• 한국식품영양과학회:학술대회논문집
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• 한국식품영양과학회 2001년도 International Symposium on Food,Nutrition and Health for 21st Century
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• pp.38-47
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• 2001

L-theanine is a unique amino acid, found almost solely in tea plants. It is the main component responsible for the exotic taste of green tea. In our studies of L-theanine, we have found a variety of biological activities including relaxation and the alleviation of PMS. In general, animals generate very weak electric pulses on the surface of the brain, called brain waves. Brain waves are classified into four types, namely $\alpha$, $\beta$, $\delta$ and $\theta$-waves, based on their frequency. Brain waves correlate with individual mental conditions. For example, generation of $\alpha$-waves is considered an index of relaxation. In human volunteers, $\alpha$-waves were generated on the occipital and parietal regions of the brain surface within 40 minutes after the oral administration of 50 or 200 mg Suntheanine$^{TM}$ without causing drowsiness. Premenstrual Syndrome (PMS) is a symptom unique to women which appears in the luteal phase from the ovulation period through the first day of menstruation. It possesses characteristics of having a peak just prior to menstruation and disappearing 1 - 2 days following the start of menstruation. Symptoms of PMS are generally categorized as mental, physical and social symptoms. When comparing the reported Symptoms of PMS by the methods of MDQ score, the Suntheanine$^{TM}$ group was found to have a lower incidence of PMS symptoms, including physical, mental and social symptoms. Overall, a significant alleviation of PMS symptoms by the administration of 200 mg Suntheanine$^{TM}$ was observed. With the successful industrial production of L-theanine, we are now able to supply Suntheanine$^{TM}$, offering a tremendous opportunity for designing functional foods targeting relaxation and the alleviation of PMS.

• 대한지역사회영양학회지
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• 제17권1호
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• pp.69-80
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• 2012

This study was conducted to examine the nutritional status, quality of diet and quality of life in postmenopausal women with mild climacteric symptoms based on their food group intake patterns. The data for nutritional status were obtained using 3-day records. Quality of diet was assessed by INQ, NAR, MAR, DDS, DVS, DQI-I. Climacteric symptoms were analyzed by the questionnaire of Kupperman's index and MENoL. The subjects were classified into the five groups, GMVDF, GMVdF, GMVDf, GMVdf, GmVDF according to their food group intake patterns. Analysis of nutrient intakes showed that the GMVDF group took significantly higher levels of kcal, carbohydrate, protein, fat, vitamin A, thiamin, riboflavin, folate, vitamin C, vitamin E, calcium, phosphorous, sodium, iron, zinc and fiber than GMVdf group did (p < 0.05). INQ of Ca and Fe appeared to be higher in GMVDF than in GMVdf groups (p < 0.05). Analysis of NARs showed that missing milk groups took lower riboflavin, Ca and P than other groups did as the same result with MAR (p < 0.05). Analysis of DDS and DQI showed that GMVdf group had the lowest quality of diet (p < 0.05); however, no difference was found on DVS. The GMVdf group showed the worst climacteric symptoms compared with those of the other groups (p < 0.05). However, we couldn't observe any differences in menopause-specific quality of life among the groups. In conclusion, it would be beneficial to meet all five food groups to increase the quality of diet and to reduce the climacteric symptoms in postmenopausal women.

• Tuberculosis and Respiratory Diseases
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• 제82권3호
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• pp.217-226
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• 2019

Background: Depression is a recognized complication of lung cancer underreported in developing countries such as Malaysia. Treating and identifying depression in cancer patients increases survival and quality of life. Our objectives are to study prevalence of depressive symptoms in newly diagnosed lung carcinoma, and examine the relationship of depressive symptoms with other influencing risk factors. Methods: A 2-year, cross sectional study February 2015-February 2017, was conducted at Hospital Tengku Ampuan Afzan, and Penang General Hospital. One hundred and three patients with newly diagnosed, biopsy confirmed primary lung carcinoma were recruited. Self-rated patient's identification sheet, validated Center for Epidemiologic Studies Depression (CES-D), and Dukes University Religion Index score from three different main languages were used. Results: Prevalence of current depressive symptoms (CES-D total score ${\geq}16$) is 37.9%. The result suggests prevalence of those at high risk of moderate to major depression, may need treatment. Multivariate analysis reveals those with good Eastern Cooperation Oncology Group factor (${\eta}2=0.24$, p<0.001) married (${\eta}2=0.14$, p<0.001) with intrinsic religiosity (IR) (${\eta}2=0.07$, p<0.02) are more resistant to depression. Conclusion: One in three of lung carcinoma patients, are at increased risk for depression. Clinicians should be aware that risk is highest in those with poor performance status, single, and with poor IR. We suggest routine screening of depression symptoms as it is feasible, to be performed during a regular clinic visit with immediate referral to psychiatrist when indicated.

