• Biomolecules & Therapeutics
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• v.31 no.6
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• pp.648-654
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• 2023

Oxidative stress-induced melanocyte apoptosis is linked to the immune system and plays a critical role in the pathogenesis of vitiligo. Aquaporin-3 (AQP3), which is downregulated in vitiligo keratinocytes, regulates intracellular H₂O₂ accumulation. However, the role of AQP3 in oxidative stress is uncertain in vitiligo. This study investigated the effect of downregulated AQP3 on oxidative stress in vitiligo using lesional and non-lesional skin specimen sets from vitiligo patients and primary cultured adult normal human epidermal keratinocytes, with or without downregulation and overexpression of AQP3 in the presence or absence of H₂O₂ treatment. The levels of nuclear factor E2-related factor 2 (NRF2) and/or its main target, NAD(P)H quinone dehydrogenase 1 (NQO-1), were lower in the lesional keratinocytes and cultured keratinocytes with AQP3 knockdown, but were increased in keratinocytes upon AQP3 overexpression. Ratios of NRF2 nuclear translocation and NQO-1 expression levels were further reduced in AQP3-knockdown keratinocytes following H₂O₂ treatment. The conditioned media from AQP3-knockdown keratinocytes treated with H₂O₂ contained higher concentrations of reactive oxygen species (ROS). Moreover, the number of viable melanocytes was reduced when the conditioned media were added to the culture media. Overall, AQP3 downregulation in the keratinocytes of patients with vitiligo can induce oxidative stress in neighboring melanocytes, leading to melanocyte death.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.52 no.5
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• pp.468-473
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• 2019

A $2{\times}4$ factorial feeding trial was conducted to examine the effect of feed type and feeding frequency on the performance of sub-adult starry flounder Platichthys stellatus. Two feed types, sinking pellets (SP) and floating pellets (FP), were given to 480 fish housed in tanks. Triplicate groups of fish were fed each feed type at one of four feeding frequencies (one meal every two days, one meal per day, two meals per day, and three meals per day) for nine weeks. Weight gain (WG) and specific growth rate (SGR) of fish were affected by feeding frequency. However, WG and SGR were the same in fish fed SP at two and three meals per day; similarly, there was no difference in WG or SGR of fish fed FP at one meal, two meals, or three meals per day. Feed utilization of fish was affected by both feed type and feeding frequency. These findings suggest that two meals per day of the SP or one meal per day of FP are sufficient for optimum growth performance of sub-adult starry flounder.

• Journal of Korean Academy of Nursing
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• v.44 no.1
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• pp.41-54
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• 2014

Purpose: The purpose of the study was to explore and describe the experience of adult Korean children who are caregivers for parents institutionalized with dementia. Methods: Participants were fourteen adult children caregivers of elders institutionalized with dementia. Data were collected through in-depth unstructured interviews with individual participants from August to November, 2012. Theoretical sampling was used to the point of theoretical saturation. Data were analyzed using Strauss and Corbin's Grounded Theory Method. Results: From open coding, 67 concepts, 29 sub-categories, and 14 categories were identified. Analysis revealed that the core category of the experience of adult children caring for their parents institutionalized with dementia was 'enduring the role of a prop' consisting of four phases: initial turmoil, exploration, role adjustment, and acclimation. To manage the role of a prop, participants utilized various action/interactional strategies such as overcoming the unfamiliarity, overseeing the nursing home care, and counterbalancing the caring roles. As a result, participants experienced ambivalence towards the existence of parents with dementia, changes in family relationships, altered viewpoint towards nursing homes, and restructuring of life. Conclusion: In-depth understanding of the experience will guide nurses to promote effective interventions in order to better support the Korean family caregivers of parents institutionalized with dementia.

• PNF and Movement
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• v.10 no.4
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• pp.33-40
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• 2012

Purpose : The purpose of this study was to investigate the effects of PNF on active lumbar flexion ROM and difficulty of activity of daily living for adult scoliosis with low back pain. Methods : A 23-aged adult scoliosis with diagnosed herniated lumbar disc. The patient was treated by PNF for 30 minutes a day, 2 times a week during six weeks. Active lumbar flexion ROM and difficulty of activity of daily living were evaluated by the Modified-Modified Schober test and Oswestry Disability Questionnaire every week after treatment including the pretest of the first day of treatment. Results : There were a significant improvement in active lumbar flexion ROM between pretest and the last test. There were significant decreased in difficulty of activity of daily living positive between pretest and the last test. Conclusion : PNF will be useful for increasing active lumbar flexion ROM and decreasing the difficulty of activity of daily living positive for adult scoliosis with low back pain.

