• Korean Journal of Remote Sensing
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• v.21 no.5
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• pp.371-382
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• 2005

We present a processing system for the Atmospheric Infrared Sounder (AIRS) sounding suite onboard Aqua satellite. With its unprecedented 2378 channels in IR bands, AIRS aims at achieving the sounding accuracy of radiosonde (1 K in 1-km layer for temperature and $10\%$ in 2-km layer for humidity). The core of the processor is the International MODIS/AIRS Processing Package (IMAPP) that performs the geometric and radiometric correction for generation of Level 1 brightness temperature and Level 2 geophysical parameters retrieval. The processor can produce automatically from received raw data to Level 2 geophysical parameters. As we process the direct-broadcast data almost for the first time among the AIRS direct-broadcast community, a special attention is paid to understand and verify the Level 2 products. This processor includes sub-systems, that is, the near real time validation system which made the comparison results with in-situ measurement data, and standard digital information system which carry out the data format conversion into GRIdded Binary II (GRIB II) standard format to promote active data communication between meteorological societies. This processing system is planned to encourage the application of geophysical parameters observed by AIRS to research the aqua cycle in the Korean peninsula.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.360-360
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• 2019

도시화 및 산업화로 인해 불투수면이 지속적으로 증가하고 있으며, 불투수면 증가로 인해 유역의 물순환 구조가 왜곡되고, 비점오염 배출량이 증가하는 등의 문제가 야기되고 있다. 왜곡된 물순환 체계 회복 및 비점오염 배출 저감 등을 위해 중장기 물순환 개선 목표 수립과 관련된 조항이 물환경보전법 상에 추가되어 2020년 시행예정이며, 광주, 대전, 울산, 안동, 김해시 등은 물순환 선도도시로 선정되어 관리되고 있는 등 물순환 개선을 위한 노력이 높아지고 있다. 본 연구에서는 경안천 중권역을 대상으로 HSPF (Hydrological Simulation Program - FORTRAN) 모형을 이용하여 유출량을 모의하여, 소권역별로 물순환요소를 도출하고, 물순환율을 산정 하고자 한다. 모형의 구동을 위한 기상자료는 기상청으로부터 취득하였으며, 지형자료는 환경부의 소권역도, 국토지리정보원의 수치지형도를 활용하였고, 토지피복도는 국가공간정보포털에서 취득한 연속지적도를 토지피복 분류에 따라 재분류하여 구축하였다. 모형의 보정을 위한 유량자료는 환경부 유량측정망과 수위관측소의 유량자료를 활용하였으며, 2013~2017년은 보정, 2008~2012년은 검정기간으로 활용하였다. 도출된 수문모의 결과를 활용하여 2008년부터 2017년까지 소권역별로 매년 물순환율을 산정하고 비교하였다. 본 연구의 결과는 추후 물순환 현황파악을 위한 기초자료로 활용될 수 있을 것으로 사료된다.

• Proceedings of the Ginseng society Conference
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• 2002.10a
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• pp.545-555
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• 2002

Ginsenosides of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol classification including the aglycones, PD, PI and ginsenosides Rh2, Rhl were shown to posses characteristic effects on proliferation of THP-l human leukaemia cells. A similar result was not apparent for ginsenoside Rg3 or dexamathasone. The concentration to inhibit $50\%$ of cells $(LC_{50})$ for PD, Rh2, PI and Rhl were 13 ${\mu}g/mL,\;15{\mu}g/mL,\;19{\mu}g/mL\;and\;210\;{\mu}g/mL$ respectively. Cell cycle analysis showed apoptosis with PD and PI treatment of THP-1 cells resulting in a build up of sub-G1 cells after 24, 48 and 72 hours of treatment. Rh2, and dexamathasone treatments also increased apoptotic cells after 24 hours, where as Rhl did not. After 48 and 72 hours Rh2, Rhl and dexamathasone similarly increased apoptosis, but these effects were significantly (P<0.05) lower than observed for both PD and PI treatments. Furthermore, treatments that produced the largest build up of apoptotic cells were also found to have the largest release of lactate dehydrogenase (LDH). It can be concluded from these studies that the presence of sugars to PD and PI aglycone structure reduces the potency to induce apoptosis, and alternately alter membrane integrity. These cytotoxic effects to THP-l cells were different from dexamethasone.

