• 가정과삶의질연구
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• 제33권4호
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• pp.33-50
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• 2015

The purpose of this study was examining the effects of family sandplay therapy with structural family therapy in improving the family strengths of children with emotional and behavioral disorders. First, we looked for a way to combine family sandplay therapy with structural family therapy and formulated an approach that could maximize the strengths of each theory and complement each other's weaknesses. And then we applied family sandplay therapy together with structural family therapy and analyzed its effects on family strengths. The subjects of this study were 10 families of children with emotional and behavioral disorders, and they were divided into an experimental group with 5 families and a control group with the other 5. To the experimental group received 16 sessions of family sandplay therapy with structural family therapy. In order to prove the effectiveness of family sandplay therapy with structural family therapy on family strengths, a family relationship( husband-wife relationship, parent-child relationship, and sibling relationship) scale and a family function(family cohesion, family adaptability) scale were used. The main findings of this study are as follows. First, the family relationships of the families with emotional-behavioral disorder children were improved after the application of family sandplay therapy with structural family therapy. Second, the application of family sandplay therapy with structural family therapy improved the family function of families with emotional-behavioral disorder children. Third, in the course of family sandplay therapy with structural family therapy, family sand tray was changed in a pro-healing direction, and family structure was also transformed from a dysfunctional structure to a functional one. As previously stated, family sandplay therapy with structural family therapy for families of children with emotional and behavioral disorders enhanced family strengths through improving family relationships and restoring family functions.

• 가정과삶의질연구
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• 제9권2호
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• pp.345-366
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• 1991

The concrete purpose of this study is to examine the possibility of applying S.Minuchin's structural family therapy theory to each clinical families so that it can solve efficiently the clinical problems Korean family. The test results are as follows: 1)The Results of Question I : Types of Korean family problems can be divide into six. Then the most frequent type of problem was marital problem. 2) The Results of Question II: Korean normal family showed rater difussed boundary and higher rate of wife dominant type than that of husband dominant type in aspect of boundary and power, and had low tendency toward alignment and neutral adjustment. 3)The Results of Quesion III; Amidst the clinical families, family structural traits of the families which have marital problems showed a clear boundary, the tendency toward alignment, and higher tate of husband dominant type than that of wife dominant type. And family structural traits of children problem family had the tendency of alignment and showed little wife-dominanted families in power. Finally, mother-in -law and daughter-in-law problemed family had several characters such as diffused boundary, the tendency of alignment and high adjustment. 4)The Results of Question IV : As a result of camparing problemed families with normal families in family structure, there was high adaptability of S.Minuchin's structural theory to the two family groups; the groups of marital problems and those of children problem.

• BMB Reports
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• 제47권3호
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• pp.167-172
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• 2014

Reactivating the p53 pathway in tumors is an important strategy for anticancer therapy. In response to diverse cellular stresses, the tumor suppressor p53 mediates apoptosis in a transcription-independent and transcription-dependent manner. Although extensive studies have focused on the transcription-dependent apoptotic pathway of p53, the transcription-independent apoptotic pathway of p53 has only recently been discovered. Molecular interactions between p53 and Bcl-2 family proteins in the mitochondria play an essential role in the transcription-independent apoptosis of p53. This review describes the structural basis for the transcription-independent apoptotic pathway of p53 and discusses its potential application to anticancer therapy.

• 대한지역사회작업치료학회지
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• 제4권1호
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• pp.59-73
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• 2014

