• 분석과학
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• 제30권5호
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• pp.221-225
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• 2017

Thioctic acid is a vitamin-like antioxidant which is prepared as tablets and injection. The Korean Pharmacopoeia (KP XI) contains monograph for the quality control of raw thioctic acid using ultra-violet visible spectrophotometry and its formulations using high performance liquid chromatography (HPLC). In British Pharmacopoeia 2013 (BP2013), another HPLC method is used for the assay test of thioctic acid material. For the international harmonization, we present an HPLC method for quantitation of thioctic acid in both raw material and tablets. Method validation was performed to determine linearity, precision, accuracy, system suitability, and robustness. The linearity of calibration curves in the desired concentration range was high ($r^2=0.9995$), while the RSDs for intra- and inter-day precision were 0.93 ~ 1.26 % and 1.40 ~ 1.76 %, respectively. Accuracies ranged from 98.13-100.00 %. Since the system suitability, intermediate-precision and robustness of the assay were satisfactory, this method will be a valuable addition to the Korean Pharmacopoeia (KP XI).

• 디지털콘텐츠학회 논문지
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• 제16권6호
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• pp.943-950
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• 2015

본 연구에서는 전시 환경에서 증강 현실을 이용한 전시 보조역할의 주석 정보 시스템을 제안한다. 일반적인 전시장에 그림이나 사진의 설명을 안내책자나 오디오 기기를 활용하는 방법 그리고 사람이 설명하면서 전시를 관람하는 형태의 방법이 사용되고 있다. 우리는 이러한 기존 방법과 더불어 증강현실 기술을 이용하여 전시물에 대한 다양한 정보를 텍스트와 사진, 영상 그리고 오디오의 다양한 멀티미디어 매체를 활용하여 제공하고자 한다. 관람객이 손에 들고서 사용할 수 있는 스마트폰, 태블릿 기반의 장비에서 증강현실 기술을 적용하여 전시 관람의 보조 역할을 하게 된다.

• Journal of Pharmaceutical Investigation
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• 제23권3호
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• pp.145-153
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• 1993

Retaining a drug in the stomach by some means is sometimes necessary to extend the G1 absorption time of the drug more than 6-8 hrs. Hydrogel has often been examined for its feasibility as a dosage form, so called platform, that could be retained in the stomach due to its excellent swelling properties in the gastric fluid. In this study, polyvinylpyrrolidone (PVP) hydrogel crosslinked by albumin or acrylated albumin was synthesized in a tablet form and evaluated for its possibility as the platform. The synthesis of the hydrogel was performed by $^{60}Co\;{\gamma}-ray$ irradiation of N-vinyl-2-pyrrolidone (monomer) in the presence of a crosslinking agent: aqueous solution of albumin or acrylated albumin. Synthetic conditions such as radiation dose, dose rate and concentration of crosslinking agent were varied in order to optimize the swelling and mechanical properties of the hydrogels. Degree of swelling of albumin-crosslinked PVP (Al-PVP) was highly dependent on radiation dose, dose rate and albumin concentration: it was decreased as they increased. On the other hand, that of acrylated albumin-crosslinked PVP (Acryl-PVP) was almost independent on them except dose rate: it was decreased as the radiation dose rate increased. The compressive strength of the two hydrogels was decreased as the dose rate increased. Digestion of both PVP in artificial gastric fluid containing pepsin was delayed by the ${\gamma}-ray$ irradiation. In conclusion, Al-PVP and Acry-PVP with diverse swelling and mechanical properties could be obtained by controlling synthetic conditions, mainly the irradiation dose rate.

• Journal of Pharmaceutical Investigation
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• 제41권2호
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• pp.67-73
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• 2011

Ion exchange resins can be one of the good carriers for sustained drug release. However, the sustained release may not be enough only with themselves and hence film coating with rate controlling polymers can be applied to have a further effect on the drug release. Due to the environmental and economic issues of organic solvent for the polymer coating, aqueous polymeric systems were selected to develop dosage forms. Among the many aqueous polymeric dispersions for the film coating, EC (ethylcellulose) based polymers such as Aquacoat$^{(R)}$ ECD and Surelease$^{(R)}$ were evaluated.A fluid-bed coating was applied as a processing method. The drug release rate was quite dependent on the coating level so the release rate could be modified easily by changing different levels of the coating. The drug release rate in the Aquacoat$^{(R)}$ coated resin particles was strongly dependent on curing, which is a thermal treatment to make homogeneous films and circumvent drug release changes during storage. After dissolution test using the compressed tablets in which the coated resin particles are contained, inhomogeneous coating and even pores could be observed showing that the mechanical properties of EC were not resistant to granulation and compaction process. However, when tablets were prepared in different batches, the release profiles were almost identical showing the feasibility of the coated resin particle as incorporated into the tablet formulation.