• Journal of Korean Academy of Dental Administration
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• v.9 no.1
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• pp.51-60
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• 2021

The purpose of this study is to examine the importance of healthy attachment formation by examining the effects of dental hygiene students' adult attachment patterns on depression, self-esteem, empathy, and career choice, and to present basic data for career guidance that considers individual characteristics. Students enrolled in the dental hygiene department at a university in Daejeon were the subjects of this study, and data were collected from September 14 to October 14, 2020 through self-reported questionnaires. Frequency analysis, ANOVA, correlation analysis, and multiple regression analysis were performed. As a result of classifying adult attachment styles into three types, out of a total of 158 people, 62 (39.2%) had the avoidant attachment style, 56 (35.4%) had the secure attachment style, and 40 (25.3%) had the anxious-ambivalent attachment style appear. Self-esteem according to attachment type (F=26.224, p<0.0001), empathy (F=3.944, p<0.05), depression (F=12.702, p<0.0001), career indecisiveness (F=4.367, p<0.05). Based on the results of identifying the sub-factors that affect the dental hygiene and adult attachment styles of students with depression, self-esteem, empathy and career choice, this study intends to use them as reference materials for career decision taking into account individual characteristics.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.42 no.3
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• pp.262-267
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• 2009

Two 15-week feeding trials were conducted to investigate feeding rate and feeding frequency for growth of sub-adult flounder in suboptimal water temperature ($12^{\circ}C$). In the first experiment, duplicated groups of fish (initial mean weight of 279 g) were fed a extruded pellet once a day at the different feeding rates of 0.1, 0.15, 0.2, 0.3% body weight per day (BW/d), and satiation (0.32% BW/d). Weight gain and feed efficiency were increased significantly (P<0.05) with increase in feeding rates from 0.1 to 0.3% BW/d, but there were no significant differences in weight gain and feed efficiency of fish fed the diet between 0.3% BW/d and to satiation. Crude protein content of dorsal muscle of fish fed the 0.1% BW/d diet was significantly (P<0.05) lower than that of the other groups. In the second experiment, duplicated groups of fish (initial mean weight of 281 g) were fed to apparent satiation with a extruded pellet at three different feeding frequencies (one meal every two days, one meal a day and two meals a day). Weight gain, feed efficiency and condition factor of fish fed one meal every two days were significantly (P<0.05) lower than those of fish fed one meal and two meals a day, but there were no significant differences in weight gain, feed efficiency and condition factor of fish fed between one meal and two meals a day. Based on the results of this study, optimum feeding frequency is one meal a day with satiation feeding for growth and feed efficiency of sub-adult flounder (270-350 g) in suboptimal water temperature ($12^{\circ}C$).

• Journal of Aquaculture
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• v.21 no.2
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• pp.102-106
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• 2008

This study was conducted to evaluate extruded pellets(EP) for the growth of sub-adult flounder Paralichthys olivaceus by comparing with raw fish-based moist pellet(MP). Two replicate groups of 150 fish per each tank(initial mean weight $594{\pm}6.5g$) were fed one of two EPs(EP1 and EP2) and a MP for 32 weeks. Survival was not significantly affected by experimental diets. Final mean weight of fish fed the EP1 was not significantly different from that of fish fed the MP, but that of fish fed EP2 was significantly lower than that of fish fed EP1 and MP (P<0.05). Feed efficiency and protein efficiency ratio of fish fed the EP1 and EP2 were significantly higher than those of fish fed MP(P<0.05). Daily feed intake of fish fed the EPs was significantly lower than that of fish fed MP(P<0.05). Condition factor was not significantly different among all groups. The contents of moisture, crude protein and lipid in dorsal muscle were significantly affected by experimental diets(P<0.05). Based on the results of this study, the dietary formulations used in EP1 and EP2 could be applied in the practical extruded pellet feeds for sub-adult flounder(594-1,126 g).

