• The Journal of Internal Korean Medicine
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• v.36 no.3
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• pp.297-307
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• 2015

Objectives: We aimed to evaluate the effect of Cervi Cornu and coenzymeQ10 on exercise and endurance capacity in rats and mice. Methods: The extract of Cervi Cornu was manufactured by the pharmacy department of Kyung Hee Oriental Medical Hospital, and CoQ10 soft cap (Ildong Pharmaceutical) was used. In total, 24 rats and 30 mice were divided into 3 groups: Control (rat=8, mouse=10), CoQ10 alone (rat=8, mouse=10), Cervi Cornu extract, and CoQ10 (rat=8, mouse=10). Ergogenic effect was evaluated by administering the Cervi Cornu extract and coenzymeQ10 to rats and measuring the time to exhaustion during treadmill running; endurance capacity was assessed by measuring cold water swimming time, serum lactate level, and serum corticosterone level in each group. At 1 week from the end of treatment, we recalculated time to exhaustion during treadmill running in rats to investigate the long-term effect of the Cervi Cornu extract and coenzymeQ10. Results: Cervi Cornu extract has long-term benefits in that it preserves the ergogenic effect caused by exercise. Cervi Cornu and coenzymeQ10 have no effect on increasing cold water swimming time in ICR mice. CoenzymeQ10 decreases the serum corticosterone level in ICR mice performing cold water swimming test. Conclusions: Cervi Cornu seems to preserve the ergogenic effect caused by exercise, but a larger study is needed to investigate effect of Cervi Cornu and coenzymeQ10 on improving endurance capacity. CoenzymeQ10 decreases serum corticosterone level and it is related with the anti-psychological fatigue effect.

• The Korea Journal of Herbology
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• v.31 no.3
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• pp.49-57
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• 2016

Objectives： Polygonati Rhizoma (PR) has containing the bioactive compounds such as poly sccharide A,B,C, oligosaccharide, amino acid, it has reported to anti-diabetes and hypertension, atherosclerosis. In this study, we were evaluates antioxidant and anti-physical fatigue effects of PR and steamed PR.Methods : The sample was divided into 5 groups-PR0 (PR without steaming process), PR1 (PR with once steaming process), PR3 (PR with third steaming process), PR6 (PR with sixth steaming process), PR9 (PR with ninth steaming process). We measured anti-oxidant activity through contents of polyphenol, flavonoid and DPPH, ABTS free radical scavenging capacity. And, anti-physical fatigue effect was evaluated using the swimming test, and the AMPK protein expressions in soleus muscle.Results ： As a result, polyphenol, flavonoid, DPPH, ABTS free radical scavenging capacity of PR were increased as steaming times. Anti-physical fatigue effects by swimming test, PR0 have significantly increased, but steamed PR groups were decreased. The AMPK protein expressions of PR0 and PR1 groups were increased comparing with PR3, PR6 and PR9. All groups had effects on decreasing TG, creatine in blood serum, but had no effects on TC in blood serum.Conclusions ： In conclusion, PR with 9 steaming process was more excellent than not-processed PR in anti-oxidant effect such as DPPH, ABTS radical scavenging activity and contents of polyphenol, flavonoid, but, not-processed PR increased swimming times than processed PR. These results suggest that processed PR has anti-oxidant effect as steaming times, and not-processed PR may be a novel potential anti-physical fatigue agents than processed PR.

• Korean Journal of Pharmacognosy
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• v.47 no.3
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• pp.258-263
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• 2016

In this study, we tested anti-fatigue effect of Kyung-Ok-Ko (KOK). We examined the exercise performance effects of KOK (600 mg/kg) at 2nd, 3rd and 4th week. The exercise performance of KOK treated group was significantly improved than that of vehicle control (VC) group on grip strength (2nd week), exhausted time of treadmill (3rd week) and exhausted time of weight loaded swimming (4th week). We also investigated the effects of KOK on the change of fatigue parameters in blood, skeletal muscle and liver after swimming exercise. KOK significantly reduced lactate level and enhanced glucose level in blood. Equally KOK significantly increased glycogen in skeletal muscle. However, the glycogen level of KOK in the liver was not significantly increased compared to VC group. These results show that supplementation of KOK may improve the anti-fatigue activity and exercise capacity.

