• Restorative Dentistry and Endodontics
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• 제29권3호
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• pp.239-248
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• 2004

The purpose of this study was to investigate the influence of NK1 receptor antagonists on the pulpal blood flow (PBF) when applied iontophoretically through the dentinal cavity of the teeth in order to understand whether iontophoretically applied NK1 receptor antagonists can control the pulpal inflammation. Eleven cats were anesthetized with alpha-chloralose and urethane, and substance P (SP) was administered to the dental pulp through the catheterized lingual artery in doses that caused PBF change without the influence of systemic blood pressure. NK1 receptor antagonists were applied iontophoretically to the prepared dentinal cavity of ipsilateral canine teeth of the drug administration, and PBF was monitored. Data were analyzed statistically with paired t-test. PBF increase after iontophoretic application of the NK1 receptor antagonists followed by the intra-arterial administration of SP was significantly less than PBF increase after iontophoretic application of the 0.9% saline followed by the intra-arterial administration of SP as a control (p < 0.05). Iontophoretic application of the NK1 receptor antagonists (0.2~3.4 mM) following the intra-arterial administration of SP resulted in less increase of PBF than the iontophoretic application of the 0.9% saline following the intra-arterial administration of SP as a control (p < 0.05). Therefore. the results of the present study provide evidences that the iontophoretic application is an effective method to deliver drugs to the dental pulp. and that iontophoretically applied NK1 receptor antagonists block SP-induced vasodilation effectively. The above results show the possibility that the iontophoretical application of NK1 receptor antagonists can control the neurogenic inflammation in the dental pulp.

• 농약과학회지
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• 제2권3호
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• pp.126-136
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• 1998

신규화합물인 thiamethoxam의 목화진딧물과 배추좀나방에 대한 살충효과를 분석하기 위하여 일반적인 생물검정 방법을 이용하여 접촉 및 섭식독성반응과 속효성, 침투이행성, 잔효성 등을 다른 약제들과 비교 검토하였다. Spray법을 이용하여 접촉독성을 조사한 결과 목화진딧물에 대한 반수치사농도($LC_{50}$)는 유기인계인 acephate 41.9 ppm, 카바메이트인 carbosulfan 5.2 ppm, 니코틴계인 imidacloprid와 thiamethoxam은 각각 1.1, 0.7 ppm을 나타냈다. 배추좀나방을 대상으로 엽침적법으로 처리했을 경우 섭식독성은 2령 유충의 경우 $LC_{50}$값이 imidacloprid 64.9 ppm, thiamethoxam 24.6 ppm, acetamiprid 15.2 ppm, 3령 유충에서는 각각 125.1, 42.7, 27.8 ppm이었고, 4령 유충에서는 각각 241.1, 44.5, 23.9 ppm으로 령기별로 약간의 차이를 보였다. 한편, 목화진딧물을 대상으로 한 약제의 속효성을 측정하는 반수치사시간 ($LT_{50}$)은 접종 후 약제살포시에 imidaclopid 26.6분, thiamethoxam 28.0분, carbosulfa 30.3분, acephate 41.7분의 순이었고, 약제살포 후 접종하였을 때에는 thiamethoxam 95.5분, imidaclopid 118.0분, carbosulfan 122.9분으로 진딧물에 직접 살포한 것이 살충시간을 단축시켰다. 또한, 잎표면으로부터 이면으로의 약효성분의 이행성을 비교한 결과 $LT_{50}$값은 thiamethoxam 162.2분, imidacloprid 168.9분, carbosulfan 564.1분이었고, 하위 잎으로부터 최상위 잎으로의 이행성에서는 carbosulfan 2.3일, thiamethoxam 2.9일, imidacloprid 3.0일, acephate 8.8일이었다. 뿌리로부터 잎으로의 이행성은 carbosulfan 0.6일, imidacloprid 1.0일, thiamethoxam 1.0일, acephate 13.8일로서 thiamethoxam의 침투이행성이 가장 빠른 것으로 나타났다. Spray법을 이용한 잔효성 시험결과 thiamethoxam과 imidaclopid는 약제처리 후 10일째에도 80%이상의 높은 살충효과를 나타내어 잔효성이 우수하였다.

