• International Journal of Oral Biology
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• v.39 no.2
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• pp.97-105
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• 2014

The aim of this study was to determine the beneficial effect of propofol on human keratinocytes that have undergone hypoxia reoxygenation (H/R) injury and to investigate whether autophagy is associated with the protective mechanism. Thus, we evaluated how propofol influences the intracellular autophagy and apoptosis during the H/R process in the HaCaT cells. The cultured human keratinocyte cells were exposed to 24 h of hypoxia (5% $CO_2$, 1% $O_2$, 94% $N_2$) followed by 12 h of reoxygenation (5% $CO_2$, 21% $O_2$, 74% $N_2$). The experiment was divided into 4 groups: (1) Control=Normoxia ; (2) H/R=Hypoxia Reoxygenation ; (3) PPC+H/R=Propofol Preconditioning+Hypoxia Reoxygenation; (4) 3-MA+PPC+ H/R=3-MA-Methyladenine+Propofol Preconditioning+ Hypoxia Reoxygenation. In addition, Western blot analysis was performed to identify the expression of apoptotic pathway parameters, including Bcl-2, Bax, and caspase 3 involved in mitochondrial-dependent pathway. Autophagy was determined by fluorescence microscopy, MDC staining, AO staining, and western blot. The H/R produced dramatic injuries in keratinocyte cells. In our study, the viability of Propofol in H/R induced HaCaT cells was first studied by MTT assay. The treatment with 25, 50, and $100{\mu}M$ Propofol in H/R induced HaCaT cells enhanced cell viability in a dose-dependent manner and $100{\mu}M$ was the most effective dose. The Atg5, Becline-1, LC3-II, and p62 were elevated in PPC group cells, but H/R-induced group showed significant reduction in HaCaT cells. The Atg5 were increased when autophagy was induced by Propofol, and they were decreased when autophagy was suppressed by 3-MA. These data provided evidence that propofol preconditioning induced autophagy and reduced apoptotic cell death in an H/R model of HaCaT cells, which was in agreement with autophagy playing a very important role in cell protection.

• Journal of the East Asian Society of Dietary Life
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• v.22 no.6
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• pp.851-859
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• 2012

This study was conducted to investigate the effects of addition of lotus (Nelumbo nucifera) leaf and root extracts on the quality and sensory characteristics of ground pork meat. Four types of ground pork were evaluated: 5% ice water added (T0), 5% lotus leaf extract added (T1), 2.5% lotus leaf extract and 2.5% root extract added (T2), and 5% lotus root extract added (T3). There were no significant differences in moisture, protein, fat, ash, cooking yield, moisture retention, water holding capacity, reduction in diameter, a-value (redness), b-value (yellowness), VBN content (volatile basic nitrogen), hardness, springiness, cohesiveness or chewiness. The fat retention was highest in T0 (p<0.05). The L-values (lightness) of T2 and T3 were higher than those of T0 and T1 (p<0.05). The pH was lowest in T1 (p<0.05). The TBARS (2-thiobarbituric acid reactive substances) values of T0, T1, T2, and T3 were 0.47, 0.17, 0.21, and 0.32 mgMA/kg, respectively, with that of T1 being significantly lower than those of the other samples (p<0.05). The contents of free amino acids related to sweet taste was 642.5 ppm for T1, which was highest among the samples (p<0.05). The flavor was highest in T1 (p<0.05). These results suggest that lotus leaf extracts improved the lipid oxidation and flavor of ground pork meat.

• Review of Korean Society for Internet Information
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• v.19 no.1
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• pp.39-45
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• 2018

• Journal of Digital Convergence
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• v.16 no.2
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• pp.47-56
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• 2018

The purpose of this study was to identify the relation among the CRR, MA, and MS of military solder's who have experienced couple relationship troubles. Data collected from 239 soldiers in front-line division and post line division was analyzed by correlation analysis, t-test and hierarchical analysis using SPSS 18.0. As the results, 1. CRR and MA showed a positive correlation and CRR and MS showed a negative corelation. 2. CRR showed a significant influence on the MA. 3. CRR had a mediating effects on the process where MS influenced MA. The results of this study are expected to be used as the primary data for raising the adaptability to the military especially on the subject of couple relationship, and as an educational guidance for helping soldiers to see the positive aspect of the adversity and stress of military life.

