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http://dx.doi.org/10.5483/BMBRep.2016.49.9.094

Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases  

Im, Eunju (Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University)
Chung, Kwang Chul (Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University)
Publication Information
BMB Reports / v.49, no.9, 2016 , pp. 459-473 More about this Journal
Abstract
Neurodegenerative diseases (NDs) often involve the formation of abnormal and toxic protein aggregates, which are thought to be the primary factor in ND occurrence and progression. Aged neurons exhibit marked increases in aggregated protein levels, which can lead to increased cell death in specific brain regions. As no specific drugs/therapies for treating the symptoms or/and progression of NDs are available, obtaining a complete understanding of the mechanism underlying the formation of protein aggregates is needed for designing a novel and efficient removal strategy. Intracellular proteolysis generally involves either the lysosomal or ubiquitin-proteasome system. In this review, we focus on the structure and assembly of the proteasome, proteasome-mediated protein degradation, and the multiple dynamic regulatory mechanisms governing proteasome activity. We also discuss the plausibility of the correlation between changes in proteasome activity and the occurrence of NDs.
Keywords
Assembly; Gate opening; Neurodegenerative diseases; Post-translational modification; Proteasome; Regulators;
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