• Journal of Trauma and Injury
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• 제18권2호
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• pp.81-86
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• 2005

Background: Cardiac troponin I (cTnI) is a sensitive cardiac marker of myocardial injury. In normal coronary angiogram, positive cTnI values may be detected in various events such as sepsis, stroke, trauma and so on. To investigate characteristics of cTnI positive group in trauma patients, we designed this study between cTnI positive group and cTnI negative group. Method: Trauma patients who visited emergency room within 24 hours after accidents were included. Patients who had renal failure, acute coronary syndrome, sepsis, spontaneous SAH were excluded. Retrospective study of 97 trauma patients was done. We investgated ISS (injury severity score), positive cTnI, EKG abnormality, shock class, ICU admission rate and mortality. Result: In comparing with non chest trauma group, chest trauma group, whose chest AIS (Abbreviated Injury Score) is more than 3 point, had significant values in ISS, positive cTnI, EKG abnormality, shock class and ICU admission rate. Also, in non chest trauma group, we found several patients whose cTnI level was positive. When non chest trauma group was divided into two subgroups, the mortality and shock class of positive cTnI group were higher than that of negative cTnI group. When all trauma patients were divided into two groups, a positive cTnI group had higher values in ISS, shock class, ICU admission rate and mortality than that in a negative cTnI group. Conclusion: We found that cTnI were positive in patients of cardiac contusion but also in various trauma cases. In non chest trauma patients, we assumed that hypotension caused cTnI elevating. The cTnI could play a role in predicting prognosis in trauma patients.

• 한국토양비료학회지
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• 제25권3호
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• pp.213-219
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• 1992

충북(忠北) 괴산군(槐山郡)에 위치한 옥천계(沃川系) 천매암토양(千枚岩土壤)의 특성을 사면경사(斜面傾斜)에 따라 토양(土壤) catena를 구명하고, 옥천계토양(沃川系土壤)의 분포를 조사하고자 수행하였다. 1. 옥천계모암(沃川系母岩)은 216천ha 분포하였으며, 옥천계토양(沃川系土壤)은 목(目) 2 아목(亞目) 3 대군(大群) 4 아군(亞群) 5 토양통(土壤統) 9개로 밝혀졌다. 2. 사면경사(斜面傾斜)는 토색연속계(土色連續系)를 이루었으며, 토색지수와 $Fe_2O_3$ 함량은 배수가 양호할 수록 증가하였다. 3. 미사/점토비(比)와 Ca/Mg比는 상대표고(相對標高)가 높을 수록 그리고 토심이 깊을 수록 좁아졌다. 4. 토양의 생성년령은 산견(山肩)>산복(山腹)>산록(山麓)>산지경사(山肢傾斜), 토양모재의 생선년령은 C>B>A층의 순이었다. 5. 토양단면내 토색지수와 $Fe_2O_3$ 함량은 고도의 유의성을 나타내었다. 6. 생성학적 유형은 C/D형이었으며, 토심>12cm에서의 토양성질 변화는 연속함수(連續函數)를 갖는다.

• Journal of Preventive Medicine and Public Health
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• 제55권3호
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• pp.234-242
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• 2022

Objectives: This study assessed the validity and reliability of the Health-related Quality of Life Instrument with 8 Items (HINT-8) in patients with diabetes. HINT-8 is a newly-developed, generic health-related quality of life (HRQoL) instrument. Methods: Three HRQoL instruments-HINT-8, EuroQoL 5-Dimension 5-Level (EQ-5D-5L), and Short Form Health Survey version 2.0 (SF-36v2)-were provided to 300 patients with diabetes visiting a tertiary hospital for follow-up visits in Korea. The HRQoL scores obtained using the HINT-8 were evaluated for subgroups with known differences based on demographics and diabetes-related characteristics (known-group validity). The mean scores of the instruments were compared between groups segmented by their responses to the HINT-8 (discriminatory ability). Correlation coefficients of the HINT-8 with other instruments were calculated (convergent and divergent validity). The Cohen kappa and intra-class correlation coefficient (ICC) were also evaluated (test-retest reliability). Results: The average HINT-8 indexes were lower among women, older, and less-educated subjects. Subjects who did not list any problems on the HINT-8 had significantly higher HRQoL scores than those who did. The correlation coefficients of the HINT-8 with the EQ-5D-5L index and EuroQoL visual analogue scale were 0.715 (p<0.001) and 0.517 (p<0.001), respectively. The correlation coefficients between the HINT-8 index and the scores of 8 domains of the SF-36v2 ranged from 0.478 (p<0.001) to 0.669 (p<0.001). The Cohen kappa values for the HINT-8 ranged from 0.268 to 0.601, and the ICC of the HINT-8 index was 0.800 (95% confidence interval [CI], 0.720 to 0.860). Conclusions: This study showed that the HINT-8 is a valid and reliable HRQoL instrument for patients with diabetes.