• 한국통신학회논문지
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• 제30권12B
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• pp.831-837
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• 2005

개인용 일반적 용도의 컴퓨터는 탁상용에서 태블릿 PC나 PDA와 같은 이동가능한 모바일 디바이스로 발전되어 왔다. 반도체 분야의 기술혁신은 그러한 형태적 요소를 진보된 입출력장치들과 함께 상당히 강력한 프로세서와 메모리 부시스템으로 패키징을 하는 것을 가능하게 하였다. 마침내 이들 부시스템들은 작게 구성되어 입을 수 있는 컴의 형태로 만들어질 수 있게 되었다. 입을 수 있는 컴퓨터는 최근 유비쿼터스 환경에서 차세대 PC로서 주의를 얻게 되었으며 입을 수 있는 컴퓨팅기술은 더욱 더 실현 가능한 것이 되었고 소비시장과 산업에 걸쳐 더 많은 관심을 받게 되었다. 본 논문에서는 기존에 개발된 입을 수 있는 내장형 시스템 플랫품에 멀티미디어와 네트워크 기능을 강화하여 진보된 입을 수 있는 내장형 플렛폼인 WPS(Wearable Personal Station)을 제안하고 개발했다. 본 논문은 이러한 WPS의 형태, 전체적인 구성, 기능 그리고 응용프로그램에 관한 것들을 설명한다. 또한 본 논문에서는 미래의 직관적인 사용자 인터페이스와 잘 디자인된 응용들을 갖춘 차세대 컴퓨터 플랫폼의 형태에 대해 논의한다.

• 농촌계획
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• 제13권1호
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• pp.73-84
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• 2007

The first theme of this study is to preserve and manage rural multi-functionality resource Information. This study is to suggest the method that can irradiate rural multi-functionality resource Information efficiently and constructively. GIS uses PDA and Tablet PC as an investigation tool and verifies the outcome of the development in the investigation system. This study enhanced the mobility function of PDA by installing recording system and camera to the PDA. Also, Using GPS has been ensured scientific precision and realism to the investigation. Direct input on spot can save time, cost and minimize human error by simplifying the investigation process. Database is composed of characters like scale, form, location, distance, resident's opinion and image of 37 resources. The survey system was applied in 170 villages and got a total of 12,270 resources data. Management system should be easy to input and output the surveyed information and to get reports in any kind of form ( i.e. final result can be produced as a map). By utilizing of the Rural Resource information system, the study made a simulation to compare the target areas before and after. Also, digitalized investigation system, minimized re-input and reprocessing of data and enabled to simplify and standardize the process than memorandum investigation. Data collected through digital system could offer people useful information by Web-GIS. It was need to specify practical way in decision-making and a way to measure the value of resources to align with the regional plan. Also, need to keep on developing statistical data and application program that can connect us to present the best solution to support regional planning. Therefore, quality of data is very important. Finally, it is very important to develop various programs to analyze space md rural resource by monitoring rural environment.

• 대한소아치과학회지
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• 제38권2호
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• pp.146-154
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• 2011

어린이용 시럽제의 우식유발능에 관해 알아보기 위하여 국내에서 시판 중인 일반의약품 어린이용 시럽제 8종에 대한 생체 외 연구를 사행하였다. 어린이용 시럽제 8종을 실험군으로 10% 자당을 양성 대조군, 인공 타액을 음성 대조군으로 하였다. 실험군 및 대조군의 pH를 측정하고 시료용액 20 ml의 pH를 7로 맞추는데 필요한 2 N NaOH의 부피로 완충능을 측정하였다. Ostwald 파이햇을 시료용액 2 ml가 통과하는데 걸린 시간을 측정하여 비점조도를 계산하였다. Streptococcus mutans의 배양액을 접종 후 48시간 배양하여 pH의 변화를 측정해서 산생성능을 살펴보았다. 하루에 3번 시료용액에 유치 법랑질 시편을 20분간 넣은 후 인공타액에 보관하는 pH 순환모텔을 5일간 적용하였고 표면미세정도의 변화를 측정하여 유치 법랑질 침식능을 검사하였다. 본 연구 결과로부터 어린이용 시럽제는 자체 산도 및 완충능, 점조도, 유치 법랑질 침식능에서 모두 우식유발 가능성이 높음을 알 수 있으며 산생성능에서도 3종를 제외한 어린이용 시럽제가 양성대조군보다 높게 나타남으로써 우식 유발가능성이 높음을보여준다.

• Journal of Pharmaceutical Investigation
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• 제32권3호
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• pp.185-190
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• 2002