목적 : 본 연구는 세월호 사건으로 가족을 잃은 피해자 가족의 고통 체험에 대해 알아보고 피해자 가족의 정신적 외상에 대한 작업치료의 필요성을 제시하고자 하였다. 연구방법 : 세월호 사건으로 가족을 잃은 대상자 5명의 고통 체험을 확인하고자 Parse의 인간되어감 연구방법을 적용하였다. Parse의 연구 방법 패러다임에 따라 세월호 사건으로 가족을 잃은 고통 체험을 다룬 다큐 영상인 2차 자료를 선택하여 분석하였다. 결과 : 세월호 사건으로 가족을 잃은 가족의 고통 체험에 대한 세 개의 핵심구조는 1) 가족을 잃은 절망과 슬픔, 2) 일상이 무너져 내리는 듯한 무력감과 죄책감, 3) 남아있는 가족을 바라보며 고통에서 벗어나고 싶은 마음으로 나타났다. 구조적인 전환은 세월호 사건으로 가족을 잃은 애통함과 슬픔 속에서 압도적인 무력감을 느끼지만 희생된 가족이 세상에 없다는 것을 인정하고 싶지 않은 현실 부인과 살아있는 가족을 보면서 버티어 나가는 과정으로 제시되었다. 개념적 통합은 가치화와 언어화를 연결-분리, 노출-은폐하면서 강화시켜 나아가는 과정으로 표현되었다. 결론 : 세월호 사건으로 가족을 잃은 피해자 가족의 고통 체험은 무기력과 절망, 우울의 감정으로 인해 삶의 의미와 목적을 잃은 상태이다. 가족들에게 의미있는 작업을 통한 중재 프로그램을 개발하여 무너진 일상의 회복과 지역사회 참여를 향상시킬 수 있는 작업치료 중재가 필요하며 이에 기초자료로 활용할 수 있다.

• BMB Reports
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• 제48권2호
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• pp.81-90
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• 2015

p73 is a structural and functional homologue of the p53 tumor suppressor protein. Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive genes, conferring its tumor suppressive activity. In addition, p73 has unique roles in neuronal development and differentiation. The importance of p73-induced apoptosis lies in its capability to substitute the pro-apoptotic activity of p53 in various human cancer cells in which p53 is mutated or inactive. Despite the great importance of p73-induced apoptosis in cancer therapy, little is known about the molecular basis of p73-induced apoptosis. In this review, we discuss the p73 structures reported to date, detailed structural comparisons between p73 and p53, and current understanding of the transcription-dependent and -independent mechanisms of p73-induced apoptosis.

• 대한가정학회지
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• 제42권3호
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• pp.179-193
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• 2004

The purpose of this study was to develop the Family System Diagnosis Scale and to examine its reliability and validity. The subscales of the questionnaire included scores on seven constructs. In order to define constructs accurately, a careful review of Minuchin's writings, the writings of other family therapists, and relevant articles on family interaction was undertaken. A pool of 150 items was given to eight family counselors along with a description of Minuchin' s concepts. The counselors were asked to choose the category each statement fit and to rate the degree of fit using the 3-point scale. Using exploratory factor analysis, confirmatory factor analysis and Linear Structural Relationship(LISREL), six subdimensions of individuation and 55 items of FSDS were identified; enmeshmen disengagement(16 items), parent coalition generational coalition(6 items), flexibility rigidity(5 items), spouse conflict resolved unresolved(8 items), mother-child cohesion estrangement(10 items), father-child cohesion estrangement(10 items). 356 adolescents(ages 13∼18), 356 fathers, 356 mothers in Seoul, Busan, Dague, Incheun, Dajeun, Ulsan, and Kwangju were completed the Family System Diagnosis Scale(FSDS). The reliability of the scale was calculated by Cronbach's a Coefficient and the total a = .94 and the calculation for each factor was .87, .60, .77, .80 and .79 respectively.

• 대한가정학회지
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• 제42권5호
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• pp.145-160
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• 2004

The purpose of this study was to explore family perception of adolescence through the Kinetic Family Drawing (KFD), and to explore its relation with the family system. The Kinetic Family Drawing (KFD) and Family System Diagnosis Scale (FSDS) were administered to 356 adolescent children. Data were analyzed using the regression analysis and the discriminant analysis. The results were as follows: First, there was a significant difference among the KFD family adaptability variables of boys' KFD and the flexibility and rigidity variables of the FSDS in the family relationship. For example, That is; for sons', it means that if there is a greater the satisfaction for their family in their drawings, then the family relationship will be more flexible. Especially with the son's KFD, there was an indication that if there is a greater the activity level of the self, then he has more flexibility in his family relationship. Second, there is a significant difference in the relationship between the KFD family hierarchy variables of girls' KFD and the parent coalition·cross-generational triads variable of the FSDS. For girls 'KFD, the result of this study indicated that when there is a greater the distance between the father figure and the child figure, the cross-generational triads we greater.