• Human Ecology Research
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• v.54 no.2
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• pp.181-195
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• 2016

This study use the influences of parenting style as perceived by and adult child and recognizes gender roles for the purpose of marriage perspectives. I provided a general tendency of parenting style as perceived by and adult child, recognize gender roles, and perspective of marriage to achieve the established goals. We analyzed the relative influence of socio-demographic characteristics, parenting style as perceived by and adult child and recognize gender roles for marriage perspectives. Finally, parenting style as perceived by and adult child are recognized gender roles mediated by the investigated influence of marriage perspectives. We used a structured questionnaire that targeted unmarried men and women 20 to 30 years of age to verify the this study. Data analysis used SPSS ver. 19.0; in addition, we performed reliability, frequency analysis, t-test, hierarchical regression analysis, multiple regression analysis, and variance inflation factor. Looking at these results, both adult children had a higher perception of rearing parents with the usual recognition of gender roles. The analysis indicated a conservative perspective of marriage. Adult children of mothers rearing and recognize gender roles sub-area of masculinity and femininity are perceived to be a significant change observed in marriage perspectives in addition to socio-demographic characteristics of gender and education. However, the relationship between parenting style, as perceived by adult child and marriage perspectives and as analyzed by recognize gender roles, did not have a mediating effect.

• The Journal of Industrial Distribution & Business
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• v.12 no.6
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• pp.7-21
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• 2021

Purpose: Modern globalization and Western markets saturation has catalyzed the growth of culinary globalization into developing countries. The question was whether fast food consumers in frontier markets of Sub-Saharan Africa (Zimbabwe), either upholds national gastronomic tendencies in terms of consumer ethnocentrism and buy local or they adopt global fast food brands. Demographic consumer profiles were also analyzed as antecedents of consumer ethnocentrism. Research design, data and methodology: A sample size of 400 fast food-adult consumers was surveyed in the City of Harare. Data was captured on SPSS and Analysis of Moment Structure (AMOS). Hypothesis testing was done using sample t test (H₁), logistic regression (H₂) and multiple regression (H₃, ₄, ₅) analysis. Results: Consumer ethnocentrism in Zimbabwe was marginally above average and no statistically significant relationship between the levels of consumer ethnocentrism and adoption of foreign fast food brands was noted. Age had an inverse relationship; income had a positive association whilst gender had no statistical significance with consumer ethnocentrism. Conclusions: Despite the Zimbabwean consumers being marginally ethnocentric, international restaurateurs should invest in the Zimbabwean fast food market since their nature of being foreign has got an exotic appeal to the Zimbabwean consumers thereby enhancing their likelihood of success.

• Physical Therapy Korea
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• v.29 no.3
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• pp.200-207
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• 2022

Background: The oxygen uptake efficiency slope (OUES) is the most important index for accurately measuring cardiopulmonary function in patients with acute ischemic heart disease. However, the relationship between the OUES variables and important cardiopulmonary function parameters remain unelucidated for patients with acute ischemic heart disease, which accounts for the largest proportion of heart disease. Objects: The present cross sectional clinical study aimed to determine the multiple relationships among the cardiopulmonary function variables mentioned above in adults with acute ischemic heart disease. Methods: A convenience sample of 110 adult inpatients with ischemic heart disease (age: 57.4 ± 11.3 y; 95 males, 15 females) was enrolled at the hospital cardiac rehabilitation center. The correlation between the important cardiopulmonary function indicators including peak oxygen uptake (VO₂ peak), minute ventilation (VE)/carbon dioxide production (VCO₂) slope, heart rate recovery (HRR), and ejection fraction (EF) and OUES was confirmed. Results: This study showed that OUES was highly correlated with VO₂ peak, VE/VCO₂ slope, and HRR parameters. Conclusion: The OUES can be used as an accurate indicator for cardiopulmonary function. There are other factors that influence aerobic capacity besides EF, so there is no correlation with EF. Effective cardiopulmonary rehabilitation programs can be designed based on OUES during submaximal exercise in patients with acute ischemic heart disease.