• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.1
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• pp.55-60
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• 2012

This experimental study investigated the characteristics of flow-induced vibration of two elastically supported circular cylinders in a side-by-side arrangement. In particular, the characteristics of the flow-induced vibration of the two cylinders are investigated by changing the flow speed at each spacing ratio L/D (L is the space between two cylinders and D is the diameter of the cylinder). To clarify the mechanism generating the flow-induced vibration of the cylinders, the flow patterns around the two vibrating cylinders are also investigated using a flow visualization test that reproduces the flow-induced vibration of the cylinders with a forced vibration apparatus. As a result, it is clarified that the flow-induced vibration characteristics of the two cylinders arranged side-by-side switch among four patterns as the flow between the two cylinders is switched. Among the three arrangements considered (tandem, staggered, and side-by-side), the arrangement that generates flow-induced vibration of the two cylinders most easily is the side-by-side arrangement.

• Molecules and Cells
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• v.42 no.3
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• pp.218-227
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• 2019

This study was designed to determine the effects of the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) on vascular smooth muscle cell (VSMC) apoptosis and extracellular matrix (ECM) disruption in a murine abdominal aortic aneurysm (AAA) model. After injection of PVT1-silencing lentiviruses, AAA was induced in Apolipoprotein E-deficient ($ApoE^{-/-}$) male mice by angiotensin II (Ang II) infusion for four weeks. After Ang II infusion, mouse serum levels of pro-inflammatory cytokines were analysed, and aortic tissues were isolated for histological, RNA, and protein analysis. Our results also showed that PVT1 expression was significantly upregulated in abdominal aortic tissues from AAA patients compared with that in controls. Additionally, Ang II treatment significantly increased PVT1 expression, both in cultured mouse VSMCs and in AAA murine abdominal aortic tissues. Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1. Furthermore, knockdown of PVT1 reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines. In conclusion, our findings demonstrate that knockdown of lncRNA PVT1 suppresses VSMC apoptosis, ECM disruption, and serum pro-inflammatory cytokines in a murine Ang II-induced AAA model.

• Journal of Aerospace System Engineering
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• v.17 no.1
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• pp.10-15
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• 2023

Wet multi-disk clutch, a power switching device of the ducted fan, was optimized and results were analyzed. The clutch was divided into two types depending on whether a mechanical lock-up was applied or not. It was optimized under each design condition. Transfer torque capacity, friction material surface pressure, friction surface temperature, and drag torque were calculated as factors to optimize the clutch. The volume of separator plate and drag torque were used as the objective function for optimization. In the case of Type 1, which did not include a mechanical lock-up, the clutch could be operated regardless of the pitch angle of the ducted fan. However, the outer diameter of the friction surface was doubled, the volume was increased by 5~7 times, and the drag torque was increased by 7~12 times compared to those of Type 2, which included a mechanical lock-up.

• Journal of the Korean Society of Radiology
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• v.14 no.4
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• pp.487-494
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• 2020

The distance between the source and the detector, the diameter of the detector, and the volume effect of the radiation source result in a change in solid angle at the detector entrance, which affects the determination of detection efficiency by causing a difference in path length within the detector. A typical analysis method for calculating solid angles was useful only for a source (⁶⁰Co) with a simple geometric structure, so in this experiment, the distance between the detector and the source was measured by switching on for up to 25 cm with the reference point of window cap 0.5 cm. In addition, 450 and 1000 ㎖ Marinelli beaker of standard volumetric sources were closely adhered to the detector. For circular point sources co-axial with the detector, the change in the solid angle to the distance from the detector window is equal to half the square radius of the source versus the square radius of the detector, if the resulting relationship of the calculation analysis results in the detector being less than the radius of the source. Since the solid angular difference is 0.5 the result of Monte Carlo is acceptable. The relationship between detector and source distance is shown. Solid angles have been verified to decrease rapidly with distance. Measurement and simulation results for a volumetric source show a difference of ±1.01% from a distance of 0 cm and less than 4 % when the distance is reduced to 5 and 10 cm. It can be seen that the longer distance, the smaller efficiency angle, and the exponential increase in attenuation as the energy decreases, is reflected in the calculation of efficiency. Thus, the detection efficiency has proved sufficient for the use of solid angle and Monte Carlo codes.