• 한국전산구조공학회논문집
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• 제25권5호
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• pp.405-411
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• 2012

회전익항공기의 연료셀 내부는 연료보관 및 연료를 엔진으로 공급하기 위한 배관과 구성품들이 배치되어 있다. 특히, 기동헬기는 전장에서 사용되는 헬기로써, 수 km 고도에서 비행하는 고정익기보다 비행고도가 낮기 때문에 피탄될 가능성이 높다. 따라서, 항공기의 생존성을 극대화하기 위해서는 피탄시 유체내부 상승압력에 의한 내부 구성품들이 받는 영향성을 검토하여 설계되어야 함은 주지의 사실이다. 그러나 내탄시험은 연료셀 자체의 제작비용 및 준비기간이 상당히 소요되고, 실탄 사용에 따른 시험수행의 제약 때문에 수치모사를 통한 관련 데이터의 확보가 필요하다. 이를 위해 본 연구에서는 유체-구조 수치모사 프로그램인 Autodyn을 이용하여 회전익항공기 연료셀의 내탄 수치모사를 수행하여, 피탄 후 연료셀 내부에서의 탄 거동을 분석하고 유체내부의 압력과 연료 셀 자체의 등가응력을 평가하였다.

• 한국가금학회지
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• 제34권4호
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• pp.301-318
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• 2007

Marek's disease (MD) is a highly contagious lymphoproliferative disease of poultry caused by the oncogenic herpesvirus designated Marek's disease virus (MDV). MD has a worldwide distribution and is thought to cause an annual loss over US$ one billion to the poultry industry. Originally described as a paralytic disease, today MD is mostly manifested as an acute disease with tumors in multiple visceral organs. MD is controlled essentially by the widespread use of live vaccines administered either in ovo into 18-day-old embryos or into chicks immediately after they hatch. In spite of the success of the vaccines in reducing the losses from the disease in the last 30 years, MDV strains have shown continuous evolution in virulence acquiring the ability to overcome the immune responses induced by the vaccines. During this period, different generations of MD vaccines have been introduced to protect birds from the increasingly virulent MDV strains. However, the virus will be countered each new vaccine strategy with ever more virulent strains. In spite of this concern, currently field problem from MD is likely to be controled by strategy of using bivalent vaccine. But, potential risk factors for outbreak of MD are still remained in this condition. The major factors can be thought that improper handling and incorrect administration of the vaccine, infection prior to establishment of immunity, suppression of immune system by environmental stress and outbreaks of more virulent MDV strain by using vaccine and genetic resistance of host.

• Journal of Ginseng Research
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• 제44권4호
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• pp.527-537
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• 2020

Panax ginseng, a medicinal plant, has been used as a blood-nourishing tonic for thousands of years in Asia, including Korea and China. P. ginseng exhibits adaptogen activity that maintains homeostasis by restoring general biological functions and non-specifically enhancing the body's resistance to external stress. Several P. ginseng effects have been reported. Korean Red Ginseng, in particular, has been reported in both basic and clinical studies to possess diverse effects such as enhanced immunity, fatigue relief, memory, blood circulation, and anti-oxidation. Moreover, it also protects against menopausal symptoms, cancer, cardiac diseases, and neurological disorders. The active components found in most Korean Red Ginseng varieties are known to include ginsenosides, polysaccharides, peptides, alkaloids, polyacetylene, and phenolic compounds. In this review, the identity and bioactivity of the non-saponin components of Korean Red Ginseng discovered to date are evaluated and the components are classified into polysaccharide and nitrogen compounds (protein, peptide, amino acid, nucleic acid, and alkaloid), as well as fat-soluble components such as polyacetylene, phenols, essential oils, and phytosterols. The distinct bioactivity of Korean Red Ginseng was found to originate from both saponin and non-saponin components rather than from only one or two specific components. Therefore, it is important to consider saponin and non-saponin elements together.

