• Journal of Families and Better Life
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• v.33 no.4
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• pp.33-50
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• 2015

The purpose of this study was examining the effects of family sandplay therapy with structural family therapy in improving the family strengths of children with emotional and behavioral disorders. First, we looked for a way to combine family sandplay therapy with structural family therapy and formulated an approach that could maximize the strengths of each theory and complement each other's weaknesses. And then we applied family sandplay therapy together with structural family therapy and analyzed its effects on family strengths. The subjects of this study were 10 families of children with emotional and behavioral disorders, and they were divided into an experimental group with 5 families and a control group with the other 5. To the experimental group received 16 sessions of family sandplay therapy with structural family therapy. In order to prove the effectiveness of family sandplay therapy with structural family therapy on family strengths, a family relationship( husband-wife relationship, parent-child relationship, and sibling relationship) scale and a family function(family cohesion, family adaptability) scale were used. The main findings of this study are as follows. First, the family relationships of the families with emotional-behavioral disorder children were improved after the application of family sandplay therapy with structural family therapy. Second, the application of family sandplay therapy with structural family therapy improved the family function of families with emotional-behavioral disorder children. Third, in the course of family sandplay therapy with structural family therapy, family sand tray was changed in a pro-healing direction, and family structure was also transformed from a dysfunctional structure to a functional one. As previously stated, family sandplay therapy with structural family therapy for families of children with emotional and behavioral disorders enhanced family strengths through improving family relationships and restoring family functions.

• Journal of Families and Better Life
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• v.9 no.2
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• pp.345-366
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• 1991

The concrete purpose of this study is to examine the possibility of applying S.Minuchin's structural family therapy theory to each clinical families so that it can solve efficiently the clinical problems Korean family. The test results are as follows: 1)The Results of Question I : Types of Korean family problems can be divide into six. Then the most frequent type of problem was marital problem. 2) The Results of Question II: Korean normal family showed rater difussed boundary and higher rate of wife dominant type than that of husband dominant type in aspect of boundary and power, and had low tendency toward alignment and neutral adjustment. 3)The Results of Quesion III; Amidst the clinical families, family structural traits of the families which have marital problems showed a clear boundary, the tendency toward alignment, and higher tate of husband dominant type than that of wife dominant type. And family structural traits of children problem family had the tendency of alignment and showed little wife-dominanted families in power. Finally, mother-in -law and daughter-in-law problemed family had several characters such as diffused boundary, the tendency of alignment and high adjustment. 4)The Results of Question IV : As a result of camparing problemed families with normal families in family structure, there was high adaptability of S.Minuchin's structural theory to the two family groups; the groups of marital problems and those of children problem.

• BMB Reports
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• v.47 no.3
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• pp.167-172
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• 2014

Reactivating the p53 pathway in tumors is an important strategy for anticancer therapy. In response to diverse cellular stresses, the tumor suppressor p53 mediates apoptosis in a transcription-independent and transcription-dependent manner. Although extensive studies have focused on the transcription-dependent apoptotic pathway of p53, the transcription-independent apoptotic pathway of p53 has only recently been discovered. Molecular interactions between p53 and Bcl-2 family proteins in the mitochondria play an essential role in the transcription-independent apoptosis of p53. This review describes the structural basis for the transcription-independent apoptotic pathway of p53 and discusses its potential application to anticancer therapy.