• 농업과학연구
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• 제41권1호
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• pp.17-22
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• 2014

This study was conducted to evaluate the efficacy of formulations and application timings of imazosulfuron+fentrazamide in rice field. Weeding efficacy of imazosulfuron+fentrazamide SC (75+300 g a.i./ha) was more than 95% except Bidens tripartita. The efficacy of this formulation was not related to its formulations but was highly related to application timing. Herbicide application before 5 days after transplanting was best timing to get a maximum weed control. Systemic application before and after transplanting was much higher than single application for weed control. Second leaf stage of Echinochloa spp. and sulfonylurea resistant Monochoria vaginalis was controled over 90% in the imazosulfuron+fentrazamide SC (75+300 g a.i./ha). Based on these data, imazosulfuron+fentrazamide can be applied to provide effective weed control especially in the field infested with herbicide resistant M. vaginalis.

• 천문학회지
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• 제46권5호
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• pp.191-200
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• 2013

Full-disk solar images are provided by many solar telescopes around the world. However, the observed images show Non-Radial Variation (NRV) over the disk. In this paper, we propose algorithms for detecting distortions and restoring these images. For detecting NRV, the cross-correlation coefficients matrix of radial profiles is calculated and the minimum value in the matrix is defined as the Index of Non-radial Variation (INV). This index has been utilized to evaluate the H images of GONG, and systemic variations of different instruments are obtained. For obtaining the NRV's image, a Multi-level Morphological Filter (MMF) is designed to eliminate structures produced by solar activities over the solar surface. Comparing with the median filter, the proposed filter is a better choice. The experimental results show that the effect of our automatic detection and restoration methods is significant for getting a flat and high contrast full-disk image. For investigating the effect of our method on solar features, structural similarity (SSIM) index is utilized. The high SSIM indices (close to 1) of solar features show that the details of the structures remain after NRV restoring.

• 한국콘텐츠학회논문지
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• 제17권3호
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• pp.274-284
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• 2017

우리 사회는 고령화에 따라 치매 유병률이 지속적으로 증가하여 사회적으로 큰 문제가 되고 있다. 국가적으로 장기 요양 보험 제도를 시행하고 있으나, 조건이 안되는 치매 노인은 기본적인 요양서비스도 이용할 수 없는 상황이다. 이러한 사회적 배경 아래 스마트폰 사용이 보편화되는 환경 하에서 현재 서비스되는 애플리케이션의 기능 분석과 대상자 설문조사를 토대로 초기(경증) 치매 노인에게 질병 관리 및 가족 간의 소통에 도움을 주는 애플리케이션에 대해 연구하고자 하였다. 연구 방법은 연구주제와 관련된 이론 연구를 배경으로 경증 치매 노인을 위해 서비스되는 애플리케이션 사용 환경을 분석하였으며, 이 분석을 통해 치매 노인을 위한 앱이 없다는 사실을 알게 되었다. 이 기본연구를 바탕으로 경도 치매 노인에게 필요한 약물 복용 관리, 신체 활동 관리, 두뇌 활동 관리, 치매 정보, 메모 등의 기능이 포함된 애플리케이션의 디자인기획 방향을 제시하였다. 나라에서 시행하는 제도적 지원에 이와 같은 서비스가 확대된다면, 애플리케이션 사용을 통해 수집된 데이터를 기반으로 경증 치매의 제도적 관리 선진화에 기여를 할 것으로 기대한다.