• Journal of Pharmacopuncture
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• v.21 no.4
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• pp.268-276
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• 2018

Objectives: The purpose of this study is to investigate the anti-cancer effects of different fractions of Astragalus membranaceus (AM) in human non-small cell lung cancer (NSCLC) cells. Methods: We isolated hexane, ethyl acetate, and butanol fractions from crude ethanol extract of AM. The cell death was examined by MTT assay and trypan blue exclusion assay. Apoptosis was detected by DAPI staining, annexin V-PI double staining and cell cycle analysis. The expression of apoptosis-related proteins and mitogen-activated protein kinases (MAPKs) was examined by western blot. Results: Among various fractions of AM, the ethyl acetate fraction of AM (EAM) showed the strongest cytotoxic effect in NSCLC cells. EAM reduced the cell proliferation in a time- and dose-dependent manner in NSCLC cells. In addition, EAM induced the chromatin condensation, and increased the population of sub-G1 phase and annexin V-positive cells in a time-dependent manner, indicating that EAM induced apoptosis in NSCLC cells. Consistently, EAM enhanced the expression of cleaved caspase-8 and -9, and induced the accumulation of cleaved- poly (ADP-ribose) polymerase (PARP). Among MAPK proteins, only ERK was dephosphorylated by EAM, suggesting that ERK might be related with EAM-induced apoptosis. Conclusion: Our results clearly demonstrate that EAM exhibited anti-cancer effects in NSCLC cells by induction of apoptosis. We provide a valuable evidence which suggests that AM could be a desirable therapeutic option for treatment of NSCLC.

• International Journal of Oral Biology
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• v.44 no.2
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• pp.43-49
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• 2019

Tannic acid (TA) is a water-soluble polyphenol compound found in various herbal plants. We investigated the chemopreventive effects of TA on FaDu hypopharyngeal squamous carcinoma cells. In an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, TA showed dose-dependent cytotoxicity with a half maximal inhibitory concentration (IC50) of 50 ?M. Cell cycle analysis and immunofluorescence imaging demonstrated that under low-dose ($25{\mu}M$) treatment, FaDu cells were arrested in G2/M phase, and as the dose of TA was increased, apoptosis was induced with the increase of cell population at sub-G1 phase. The expressions of various cyclins, including cyclin D1 and cyclin-dependent kinases (CDK-1 and CDK-2), were down-regulated at low doses of TA, whereas apoptotic effectors such as cleaved caspase 3, cleaved caspase 7, and poly (ADP-ribose) polymerase (PARP) were expressed in a dose-dependent manner in Western blotting. In addition, TA-induced apoptosis of FaDu cells might be mediated by the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase pathway, with the upregulation of p-AKT/p-PKB (phosphorylated protein kinase B) and p-ERK. Overall, our data support the hypothesis that TA is a potential candidate agent for the treatment of hypopharyngeal cancer.

• Transactions of Materials Processing
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• v.28 no.5
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• pp.247-256
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• 2019

In this study, the development of annealing textures in cold rolled and annealed tantalum sheets was analyzed using electron backscatter diffraction. At $900^{\circ}C$, the textures of the recrystallized grains in the partially and completely recrystallized microstructures displayed significant similarities. The average diameter of the recrystallized grains with ${\gamma}-fiber$ orientations exceeded that of grains with different orientations, and the average growth rates were unrelated to the orientations after an initial stage of recrystallization. Additional cold rolling and annealing was done for controlled initial microstructures and textures inherited from various processes of prior cold rolling and annealing. This second cycle of the process resulted in stronger textures with major ${\gamma}-fiber$ orientations as a result of the enhanced ${\gamma}-fiber$ orientations in the preceding textures. A coarse-grained prior microstructure resulted in a weaker annealing texture than a fine grained one regardless of the stronger previous texture, which was occasioned by the sub-structures of the minor orientations at local deformation inhomogeneities such as sharp in-grain shear bands.

