• Ocean and Polar Research
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• 제36권2호
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• pp.145-156
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• 2014

Macrobenthic biodiversity in the rocky intertidal areas of the Tae-an region, Republic of Korea, has decreased since the Hebei Spirit oil spill in December 2007. We aimed to investigate ecological roles of Pacific oyster (Crassostrea gigas) because recruitment and growth of oysters are critical to the recovery of damaged rocky shore ecosystem. We surveyed two sites monthly: natural rocky substrate and farming substrate, from July 2012 to January 2013 to identify and compare the changes in macrobenthic fauna. The abundance of young oysters was higher at the natural site. On the other hand, the mean height of oyster on the farming substrate was more than twice as great. The abundance of oyster at the natural site increased until October and then continuously decreased until end of study period. However, the abundance of oyster at the farming site constantly decreased from the beginning of study period. These different growth patterns might be attributable to spatial competition between oyster and a barnacle species (Balanus albicostatus) and environmental factors. At the natural site, physical stress factors including dramatic temperature changes and desiccation a few of the major factors limiting growth during aerial exposure. In addition, motile macrobenthos could be detrimental to oysters because they interrupt filter-feeding activities and hence hamper the growth of oysters. We show the higher recruitment of oysters at the natural site and healthy growth in the farming substrate are due to complicated differences in physical and biological stress factors.

• BMB Reports
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• 제41권5호
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• pp.388-393
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• 2008

The Pphsc70 (heat shock cognate 70) gene was isolated from the endoparasitoid Pteromalus puparum and then characterized. The full-length cDNA was 2204 base pair (bp) and contained a single 1968 bp ORF that encoded a polypeptide of 656 amino acids with a predicted molecular mass of 71.28 kDa. Phylogenetic analysis based on Hsc70 amino acid sequences from fifteen insect species agreed with the present phylogeny. In addition, genomic DNA confirmed the presence of three introns located at the coding region as well as the 5'UTR. A significant elevation of Pphsc70 expression was observed following heat treatment, however, continued exposure to heat shock or recovery caused the expression of induced mRNA to gradually decline to levels that were significantly lower than those of control pupae (P < 0.05). In addition, a significant increase was observed in the emergence rate of pupae that were preheated at $40^{\circ}C$ and then exposed to $50^{\circ}C$ for 1 h when compared with the pupae that were not preheated, but instead directly exposed to $50^{\circ}C$. Taken together, these results revealed that exposure to gradually increasing temperatures can enhance an insects thermo-tolerance.

• 한국어병학회지
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• 제7권1호
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• pp.53-62
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• 1994

본 실험에서는 잉어의(Cyprinus carpio)의 혈액지수 및 혈장화학성분에 대한 lidocaine의 효과를 조사하였다. Lidocaine은 저농도군(100 및 200ppm)에서는 조사된 모든 혈액지수 및 혈장화학성분에 대하여 대조군에 비해 유의성 있는 효과를 나타내지 않았으나 고농도군(300 및 400 ppm)에서는 혈색소농도(hemoglobin concentration), 총단백량(total protein value) 그리고 GOT 및 GPT의 활성에 대해서는 유의성 있는 변화를 일으키지 않았고, 적혈구수(RBC count), 헤마토크리트(hematocrit), 혈중포도당농도 및 LDH활성은 대조군에 비해 현저히 증가시켰다. 그리고 이들 값의 증가는 적어도 60분 이상 유지되었다. 이상의 결과들을 종합하여 보면 lidocaine은 일반적으로 어류에 대하여 독작용은 나타내지 않으나 고농도에서는 어류에 대하여 마취효과 뿐만 아니라 그 자체가 스트레스 인자로 작용하여 어류체내에 여러가지 생리적 변화를 일으킨다고 사료된다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2007년도 Proceedings of The Convention of The Korean Society of Applied Pharmacology
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• pp.147-153
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• 2007