• Physical Therapy Rehabilitation Science
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• v.10 no.2
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• pp.175-184
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• 2021

Objective: Fatigue can decrease both quality of life and work efficiency. Ginseng is one of the most popular herbal treatments for improving personal health, with applications in treating fatigue. However, the exact mechanisms of anti-fatigue effects are still unclear. Thus, we investigated the effect of red ginseng powder (RGP) on exercise capacity and peripheral fatigue using both behavioral and molecular experiments in mice. Design: Four-groups behavioral and molecular experiment. Methods: Male 6-weeks-old ICR mice were treated with distilled water, 100, and 200 mg/kg RGP for 5 days via oral administration. The exercise capacity of each animal group was measured by locomotor activity, rota-rod, hanging wire, and cold swimming tests. Additionally, after performing the treadmill to induce fatigue, lactate expression and molecular experiments were investigated using mice gastrocnemius. Results: Mice treated with RGP exhibited increased exercise capacity in the behavioral tests. Additionally, RGP induced a dose-dependent decrease in lactate levels after high-intensity exercise, and Monocarboxylate transporter (MCT) 4 expression increased in groups treated with RGP. However, there was no significant change in MCT1. Conclusions: These results suggest that RGP exerts several anti-fatigue properties by lower lactate and improved exercise capacity. Increased MCT4 expression may also affect lactate transport. Thus, this study suggests that the anti-fatigue properties of RGP might be associated with MCT4 activity.

• Food Science and Biotechnology
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• v.18 no.6
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• pp.1351-1357
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• 2009

KH-red ginseng/chlorella (KH-RG/C) is the mixed material of the Korean red ginseng powder (Panax ginseng, 75%) and extract of Chlorella vulgaris (25%). To evaluate the effects of KH-RG/C on endurance capacity and immune regulation, the forced swimming test (FST) was conducted. The immobility time in the FST was significantly decreased in KH-RG/C treated group compared with the DW-treated group at the 3 and 10 days, respectively. In the analysis of the blood biochemical parameters, KH-RG/C treatment significantly increased the glucose level. However, the lactic dehydrogenase level decreased. Although KH-RG/C increased aspartate aminotransferase, it was not different significantly. And KH-RG/C had no affects in the alanine aminotransferase, and blood urea nitrogen levels. In splenocytes and macrophages, KH-RG/C also did not affect the interleukin (IL)-2, IL-4, and IL-12 production. These results suggest that KH-RG/C may influence to immune regulation through increasing the physical endurance capacity without effect in activation of immune cells.

• The Korean Journal of Physiology
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• v.15 no.1
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• pp.45-51
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• 1981

The aim of this study was to investigate the pulmonary function tests of athletes related to Running, Swimming, Cycle, Taekwando, Wrestling, Boxing, Yudo, Badminton, Base-ball, Soccer, Hand-ball, Basket-ball and Volley-ball. Subjects were 269 athletes from 18 to 22 years of age. They were college students and citizens. The results are as follows: 1) Frequency of breath: (cycles/min., $M{\pm}S.D$) Running shows $13{\pm}3.6$, Swimming $12{\pm}3.2$, Cycle $13{\pm}3.4$, Taekwondo $12{\pm}4.0$, Wrestling $14{\pm}2.5$, Boxing $15{\pm}4.5$, Yudo $13{\pm}3.2$, Badminton $14{\pm}5.7$, Base-ball $15{\pm}6.2$, Soccer $13{\pm}2.5$, Hand-ball $14{\pm}2.5$, Basket-ball $12{\pm}5.6$, Volley-ball $12{\pm}4.2$(Table 2, Fig. 1). 2) Vital capacity: (1, $M{\pm}S.D$) Running shows $4.29{\pm}0.634$, Swimming $4.30{\pm}0.608$, Cycle $4.08{\pm}0.718$, Taekwondo $4.32{\pm}0.595$, Wrestling $4.40{\pm}0.663$, Boxing $4.45{\pm}0.779$, Yudo $4.58{\pm}0.389$, Badminton $3.98{\pm}0.556$, Base-ball $3.99{\pm}0.617$, Soccer $4.42{\pm}0.728$, Hand-ball $4.23{\pm}0.397$, Basket-ball $4.28{\pm}0.426$, Volley-ball $4.60{\pm}0.620$(Table 2, Table 3, Fig. 2). 3) Tidal volume: (ml, $M{\pm}S.D$) Running shows $615{\pm}180$, Swimming $603{\pm}121$, Cycle $529{\pm}189$, Taekwondo $726{\pm}112$, Wrestling $512{\pm}90$, Boxing$622{\pm}134$, Yudo $583{\pm}89$, Badminton $672{\pm}121$, Base-ball $714{\pm}97$, Soccer $579{\pm}89$, Hand-ball $507{\pm}69$, Basket-ball $628{\pm}133$, Volley-ball $597{\pm}144$(Table 2, Fig.3). 4) Breath holding time : (sec., $M{\pm}S.D$) Running shows $64{\pm}18.8$, Swimming $81{\pm}23.0$, Cycle $54{\pm}13.6$, Taekwondo $55{\pm}11.8$, Wrestling $78{\pm}12.5$, Boxing $63{\pm}9.6$, Yudo $71{\pm}14.4$, Badminton $62{\pm}9.8$, Base-ball $58{\pm}8.9$, Soccer $65{\pm}10.9$, Hand-ball $66{\pm}7.6$, Basket-ball $62{\pm}8.8$, Volley-ball $57{\pm}13.4$(Table 2, Fig.4).

