• Journal of the Korea Convergence Society
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• v.11 no.7
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• pp.35-40
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• 2020

Recently, devices such as smart watches capable of measuring small biosignals have been released. Body composition, blood pressure, heart rate, and oxygen saturation can be easily obtained. However, the part that is not trusted by the user is accuracy. These biosignals are sensitive to the external environment and have large fluctuations depending on the conditions inside the subject's body. Blood pressure measurements, in particular, still give different results, depending on how the conditions in the body are handled. Therefore, in this study, PPG was analyzed to measure PTT at two points of 80% and 100%, the highest in PTT measurement. The effect of the measured value on SBP and DBP was analyzed and a method was proposed to increase the accuracy. As a result of the study, the measured value of PTT at 80% of the peak PPG is more effective in estimating blood pressure of SBP and DBP than the value measured at 100%. In the regression analysis of the rate of change blood pressure estimation, the coefficient of determination of SBP (80%) was 0.6946, and DBP (100%) was 0.547.

• Journal of the korean academy of Pediatric Dentistry
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• v.32 no.3
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• pp.499-508
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• 2005

The purpose of this study were to evaluate the effect on the reversion of sedation induced by midazolam with flumazenil and to determine the plasma concentration of flumazenil according to the method of administration. Intranasal and intravenous flumazenil were administered to sedated health volunteers aged from 23 to 25 years, in doses typical of those used clinically to induce sedation with midazolam and for reversal with flumazenil. Objective assessment for degree of sedation and vital signs, plasma concentration were made for 2 hours period. 1. Systolic and diastolic blood pressure, $SpO_2$ were not changed by adminstration of flumazenil in sedated subject with midazolam, but pulse rate was increased temporarily. 2. Flumazenil showed the reversal of the sedative effect induced by midazolam regardless of administration methods. But intravenous administration showed more effect on the degree and the duration of reversion than intranasal administration with the exception of on set time. 3. Peak plasma concentration of flumazenil administered by intranasal route reached after 2 min and that of flumazenil administered by intravenous route was 4 min. Thus uptake of flumazenil did not showed any difference in accordance with the adminstration route. 4. Administration of flumazenil resulted in the temporary increase of midazolam plasma concentration.