• Journal of Dental Anesthesia and Pain Medicine
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• 제19권4호
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• pp.181-189
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• 2019

Local anesthetic systemic toxicity (LAST) refers to the complication affecting the central nervous system (CNS) and cardiovascular system (CVS) due to the overdose of local anesthesia. Its reported prevalence is 0.27/1000, and the representative symptoms range from dizziness to unconsciousness in the CNS and from arrhythmias to cardiac arrest in the CVS. Predisposing factors of LAST include extremes of age, pregnancy, renal disease, cardiac disease, hepatic dysfunction, and drug-associated factors. To prevent the LAST, it is necessary to recognize the risk factors for each patient, choose a safe drug and dose of local anesthesia, use vasoconstrictor, confirm aspiration and use incremental injection techniques. According to the treatment guidelines for LAST, immediate application of lipid emulsion plays an important role. Although lipid emulsion is commonly used for parenteral nutrition, it has recently been widely used as a non-specific antidote for various types of drug toxicity, such as LAST treatment. According to the recently published guidelines, 20% lipid emulsion is to be intravenously injected at 1.5 mL/kg. After bolus injection, 15 mL/kg/h of lipid emulsion is to be continuously injected for LAST. However, caution must be observed for >1000 mL of injection, which is the maximum dose. We reviewed the incidence, mechanism, prevention, and treatment guidelines, and a serious complication of LAST occurring due to dental anesthesia. Furthermore, we introduced lipid emulsion that has recently been in the spotlight as the therapeutic strategy for LAST.

• 대한장애인치과학회지
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• 제10권1호
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• pp.31-37
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• 2014

The general local cause of gingival bleeding is the vessel engorgement and erosion by odontogenic infection. Abnormal gingival bleeding is also associated with systemic causes. Bleeding disorders in which continuous gingival bleeding is encountered include the followings : vascular abnormalities, platelet disorders, hypoprothrombinemia and other coagulation defects. There are classic methods for gingival bleeding control, such as, direct pressure, electrocoagulation, suture, crushing and application of hemostatic agents. If the continuous gingival bleeding is not stopped in spite of the conventional methods, the life of patient is threatened owing to upper airway obstruction, syncope, vomiting and hypovolemic shock. Therefore, the rapid and correct hemostatic method is very important in the emergency condition. This is a case report of continuous gingival bleeding control by primary endodontic drainage & suture in a disabled patient with systemic bleeding disorders.

• 혜화의학회지
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• 제24권2호
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• pp.65-83
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• 2016

Objectives : The purpose of this study is to present the clinical practice guidelines for colorectal cancer through the analysis of existing clinical practice guidelines and randomised clinical trials (RCTs) in Western and Chinese medicine. Methods : The data related to Western and Oriental medical treatment of colorectal cancer were collected using various search engines such as Google Scholar, KIOM OASIS, PUBMED and Jisan library of Daejeon university. Results & Discussion : Colorectal cancer is the third most common cancer in Korea. In recent studies, applying combined oriental and western medicine can improve the survival, quality of life, immune function, and suppress of tumor growth in colorectal cancer. However there isn't still an objective and systemic clinical guideline for colorectal cancer, so we have difficulty in clinical application. This study will be a preliminary study to establish clinical practice guidelines of Korean Medicine for colorectal cancer. Conclusions : Further objective and systemic clinical studies related to Korean Medicine are needed to develop more advanced clinical practice guidelines of colorectal cancer.

• BMB Reports
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• 제39권3호
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• pp.229-239
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• 2006

Sj$\"{o}$gren's syndrome (SS) is an autoimmune disorder that affects the salivary glands, leading to xerostomia, and the lacrimal glands, resulting in xerophthalmia. Secondary SS is associated with other autoimmune disorders such as systemic rheumatic diseases and systemic lupus erythematosis (SLE), which can affect multiple organs, including the epidermis. Recent studies have demonstrated that green tea polyphenols (GTPs) possess both anti-inflammatory and anti-apoptotic properties in normal human cells. Epidemiological evidence has indicated that, in comparison to the United States, the incidence of SS, clinical xerostomia and lupus is considerably lower in China and Japan, the two leading green tea-consuming countries. Thus, GTPs might be responsible, in part, for geographical differences in the incidence of xerostomia by reducing the initiation or severity of SS and lupus. Consistent with this, molecular, cellular and animal studies indicate that GTPs could provide protective effects against autoimmune reactions in salivary glands and skin. Therefore, salivary tissues and epidermal keratinocytes could be primary targets for novel therapies using GTPs. This review article evaluates the currently available research data on GTPs, focusing on their potential application in the treatment of the oral manifestations of SS and skin manifestations of SLE.

• 대한인간공학회지
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• 제32권1호
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• pp.107-115
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• 2013

Objective: The aim of this study is to identify the training requirements of new nuclear power plant by a comprehensive literature review. Background: The design of instrumental and control systems for New NPP is applied fully digitalized systems. For example, soft-control, large display panels(LDP), and an advanced alarm system were applied to the APR-1400 or SMART. Method: The NUREG-0711 and international guideline of training program was analyzed from the following four phases of SAT(Systemic Approach to Training): Analysis, Design, Development, Implementation and Evaluation. Results: To identify the requirement of training program, 'Feedback' phase was considered and each phase of SAT was classified. Conclusion: A more systematic requirement of training program is needed which considers the computerized system was applied to the new NPP. Application: The results of the publishing can be useful for standardization of the systematic training program for the operators of NPP.