To improve the solubility of poorly water-soluble drug and to develop a sustained release tablets, the need for the technique, the formation of solid dispersion with polymeric materials that can potentially enhance the dissolution rate and extent of drug absorption was considered in this study. The 1:1, 1:4, and 1:5 solid dispersions were prepared by spray drying method using PVP K30, ethanol and methylene chloride. The dissolution test was carried out at in phosphate buffer solution at $37^{\circ}C$ in 100 rpm. Solid dispersed drugs were examined using differential scanning calorimetry and scanning electron microscopy, wherein it was found that felodipine is amorphous in the PVP K30 solid dispersion. Felodifine SR tablets were prepared by direct compressing the powder mixture composed of solid dispersed felodipine, lactose, Eudragit and magnesium stearate using a single punch press. In order to develop a sustained-release preparation containing solid dispersed felodipine, a comparative dissolution study was done using commercially existing product as control. The dissolution rate of intact felodipine, solid dispersed felodipine and its physical mixture, respectively, were compared by the dissolution rates for 30 minutes. The dissolution rates of felodipine for 30 minutes from 1:1, 1:4, 1:5 PVP K30 solid dispersion were 70%, 78% and 90%. However, dissolution rate offelodipine from the physical mixture was 5% of drug for 30 minutes. Our developed product Felodipine SR Tablet showed dissolution of 17%, 50% and 89% for 1, 4, and 7 hours. This designed oral delivery system is easy to manufacture, and drug releases behavior is highly reproducible and offers advantages over the existing commercial product. The dissolution rate of felodipine was significantly enhanced, following the formation of solid dispersion. The solid dispersion technique with water-soluble polymer could be used to develop a solid dispersed felodipine SR tablet.

• 헤리티지:역사와 과학
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• 제44권4호
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• pp.56-69
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• 2011

감실은 고조부모부터 부모까지 사대 신주를 모시는 의례용구로 사당 안에 배치하였다. 구조와 형태는 고려시대에 수용된 주자의 "가례"의 도설에 따르면 네모반듯한 네 칸으로 구성되었다. 감실은 고조부터 아버지 대까지 사대 조상의 신주를 각 칸 마다 한 대씩을 남향으로 세워서 서쪽에서 동쪽의 순서로 안치하며 후손이 없는 조상의 신주도 함께 모셨다. 감실은 신주를 봉안하는 단순한 공간에서 벗어나서 그들의 영혼이 깃든 공간이자, 가족 내 위계질서가 살아있는 공간이다. 사당 건립과 관리는 후손의 사회적 신분과 가정 경제력 등으로 일정부분 제약을 받았다. 조선시대 조정은 관직자의 품계에 따라서 조상의 봉사 대수와 건축을 제한하였기 때문이다. 관직자는 녹을 받음으로써 일정부분 경제적인 안정을 취할 수 있는 집안이어서 사당을 건립할 수 있었다. 그렇지 않은 집안은 자신의 살림살이 집 한 곳에 감실을 배치하고 신주를 안치했을 가능성이 있다. 그 과정에서 감실은 배치 장소, 크기, 구조와 형태 등이 변하는 특징을 보였다. 구조적으로 건물형상을 띤 감실은 가옥과 사당형으로 영혼불멸사상과 조상관을 엿볼 수 있다. 그리고 사당 밖에 배치된 감실은 탁자를 들여놓을 수 있는 정도의 크기에서 신주를 안치할 수 있는 크기로 변하였다. 이런 감실은 이동하기 편리하고 거주공간의 너비와 높이를 고려해서 제작하였다. 감실의 변용으로 사회변화와 제도, 가정 경제력과 아주 밀접한 관계가 있음을 보여주었다. 조선 초기에는 "가례"를 바탕으로 한 가묘 건립과 조상의 봉사 정책을 사대부가에서 결과가 나타났다. 서인들은 사회적, 제도적으로 제약을 받음으로써 실질적으로 정책에 부응할 수 없었다. 사당을 갖지 못하는 집안도 감실의 변용을 통해서 그들에게 4대를 봉사할 수 있는 기회를 스스로 가졌다. 결과적으로 조선 후기로 접어들면서 명분과 현실을 절충하여서 사대봉사가 보편화되는 기반이 되었다. 감실의 변용은 혈연의 정통성 찾기와 가문의 위신 노출, 사대봉사의 확산계기 마련, 신성공간화, 가정경제력 증대 등으로 사회적 의미를 함축하고 있다고 결론을 지을 수 있다.

• 한국IT서비스학회지
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• 제11권3호
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• pp.161-175
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• 2012

A novel concept of ICT based service, which is called N-device service, is proposed and implemented in the form of N-device smart education services. The N-device services are different from the existing N-screen services in terms of the number of devices a user is using for a specific service at the same time. A N-device service consists of several smart devices which are different in size, software and hardware platform, mobility, manufacturer and the like by fully utilizing the characteristic of each device. The major and unique features of N-device services are analyzed and depicted in a strict way. Those are shared role for each device, service by configurable device, one sensor multiple use, real-time data sharing, role shifting and new market creation. It is turned out that the N-device service is more human centric compared with existing ICT based services and can give richer digital experience to users because non-existent services become possible with the new concept. However, there exist several barriers to be implemented and commercialized in the real world. Those include high development cost and time, small market and different application platforms of devices. These barriers can be overcome by technical advances and cooperation between relevant parties. The smart education is very prominent area, in which the novel concept can be applied with high priority because Korean government announced its plan to boost up new educational services with big budget and these are acceptable by enthusiastic Korean parents and students. That's why the N-device service is implemented in the education area, which is called as "livessam(live teacher)," with four smart devices, IPTV, tablet PC, PC and smart phone. By providing both detailed service scenario and techniques, we shows that the novel education service is technically feasible and acceptable by teachers and students.