• Restorative Dentistry and Endodontics
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• 제20권2호
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• pp.527-537
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• 1995

The effect of calcitonin gene-related peptide (CGRP), substance P (SP) and electrical stimulation of the tooth on the intradental nerve activtiy (INA) was investigated in anesthetized cats. The INA was recorded from single pulp nerve units dissected from the inferior alveolar nerve under stereomicroscope. The INA elicited by 3 minute application of 4M NaCl in deep dentinal cavity was compared before and after stimulation at 10 minute intervals. The magnitude of INA was calculated as the total number of nerve impulses produced in given period, and the changes of INA are expressed as % of control INA. The results obtained were as follows. 1. 16 single pulp nerve units were classified as 14 $A{\delta}$-fibers (3.4~19.4m/sec) and 2-fibers (1.5~1.7m/sec) according to the conduction velocity. 2. 4M NaCl evoked an irregular bursts of spikes which continued until washing out. Isotonic saline did not affect INA to subsequent applications of the hypertonic NaCl solution (P>0.05). 3. Local application of CGRP ($200{\mu}g$/ml) in deep dentinal cavity reduced the INA induced by 4M NaCl in $A{\delta}$-fiber units (P<0.01) and some units of those responded to CGRP during application. 4. Local application of SP ($100{\mu}g$/ml) in deep dentinal cavity reduced the INA induced by 4M NaCl in AS-fiber units (p<0.05), but increased the INA in C-fiber unit coincided with large reduction of the INA of $A{\delta}$-fiber units. 5. Monopolar electrical stimulation applied to the crown at intensities high enough to excite C-fibers (12V, 5ms, 10Hz, 10~30min) decreased the INA in $A{\delta}$-fiber units (P<0.01) and systemic pretreatment with phenoxybenzamine (3mg/kg, i.v.) enhanced this inhibitory effect (P<0.01). On the contrary, electrical stimulation increased the INA in C-fiber unit.

• Journal of Korean Neurosurgical Society
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• 제66권5호
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• pp.536-542
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• 2023

Objective : Surgical site infection is the most detrimental complication following cranioplasty. In other surgical fields, intrawound vancomycin powder application has been introduced to prevent surgical site infection and is widely used based on results in multiple studies. This study evaluated the effect of intrawound vancomycin powder in cranioplasty compared with the conventional method without topical antibiotics. Methods : This retrospective study included 580 patients with skull defects who underwent cranioplasty between August 1, 1998 and December 31, 2021. The conventional method was used in 475 (81.9%; conventional group) and vancomycin powder (1 g) was applied on the dura mater and bone flap in 105 patients (18.1%; vancomycin powder group). Surgical site infection was defined as infection of the incision, organ, or space that occurred after cranioplasty. Surgical site infection within 1-year surveillance period was compared between the conventional and vancomycin powder groups with logistic regression analysis. Penalized likelihood estimation method was used in logistic regression to deal with zero events. All local and systemic adverse events associated with topical vancomycin application were also evaluated. Results : Surgical site infection occurred in 31 patients (5.3%) and all were observed in the conventional group. The median time between cranioplasty and detection of surgical site infection was 13 days (range, 4-333). Staphylococci were the most common organisms and identified in 25 (80.6%) of 31 cases with surgical site infections. The surgical site infection rate in the vancomycin powder group (0/105, 0.0%) was significantly lower than that in the conventional group (31/475, 6.5%; crude odds ratio [OR], 0.067; 95% confidence interval [CI], 0.006-0.762; adjusted OR, 0.068; 95% CI, 0.006-0.731; p=0.026). No adverse events associated with intrawound vancomycin powder were observed during the follow-up. Conclusion : Intrawound vancomycin powder effectively prevented surgical site infections following cranioplasty without local or systemic adverse events. Our results suggest that intrawound vancomycin powder is an effective and safe strategy for patients undergoing cranioplasty.