• 디지털융복합연구
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• 제11권9호
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• pp.239-246
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• 2013

본 연구는 가족탄력성이 장애아동 가족의 비 장애형제자매가 장애아동을 대하는 긍정적 태도에 어떠한 영향을 미치는지 알아보고자 실시하였다. 이를 검증하기 위해 6개 기관의 협력을 받아 총 110명의 비 장애형제자매를 대상으로 설문조사를 실시하였다. 설문지는 부모의 일반적 특성과, 장애아동의 일반적 특성, 비 장애 형제자매의 일반적 특성, 수용적 지지적 태도, 가족탄력성으로 구성되었다. 수집된 자료는 일반적 특성에 따른 비 장애 형제자매의 긍정적 태도의 유의성 검정을 위해 t-검정, ANOVA을 실시하였고, 가족탄력성이 비 장애 형제자매의 긍정적 태도에 미치는 영향을 알아보기 위해 상관관계와 회귀분석을 실시하였다. 구조방정식검정을 위해 AMOS18을 사용하였다. 그 결과, 장애아동에 대한 비 장애 형제자매의 긍정적 태도와 가족탄력성은 신념체계와 조직패턴, 의사소통과정의 하부 영역들과 정적인 상관관계를 보이고 있으며, 가족탄력성의 전체 설명량은 50%로 높은 영향력을 보이고 있다. 본 연구의 결과로 보아 가족이 위기에 처했을 때 가족 구성원이 협력적 노력과 문제해결을 위한 소통, 그리고 적극적인 노력을 하려는 경향을 보일 때 장애아동에 대한 비 장애형제의 긍정적 태도는 높아진다는 것을 증명할 수 있었다.

• Current Research on Agriculture and Life Sciences
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• 제28권
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• pp.63-68
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• 2010

The epigenetic therapy of cancers is emerging as an effective and valuable approach to both chemotherapy and the chemoprevention of cancer. The utilization of epigenetic targets that include histone methyltransferase (HMTase), Histone deacetylatase, and DNA methyltransferase, are emerging as key therapeutic targets. SET containing proteins such as the HMTase Setd1b has been found significantly amplified in cancerous cells. In order to shed some light on the histone methyl transferase family, we cloned the Setd1b gene from Mus musculus and build a collection of vectors for recombinant protein expression in E.coli that will pave the way for further structural biology studies. We prospect the role of the Setd1b pathway in cancer therapy and detail its unique value for designing novel anti-cancer epigenetic-drugs.

• 한국학교보건학회지
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• 제12권2호
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• pp.243-262
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• 1999

Today, obesity is not recognized as a disease itself but is known to be the indirect cause of much chronic illness. Obesity has an impact on psychological disorders including severe inferiority, damage of body self-image, low self-esteem, personality disorders. The results in an increase of the mortality rate. Therefore, this study attempts to discover and evaluate stressful experience in obese teenagers. For this study, 21 girl students and 19 boy students in Pusan middle or high school located were selected. The data were collected from March to May at 1999. A tape-recorder was used under the permission of the subjects to prevent the loss of spoken information and communication. This study consisted of 563 reponses from girls and 461 responses from boys which were then classified with descriptive expressions and priority classifications. The results generated 72 common elements in girls and 54 common elements in boys. From these elements 24 syntheses of hypothetical definitions and 8 identifications of the structural definitions in both girls and boys were developed. The structural and hypothetical definitions were as follows: The analysis of the data was made through a phenomenological analytic method suggested by Van kamm, which is as follows: 1. Maladjustment to school life; lack of understanding of the teacher, insufficient exercise ability, and a feeling of burden in attending the school obesity program. 2. Conflict in family relationships; lack of understanding from the family, a feeling of alienation. 3. Conflict in friend relationships; lack of understanding among friends, constant comparisons in appearance and body with friends (in girls) and estrangement from friends (in boys). 4. Conflict in acquaintance of the opposite sex; hoping to meet the opposite sex, lack of understanding of boy friends (in girls), feelings of pain, feelings of anxiety (in girls) feelings of burden (in girls) feelings of envy (in boys). 5. Negative body image: shape of body; feelings of pain; feelings of powerlessness; feelings of discomfort, and reception; emotional disorders (in boys), and change of personality (in boys). 6. Health disorder: Physical and psychological discomfort. 7. Feelings of burden in weight control; negative experiences in weight control, interference with family and friends, the difficulty in diet therapy, feelings of burden in exercise (in girls), to be teased by the public through mass media (in boys).