• Genomics & Informatics
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• 제4권4호
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• pp.147-160
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• 2006

GATA transcription factors are widespread eukaryotic regulators whose DNA-binding domain is a class IV zinc finger motif in the form $CX_{2}CX_{17-20}CX_{2}C$followed by a basic region. In fungi, they act as transcriptional activators or repressors in several different processes, ranging from nitrogen source utilization to mating-type switching. Using an in-house bioinformatics portal system, we surveyed 50 fungal and 9 out-group genomes and identified 396 putative fungal GATA transcription factors. The proportion of GATA transcription factors within a genome varied among taxonomic lineages. Subsequent analyses of phylogenetic relationships among the fungal GATA transcription factors, as well as a study of their domain architecture and gene structure, demonstrated high degrees of conservation in type IVa and type IVb zinc finger motifs and the existence of distinctive clusters at least at the level of subphylum. The SFH1 subgroup with a 20-residue loop was newly identified, in addition to six well-defined subgroups in the subphylum Pezizomycotina. Furthermore, a novel GATA motif with a 2f-residue loop ($CX_{2}CX_{21}CX_{2}C$, designated 'zinc finger type IVc') was discovered within the phylum Basidiomycota. Our results suggest that fungal GATA factors might have undergone multiple distinct modes of evolution resulting in diversified cellular modulation in fungi.

• Restorative Dentistry and Endodontics
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• 제46권1호
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• pp.3.1-3.14
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• 2021

Objectives: This study aimed to evaluate the interface between a calcium silicate cement (CSC), Biodentine and dental adhesives in terms of sealing ability. Materials and Methods: Microleakage test: 160 standardized class II cavities were prepared on 80 extracted human molars. The cavities were filled with Biodentine and then divided into 2 experimental groups according to the time of restoration: composite resin obturation 15 minutes after Biodentine handling (D0); restoration after 7 days (D7). Each group was then divided into 8 subgroups (n = 5) according to the adhesive system used: etch-and-rinse adhesive (Prime & Bond); self-etch adhesive 2 steps (Optibond XTR and Clearfil SE Bond); self-etch adhesive 1 step (Xeno III, G-aenial Bond, and Clearfil Tri-S Bond); and universal used as etch-and-rinse or self-etch (ScotchBond Universal ER or SE). After thermocycling, the teeth were immersed in a silver nitrate solution, stained, longitudinally sectioned, and the Biodentine/adhesive percolation was quantified. Scanning electron microscopic observations: Biodentine/adhesive interfaces were observed. Results: A tendency towards less microleakage was observed when Biodentine was etched (2.47%) and when restorations were done without delay (D0: 4.31%, D7: 6.78%), but this was not significant. The adhesives containing 10-methacryloyloxydecyl dihydrogen phosphate monomer showed the most stable results at both times studied. All Biodentine/adhesive interfaces were homogeneous and regular. Conclusions: The good sealing of the CSC/adhesive interface is not a function of the system adhesive family used or the cement maturation before restoration. Biodentine can be used as a dentine substitute.

• 한국컴퓨터정보학회논문지
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• 제16권4호
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• pp.83-91
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• 2011

본 논문의 목적은 정보통신윤리 교육을 위한 효과적인 블랜디드 문제중심학습 시스템을 구현하는데 있다. 교수-학습 목표 달성을 위해서 온라인 학습과 면대면 수업이 체계적으로 혼합되었고 온라인 학습을 위한 주요 모듈은 오픈소스 학습 관리시스템인 무들에서 운영되었다. 제안 시스템의 교육적인 효과를 검증하기 위해서 ${\bigcirc}{\bigcirc}$시 소재의 대학교 2학년 2개 반을 대상으로 논문에서 제시한 방법을 사용하여 실험연구를 하였다. 실험 대상의 학생 수는 60명(실험집단: 30명, 통제집단: 30명)이며 각 그룹에 6명의 학생으로 10개의 그룹으로 편성되었다. 연구 결과는 다음과 같다. 첫째, 제안한 블랜디드 PBL을 활용한 교육이 면대면 PBL 방법을 활용한 교육보다 정보통신윤리 의식 함양에 효과적이었다. 둘째, 제안한 블랜디드 PBL에 참여한 학습자들이 면대면 PBL에 참여한 학습자들보다 문제해결능력 향상, 협동학습의 이해와 같은 다양한 PBL 효과를 체험하였다.

