• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.6
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• pp.800-808
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• 2015

In this study, gastritis inhibitory substance was ethanol-extracted from Saururus chinensis in order to examine the effect as a part of natural bioactive substance research. In an oral administration experiment, S. chinensis was administered at doses of 0.25 g/kg B.W. to 2 g/kg B.W., resulting in stabilization at 1.5 g/kg B.W. and an $LD_{50}$ of 1.81 g/kg B.W. In a chronic toxicity experiment, 0.5 g/kg B.W. of S. chinensis was administered for 13 weeks, but toxicity was not observed. S. chinensis ethanol-extracts were administered at a concentration of 250 or 500 mg/kg B.W. before induction of gastritis. Gastrorrhagia, stomach edema, cytokine production, and cell damage were reduced in a concentration-dependent manner. Therefore, S. chinensis ethanol extracts inhibit cell damage by stress-induced hemorrhagic gastritis in a concentration-dependent manner via inhibition of cytokine expression.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.3 no.1
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• pp.84-88
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• 2000

Secondary peptic ulceration and gastritis have been known to be associated with stress, exogenous agents, drugs or infection. Salicylate (aspirin) ingestion has been known to be associated with increased incidence of gastric ulcer and more frequently as the cause of hemorrhagic gastric erosions and gastritis. Some medications such as tetracyclines and iron preparations have been associated with ulceration of the gastrointestinal tract. Chemotherapeutic agents including cytoxan and methotrexate also have been implicated in the development of mucosal and gastrointestinal ulcers. We have experienced two cases of hemorrhagic gastric ulcers due to creosote ingestion in a 13 month and a 5 year old boys. Creosote is a main component of one of the popular digestives, Jungrohwan in Japan and Korea.

• Journal of Pharmacopuncture
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• v.18 no.1
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• pp.72-78
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• 2015

Objectives: The stomach is a sensitive digestive organ that is susceptible to exogenous pathogens from the diet. In response to such pathogens, the stomach induces oxidative stress, which might be related to the development of both gastric organic disorders such as gastritis, gastric ulcers, and gastric cancer, and functional disorders such as functional dyspepsia. This study was accomplished to investigate the effect of Ganoderma lucidum pharmacopuncture (GLP) on chronic gastric ulcers in rats. Methods: The rats were divided into 4 groups of 8 animals each: the normal, the control, the normal saline (NP) and the GLP groups. In this study, the modified ethanol gastritis model was used. The rats were administrated 56% ethanol orally every other day. The dose of ethanol was 8 g/kg body weight. The normal group received the same amount of normal saline instead of ethanol. The NP and the GLP groups were treated with injection of saline and GLP respectively. The control group received no treatment. Two local acupoints CV12 (中脘) and ST36 (足三里) were used. All laboratory rats underwent treatment for 15 days. On last day, the rats were sacrificed and their stomachs were immediately excised. Results: Ulcers of the gastric mucosa appeared as elongated bands of hemorrhagic lesions parallel to the long axis of the stomach. In the NP and GLP groups, the injuries to the gastric mucosal injuries were not as severe as they were in the control group. Wound healings of the chronic gastric ulcers was promoted by using GLP and significant alterations of the indices in the gastric mucosa were observed. Such protection was demonstrated by gross appearance, histology and immunehistochemistry staining for Bcl-2-associated X (BAX), B-cell lymphoma 2 (Bcl-2) and Transforming growth factor-beta 1 (TGF-${\beta}1$). Conclusion: These results suggest that GLP at CV12 and ST36 can provide significant protection to the gastric mucosa against an ethanol induced chronic gastric ulcer.