• The Journal of Korean society of community based occupational therapy
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• v.4 no.1
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• pp.59-73
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• 2014

Objective : The purpose of this study is to understand Lived Experience of Suffering for family of victim with Sewol-ho ferry accident and to suggest the necessity of mental health occupational therapy regarding of psychological trauma of family of victim. Methods : This study was applied with Parse's Human becoming research method to recognize experience pain for 5 objects losing family with with Sewol-ho ferry accident. According to Parse's research mothod, secondary data, documentary video about experience pain of family of victim with Sewol-ho ferry accident was selected and analyzed. Results : Three core concept for lived experience of suffering of family with victim with Sewol-ho ferry accident as below statements. 1. Despair and sadness losing family, 2. Impotent feeling and guilty conscience breaking down daily life, 3. Seeking relief from suffering for remaining family. Although there were extreme impotent feeling of losing family with Sewol-ho ferry accident, structural conversion presented as process with denial reality which do not want to accept a death in the family and standing for remaining family. The conceptual integration was expressed to powering from valuing and languaging to connection-separation, revealing-concealingl. Conclusion : Family of victim with Sewol-ho ferry accident is losing meaning of life the goal of life with impotent feeling, despair and depression. It is urgently needed for mental health occupational therapy program to restore disruptive everyday activity and participation in community by developing occupational therapy program through meaningful occupation to family of victim.

• BMB Reports
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• v.48 no.2
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• pp.81-90
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• 2015

p73 is a structural and functional homologue of the p53 tumor suppressor protein. Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive genes, conferring its tumor suppressive activity. In addition, p73 has unique roles in neuronal development and differentiation. The importance of p73-induced apoptosis lies in its capability to substitute the pro-apoptotic activity of p53 in various human cancer cells in which p53 is mutated or inactive. Despite the great importance of p73-induced apoptosis in cancer therapy, little is known about the molecular basis of p73-induced apoptosis. In this review, we discuss the p73 structures reported to date, detailed structural comparisons between p73 and p53, and current understanding of the transcription-dependent and -independent mechanisms of p73-induced apoptosis.

• Journal of the Korean Home Economics Association
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• v.42 no.3
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• pp.179-193
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• 2004

The purpose of this study was to develop the Family System Diagnosis Scale and to examine its reliability and validity. The subscales of the questionnaire included scores on seven constructs. In order to define constructs accurately, a careful review of Minuchin's writings, the writings of other family therapists, and relevant articles on family interaction was undertaken. A pool of 150 items was given to eight family counselors along with a description of Minuchin' s concepts. The counselors were asked to choose the category each statement fit and to rate the degree of fit using the 3-point scale. Using exploratory factor analysis, confirmatory factor analysis and Linear Structural Relationship(LISREL), six subdimensions of individuation and 55 items of FSDS were identified; enmeshmen disengagement(16 items), parent coalition generational coalition(6 items), flexibility rigidity(5 items), spouse conflict resolved unresolved(8 items), mother-child cohesion estrangement(10 items), father-child cohesion estrangement(10 items). 356 adolescents(ages 13∼18), 356 fathers, 356 mothers in Seoul, Busan, Dague, Incheun, Dajeun, Ulsan, and Kwangju were completed the Family System Diagnosis Scale(FSDS). The reliability of the scale was calculated by Cronbach's a Coefficient and the total a = .94 and the calculation for each factor was .87, .60, .77, .80 and .79 respectively.

• Journal of the Korean Home Economics Association
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• v.42 no.5
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• pp.145-160
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• 2004

The purpose of this study was to explore family perception of adolescence through the Kinetic Family Drawing (KFD), and to explore its relation with the family system. The Kinetic Family Drawing (KFD) and Family System Diagnosis Scale (FSDS) were administered to 356 adolescent children. Data were analyzed using the regression analysis and the discriminant analysis. The results were as follows: First, there was a significant difference among the KFD family adaptability variables of boys' KFD and the flexibility and rigidity variables of the FSDS in the family relationship. For example, That is; for sons', it means that if there is a greater the satisfaction for their family in their drawings, then the family relationship will be more flexible. Especially with the son's KFD, there was an indication that if there is a greater the activity level of the self, then he has more flexibility in his family relationship. Second, there is a significant difference in the relationship between the KFD family hierarchy variables of girls' KFD and the parent coalition·cross-generational triads variable of the FSDS. For girls 'KFD, the result of this study indicated that when there is a greater the distance between the father figure and the child figure, the cross-generational triads we greater.