• Journal of Periodontal and Implant Science
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• 제24권3호
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• pp.561-571
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• 1994

The comparative study on the predominant cultivable periodontopathic bacteria were done 2 weeks after the application of the e-PTFE membrane and collagen membrane in the controlled tissue regeneration procedures. The purpose of the present study also included the antibiotic susceptibility test (ciprofloxacin, tetracycline, clindamycin) of these cultured organisms. 0.1% chlorhexidine mouthwash (10ml twice/day for 6 weeks) and systemic doxycycline (200mg/day for 2 weeks) were administered for supragingival and subgingival plaque control respectively. Four clinical isolates of A.a. from 2 patients were found to be resistant to tetracycline which were susceptible to clindamycin and ciprofloxacin. One isolate of W.r. and two unidcntified microorganisms were resistant only to clindamycin and one isolate of NID BPB and E.c. and two isolates of unidentified microorganisms were resistant only to ciprofloxacin. Overall susceptibility of tested microorganisms to ciprofloxacin, tetracycline and clindamycin were 85%, 77% and 89% respectively. The results indicated no significant differences in the percentage of cultivable periodontopathic bacteria between the two membranes, and also the microorganisms resistant to tetracycline after systemic administration of doxycycline turned out to be susceptible to either ciprofloxacin or clindamycin.

• 음성과학
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• 제13권4호
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• pp.187-200
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• 2006

The speech synthesis technology is widely used and its application area is also being broadened to an automatic response service, a learning system for handicapped person, etc. However, the sound quality of the speech synthesizer has not yet reached to the satisfactory level of users. To make a synthesized speech, the existing synthesizer generates rhythms only by the interval information such as space and comma or by several punctuation marks such as a question mark and an exclamation mark so that it is not easy to generate natural rhythms of people even though it is based on mass speech database. To make up for the problem, there is a way to select rhythms after processing language from a higher level information. This paper proposes a method for generating tags for controling rhythms by analyzing the meaning of sentence with speech situation information. We use the Systemic Functional Grammar (SFG) [4] which analyzes the meaning of sentence with speech situation information considering the sentence prior to the given one, the situation of a conversation, the relationship among people in the conversation, etc. In this study, we generate Semantic Speech Control Tag (SSCT) by the result of SFG's meaning analysis and the voice wave analysis.

• 가정과삶의질연구
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• 제21권2호
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• pp.87-101
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• 2003

The purposes of this study were to analyze causes of wife abuse through married couples as the research subject. The study employed ecological perspective to the study of wife abuse as an multiple dimensional and integrated paradigm combined with isolated theories of other research. The subjects were 369 married couples who live in Gwangju area. Data were analyzed with Cronbach'α, factor analysis, basic statistics, paired-t test, 1-test, ANOVA, Duncan's test, correlation analysis, stepwise multiple regression analysis. and hierarchical regression analysis using the SPSS 10.0 for windows. The major findings were as follows; 1. The psychological abuse score, physical abuse score, and sexual abuse score were lower than median without exception. Hut prevalence rates of wife abuse were considerably serious; 91.9% psychological abuse, 44.4% physical abuse, and 53.7% sexual abuse. 2. The results of the hierarchical regression analysis indicated that the marital conflict had the strongest impact on wife abuse. And the attitude toward wife abuse of husband, hostility of husband, exposure experience of domestic violence during a growth period of husband, perception toward social violence of husband, exposure experience of domestic violence during a growth period of wife, drinking problem of husband, and interpersonal relationships stress of husband had influenced on wife abuse. These variables accounted for 49.5% of variance of wife abuse behaviors. As the result of the study, it concludes that the ecological systemic approach on the cause of wife abuse is useful as a theoretical instrument. Suggestions and implications are made for further research and practical application.

• The Plant Pathology Journal
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• 제27권1호
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• pp.53-58
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• 2011

Systemic acquired resistance is a form of inducible resistance that is triggered in systemic healthy tissues of local-infected plants. Several candidate signaling molecules emerged in the past two years, including the methylated derivatives of well-known defense hormones salicylic acid (SA) and jasmonic acid (JA). In our present study, the symptom on Cucumber mosaic virus (CMV) infected Arabidopsis leaves in 0.1 mM SA or 0.06 mM JA pre-treated plants was lighter (less reactive oxygen species accumulation and less oxidative damages) than that of the control group. JA followed by SA (JA${\rightarrow}$SA) had the highest inhibitory efficiency to CMV replication, higher than JA and SA simultaneous co-pretreatment (JA+SA), and higher than a JA or a SA single pretreatment. The crosstalk between the two hormones was further investigated at the transcriptional levels of pathogenesis-related genes. The time-course measurement showed JA might play a more important role in the interaction between JA and SA.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제32권6호
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• pp.592-596
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• 2010

The common local causes of active gingival bleeding are the vessel engorgement and erosion by severe inflammation and injury to hypervascularity lesion. Abnormal gingival bleeding is also associated with systemic bleeding disorders (liver disease, leukemia etc.). There are many conventional methods for gingival bleeding control, such as, direct pressure, packing, electrocoagulation, tight suture and application of hemostatic agents. If the continuous gingival bleeding is not stopped in spite of the all local application methods, the medical consultation should be obtained for systemic condition care and the major feeding arterial embolization. This is a case report of severe gingival bleeding and periodontitis control in a patient with liver cirrhosis and oral metastatic lesion of hepatocellular carcinoma. The bleeding lesion was placed in left buccal mucosa and gingiva of the left mandibular molars. The control methods were dental crown removal, primary endodontic drainage, gingival sulcus drainage and maxillary arterial embolization with medical consultation.