• Mycobiology
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• v.49 no.4
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• pp.421-433
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• 2021

Morchella is a genus of fungi with the ability to concentrate Cd both in the fruit-body and mycelium. However, the molecular mechanisms conferring resistance to Cd stress in Morchella are unknown. Here, RNA-based transcriptomic sequencing was used to identify the genes and pathways involved in Cd tolerance in Morchella spongiola. 7444 differentially expressed genes (DEGs) were identified by cultivating M. spongiola in media containing 0.15, 0.90, or 1.50 mg/L Cd²⁺. The DEGs were divided into six sub-clusters based on their global expression profiles. GO enrichment analysis indicated that numerous DEGs were associated with catalytic activity, cell cycle control, and the ribosome. KEGG enrichment analysis showed that the main pathways under Cd stress were MAPK signaling, oxidative phosphorylation, pyruvate metabolism, and propanoate metabolism. In addition, several DEGs encoding ion transporters, enzymatic/non-enzymatic antioxidants, and transcription factors were identified. Based on these results, a preliminary gene regulatory network was firstly proposed to illustrate the molecular mechanisms of Cd detoxification in M. spongiola. These results provide valuable insights into the Cd tolerance mechanism of M. spongiola and constitute a robust foundation for further studies on detoxification mechanisms in macrofungi that could potentially lead to the development of new and improved fungal bioremediation strategies.

• Journal of the Korean Society of Systems Engineering
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• v.17 no.1
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• pp.107-113
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• 2021

Plant Configuration Management(CM) is an activity to maintain consistency of design requirements, physical configuration, facility configuration information throughout the life cycle of the plant by systematically managing changes that occur during the plant design and operation process. Conformity between information must be ensured not only in the design stage, but also in the case of design changes in the operation and maintenance stages, and thus a computer system capable of efficiently managing them is required. In particular, in consideration of an application to small and medium-sized domestic plants, a computer system that can support configuration management at a low cost is needed. Accordingly, in this study, a configuration management system has been developed to support the management of plant design information and change procedures in the operation stage of small and medium-sized plants. Here, a case for quantitatively evaluating the effectiveness of the developed system is described.

• Journal of Korean Society on Water Environment
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• v.36 no.6
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• pp.592-610
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• 2020

In South Korea, the concept of water environment was expanded to include aquatic ecosystems with the Integrated Water Management implementation. Watershed-scale modeling is typically performed for hydrologic component analysis, however, there is a need to expand to include ecosystem variability such that the modeling corresponds to the social and political issues around the water environment. For this to be viable, the modeling must account for several distinct features in South Korean watersheds. The modeling must provide reasonable estimations for peak flow rate and apply to paddy areas as they represent 11% of land use area and greatly influence groundwater levels during irrigation. These facts indicate that the modeling time intervals should be sub-daily and the hydrologic model must have sufficient power to process surface flow, subsurface flow, and baseflow. Thus, the features required for watershed-scale modeling are suggested in this study by way of review of frequently used hydrologic models including: Agricultural Policy/Environmental eXtender(APEX), Catchment hydrologic cycle analysis tool(CAT), Hydrological Simulation Program-FORTRAN(HSPF), Spatio-Temporal River-basin Ecohydrology Analysis Model(STREAM), and Soil and Water Assessment Tool(SWAT).

• Biomolecules & Therapeutics
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• v.30 no.1
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• pp.64-71
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• 2022

Norovirus (NV) is the most common cause of viral gastroenteritis, with the potential to develop into a fatal disease in those who are immuno-compromised, and effective vaccines and treatments are still non-existent. In this study, we aimed to elucidate the molecular mechanism of the previously identified NV replication inhibitor utilizing a vinyl-stilbene backbone, AC-1858. First, we confirmed the inhibition of the NV RNA replication by a structural analog of AC-1858, AC-2288 with its exclusive cytoplasmic sub-cellular localization. We further validated the induction of one specific host factor, the phosphorylated form of heat shock factor (HSF)-1, and its increased nuclear localization by AC-1858 treatment. Finally, we verified the positive and negative impact of the siRNA-mediated downregulation and lentivirus-mediated overexpression of HSF-1 on NV RNA replication. In conclusion, these data suggest the restrictive role of the host factor HSF-1 in overall viral RNA genome replication during the NV life cycle.