• 한국전산구조공학회논문집
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• 제21권4호
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• pp.347-355
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• 2008

본 연구에서는 수평하중을 받는 깊은 기초에서 나타나는 지반과 기초의 상호작용을 분석할 목적으로 전통적인 소성이론을 응용하여 개발한 단자유도의 매크로요소 모델을 제시하였다. 제시한 매크로요소 모델은 지반에 매립된 깊은 기초가 수평하중을 받을 때 지반과 기초사이에 발생하는 응력의 제 성분을 각각 모델링하고 합성함으로써 구성하였는데, 이는 기초와 지반의 상호작용을 단순 스프링으로 모델링하는 기존의 방법에 비해 상호작용에 관련한 응력을 성분별로 분리하여 제공하는 장점이 있다. 본 연구에서는 상호작용과 관련한 응력의 제 요소를 마찰력과 측압저항으로 크게 분류하고 각 요소를 소성이론을 이용하여 모델링하였으며, 최종적으로 이들을 병렬로 조합하는 방식으로 매크로요소를 구성하였다. 제시한 매크로요소를 이용하여 점성토에 매립한 깊은 기초가 수평하중을 받는 경우를 해석한 결과 기초의 전체적인 거동과 더불어 상호작용 매크로요소를 구성하는 각 요소들로부터 상호작용 음력의 제 요소들을 분석해 냄으로써 기존 모델에 비해 개선된 결과를 얻을 수 있었다.

• 대한한방부인과학회지
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• 제19권2호
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• pp.92-106
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• 2006

Purpose : To address the ability of Olibanum to induce cell death, we investigated the effect of olibanum on cell apoptosis. Twenty-four hours later, apoptosis occurred following olibanum exposure in a dose-dependent manner. Methods : We culture HeLa cell which is human metrocarcinoma cell in D-MEM included 10% fetal bovine serum(Hyclone Laboratories) below $37^{\circ}C$, 5% CO2. Then we observed apoptosis of log phage cell which is changed cultivation liquid 24 Hours periodically. Results : The treatment of BAPTA-AM regulated olibanum-induced apoptosis in HeLa human cervical carcinoma cells. The 24 hr-earlier -thapsigargin-pretreated cell showed the resistance against olibanum-induced apoptosis and the Ru360-mitochondrial uniporter-inhibited olibanum-induced apoptosis, too. It means that olibanum leads to the accumulation of calcium and the resultant apoptosis in HeLa cells. Immunoblotting data also shows that the expression of GRP78, ER stress marker protein, was induced by the olibanum. Bcl-2, anti-apototic protein, was decreased and that the expression of Bax, pro-apoptotic protein, was increased by the addition of olibanum. Interestingly, the olibanum increased the activity of caspase-8 as well as calpain cysteine pretense in HeLa cervical carcinoma cells. Calpain inhibitor-calpastatin as well as caspase-8C/A expression abrogated olibanum-induced apoptosis in the carcinoma cells. The inhibition of caspase-8 regulated olibanum-induced calpain activation but the inhibition of calpain did not have any effect on the caspase-8 activation in HeLa human cervical carcinoma cells. Conclusion : We conclude that olibanum induces the accumulation of calcium and the resultant apoptosis in which caspase-8 and calpain are involved.

• 대한조선학회논문집
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• 제47권2호
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• pp.150-162
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• 2010

Assessment of hydrodynamic performance of a ship hull has been focused on a model ship rather than a full-scale ship. In order to design the propeller of a ship, model-scale wake is often extended to full-scale based upon an empirical method or designer's experience, since wake measurement data for a full-scale ship is very rare. Recently modern CFD tools made some success in reproducing wake field of a model ship, which implicates that there are some possibilities of the accurate prediction of full-scale wakes. In this paper firstly the evaluation of model-scale wake obtained by Fluent package was performed. It was found that CFD calculation with the Reynolds-stress model (RSM) provided much better agreement with wake measurement in the towing tank than with the realizable k-$\varepsilon$ model (RKE). In the next full-scale wake was calculated using the same package to find out the difference between model and full-scale wakes. Three hull forms of KLNG, KCS, KVLCC2 having measurement data open for the public, were chosen for the comparison of resistance, form factor, and propeller plane wake between model ships and full-scale ships.

• Archives of Pharmacal Research
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• 제29권2호
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• pp.159-164
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• 2006

The protective properties of Satureja hortensis L. on the rat lymphocytes DNA lesions were tested. Lymphocytes were isolated from blood samples taken from healthy rats. DNA breaks and resistance to $H_{2}O_{2}$-induced damage were measured with the comet assay. Rat lymphocytes were incubated in S. hortensis ethanolic extract (SHE) (0.05, 0.1, 0.5, 1.0, and 2.5 mg/mL), essential oil (SHEO)(0.05, 0.1, 0.5, 1.0, and 2.5 ${mu}L/mL$), $H_{2}O_{2}$ (50, 100, and 200 ${\mu}M$), a combination of $H_{2}O_{2}$ (200 mM) with either SHE (1.0, 2.5 mg/mL) or SHEO (1.0, 2.5 ${\mu}L/mL$) at $4^{\circ}C$ for 30 min, and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions. Treatment of rat lymphocytes with SHE or SHEO resulted in significant reduction of $H_{2}O_{2}$-induced DNA damage compared to controls. SHE exhibited a significant (P<0.01) inhibitory effect on oxidative DNA damage at 2.5 mg/mL. SHEO (1.0 and 2.5 ${\mu}L/mL$) also showed significant inhibitory effects (P<0.01) on $H_{2}O_{2}$ induced chromosomal damage. In conclusion both the ethanolic extract and the essential oil of the plant reversed the oxidative damage to rat lymphocytes induced by hydrogen peroxide.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 춘계 학술발표회 제20권1호
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• pp.597-600
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• 2008

