• Journal of The Korean Society of Clinical Toxicology
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• v.4 no.2
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• pp.180-186
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• 2006

The various species of aconitum contain diterpene (C-20) and norditerpene (C-19) forms of the natural alkaloid aconitine that cause neurologic, gastrointestinal, cardiovascular symptoms. In chinese medicine, these plants has been used as drugs to treat pain, dyspepsia, cerebrovascular disease, and so on. Because the therapeutic window is narrow, poisoning may occur from unintentional exposure, with a variety of toxic effects such as arrhythmia, hypotension, paresthesia, paralysis, nausea, vomiting, and abdominal pain. Aconitine-containing folk remedies are widely used in Korea. We encountered two cases of ventricular arrhythmia in patients who ingested tablets, known as 'Wha-Pung-Dan' made with aconitine extracts and were subsequently admitted to the ED. A 42 year-old man who took 35 tablets presented with ventricualr tarchycardia, and 40 year-old woman who took 40 tablets showed premature ventricular contractions. Both patients were discharged normally without any complications after three days.

• Korean Journal of Clinical Pharmacy
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• v.6 no.2
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• pp.14-18
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• 1996

This study was attempted to investigate the dissolution rate and the bioavailability after oral administration of commercially available norfloxacin tablets in rabbits. The dissolution test was conducted in artificial gastric juice using basket method with for norfloxacin preparations (A, B, C and D) which were chemically equivalent. The results were as follows ; The dissolution rate was increased in the order of four different brand A>D>B>C. Area under the plasma concentration curve and peak plasma concentration were increased in the order of brand A>D>B>C. Absorption rate constant and peak time were increased in the order of brand B>A>C>D, and there was a little difference in elimination rate constant and biological half-life. The correlation of the dissolution rate and relative bioavailability showed significant linear relationship. From the results of this experiment, the bioavailability of norfloxacin tablets in rabbits may be predicted from the results of dissolution rate studies.

• YAKHAK HOEJI
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• v.48 no.1
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• pp.60-64
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• 2004

Near-infrared (NIR) spectroscopy was used to determine rapidly and nondestructively the content of ambroxol in intact ambroxol tablets containing 30 mg (12.5％ m/m nominal concentration) by collecting NIR spectra in range 1100-1750 nm. The laboratory-made samples had 10.3∼15.9％ m/m nominal ambroxol concentration. The measurements were made by reflection using a fiber-optic probe and calibration was carried out by partial least square regression (PLSR) with autoscaling. Model validation was performed by randomly splitting the data set into calibration and validation data set (7 samples as a calibration data set and 5 samples as a validation data set). The developed NIR method gave results comparable to the known values of tablets in a laboratorial manufacturing Process, standard error of calibration (SEC) and standard error of prediction (SEP) being 0.49％ and 0.49％ m/m respectively. The method showed good accuracy and repeatability NIR spectroscopic determination in intact tablets allowed the potential use of real time monitoring for a running production process.

• Journal of Pharmaceutical Investigation
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• v.23 no.1
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• pp.55-59
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• 1993

Dissolution of mucosal adhesive tablets prepared with two polymers using hydroxypropylcellulose-H (HPC) and carbopol 934 (CP) was tested. Adhesive tablets containing HPC/CP and brilliant blue FCF (BB) were prepared from direct compression. Three factors of polymer ratio (HPC:CP), BB content and compression force were chosen as important factors of preparation and factorial analysis for these factors was carried out. Eight kinds of formulations from different combinations of three factors were prepared and dissolution test in pH 6.8 phosphate buffer solution was performed. Dissolution rate was significantly affected by HPC:CP ratio and BB content, but was not affected by compression force.

• Journal of Pharmaceutical Investigation
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• v.10 no.1
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• pp.24-33
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• 1980

Drug product design of phenylbutazone tablets by direct compressing was investigated. Weight variation, hardness, friability, disintegration time, apparent volume and dissolution rate for experimental tablets of nine formulations which were considered to be the effect of the additive concentration were measured. It was found out that direct compressing by the formulation No. 5 was the most suitable condition (phenylbutazone 16.7%, lactose 25%, calcium phosphate dibasic 15%, $Avicel^{\circledR}$ 41.83% and magnesium stearate 1.5%). The coefficient of correlation between disintegration time and dissolution rate, r, was = -0.97 (P<0.01).

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.106.3-107
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• 2003

VIAGRATM, an oral therapeutic agent for erectile dysfunction, is the citrate salt of sildenafil. VIAGRATM is formulated as blue, film-coated rounded-dia-mond-shaped tablets, equivalent to 25mg, 50mg and 100mg of sildenafil for oral administration. ViagraTM has been allowed to be sold at the drug store in Korea officially, but it is still increased to sell or use counterfeits or smuggled goods, because of its high price or strict restriction on both sale and purchase. Discrimination and analysis of 13 cases of VIAGRATM tablets for verification of genuineness or counterfeit were requested to our institute on the period, from January 1999 to July 2003. (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.117.1-117.1
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• 2003