• Journal of Digital Convergence
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• v.11 no.9
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• pp.239-246
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• 2013

The purpose of this study was to identify the effects of family resilience on the positive attitudes toward a children with disabilities of non-disabled siblings. For this purpose, a survey data was collected from 110 siblings with disabled children. The general characteristics of the parent questionnaire, and the general characteristics of a child with a disability, non-disability sibling's general characteristics, be receptive attitude, consisted of family resilience, and the data were analyzed by frequency analysis, descriptive statistics, t test, ANOVA and regression analysis by SPSS 18.0. Structural equation was used for black AMOS18. The results of the measurement analysis were summarized as follows: 1. family resilience showed positive correlation with positive attitudes toward a children with disabilities of non-disabled siblings. 2. as a result of regression analysis for find out influence of family resilience on the positive attitude of non-disabled siblings, family resilience was statistically significant influence factors, which 50%, 50% explanatory power. In conclusion, these results reinforce the important of considering family context as a contributor to the positive attitudes toward a children with disabilities of non-disabled siblings, so it could be suggested that family resilience needs to be improve.

• Current Research on Agriculture and Life Sciences
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• v.28
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• pp.63-68
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• 2010

The epigenetic therapy of cancers is emerging as an effective and valuable approach to both chemotherapy and the chemoprevention of cancer. The utilization of epigenetic targets that include histone methyltransferase (HMTase), Histone deacetylatase, and DNA methyltransferase, are emerging as key therapeutic targets. SET containing proteins such as the HMTase Setd1b has been found significantly amplified in cancerous cells. In order to shed some light on the histone methyl transferase family, we cloned the Setd1b gene from Mus musculus and build a collection of vectors for recombinant protein expression in E.coli that will pave the way for further structural biology studies. We prospect the role of the Setd1b pathway in cancer therapy and detail its unique value for designing novel anti-cancer epigenetic-drugs.

• Journal of the Korean Society of School Health
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• v.12 no.2
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• pp.243-262
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• 1999

Today, obesity is not recognized as a disease itself but is known to be the indirect cause of much chronic illness. Obesity has an impact on psychological disorders including severe inferiority, damage of body self-image, low self-esteem, personality disorders. The results in an increase of the mortality rate. Therefore, this study attempts to discover and evaluate stressful experience in obese teenagers. For this study, 21 girl students and 19 boy students in Pusan middle or high school located were selected. The data were collected from March to May at 1999. A tape-recorder was used under the permission of the subjects to prevent the loss of spoken information and communication. This study consisted of 563 reponses from girls and 461 responses from boys which were then classified with descriptive expressions and priority classifications. The results generated 72 common elements in girls and 54 common elements in boys. From these elements 24 syntheses of hypothetical definitions and 8 identifications of the structural definitions in both girls and boys were developed. The structural and hypothetical definitions were as follows: The analysis of the data was made through a phenomenological analytic method suggested by Van kamm, which is as follows: 1. Maladjustment to school life; lack of understanding of the teacher, insufficient exercise ability, and a feeling of burden in attending the school obesity program. 2. Conflict in family relationships; lack of understanding from the family, a feeling of alienation. 3. Conflict in friend relationships; lack of understanding among friends, constant comparisons in appearance and body with friends (in girls) and estrangement from friends (in boys). 4. Conflict in acquaintance of the opposite sex; hoping to meet the opposite sex, lack of understanding of boy friends (in girls), feelings of pain, feelings of anxiety (in girls) feelings of burden (in girls) feelings of envy (in boys). 5. Negative body image: shape of body; feelings of pain; feelings of powerlessness; feelings of discomfort, and reception; emotional disorders (in boys), and change of personality (in boys). 6. Health disorder: Physical and psychological discomfort. 7. Feelings of burden in weight control; negative experiences in weight control, interference with family and friends, the difficulty in diet therapy, feelings of burden in exercise (in girls), to be teased by the public through mass media (in boys).