본 연구는 보수보강재료로 사용되고 있는 경질형 FRP의 문제점인 바탕면과의 부착력 부족에 의한 계면박리를 해결하고자 연질형의 불포화폴리에스테르 수지를 사용한 연질형 FRP와 바탕면에 정방형 홈("+"자형) 컷팅 기술을 이용한 노출형 방수공법의 특징을 중심으로 연구하고자 한다. 본 공법의 특징은 연질형 FRP 수지에 의한 콘크리트바탕면과의 일체화 거동과 유리섬유 보강에 의한 피로응력의 분산과 강도보강이며, 정방형 홈 컷팅 기술에 의한 바탕콘크리트의 균열발생 대응과 부착안전성 향상에 관하여 중점 고찰하였다. 연구결과 연질형 FRP를 노출방수층으로 적용 시 부풂 대응과 균열대응력 및 부착안전성 향상을 기대 할 수 있을 것으로 판단된다.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 춘계 학술발표회 제20권1호
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• pp.705-708
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• 2008

본 연구에서는 화재시 터널 콘크리트의 안전성 확보를 목적으로, 내화공법 변화에 따른 내화특성을 분석한 것으로서, 그 결과를 요약하면 다음과 같다. RABT온도가열곡선에 따른 내화특성으로, 플레인 콘크리트는 초기의 극심한 고온에 의해 심한 폭렬현상이 발생하였고, 내화공법변화에 따라서는, 유기섬유를 혼입하는 방식과 보드방식의 경우는 폭렬이 방지되는 것으로 나타났으며, 스프레이 방식의 경우는 보강재인 메탈라스가 뿜칠재와 같이 탈락되면서 열응력 등에 의해 구조체 콘크리트가 철근이 노출되는 등 100mm이상 깊이의 심한 폭렬이 발생하였다. RWS 온도가열곡선에 따른 내화특성으로, 유기섬유를 혼입한 경우는 콘크리트 표면이 약 5mm이내 깊이의 융해현상이 발생하였고, 스프레이 방식의 경우는 뿜칠재가 박리되어 구조체 콘크리트가 철근이 노출되는 등 100mm이상 깊이의 심한 폭렬이 발생하였으며, 보드방식의 경우도 보드가 고온에 융해되면서 구조체 콘크리트가 고온에 직접 노출되어 전면적으로 탈락현상이 발생하였는데, 이와같은 특고온 가열조건에서는 특별한 내화대책수립이 필요한 것으로 사료된다.

• 한국해양공학회지
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• 제30권6호
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• pp.505-519
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• 2016

If the seabed is exposed to high waves for a long period, the pore water pressure may be excessive, making the seabed subject to liquefaction. As the water pressure change due to wave action is transmitted to the pore water pressure of the seabed, a phase difference will occur because of the fluid resistance from water permeability. Thus, the effective stress of the seabed will be decreased. If a composite breakwater or other structure with large wave reflection is installed over the seabed, a partial standing wave field is formed, and thus larger wave loading is directly transmitted to the seabed, which considerably influences its stability. To analyze the 3-D dynamic response characteristics of the seabed around a composite breakwater, this study performed a numerical simulation by applying LES-WASS-3D to directly analyze the wave-structure-soil interaction. First, the waveform around the composite breakwater and the pore water pressure in the seabed and rubble mound were compared and verified using the results of existing experiments. In addition, the characteristics of the wave field were analyzed around the composite breakwater, where there was an opening under different incident wave conditions. To analyze the effect of the changed wave field on the 3-D dynamic response of the seabed, the correlation between the wave height distribution and pore water pressure distribution of the seabed was investigated. Finally, the numerical results for the perpendicular phase difference of the pore water pressure were aggregated to understand the characteristics of the 3-D dynamic response of the seabed around the composite breakwater in relation to the water-structure-soil interaction.