• Biomolecules & Therapeutics
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• v.24 no.2
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• pp.109-114
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• 2016

In Drosophila, rhomboid proteases are active cardinal regulators of epidermal growth factor receptor (EGFR) signaling pathway. iRhom1 and iRhom2, which are inactive homologs of rhomboid intramembrane serine proteases, are lacking essential catalytic residues. These are necessary for maturation and trafficking of tumor necrosis factor-alpha (TNF-${\alpha}$) converting enzyme (TACE) from endoplasmic reticulum (ER) to plasma membrane through Golgi, and associated with the fates of various ligands for EGFR. Recent studies have clarified that the activation or downregulation of EGFR signaling pathways by alteration of iRhoms are connected to several human diseases including tylosis with esophageal cancer (TOC) which is the autosomal dominant syndrom, breast cancer, and Alzheimer's disease. Thus, this review focuses on our understanding of iRhoms and the involved mechanisms in the cellular processes.

• Journal of Sasang Constitutional Medicine
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• v.21 no.3
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• pp.202-208
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• 2009

1. Objectives: The purpose of this study is to report one case of the Taeumin Hangwol Syndrome diagnosed as Upper Respiratory Infection with unknown cause. 2. Methods: The patient had the symptoms including chilling sensation, general weakness and fatigue. We diagnosed him as Taeeumin Hangwol Syndrome. So we treated him by Handayeolso-tang(寒多熱少湯), and acupuncture. The serial changes of his symptoms were evaluated in hospital. 3. Results and Conclusions: After treated by Handayeolso-tang(寒多熱少湯), his symptoms were improved.

• Childhood Kidney Diseases
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• v.2 no.2
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• pp.200-203
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• 1998

The Laurence Moon-Bardet Biedl syndrome is characterized by obesity, mental retardation, visual impairment with retinitis pigmentosa, polydactyly, hypogonadism and renal manifestations. We experienced an 11 years old female with Laurence Moon-Baret Biedl syndrome associated chronic renal failure. She was diagnosed to have LMB syndrom according to the clinical manifestations of polydactyly on hands and feet, mental retardation, obesity, retinitis pigmentosa and chronic renal failure. She is on maintenance hemodialysis now.

• Journal of Veterinary Clinics
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• v.11 no.1
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• pp.393-399
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• 1994

This study was carried out to investigate the analgesic and antipyretic effects of acupuncture in goat suffered from pain and fever induced experimentally : electroacupuncture and laser acupuncture for the relief of pain and traditional needing for the of fever. Pain was induced by intraperitoneal injection of 0.7% acetic acid solution and it's extent was estimated with the number of writhing syndrom as indicator of pain. When lipopolysaccharide was given into the vein in goat, fever with biphasic type was produced. In the goats with pain the superior analgesic effects of electroacupuncture to aminopyrine and sulpyrine were found, but the effects of laser acupuncture were not satisfactory. The high body temperature of goats was gradually decreased with the lapse of time following traditional needling(venesection by needle) and showed a tendency to return to normal body temperature. Serum GOT, GPT:, BUN, creatinine values and acetylcholinesterase activity following electroacupuncture were not altered. It is considered that electroacupuncture combined with medicament can sucure exellent analgesic and antipyretic effects in animal practice.

• The Journal of Pediatrics of Korean Medicine
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• v.13 no.2
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• pp.225-235
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• 1999

MELAS is the condition associated with mutant mtDNA that most closely mimics thrombotic cerebrovascular disease. Characteristic abnormalities are two. first, 'ragged-red fibers' in muscle biopsy. second, point mutation in the mitochondrial DNA analyses. The characteristic clinical presentations of MELAS are short stature, recurrent stroke like episodes, migraine-like headache, sensorineural hearng loss, glucose intolerance and neuropathy. We now report a case of MELAS syndrome having mitochondrial DNA mutation with an A to G transition at the 3,243rd position diagnosed in Chung-ang Hospital.

• Proceedings of the Korean Society of Toxicology Conference
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• 2005.05a
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• pp.162-162
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• 2005

• Journal of Chest Surgery
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• v.34 no.8
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• pp.634-639
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• 2001

Central anticholinergic syndrome is defined as an absolute or relative reduction in cholinergic activity in the central nervous system and has a wide variety of manfestations. It is associated with almost any drug given during anesthesia, except neuromuscular relaxants, and treated with the cholinesterase inhibitor physostigmine. The diagnosis of central anticholinergic syndrome is often made when symptoms resolve promptly after the administration of physostigmine. We present a case of a central anticholinergic syndrome diagnosed by treatment with physostigmine, in a patient who received closure of patent foramen ovale associated with stroke.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2005.11a
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• pp.163-166
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• 2005

Amenity is an essential factor of Modern Apartment. But because of many chemical products and noxious volatile organic compound(VOC) used in the apartment, many people are exposed to them. This fact implies that there can be many disease caused by them. Therefore to reduce pollutant matters inducing sick house syndrom, measures for new furniture and apartment dweller were suggested in this study.

• The Journal of Pediatrics of Korean Medicine
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• v.13 no.1
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• pp.227-238
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• 1999

The author studied 49 cases having neurologic disorders grossly, who admitted to the Oriental Medicine Hospital in Kyunghee university from May 1995 to March 1999. We have got the following results: 1. Age and sex distribution of children: from 4 to 6 was 34.7%, over 7 was 32.7%, 2 to 3 was 28.6%, below 1 was 4.0%, Male to female ratio was 1.33:1. 2. Distribution of chief complain as follows : Hemiplegia 59.2%, Quadriplegia 30.6%, Aphasia 42.9%, Facial palsy 18.4%, Convulsion 16.3%, Aphagia 12.2%. 3. Distribution of diagnosis as follows : Cerebral infarction 32.7%, Cerebral hemorrhage 12.2%, Hypoxic brain damage 10.2%, Brain tumor 6.1%, Guillian-Barre syndrom 6.1%, Moya-Moya disease 4.1% etc. 4. Improvement ratio as follows : Poor 14.3%, Fair 59.2%, Good 26.5%.

• Physical Therapy Korea
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• v.3 no.3
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• pp.59-66
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• 1996

The purpose of this study was to assess the biomechanical effects of corset and back brace for low back pain syndroms patients. The subjects of this study were 69 patients with low back pain syndroms who had been hospitalized or were visited out-patient department of the rehabilitation hospital, college of medicine, Yonsei University, from October 5, 1995 through November 5, 1995. Clinical results and datum were obtained by phone calls and chart reviews of low back pain patients. The results were as follows: 1) Fifty - nine subjects recovered over a good grade (85.6%). 2) The standing workers had a little effect of brace for low back pain. 3) After using a corset and back brace, the test of SLR increased from 36.23% to 72.47%, and the ability of ambulation improved from 40.57% to 85.5%. In conclusion, the biomechanical effects of corset and back brace for low back pain patients were found to be decrease pains and improve posture and ADL function.