• Korean Journal of Pharmacognosy
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• v.44 no.1
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• pp.83-90
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• 2013

The aim of this study was to evaluate the effect of hot water extract of peduncle obtained from Hovenia dulcis Thunb (HD) which is commercially developed for the protective effect on the alcoholic hepatotoxicity, on the endurance capacity for weight loaded forced swimming mice. The swimming times to exhaustion in mice fed 100 and 200 mg/kg HD for 2 weeks were prolonged 3.6 and 3.7 fold, and for 4 weeks 1.9 and 2.7 fold compared with each vehicle control ($42.8{\pm}20.5$ min and $67.7{\pm}47.8$ min, for 2 and 4 weeks), respectively. Blood biochemical parameters for ALT, AST, creatinine and BUN were not significantly different between from HD fed or control mice. Although HD fed mice swam over 2 fold longer time than vehicle control mice at 4 weeks, blood biomarkers of physical fatigue such as glucose, triglyceride and free fatty acid, lactate were not significant different and even tended to ameliorate. Hepatic lipid peroxidation and SOD activity did not significantly change in HD fed- and vehicle control exhausted swimming mice at 2 or 4 weeks. However, catalase activity in HD-fed mice was significantly increased in a dose-dependent manner compared with vehicle control mice. The present study indicates that HD improved physical fatigue and exercise performance in mice. Therefore, it has a potential for the pharmacological effect of anti-fatigue.

• 한국신재생에너지학회:학술대회논문집
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• 2005.06a
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• pp.678-683
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• 2005

Korea is utilizing geothermal resources mainly in the bathing and swimming facilities with very few applications for industrial processes or space heating. It is estimated that geothermal capacity and annual utilization are 36.2MWt and 761TJ/year as compared to global capacity and annual utilization of 15,145MWt and 190,699 TJ/year. RETScreen software is a user's friendly tool for analyzing the technical and financial pre-feasibility of potential Renewable Energy (RE) projects that promotes the use of RE applications through the capacity building of planners, decision-makers and industries for successful implementation of RE projects. Strong ties between Canada and Korean organizations such as Korean Solar Energy Society (KSES) and the Korea Institute of Energy Research (KIER) exist for knowledge transfer about RETScreen. In this paper, an overview of RETScreen and its ground source heat pump (GSHP) model with a practical example of an existing project of a community hall in Canada are described to illustrate effectiveness of RETScreenin the implementation of RE technologies. The same community hall project is then evaluated hypothetically considering its location at Kangnyng, Korea. The main objective is to demonstrate how RETScreen GSHP model can also be utilized effectively for GSHP applications in Korea.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.12
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• pp.1937-1941
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• 2014

The effects of Tabebuia avellanedae (Taheebo) on exercise endurance capacity were investigated using mice in an adjustable-current water pool. Compared to the control group, a 1.8~2.0 fold increase in swimming time was observed in mice administered hot water extract (TAW) and 80% ethanol extract (TAE) of inner bark from T. avellanedae. Blood lactate level, an important fatigue relevance factor, was significantly lower in the TAW and TAE groups than in the control group. The total phenolic contents of TAW and TAE were $93.3{\pm}1.6$ and $115.7{\pm}1.5mgGAE/g$, respectively. The levels of flavonoids in the extracts were $77.3{\pm}1.3$ and $95.9{\pm}1.7mgCE/g$, respectively. Higher antioxidant activities of TAE were observed in each assay at the same concentration as compared to TAW. Correlation between antioxidant activities of TAE with total polyphenol contents was observed. These results suggest that extracts of Taheebo increase exercise endurance capacity by elevating antioxidative potentials.

• The Korean Journal of Food And Nutrition
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• v.33 no.4
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• pp.363-371
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• 2020

This study was designed to evaluate the improvement in exercise endurance by Hovenia dulcis fruit hot water extract (HDWE) for the potential application as a functional food material. The effect was based on the evaluation of the forced-swimming capacity and changes in biochemical parameters in mice. Six-week-old mice were classified into four groups based on a randomized block design: the negative control group, the HDWE 50 mg/kg body weight group, the HDWE 200 mg/kg body weight group, and the 1-octacosanol 50 mg/kg body weight group (n=8 mice per group). The swimming exercise time in the HDWE-50 group was increased at 545±43 sec compared to the control group at 263±28 sec. The HDWE-200 fatigue indicators, lactate acid and ammonia content, decreased to 4.99±0.33 mg/mL and 0.63±0.05 mg/mL, respectively. In addition, the content of glycogen in the liver and muscle tended to increase in the group administered HDWE but was not significant. Likewise, the LDH and glucose contents were increased compared to the control group. The muscle damage indicators ALT (52.7±2.6 U/L) and AST (42.5±5.2 U/L) tended to decrease compared to the control group (76.4±10.2 U/L).