• 대한본초학회지
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• 제21권2호
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• pp.63-75
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• 2006

Objectives : We investigated the effects of Liriopis Tuber on the nervous protection. Methods : We measured the reaction behavior with EPM(Elevated Plus Maxe) and MWM(Morris Water Maze) after applying restraint stress to rats. Also, the degrees of AchE generation were measured with immunohistochemical method in the regions of hippocampus, and the degree of TH generation in the regions of VTA and LC, respectively. Results : 1. As the results of measuring how long EPM which reflects anxiety reaction stayed in the open arm, there was the trend which can suppress anxiety reaction in the MMD+stress group(Liriopis Tuber+stress) but no statistical significance. The counting results how many EPM passed between opened and closed arm showed suppression trend against a physical activity in the saline+stress group but there was no statistical significance. 2. According to the result of MWM, the saline+stress group showed the learning retardation which means increased time arriving at goal compared to ti1e normal group at the second and third day of measurement. On the contrary, a learning retardation was significantly decreased in the MMD+stress group. Among the probe trial test a memory loss occurred in the saline+stress group, meanwhile memory ability was notably increased in the saline-stress group. 3. The degree of TH generation was investigated at the VTA and LC respectively after test animals treated with drug. In the saline+stress group, TH-immunoreactive cells were significantly increased, and these stress-induced TH increases were suppressed in the saline+stress group at the VTA region. However, the saline+stress group did not show any significant difference. 4. the degree of AchE generation was investigated at the CA3 of hippocampus. The saline+stress group showed that AchE-immunoreactive cells were significantly decreased. Those stress-induced reductions of AchE cells were meaningfully recovered in the saline+stress group. Although the cells showed recovery trend in the region of CA1 of hippocampus, statistical significance was not observed. Conclusion : The results of our study indicate that Liriopis Tuber can improve spatial memory ability of rats applied a restraint stress. This improvement of the spatial memory ability is considered to have an efficacy of nervous protection that Liriopis Tuber suppresses the generation of AchE in the hippocampus region and enhances the generation of TH in the VTA.

• 한국안전학회지
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• 제34권1호
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• pp.76-81
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• 2019

In this study, the causes of human error were identified through the survey of the drivers of the three organizations: Seoul Metro, Seoul Metropolitan Rapid Transit Corporation, and Korail. It was started with the aim of finding and eliciting causes in various directions including human factors, job factors, and environmental factors. The Cronbach alpha value was 0.95 for the reliability significance of the stress-induced factors in the operational area. The significance probability for organisational factors was shown to be 0.82, and the significance of the sub-accident experience and the driving skill factors in operation was 0.81 In addition, the analysis results showed that stress-induced in the field of driving is higher than the human factors in the reliability analysis. The results of the analysis confirmed that the reliability of the organizational and operational stress-induced factors was higher than other causes. In order to reduce urban railroad accidents, this paper suggests a method for operating safe urban railroad through the minimization human errors.

• BMB Reports
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• 제51권10호
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• pp.538-543
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• 2018

Pancreatic beta cell destruction and dysfunction induced by cytokines is a major cause of type 1 diabetes. Paraoxonase 1 (PON1), an arylesterase with antioxidant activity, has been shown to play an important role in preventing the development of diabetes in transgenic mice. However, no studies have examined the anti-diabetic effect of PON1 delivered to beta cells using protein transduction. In this study, we expressed the cell-permeable PON1 fused with PEP-1 protein transduction domain (PEP-1-PON1) to investigate whether transduced PEP-1-PON1 protects beta cells against cytokine-induced cytotoxicity. PEP-1-PON1 was effectively delivered to INS-1 cells and prevented cytokine-induced cell destruction in a dose-dependent manner. Transduced PEP-1-PON1 significantly reduced the levels of reactive oxygen species (ROS) and nitric oxide (NO), DNA fragmentation, and expression of inflammatory mediators, endoplasmic reticulum (ER) stress proteins, and apoptosis-related proteins in cytokine-treated cells. Moreover, transduced PEP-1-PON1 restored the decrease in basal and glucose-stimulated insulin secretion induced by cytokines. These data indicate that PEP-1-PON1 protects beta cells from cytokine-induced cytotoxicity by alleviating oxidative/nitrosative stress, ER stress, and inflammation. Thus, PEP-1-mediated PON1 transduction might be an effective method to reduce the extent of destruction and dysfunction of pancreatic beta cells in autoimmune diabetes.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2003년도 Proceedings of the international symposium on the fusion technology
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• pp.272-280
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• 2003

A definite shut-in pressure in hydraulic fracturing techniques is needed for obtaining the correct information on the in-situ stress regimes in rock masses. The relation between the behaviour of hydraulically induced fractures and the condition of remote stress is considered to be major reasons of an ambiguous shut-in pressure in hydraulic fracturing pressure-time history curves. This paper describes the results of a series of numerical analyses carried out using UDEC(Universal Distinct Element Code, Itasca), which is based on the discrete element method, to compare several methods for determining the shut-in pressure during hydraulic fracturing. The fully coupling of hydraulic and mechanical analysis was applied, and the effects of four different discontinuity geometries in numerical modelling have been investigated for this purpose. The effects of different remote stress regimes and different physical properties on hydraulic fracture propagation have been also analyzed. Several methods for obtaining shut-in pressure from the ambiguous shut-in curves have been applied to all the numerical models. The graphical intersection methods, such as (P vs. t) method, (P vs. log(t)) method, (log(P) vs. log(t)) method, give smaller values of the shut-in pressure than the statistical method, (dP/dt vs. P). Care should be taken in selecting a method for shut-in pressure, because there can be existed a stress anomaly around the wellbore and fracturing from the wellbore by a constant flow rate may have a more complicate mechanism.