Central to developing new treatment strategies for late onset sporadic Parkinson's disease (PD) and early onset familial PD is resolving the enigma of the specific vulnerability exhibited by substantia nigra dopamine (DA) neurons despite multiple risk factors. Neuropathological evidence from both human and experimental models of PD firmly supports a significant role for oxidative stress (OS) and mitochondrial dysfunction in the death of nigral DA neurons. Largely unknown are the genes underlying selective susceptibility of nigral DA neuron to OS and mitochondrial dysfunction and how they effect nigral DA cell death. To overcome the paucity of nigral DA neurons as well as the dilution effect of non-DA cells in brain tissues, we have developed wild type DA cell line model, SN4741 and mutant DJ-1 (-/-) DA cells, appropriate for microarray analysis and differential mitochondrial proteomics. Mutations in the DJ-1 gene (PARK7), localized in cytoplasm and mitochondria, cause autosomal recessive early onset PD. Through microarray analysis using SN4741 cells followed by validation tests, we have identified a novel phylogenically conserved neuroprotective gene, Oxi-a, which is specifically expressed in DA neurons. The knockdown of the gene dramatically increased vulnerability to as. Importantly as down-regulated the expression level of the gene and recovery of its expression via transient transfection exerted significant neuroprotection against as insult. We also have identified altered expression of mitochondrial proteins and other familial PD genes in DJ-1 (-/-) mutant cells by differential mitochondrial proteomics. In DJ-1 (-/-) cells the knockdown of the other familial PD genes (Parkin and PINK1) dramatically increased susceptibility to as. Thus, further functional characterization of the Oxi-$\alpha$ gene family and the mitochondrial alteration in the DJ-1 (-/-) cell model will provide the rationale for the neuroprotective therapy against both sporadic and familial PD.

• 보건의료산업학회지
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• 제6권2호
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• pp.211-217
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• 2012

To identify health behavior of Peptic ulcer patients among all employees in Korea and examine relevant factors to present basic data for improving Korean adult employees' health conditions and quality of living, 3,515 employees aged 20 to 69 were sampled from the group that responded to the question concerning the presence of Peptic ulcer in the fourth Korea National Health and Nutrition Examination Survey for the third year (2009). After logistic regression analysis was carried out to see the effects of working conditions, harmful factors, shift work, stress perception, and experience of depression on the presence of Peptic ulcer, it was found that unsafe or unpleasant working conditions led to higher risk of getting Peptic ulcer, that flexible workers were more likely to get Peptic ulcer, and that depression or stress perception exerted almost no effect on Peptic ulcer. With the increase in the number of flexible workers, increasingly more interest is taken in the effects of shift work on health; occupational Peptic ulcer tends to become chronic as compared with the condition in the general population and reappear even after recovery in many cases; therefore, it is necessary to take special management measures by estimating the number of those at a risk of getting Peptic ulcer and by finding out its risk factors.

• Fibers and Polymers
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• 제4권3호
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• pp.114-118
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• 2003

The prepolymer and the final polyurethane (PU) block copolymer were synthesized by reacting 4,4-methylene bis(phenylisocyanate) with poly(tetramethylene glycol) and the prepolymer with 1,4-butanediol as a chain extender, respectively, to investigate the relation between phase separation and it's resulting properties. According to FT-IR data, the phase separation of hard and soft segments in the prepolymer and the PU block copolymer grew bigger by increasing the hard segment content, and the PU showed more dominant phase separation than the prepolymer. The heat of fusion due to soft segments decreased in both the prepolymer and the PU by increasing the hard segment content, whereas the heat of fusion due to hard segments increased in the PU did not appear in the prepolymers. The breaking stress and modulus of the prepolymer increased by increasing the hard segment content, and the elongation at break decreased gradually, and the PU showed the highest breaking stress and modulus at 58% hard segment content. However, the best shape recovery of the PU was obtained at 47% hard segment content due to the existence of proper interaction among the hard segments for shape memory effect. Consequently, the mechanical properties and shape memory effect of the PU were influenced by the degree of phase separation, depending on the incorporation of chain extender as well as the hard segment content.

• 한국실내디자인학회논문집
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• 제23권4호
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• pp.220-230
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• 2014

As office workers tend to spend more time indoors nowadays, the importance of physical environments has been emphasized. Those who work longer hours in the office are likely to get more stress from the environments. A number of studies have proved that the plants (natural elements) were effective in relieving stress. Therefore, it is concluded that interior landscape is effective on enhancing the psychological wellbeing of office workers. The purposes of this study were as follows: (1) to determine the best modulized designs through rating psychological indices, and (2) to prove its effectiveness by applying those designs onto actual office environments. This study was conducted from April, 2012 to November, 2012. The subjects of the study were comprised of 154 juniors and seniors in Seoul Women's University. They are university students who are seeking jobs upon graduation. To this end, field investigations, surveys, and literature reviews were conducted. The results of the study indicated as follows: First, the most optimal models for psychological wellbeing have been derived. Second, the interior landscape had a positive effect on the psychological wellbeing of the office workers. On the basis of these findings, interior landscape with greens plays a big role in promoting the psychological wellbeing of the office workers. Also, its effect can be maximized when modulized design is combined with interior landscape. The limit of this study lies in its simplicity of design elements as emotional design aspects were quantified for statistical processing. In the near future, further studies focusing on various design elements need to be carried out. To sum up, the researcher hopes that these findings contribute to psychological recovery of the office workers, and interior landscape becomes more prevalent in the workplace.