Colchicine is a drug well known for its use in the therapy of acute attacks of gouty arthritis. Two death caused by oral ingestion of colchicine was reported. Two persons were all women. The one was 34 years old woman and with his boyfriend in a inn and the other was a housewife. The first one was a alcoholic but his boyfriend was afflicted with gout. So her boy friend carried over about 60 tablets of colchicine, 4 tablets of naltrexone and 22 tablets of fluoxetine. After her death there were remained colchicine, 2 tabs, naltraxone 4 tabs and fluoxetine 22 tabs. (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.242.1-242.1
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• 2003

The bioequivalence of two tablet formulations of 12.72 mg domperidone maleate (Shinpoong "$\textrm{Dompi}^{?}$" tablets vs. Janssen Korea "$\textrm{Dompi}^{?}$" tablets) was assessed in healthy Korean volunteers after oral administration in a randomized crossover study. Blood samples were collected at specified time intervals, and plasma concentration was measured as the amount of domperidone base using a validated HPLC method. The pharmacokinetic parameters of $AUC_{0{\longrightarrow}48}$, $C_{max}$, $T_{max}$$t\frac{1}{2}$ were determined from plasma concentration-time profile of two formulations. (omitted)

• Journal of Microbiology and Biotechnology
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• v.27 no.4
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• pp.739-746
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• 2017

As alternatives to antibiotics in livestocks, probiotics have been used, although most of them in the form of liquid or semisolid formulations, which show low cell viability after oral administration. Therefore, suitable dry dosage forms should be developed for livestocks to protect probiotics against the low pH in the stomach such that the products have higher probiotics survivability. Here, in order to develop a dry dosage forms of probiotics for poultry, we used hydroxypropyl methylcellulose phthalate 55 (HPMCP 55) as a tablet-forming matrix to develop probiotics in a tablet form for poultry. Here, we made three different kinds of probiotics-loaded tablet under different compression forces and investigated their characteristics based on their survivability, morphology, disintegration time, and kinetics in simulated gastrointestinal fluid. The results indicated that the probiotics formulated in the tablets displayed higher survival rates in acidic gastric conditions than probiotics in solution. Rapid release of the probiotics from the tablets occurred in simulated intestinal fluid because of fast swelling of the tablets in neutral pH. As a matrix of tablet, HPMCP 55 provided good viability of probiotics after 6 months under refrigeration. Moreover, after oral administration of probiotics-loaded tablets to chicken, more viable probiotics were observed, than with solution type, through several digestive areas of chicken by the tablets.

• Journal of Pharmaceutical Investigation
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• v.2 no.2
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• pp.18-33
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• 1972

Pharmaceutical Study on the Compressed tablets. Hardness, Friability, Disintegration time and Coefficient of Variance of Compressed tablets. Soo Uck Kim, Sung Hoon seo and Hyun Woo Lee (Department of Pharmaceutics, College of Pharmacy, Kyung Hee University) In order to know Hardness, Friability, Disintegration time and Coefficient of variance of the pharmaceutical tablets the 135 tablets sampled from market were tested in the paper. The samples tested in this paper were as follows: Antipyretics and Analgetics 41 Stomach and Digestives 22 Antituberculars 19 Vitamins 12 Sulfa drugs 9 Others (Antihistaminics etc) 32 Total 135 The results of the investigation are shown in table 1-8, Fig 1-Fig 6. Mean values of Hardness, Friability, Disintegration time and Coefficient of variance in each pharmaceutical preparation are as follows. Antipyretics and Analgetics : Hardness(kg) = 5.83 Antipyretics and Analgetics : Friabil.(%) = 0.82 Antipyretics and Analgetics : Disint.t.(min) = 5.28' Antipyretics and Analgetics : Coeff. of V.(%) = 2.90 Stomach and Digestives : Hardness(kg) = 4.11 Stomach and Digestives : Friabil.(%) = 0.71 Stomach and Digestives : Disint.t.(min) = 3.43' Stomach and Digestives : Coeff. of V.(%) = 2.76 Antituberculars : Hardness(kg) = 4.78 Antituberculars : Friabil.(%) = 0.52 Antituberculars : Disint.t.(min) = 4.32' Antituberculars : Coeff. of V.(%) = 2.99 Vitamins : Hardness(kg) = 1.60 Vitamins : Friabil.(%) = 0.43 Vitamins : Disint.t.(min) = 4.10' Vitamins : Coeff. of V.(%) = 3.19 Sulfa drugs : Hardness(kg) = 4.77 Sulfa drugs : Friabil.(%) = 0.37 Sulfa drugs : Disint.t.(min) = 3.10' Sulfa drugs : Coeff. of V.(%) = 2.09 Others : Hardness(kg) = 2.40 Others : Friabil.(%) = 0.66 Others : Disint.t.(min) = 2.19' Others : Coeff. of V.(%) = 3.10 The following summeries might be shown; 1. Ranges of Hardness, Friability, Disintegration time and Coefficient of variance are respectively 1.6 to 5.38 kg, 0.37 to 0.82%, 2 minut 19 second to 5 minut 28 second and 2.09 to 3.10%. 2. According to the results, it could be indicated that higher Hardness shows lower Friability. 3. Against the general conception between Hardness and Disintegration time, higher Hardness shows lower Disintegration time. 4. It seems that higher mean weight shows lowcr Coefficient variance.