• 대한한방부인과학회지
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• 제22권2호
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• pp.189-208
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• 2009

Purpose: In oriental medicine, doctors have mainly made diagnosis and treatment with amenorrhea or delayed menstrual period based on overall analysis of symptoms and signs patients have. We think patients with amenorrhea or delayed menstrual period to have symptoms that are classified into one differentiation of syndromes, and then studied to make the index. This study has been carried out to investigate pattern identifications and classify symptoms according to them. Methods: We examined 52 patients who visited Dong-eui university oriental medical center from June 2005 to February 2009 for undergoing treatment for amenorrhea or delayed menstrual period and made OB & GY questionnaires up Results: We investigated whether the patients had symptoms concerned with symptom types by analyzing the result of DSOM(Diagnos System of Oriental Medicine, hearafter DSOM). It came out 51 cases among 52 with pathogenesis that was related to the symptom types. The symptom types of were surveyed into Insufficiency of Kidney and Liver(肝腎不足), Insufficiency of Qi and Blood(氣血虛弱), Insufficiency of Yin & Dryness of blood(陰虛血燥), stagnation of Qi and Blood(氣滯血瘀), phlegm and damp(痰濕阻滯), coldness of Blood(血寒), Heat of Heart(心火). Conclusion: As a result of the investigation, one case did not have symptoms of differentiation of syndromes of amenorrhea or delayed menstrual period. 29 cases had 1 or 2 differentiation of syndromes. 21 patients had such complex symptoms of diverse differentiation of syndromes that it was difficult to diagnose a differentiation of syndromes in clinical survey. It is necessary to put the priority among the differentiation of syndromes in diagnosis in the future.

• 한방안이비인후피부과학회지
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• 제21권3호
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• pp.150-165
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• 2008

Objective : An adequate measurement for Atopic Dermatitis(AD) is essential for studies about the treatment of AD. To establish a new and adequate scoring system for AD in Korean medicine, we reviewed existing studies on AD outcome measurement in Korean medicine. Method : We searched for reviews on measurements of AD or studies which used an AD outcome measurement at the Korean Traditional Knowledge Portal from 1995 to June, 2008. And then we reviewed the pattern identification in AD patients and the outcome measurements for AD in each study. Results : 1. Among 25 studies, the most common measurement for AD was SCORAD(the severity SCORing of Atopic Dermatitis index), there were 16 studies. There was one study which used the Jakob T scoring system, one study which used ADSI(the Atopic Dermatitis Severity Index), and there were 7 studies which established or used a new severity scoring system for AD. 2. In Korean medicine, AD caused by Damp-Heat is accompanied by erythema, papulation, oozing and crust, Damp-Heat accompanied by Spleen-Gi deficiency is frequently found in pediatric patients, and in adults who have indigestion. Symptoms of AD caused by blood deficiency and Wind-Dryness include lichenification, dryness, scale and pigmentation. AD caused by toxic Heat in the blood system has symptoms similar to some Damp-Heat pattern along with symptoms of blood deficiency and Wind-Dryness. Conclusion : We need to establish a new severity scoring system which reflects pattern identifications and treatments with Korean medicine, and we should assess the validity, reliability, and sensitivity of the new scoring system.

• Journal of Oral Medicine and Pain
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• 제11권1호
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• pp.67-78
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• 1986

This study was attempted to identify the emotional characteristics of temporomandibular disorder patients. The author applied one of the self-report modes of psychological measurement, Symptom Chechlist-90-Revision. The subjects were 219 TM disorder patients who visited the Department of Oral Diagnosis and Oral Medicine, Seoul National University Hospital during the period from December 1985 to September 1986. All the patients were divided into subgroup according sex, age, duration of symptoms, presence or absence of T-scores of each symptom dimension and global index. The obtained result were as follows : 1. Mean value of T-scores of each symptom dimension and global of the overall patients was within normal range. The two higher mean values of T-scores among 9 symptom dimensions were those of SOM and ANX. 2. Mean values of T-scores of females were higher than those of males in the O-C, DEP, ANX, HOS, PSY dimensions and all global indices, and there was a significant difference in the distribution of T-scores of the SOM dimension between males and female(P<0.05). 3. There was no significant difference between the subgroup under 30 years and the subgroup 30 years or older. 4. The subgroup with symptoms for 6 months or longer showed the higher mean values of T-scorers in the SOM, O-C, I-S, DEP, ANX, PHOB, PAR, PSY dimensions and all global indices compared with the subgroup with symptoms for shorter than 6 months. 5. The subgroup with pain showed the higher mean values of T-scores in all the symptom dimensions except the PAR in comparison with the subgroup with other complaints than pain, and there was a significant difference in the distribution of T-scores of the PST index between the pain subgroup and the non-pain subgroup(P<0.05). There was a significant difference in the distribution of T-scores of the PHOB dimension between the high-school graduates subgroup and the college graduates subgroup(P<0.05).