• Journal of the Korean Society of Safety
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• v.20 no.3 s.71
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• pp.34-41
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• 2005

For assessing residual lift of the steam pipe in fossil power plants, inspections and analysis are usually focused on the critical locations such as butt welds, elbows, Y-piece and T-piece of the steam pipes. In predicting the residual life of T-piece, determination of local stress near welds considering system load as well as internal pressure is not a simple problem. In this study, stress analysis of a T-piece pipe was conducted using a three-dimensional model which represents the T-piece of a domestic fossil power station. Elastic and elastic-creep analysis showed the maximum stress level and its location. Residual creep rupture life was also calculated using the stress analysis results. It was argued that the calculated life is reasonably same as the measured one. The stress analysis results also support life prediction methodology based on in-field replication technique.

• Journal of the Korean Society of Clothing and Textiles
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• v.20 no.1
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• pp.19-27
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• 1996

The purpose of this study is the investigation of the physical properties, handle variation of polyester fabrics grafted methacrylic acid. The results are as follow 1. In the case of moisture recovery, MA-g-PET results in an improvement of approximately 4% when the graft ratio reaches 25%, whilst Na-MA-g-PET results in an improvement of approximately 9% when the graft ratio reaches 20%. 2. The static electricity of Na-MA-g-PET, is rarely generated when the graft ratio exceeds 10% . 3. The T.H.V. indicate that the values had deteriorated in the case of MA-g-PET, whilst the N a-Ma-a.PET values demonstrated superiority. 4. The value resulting from the MA-g-PET and Na-MA-g-PET treatment methods are calculated as being 0.0130, whilst the value pursuant to graft ratio is 0.0000.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.891-894
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• 2013

The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exerted greater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be via apoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependent apoptotic processes in the T47D breast cancer cell line.

• The KIPS Transactions:PartA
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• v.8A no.3
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• pp.227-234
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• 2001

In this paper we propose a block-type parallel preconditioner for solving large sparse nonsymmetric linear systems, which we expect to be scalable. It is Multi-Color Block SOR preconditioner, combined with direct sparse matrix solver. For the Laplacian matrix the SOR method is known to have a nondeteriorating rate of convergence when used with Multi-Color ordering. Since most of the time is spent on the diagonal inversion, which is done on each processor, we expect it to be a good scalable preconditioner. We compared it with four other preconditioners, which are ILU(0)-wavefront ordering, ILU(0)-Multi-Color ordering, SPAI(SParse Approximate Inverse), and SSOR preconditiner. Experiments were conducted for the Finite Difference discretizations of two problems with various meshsizes varying up to $1025{\times}1024$. CRAY-T3E with 128 nodes was used. MPI library was used for interprocess communications, The results show that Multi-Color Block SOR is scalabl and gives the best performances.

• Bulletin of the Korean Chemical Society
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• v.30 no.6
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• pp.1245-1246
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• 2009

• The Journal of the Petrological Society of Korea
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• v.28 no.2
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• pp.143-156
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• 2019

We carried out the sensitive high resolution ion microprobe zircon U-Pb age dating and whole rock geochemical analysis of granites in the Gudambong and Sainam geosites, Danyang Geopark. The granites crop out in the western and southern parts of Danyang County, and intruded sedimentary successions of the Yeongweol and Taebaek Groups, respectively. The U-Pb isotopic compositions of zircon from the Gudambong and Sainam granite samples yielded the Cretaceous intrusion ages of $90.4{\pm}0.5Ma(t{\sigma})$ and $90.0{\pm}1.5Ma(t{\sigma})$, respectively. The major and trace elements compositions of the samples showed an affinity of typical A-type granite, indicating their petrogenesis during the late stage of the Bulguksa orogeny or a tectonic dormancy. The geochronologic and geochemical results are identical to those of granites previously reported from the Cretaceous Muamsa and Wolaksan suites.