• Archives of Pharmacal Research
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• v.19 no.2
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• pp.137-142
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• 1996

Effects of plantago-mucilage A (P-MA) on the immune responses were studied in ICR mice. Mice were divided into 4 groups (10 mice/group), and P-MA at doses of 7, 21 and 63 mg/kg were orally administered to mice once a day for 21 consecutive days. Mice were immunized and challenged with sheep red blood cells (SRBC). P-MA at 63 mg/kg/day significantly increased the body weight gain and the relative weights of spleen and thymus, as compared with those in controls. However, there were no significant effects on liver weight due to P-MA treatment. Plaque forming cells (PFC) and hemagglutination (HA) titers to SRBC were significantly enhanced in mice dosed at 21 and 63 mg/kg/day P-MA, as compared with those in controls. Delayed-type hypersensitivity (DTH) reaction to SRBC, phagocyte activity and circulating leukocyte were also significantly increased in mice dosed at 63 mg/kg/day P-MA. These results demonstrate that P-MA markedly enhances both humoral immune and allergic reaction to SRBC at concentrations which don't act on the relative weight of liver.

• Journal of Life Science
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• v.21 no.12
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• pp.1732-1739
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• 2011

This study was carried out to investigate the effect of lotus root and leaf powder on the quality characteristics of pork patty stored at $3^{\circ}C$ for 9 days. The pork patties were of four types: nothing added(control, T0), 0.5% lotus root powder added (T1), 0.25% lotus root and 0.25% lotus leaf powder added (T2), and 0.5% lotus leaf powder added (T3). The $a^*$ value tended to decrease with longer storage period (p<0.05). The $L^*$ and $a^*$ value of T3 had the lowest value among the samples, the $b^*$ value T2 and T3 were higher than those of T0 and T1 (p<0.05). Water holding capacity decreased with longer storage period (p<0.05), the water holding capacity, cooking loss, increase rate of thickness and decrease rate of diameter were not significantly different among the samples. Hardness and chewiness increased and springiness decreased with longer storage period (p<0.05). The pH creased with longer storage period (p<0.05), but the VBN content not changed during storage. The TBARS values increased with longer storage period (p<0.05), and those of T0, T1, T2 and T3 were 4.57, 1.85, 0.43 and 0.41 mg MA/kg, respectively, after 9 days of the storage. The result suggest that the addition of lotus root and leaf powder at the same time, or addition of lotus leaf powder can be applied to pork patty to its functionality.

• Economic and Environmental Geology
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• v.32 no.2
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• pp.141-150
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• 1999

The granitic rocks are distributed in the northeastern Gyeongsang basin, and are subdivided into the Youngduk, Younghae, Jangsadong and Onjeong granite. Based on the chondrite normalized patterns of REE by primitive mantle, the Jangsadong granite is more negative Eu anomaly than other granites. On the patterns of trace and rare earcth elements normalized by primitive mantle, Sr, P, Nd, Sm and Ti contents of t도 Youngduk and Younghae granites are higher than those of Jangsadong and Onjeong granites. Based on K-Ar ages, the Youngduk granite is 166.5 Ma for biotite, Younghae granite is 158.7 to 178.0 Ma for hornblende, Jangsadong granite is 113.8 to 118.4 Ma for K-feldspar and hornblende, and Onjeong granite is 67.4 Ma for biotite. Thus, geochemical and geochronological results suggest two plutonic episodes :the Youngduk-Younghae granites and Jangsadong-Onjeong granites suggest two plutonic episodes : the Youngduk-Younghae granites and Jangsadong-Onjeong granites. Jurassic plutonism cooled faster than Cretacous plutonism in the study area.