• 한국안전학회지
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• 제35권5호
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• pp.121-127
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• 2020

Since the Fukushima nuclear accident in 2011, the public were concerned about the safety of Nuclear Power Plants (NPPs) in extreme natural disaster situations, such as earthquakes, flooding, heavy rain and tsunami, have been increasing around the world. Accordingly, the Stress Test was conducted in Europe, Japan, Russia, and other countries by reassessing the safety and response capabilities of NPPs in extreme natural disaster situations that exceed the design basis. The extreme natural disaster can put the NPPs in beyond-design-basis conditions such as the loss of the power system and the ultimate heat sink. The behaviors and capabilities of NPPs with losing their essential safety functions should be measured to find and supplement weak areas in hardware, procedures and coping strategies. The Loss of Ultimate Heat Sink (LUHS) accident assumes impairment of the essential service water system accompanying the failure of the component cooling water system. In such conditions, residual heat removal and cooling of safety-relevant components are not possible for a long period of time. It is therefore very important to establish coping strategies considering all available equipment to mitigate the consequence of the LUHS accident and keep the NPPs safe. In this study, thermal hydraulic behavior of the LUHS event was analyzed using RELAP5/Mod3.3 code. We also performed the sensitivity analysis to identify the effects of the operator recovery actions and operation strategy for charging pumps on the results of the LUHS accident.

• Journal of Power Electronics
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• 제19권4호
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• pp.846-857
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• 2019

Voltage step-down converters are very popular in distributed power systems, voltage regular modules, electric vehicles, etc. However, a high step-down voltage ratio is required in many applications to prevent the traditional buck converter from operating at extreme duty cycles. In this paper, a series capacitor interleaved buck converter with a soft switching technique is proposed. The DC voltage ratio of the proposed converter is half that of the traditional buck converter and the voltage stress across the one main switch and the diodes is reduced. Moreover, by paralleling the series connected auxiliary switch and the auxiliary inductor with the main inductor, zero voltage transition (ZVT) of the main switches can be obtained without increasing the voltage or current stress of the main power switches. In addition, zero current turned-on and zero current switching (ZCS) of the auxiliary switches can be achieved. Furthermore, owing to the presence of the auxiliary inductor, the turned-off rate of the output diodes can be limited and the reverse-recovery switching losses of the diodes can be reduced. Thus, the efficiency of the proposed converter can be improved. The DC voltage gain ratio, soft switching conditions and a design guideline for the critical parameters are given in this paper. A loss analysis of the proposed converter is shown to demonstrate its advantages over traditional converter topologies. Finally, experimental results obtained from a 100V/10V prototype are presented to verify the analysis of the proposed converter.

• 전기전자학회논문지
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• 제23권3호
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• pp.962-970
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• 2019

본 논문에서는 자기구동 동기스위치를 이용한 비절연 고효율 고전압출력 DC-DC 컨버터를 제안한다. 제안하는 컨버터는 전통적인 승압형 DC-DC 컨버터 구조에 탭형 인덕터를 적용함으로써 고전압출력을 달성하며 주스위치부에 무손실 커패시터-다이오드(LCD, lossless capacitor-diode) 스너버를 적용하여 스위치 전압스트레스를 저감한다. 그리고 출력부에 다이오드 대신에 동기스위치를 적용함으로써 역회복 문제를 해결하고 고효율을 달성한다. 제안한 컨버터의 동기스위치는 자기구동방식을 이용하고 단순한 구조를 가진다. 본 논문에서는 제안한 컨버터의 동작원리를 먼저 설명하고, 후에 컨버터 프로토타입의 설계예를 제시한다. 그리고 설계된 회로파라미터로 제작된 프로토타입의 실험결과로써 제안한 컨버터의 특성을 보인다.