• Annals of Clinical Neurophysiology
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• 제6권2호
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• pp.98-102
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• 2004

Background: Carpal tunnel syndrome (CTS) is a common condition characterized by entrapment neuropathy of the median nerves. Clinical manifestations are the most important findings for diagnosis and assessment of therapeutic effects. But, objective indicators, such as electrophysiological findings, are also valuable supplementary tools. This study investigated the relationship between clinical grading and sensory nerve conduction velocity (SNCV) of median proper palmar digital nerve (MPPDN) in CTS patients. Method: This study was done on 90 upper limbs of 53 patients with CTS (men: 6, women: 47, age: 26~69 years, mean age; 52 years). Each SNCV of MPPDN was recorded with bar electrode using antidromic method. Each SNCV was compared with clinical grading of CTS. The clinical grades of CTS were designated as follows; group 1 is mild symptoms, 2 is moderate symptoms, and 3 is severe and longstanding symptoms. Result: In thumb, the SNCV of MPPDN was not different significantly between 3 groups (p=0.817). In the index finger, the SNCV was the fastest in the group 1, but faster in group 3 than in group 2 (p=0.001). In the middle and ring fingers, SNCV was decreased in higher clinical grading groups (middle finger: p=0.015, ring finger: p=0.044). Conclusion: SNCV of MPPDN of middle and ring finger correlated with the clinical grading of CTS. SNCV of index finger was the fastest in group 1. But SNCV of thumb did not correlate with the clinical grading of CTS.

• 대한한방내과학회지
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• 제39권4호
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• pp.802-813
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• 2018

This case report describes a patient with olivopontocerebellar atrophy accompanied by sleep disorder and gait disturbance whose condition was improved by treatment with Korean medicine. The 61-year-old woman, who was diagnosed with olivopontocerebellar atrophy (Multiple Systemic Atrophy-Cerebellum), was admitted to hospital twice and treated with Korean medicine (acupuncture and herbal medicine) and rehabilitation. The Korean medicine was Gwibiondam-tang-gami and Jaeumgeonbi-tang-gami. Clinical symptoms were assessed by the Modified Bathel index, functional independent measurement, Berg balance scale, and Unified Multiple System Atrophy rating scale. A brain MRI at the one-year follow up after onset showed similar progress but clinical symptoms were improved after treatment, and the evaluation index score increased. Multiple system atrophy, a type of degenerative neurological disease, has no targeted treatment. In this situation, although this report describes a single case, Korean medicine treatment could provide a meaningful improvement in the sleep disturbance and gait disorder symptoms of patients with olivopontocerebellar atrophy.

• Journal of Yeungnam Medical Science
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• 제9권1호
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• pp.68-74
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• 1992

신체화 장애의 진단의 간편성을 위해 1991년 3월부터 1992년 2월까지 영남대학교 의과대학 부속병원 정신과에 내원한 여자 환자 135명을 대상으로 7-symptom screening test를 적용한 결과 다음과 같은 결론을 얻었다. 7개증상 모두의 판별 Index는 3.0 이상이었으며, 7개증상중 2개의 증상이 있을때 정확도가 89%(민감도 99%, 특이도 77%), 3개의 증상이 있을때 정확도가 87%(민감도 83% 특이도 90%)로 나타났으며 판별 분석 결과 cut off 점수는 7개증상중 3개 이상일 때 신체화 장애 진단에 속할 확률이 87%로 나타났다. 즉 7개의 screen 증상중 3개 이상 있는 경우 신체화 장애로 진단할 수 있다는 것을 나타낸 것이며 다시말해서 7개중 3개 증상 유무가 판별의 분기점이 되는것을 의미한다. 이는 7-symptom screening test가 신체화 장애 진단에 정확하고 간편한 검사 도구임을 나타내준다 하겠다.

• 대한한의학회지
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• 제31권1호
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• pp.1-13
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• 2010

Objective: Functional dyspepsia is a prevalent disease. It impedes subjective quality of life. The purpose of this study was to examine the equivalent effect of herb medicine treatment (DA-9701) for functional dyspepsia. Methods: In this randomized, single-blinded, placebo-controlled study, we compared a herb medicine (DA-9701) with standard treatment (mosapride) and placebo for the treatment of functional dyspepsia. 42 volunteers who satisfied the requirements were enrolled in study. Severity of dyspepsia was measured by Nepean Dyspepsia Index (NDI) and Functional Dyspepsia Quality of Life (FD-QOL) before and after treatments. Results: 1. In the DA-9701 group, total key symptoms score was significantly lower and improve rate of key symptoms was higher than in the mosapride and placebo groups, but there were no statistically significant differences between three groups. 2. In the DA-9701 and mosapride groups, "nausea" and "bad breath" were significantly lower compared with the placebo group. 3. In the DA-9701 group, NDI Quality of Life scores were significantly higher, but there were no [other] statistically significant differences between the three groups. 4. In the DA-9701 and mosapride groups, FD-QOL scores were higher compared with the placebo group, but there were no statistically significant differences between the three groups. Conclusion: Herb medicine treatment (DA-9701) is effective to improve the symptoms and quality of life in patients with functional dyspepsia.