• Title/Summary/Keyword: structure-activity relationship

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Choleretic activities of coumarins and their biological precursors (Coumarin계물질 및 그 전구체의 담즙분비촉진 효과에 관한 연구)

  • 한덕용
    • YAKHAK HOEJI
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    • v.13 no.2_3
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    • pp.67-70
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    • 1969

  • Gall duct cannulated rats were given daphnetin, umbelliferone, 4-hydroxy-coumarin, dicoumarol, 4,7-dihydroxycoumarin, 4,7-dimethyl-5-hydroxy-coumarin, coumarin-3-carboxylic acid, cinnamic acid, ferulic acid, caffeic acid by duodenal catheter at room temperature and output of bile flow was detected. All of the subjected compounds in this experiment indicated a significant effect on the biliary elimination except cinnamic acid alone. It is suggested that a relationship exists between chemical pattern and biological activity for coumarin derivatives and their precursors, and that the choleretic activity of these compounds requires hydroxylated cinnamic acid structure as the most fundamental chemical pattern.

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5-Arylidene-2(5H)-furanone Derivatives: Synthesis and Structure-Activity Relationship toward Cytotoxicity

  • Bang, Seong-Cheol;Kim, Yong;Yun, Mi-Young;Kim, Dong-Hee;Ahn, Byung-Zun
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.343.2-343.2
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    • 2002

  • Ranunculin (RAN). isolated from Ranunculaceae. exhibited significant cytotoxic activity against KB and Bel-7402 cells with ED$_{50}$ values of 0.21 and 0.35).${\mu}4M respectively. Under physiological condition. the ranunculin was deglycosylated to be protoanemonin. an active form containing ${\alpha}{\beta}$-unsaturated ketone moiety. which successively dimerized to be anemonin inactive form. (omitted)

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Herbal Drug Interactions Due to Alteration of Metabolism

  • Woo, Won-Sick
    • Korean Journal of Pharmacognosy
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    • v.25 no.1
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    • pp.1-10
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    • 1994

  • The screening of 150 Chinese drugs which are most frequently prescribed in Korean traditional medicine showed that at least 30% of the drugs affected barbiturate-induced hypnosis. This effect was mainly attributable to the alteration of drug metabolism. Phytochemical works resulted in the isolation of furanocoumarins, lignans, sesquiterpenes and saponins as drug metabolism modifiers. The structure-activity relationship is discussed.

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