• 대한간호학회지
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• 제23권2호
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• pp.157-169
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• 1993

The most effective modality for cold application and the length of the application have not been determined despite many studies about the use of cold. A quasi-experimental study was conducted to examine the most effective modality among three methods of cold application, the most effective length of time for the application and the continuing effect after each type of cold application. Thirty adult patients admitted to medical and neurosurgical unit and with high fever (above 38.2 ℃) were assigned randomly to each of three cold ap-plication methods : (a) ice bag: (b) cold compress; and (c) tepid water sponge bath. Each method was applied to the whole anterior surface except the face and neck with the patient in the supine pos-ition. Rectal temperatures and skin temperatures (mid chest, upper arm, thigh and leg) were measured be-fore each application and every 10 minutes during ,each application for a period of 60 minutes. They were also measured every 10 minutes for 30 minutes after each cold application was finished. The experiments were carried out from Dec. 22. 1992 through Feb. 26, 1993. The data were analysed using means, ANCOVA Sheffe test and Pearson's Correlation Coefficient. The results of this study are as follows : 1. There were no significant differences among the three cold application methods in the reduction of body temperature, 2. Among the ice bag, cold compress and tepid water sponge bath groups, the ice bag proved to be the most effective method for lowering skin temperature while the cold compress was least effective. 3. Both rectal and skin temperature continued to decrease during the 60 minutes of cold application, but the hunting phenomena was not observed at any of the cold application sites. 4. There were no significant correlations between mean rectal and skin temperatures. 5. Skin temperatures according to the cold application sites decreased to a range of 3.46℃ to 5.20℃ (mid chest), a range of 4.48℃ 4.96℃ (upper arm), a range of 3.86℃ to 5.05℃ (thigh), and a range of 5.42℃ -7.12℃ (leg ). 6. In continuing effect after the cold applications were finished, rectal temperatures according to ice bag, cold compress and tepid sponge bath decreased to 0.29℃, 0.23℃ and 0.09℃ respectively, while the mean skin temperatures increased to 2.39℃ , 2.04℃ and 2.22℃ respectively. In this experiment the ice bag was the most effective modality for lowering skin temperature. when-ever cold is applied for systemic effect, the continuing effect of cold should be considered. The determination of the most effective length of time for cold application needs further study.

• 동의신경정신과학회지
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• 제13권1호
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• pp.133-141
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• 2002

본 증례는 광장공포증 환자를 한방정신요법인 이정변기요법(移精變氣療法), 경자평지요법(驚者平之療法), 지언고론요법(至言高論療法) 등으로 약 8주간 치료한 예이다 .내원당시 환자는 혼자 외출할 수 없었으나, 치료받으면서 증상이 점차 호전되어, 대중교통수단 등도 이용하여 외출할 수 있게 되었다. 본 저자는 한방정신요법의 체계적인 적용이 광장공포증 환자의 증세를 호전시켰기에 보고하는 바이다.

• Journal of Plant Biotechnology
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• 제37권3호
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• pp.283-291
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• 2010

Vaccine is one of the best known and most successful applications of immunological theory to human health and it protects human life through inducing the immune response in systemic compartment. However, when we consider the fact that mucosal epithelium is exposed to diverse foreign materials including viruses, bacteria, and food antigens and protects body from entry of unwanted materials using layer of tightly joined epithelial cells, establishing the immunological barrier on the lining of mucosal surfaces is believed to be an effective strategy to protect body from unwanted antigens. Unfortunately, however, oral mucosal site, which is considered as the best target to induce mucosal immune response due to application convenience, is prone to induce immune tolerance rather than immune stimulation. Since intestinal epithelium is tightly organized, a prerequisite for successful mucosal vaccination is delivery of antigen to mucosal immune induction site including a complex system of highly specialized cells such as M cells. Consequently, development of efficient mucosal adjuvant capable of introducing antigens to mucosal immune induction site and overcome oral tolerance is an important subject in oral vaccine development. In this review, various approaches on the development of oral mucosal adjuvants being suggested for effective oral mucosal immune induction.