• Journal of The Korean Astronomical Society
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• v.34 no.4
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• pp.321-323
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• 2001

Compressible, magnetohydrodynamic (MHD) turbulence in two dimension is studied through high-resolution, numerical simulations with the isothermal equation of state. First, hydrodynamic turbulence with Mach number $(M)_{rms}\;\~$1 is generated by enforcing a random force. Next, initial, uniform magnetic field of various strengths with Alfvenic Mach number Ma $\gg$ 1 is added. Then, the simulations are followed until MHD turbulence is fully developed. Such turbulence is expected to exist in a variety of astrophysical environments including clusters of galaxies. Although no dissipation is included explicitly in our simulations, truncation errors produce dissipation which induces numerical resistivity. It mimics a hyper-resistivity in our second-order accurate code. After saturation, the resulting flows are categorized as SF (strong field), WF (weak field), and VWF (very weak field) classes respectively, depending on the average magnetic field strength described with Alfvenic Mach number, $(Ma)_{rms}{\ge}1$, $(Ma)_{rms}{\~}1$, and $(Ma)_{rms}{\gg}1$. The characteristics of each class are discussed.

• Journal of the Korean institute of surface engineering
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• v.27 no.4
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• pp.215-222
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• 1994

The role dispersoids has been studied in a number of researches as a key point for the high strength application of dispersion strengthened aluminum alloy. The mechanical alloying(MA) process with high mechanical properties of dispersion strengthened MA Al-8Ti-1B alloys were invested in order to evaluate their stress corrosion cracking(SCC) application. SCC properties of the mechanically alloyed Al-8Ti-1B were studied using slow strain rate test(SSRT). In this study Al-8Ti-1B alloy were more susceptible to SCC in solutions of pH=2.01 and 13.2 than pH=6.81 solution. In this study Al-8Ti-1B alloys by MA had more SCC resistance than Al-8Ti alloys or Al 7075-T73 alloys. So Al-8Ti-1B alloys by MA had more resistance in SSRT SCC susceptinility test than any other above alloying metals.

• Biomolecules & Therapeutics
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• v.32 no.2
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• pp.231-239
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• 2024

Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma cells (MNT-1) and human keratinocyte cell line (HaCaT), and downregulated melanogenic genes, including tyrosinase, tyrosinase-related protein 1 and 2 (TRP-1, TRP-2). Additionally, MA decreased cyclic adenosine monophosphate (cAMP) production and exhibited a significant anti-pigmentary effect in Melanoderm^TM. These results suggest that MA is a promising anti-pigmentary agent for replacing or complementing existing anti-pigmentary cosmetics.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.569-573
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• 2012

Early diagnosis and better prognosis of ovarian cancer is still a challenge. Besides environmental risk factors, genetic factors have established a role in pathogenesis of ovarian cancer. Methods: A case-control and a prospective study design conducted in 224 ovarian cancer patients and 432 controls in Chinese population. MTHFR C677T genotyping was done by PCR-RFLP. Results: Patients with ovarian cancer is associated with a higher less number of delivery and less frequent oral contraceptive use. When potential confounding factors adjusted logistic regression analysis between cases and controls were performed, significant association was obtained for 677T/T genotype and ovarian cancer (OR=3.13, 95% CI=1.59-5.72). Cox regression survival analysis showed individuals carrying T/T genotype had significantly increased HR for death in ovarian cancer patients (HR=2.86, 95% CI=1.27-7.93). In conclusion, we observed that the MTHFR C677T polymorphism is associated with the susceptibility and survival of ovarian cancer in Chinese population.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.1
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• pp.247-261
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• 1999

In dieser Abhandlung wurde im Bereich der $Temporalit\"{a}t$ anhand des konzeptorientierten Ansatzes das $Verh\"{a}ltnis$ yon konzeptueller und sprachlicher $Repr\"{a}sentation$ betrachtet. Die $Temporalit\"{a}t$ ist ein abgeleiteter Begriff, den das menschliche$Bewu{\ss}tsein$ im Rahmen seiner kognitiven Entwicklung als $Ma{\ss}stab$ der qualitativen $Ver\"{a}nderung$ und Bewegung von Materie warhnimmt und systematisch konzeptualisiert. Ihre Subkategorien unterscheiden sich in den Sprachen, da bei den $Konzeptualisierungsvorg\"{a}ngen$ durch die Muttersprache bestimmte begriffliche Kategorien eine steuernde Rolle spielen. In diesem theoretischen Hintergrund betrachteten wir, inwieweit die beiden Sprachen, das Deutsche und das Koreanische, im Bereich des Zeitkonzepts auf der konzeptuellen Ebene und auf der Ausdrucksebene verschieden und gemeinsam sind, und wie das $Verh\"{a}ltnis$ zwischen den temporalen Konzepten und den $Ausdrucksm\"{o}glichkeiten$ ist. Die $Temporalit\"{a}t$ des Koreanischen ist in Bezug auf die Basiskategorien der $Temporalit\"{a}t$ mit dem Deutschen mehr oder weniger identisch. Zum Ausdruck der Zeitreferenz haben die beiden Sprachen gemeinsam zwei explizite grammatische und lexikalische $Ausdrucksm\"{o}glichkeiten$, aber die Art und Weise, wie sie zum Ausdruck der Subkategorien der $Temporalit\"{a}t$ eingesetzt werden, sind verschieden. In diesem Zusammenhang kann man sagen, $\dabeta$ es zum Verstandnis der $\dabeta$ in der Sprache nicht reicht, die sprachliche Formen zu betrachten: man $mu\ss$ die Konzepte berucksichten, die durch die sprachlichen Formen $ausgedr\"{u}ckt$ werden.