• Restorative Dentistry and Endodontics
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• 제38권2호
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• pp.73-78
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• 2013

Objectives: This study evaluated the effect of three different air-drying times on microleakage of three self-etch adhesive systems. Materials and Methods: Class I cavities were prepared for 108 extracted sound human premolars. The teeth were divided into three main groups based on three different adhesives: Opti Bond All in One (OBAO), Clearfil $S^3$ Bond (CSB), Bond Force (BF). Each main group divided into three subgroups regarding the air-drying time: without application of air stream, following the manufacturer's instruction, for 10 sec more than manufacturer's instruction. After completion of restorations, specimens were thermocycled and then connected to a fluid filtration system to evaluate microleakage. The data were statistically analyzed using two-way ANOVA and Tukey-test (${\alpha}$ = 0.05). Results: The microleakage of all adhesives decreased when the air-drying time increased from 0 sec to manufacturer's instruction (p < 0.001). The microleakage of BF reached its lowest values after increasing the drying time to 10 sec more than the manufacturer's instruction (p < 0.001). Microleakage of OBAO and CSB was significantly lower compared to BF in all three drying time (p < 0.001). Conclusions: Increasing in air-drying time of adhesive layer in one-step selfetch adhesives caused reduction of microleakage, but the amount of this reduction may be dependent on the adhesive components of self-etch adhesives.

• 정보교육학회논문지
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• 제14권3호
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• pp.437-447
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• 2010

본 논문의 목적은 정보통신윤리의식 함양을 위한 효과적인 e-PBL을 설계하고 개발하는데 있다. 제안한 e-PBL은 구성주의 교수-학습 이론에 속하는 PBL에 기반한다. 교수-학습 목표 달성을 위해서 온라인 학습과 면대면 수업이 체계적으로 혼합되었고 온라인 학습을 위한 주요 모듈은 오픈소스 학습관리시스템인 무들에서 운영되었다. 제안 e-PBL의 교육적인 효과를 검증하기 위해서 OO시 소재의 대학교 2학년 2개 반을 대상으로 논문에서 제시한 교육내용과 방법을 사용하여 실험연구를 하였다. 실험 대상의 학생 수는 60명(실험집단: 30명, 통제집단: 30명)이며 각 그룹에 6명의 학생으로 10개의 그룹으로 편성되었다. 연구 결과 제안한 e-PBL을 활용한 교육이 전통적인 면대면 PBL 학습 방법을 활용한 교육보다 정보통신윤리의식 함양에 효과적이었으며 학습자들이 보다 긍정적인 반응을 보였다.

• Journal of Community Nutrition
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• 제5권3호
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• pp.141-150
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• 2003

The purpose of the study was to investigate attitude about self-weight reduction and dietary intakes by body mass index (BMI) of university students. The subjects were Korean university students (male: 1,024, female： 1,575) who were participating in a nutritional education class via the internet. This survey was carried out using a self-administered questionnaire. The questionnaire included items about demographic characteristics, nutrient intakes, health-related lifestyles, dietary behaviors, body images and diet experiences. As for prevalence of obesity, 3.2％ of male subjects were underweight, 64.2％ were normal weight, 20.8％ were overweight, and 11.8％ were obese. In female subjects, 25.8％ were underweight, 67.1 ％ were normal weight, 5.3％ were overweight, and 1.7％ were obese. Distribution of obesity by BMI was significantly different between male and female subjects. There was a significant difference in perceptions of body weight between male and female subjects. The female subjects were more likely to perceive themselves as overweight. As for weight reduction, the higher BMI was, the more weight reduction was tried in both male and female subjects. As for average daily intakes for energy and 11 nutrients, most nutrient intakes were not significantly different by distribution of BMI. However, obese subgroup showed the lowest nutrient intakes compared to other subgroups. As BMI increased, mean adequacy ratio (MAR) significantly decreased. Therefore, nutritional education via the internet is necessary for university students to establish physically and mentally optimal health condition through nutritional intervention.

• 미생물학회지
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• 제43권4호
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• pp.285-291
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• 2007

볼티모어의 분류체계에 의하면 바이러스는 복제 및 단백질합성 전략에 따라 6개의 집단으로나눌 수 있다. 몇 종류의 작은 DNA 바이러스를 제외한 대부분의 바이러스는 게놈 복제를 위한 자신의 핵산중합효소를 유전자로 암호화하고 있다. 바이러스 핵산중합효소에는 DNA-의존DNA 중합효수, RNA-의존RNA 중합효소, RNA-의존 DNA 중합효소 세 종류가 있으며, 이들은 모두 4개의 공통된 모티프(motif)를 가진다. 우리는 볼티모어의 분류체계와 바이러스의 핵산중합효소와의 관계를 아미노산 서열을 통해 분자 계통분류학적 분석을 통해 알아보고자 하였다. NCBI GenBank에서 얻은 바이러스 중합효소의 아미노산 서열을 CLUSTAL X 프로그램으로 다중서열하고, Neighbor-joining, Maximum-likelihood, Bayesian의 세 가지 방법으로 계통도를 그려보았다. 미세한 차이는 있었으나, 세 가지 방법 모두에서 볼티모어의 분류법과 일치하는 결과를 보였고, 특이하게도 두 가닥 RNA 바이러스는 숙주의 종류에 따라, (-)RNA 바이러스는 게놈의 절편화에 따라 각각2개의 소집단으로 나뉘어지는 것을 볼 수 있었다.