• 제목/요약/키워드: systems biology.

검색결과 1,902건 처리시간 0.045초

Genetic Relationships of Korean Ocenebrine Species (Gastropoda: Prosobranchia: Muricidae)

  • Park, Joong-ki;Choe, Byung-Lae
    • Animal cells and systems
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    • 제3권3호
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    • pp.285-293
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    • 1999
  • Allele frequencies in twenty-two populations from nine Korean muricid species of five genera (Rapaninae and Ocenebrinae) wire analyzed genetically using 13 loci from 11 allozyme systems. The clustering patterns of these species were basically consistent with traditional groupings to two subfamilial categories based on shell and radula morphologies. Within six ocenebrine species it was apparent that Ceratostoma inornata and Pteropurpura adunca were most closely related to each other than to any other species belonging to the genus Ceratostoma. These results, along with other anatomical features 〔morphologies of albumin gland (female), egg capsule〕, suggest that the generic position of C. inornata, previously classified to be congeneric with other western Pacific Ceratostoma species, should be reconsidered. Our results show the close relationship of Nucella freycineti with other ocenebrine species, rather than with rapanines, which supports a previous suggestion that the genus Nucella should be placed with the subfamily Ocenebrinae rather than the subfamily Rapaninae.

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Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases

  • Im, Eunju;Chung, Kwang Chul
    • BMB Reports
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    • 제49권9호
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    • pp.459-473
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    • 2016
  • Neurodegenerative diseases (NDs) often involve the formation of abnormal and toxic protein aggregates, which are thought to be the primary factor in ND occurrence and progression. Aged neurons exhibit marked increases in aggregated protein levels, which can lead to increased cell death in specific brain regions. As no specific drugs/therapies for treating the symptoms or/and progression of NDs are available, obtaining a complete understanding of the mechanism underlying the formation of protein aggregates is needed for designing a novel and efficient removal strategy. Intracellular proteolysis generally involves either the lysosomal or ubiquitin-proteasome system. In this review, we focus on the structure and assembly of the proteasome, proteasome-mediated protein degradation, and the multiple dynamic regulatory mechanisms governing proteasome activity. We also discuss the plausibility of the correlation between changes in proteasome activity and the occurrence of NDs.

Genetic Structure In Korean Populations of Atractomorpha lata (Orthoptera: Pyrgomorphidae)

  • 정명지;강순석
    • Animal cells and systems
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    • 제1권4호
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    • pp.535-538
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    • 1997
  • Allozyme variation of seven enzyme systems was analyzed from 202 individuals from four Korean populations of Atractomorpha lata. These populations exhibit higher levels of values of in most other insects with a mean 64% of polymorphic loci and a mean 0.384 of expected heterozygosity within populations. Fixation indices indicated considerable substructuring within populations sampled (mean $F_{is}=0.403)$, indicating probable inbreeding or assortative mating coupled with restricted migration between subpopulations. This was supported by the field observation that the species exists as small, discrete colonies in meadow habitats and females carry males. In addition, significant differences in allere frequencies between males and females at polymorphic loci examined (70%, 16 of 23 cases) could account for the observed heterozygote deficiencies.

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Morphometric Variation of Six Subspecies of Striped Field Mouse, Apodemus agrarius Pallas(Mammalia, Rodentia), from China and Korea

  • Koh, Hung-Sun;Kim, Young-Ki;Lee, Woo-Jai;Wang, Jinxing;Lu, Haoquan
    • Animal cells and systems
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    • 제1권1호
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    • pp.25-29
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    • 1997
  • Four external and 27 cranial characters of striped field mice (Apodemus agrarius) from 16 regions in China and Korea, representing six subspecies, were analyzed by multivariate methods. Three subgroups were recognized: the large-size form from Cheju island, Korea (subspecies chejuensis), the middle-size form from the Korean peninsula (subspecies coreae), and the small-size form from China (subspecies manchuricus, pallidior, ningpoensis, insulaemus). It was confirmed that four subspecies of striped field mouse from China can be classified into subspecies ningpoensis, as noted by Corbet (1978), and that subspecies coreae and chjuensis are distinct subspecies, as stated by Jones and Johnson (1965). In the future, morphometric analyses with striped field mice from Europe and Russia will be necessary to confirm subspecies classification of A. agrarius agrarius.

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Two New Species of Poecilostomatoid Copepods Associated with the Bivalve Dosinella penicillata in the Yellow Sea

  • 김일호
    • Animal cells and systems
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    • 제1권1호
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    • pp.15-23
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    • 1997
  • Two new species of poecilostomatoid copepods, each belonging to the genera Myicola (Myicolidae) and Conchyliurus (Clausidiidae), are described, based on specimens taken from the mantle cavity of the bivalve Dosinella penicillata (Reeve). The host bivalve was collected from the intertidal mud flat near Inchon in the Yellow Sea.

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