• 대한치과보철학회지
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• 제45권2호
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• pp.274-282
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• 2007

Statement of problem: Main consideration was given to the stresses at the site of implant entry into the cortical bone at the alveolar crest. As a suspectible factor affecting the occurrence of stress concentrations, the contact angle between the implant and the alveolar crest bone was addressed. Purpose: The purpose of this study is to evaluate angles between the alveolar crest bone and the implant effect on the implant crestal area induced stresses using a finite element method. Material and methods: Cylindrically shaped, standard size ITI implants entering into alveolar crest with four different contact angles of 0, 15, 30, and 45 deg. with the long axis of the implant were axisymmetrically modelled. Alterations of stresses around the implants were computed and compared at the cervical cortical bone. Results and conclusion: The results demonstrated that regardless of the difference of the implant/alveolar crest bone contact angles, stress concentration occurred at the cervical bone and the angle differences led to insignificant variations in stress level.

• 한국세라믹학회지
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• 제41권8호
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• pp.578-581
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• 2004

본 연구에서는 Palladium-Metal Induced Lateral Crystallization(Pd-MILC)과 Nickel-Metal Induced Lateral Crystallization (Ni-MILC)을 동시에 사용하여 Ni-MILC의 결정화 속도를 향상시키는 방법을 제안하였다 이 방법을 사용하여 기존의 Ni-MILC 보다 거의 4배나 빠른 결정화 속도인 15 $\mu$m/h를 얻을 수 있었다. Ni과 Pd의 간격이 좁을수록 Ni-MILC의 결정화 속도가 더 빨라졌으며 Pd두께, Ni두께에, 비정질 실리콘 너비와는 큰 의존관계가 없었다. 하지만 Pd이 Ni에 의해 덮혀져 Pd-MILC가 일어나지 못하는 경우에는 이러한 현상이 발견되지 않았다. 이는 Pd물질 그 자체가 Ni-MILC를 향상시키는 것이 아니라 Pd MILC가 진행되면서 발생하는 tensile stress에 의해 향상되는 것임을 의미한다. 이와 같은 현상들을 새로운 MILC mechanism으로 설명하였다.

• International Journal of Naval Architecture and Ocean Engineering
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• 제12권1호
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• pp.552-568
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• 2020

After long-term service in deep ocean, pipelines are usually suffered from corrosions, which may greatly influence the Vortex-Induced Vibration (VIV) behavior of pipes. Thus, we investigate the VIV of defective pipelines. The geometric nonlinearity due to large deformation of pipes and nonlinearity in vortex-induced force are simulated. This nonlinear vibration system is simulated with finite element method and solved by direct integration method with incremental algorithm. Two kinds of defects, corrosion pits and volumetric flaws, and their effects of depth and range on VIV responses are investigated. A new finite element is developed to simulate corrosion pits. Defects are found to aggravate VIV displacement response only if environmental flow rate is less than resonance flow rate. As the defect depth grows, the stress responses increase, however, the increase of the defect range reduces the stress response at corroded part. The volumetric flaws affect VIV response stronger than the corrosion pits.

• 마이크로전자및패키징학회지
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• 제10권1호
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• pp.25-29
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• 2003

이 논문은 고분자 박막이 주변으로부터 수분을 흡수하게 될 때, 탄성 기판과 점탄성 박막의 계면 모서리에서 발생하는 응력 특이성을 다루고 있다. 계면에서 발생하는 응력을 조사하기 위해서 경계 요소법이 사용되고 있다. 주어진 점탄성 모델에 대해서 특이 차수가 수치적으로 계산된다. 이 논문에서 고려하고 있는 점탄성 모델에 대해서, 응력특이계수는 시간이 경과함에 따라 이완되고 있으나 특이 차수는 증가되고 있음을 보여준다.

• Biomaterials and Biomechanics in Bioengineering
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• 제2권4호
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• pp.197-206
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• 2015

This paper presents three-dimensional finite element method analyses of the distribution of equivalents stress of Von Mises. Induced around a cavity located in the bone cement polymethylmethacrylate (PMMA). The presences and effect of its position in the cement was demonstrated, thus on the stress level and distribution. The porosity interaction depending on their positions, and their orientations on the interdistances their mechanical behaviour of bone cement effects were analysed. The obtained results show that micro-porosity located in the proximal and distal zone of the prosthesis is subject to higher stress field. We show that the breaking strain of the cement is largely taken when the cement, containing the porosities very close adjacent to each other.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 추계학술대회논문집A
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• pp.470-474
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• 2000

Cold expansion of fastener holes is a mechanical process widely used in the aerospace industry. This treatment leads to an improvement of fatigue behavior due to the developed compressive residual stresses on the hole surface. The residual stress profile depends on the parameters of cold expansion, which are, expanding rate, inserting direction of mandrel, material properties etc. and the method to confirm this profile is only measurement by X-ray diffractometer. Despite its importance to aerospace industries, little attention has been devoted to the accurate modelling of the process. In this paper, Two-dimensional axisymmetric finite element simulations have been conducted for the cold expansion in an aluminium plate in order to predict the magnitude and distribution of the residual stress and plastic deformation. Maximum compressive residual stress could be increase about 7 percent using the 2-step cold expansion method.