• Nuclear Engineering and Technology
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• v.55 no.5
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• pp.1901-1910
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• 2023

The safety-class (1E) digital control system (DCS) of nuclear power plant characterized structural multiple redundancies, therefore, it is important to quantitatively evaluate the reliability of DCS in different degree of backup loss. In this paper, a reliability evaluation model based on T-S fuzzy fault tree (FT) is proposed for 1E DCS of nuclear power plant, in which the connection relationship between components is described by T-S fuzzy gates. Specifically, an output rejection control system is chosen as an example, based on the T-S fuzzy FT model, the key indicators such as probabilistic importance are calculated, and for a further discussion, the T-S fuzzy FT model is transformed into Bayesian Network(BN) equivalently, and the fault diagnosis based on probabilistic analysis is accomplished. Combined with the analysis of actual objects, the effectiveness of proposed method is proved.

• Proceedings of the Korean Environmental Health Society Conference
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• 2003.06a
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• pp.187-191
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• 2003

In this study, biomonitoring methods were developed to measure BTEXs exposure level in the air, metabolites of benzene and toluene in human urine, individual susceptibility markers in human blood for evaluation of the health effects about environmental pollution. We have also performed a small-scaled molecular epidemiology study on residents in Chuncheon and workers in workplace for these method applications. The workers in workplace were surveyed as study areas, and the residents in Chuncheon which is in the suburban area were surveyed as comparative areas in this study. Actually, 31 workers in as target group and 33 residences in as control group this epidemiological study. The results obtained from this study were as follows: 1. Benzene is a well-known carcinogen, it's median concentrations were 0.00024∼0.02057ppm at suburban area and 0.002∼00.654ppm at work place, These benzene concentrations were not exceed the OSHA(Occupational Safety and Health Administration) threshold benzene level of 1ppm in the states. 2. Metabolites product of benzene(t,t-Muconic Acid) and toluene(Hippuric Acid) were not significant both in suburban and workplace area. The median concentration of t,t-MA and HA were 0.0122, 1.44277g/g creatinine, respectively. 3. In the case of individual susceptibility markers as CYPlAl, 41.8% of them has homozygous wild type(W) and who has heterozygous variant type(H) was 35.4% and 22.8% of homozygous variant type(M) genetic type. In the case of CYP2E1, 62.82% of them has homozygous wild type(D) type, 34.62% of each has heterozygous variant type (DC) and 2.56% of them has homozygous variant type (CC). Who doesn't have GSTM1 gene was 46.25% and who has GSTM1 gene was 53.75％. Who doesn't have GSTT1 gene was 40.0％ in study groups and who has GSTT1 gene was 60.0%. Who has W genetic type, which is homozygous wild type of GSTP1, was 69.18% and H genetic type, which is heterozygous variant type was 28.4%. M genetic type which is homozygous variant type was 2.4%. 4. Concentration differences of metabolites such as t,t-MA and HA in urine, which is generated by individual susceptibility marker of GSTM1, GSTT1, GSTP1 gene of Phase I and CYP1A1, CYP2E1 gene of Phase II, was examined. As a result, GSTP1 and GSTM1 indicate slight differences depend on the amount of metabolites in urine, it was not statistically significant.