicable as a prod rug for the immunosuppressant.