• 전력전자학회논문지
• /
• 제14권4호
• /
• pp.315-322
• /
• 2009

기존의 부스트 컨버터는 출력 전압이 커질수록 스위치와 다이오드의 전압, 전류 스트레스가 커지고 다이오드 역 방향회복에 의한 서지로 인해 실제 사용 가능한 승압비가 제한된다. 본 논문에서는 고승압 응용에 적합한 새로운 비절연 부스트 컨버터를 제안한다. 제안한 컨버터는 듀티비 0.5로 약 6배의 승압비를 가지며 CCM에서도 ZVS 스위칭이 가능하므로 넓은 ZVS 영역을 갖는다. 또한 스위치와 다이오드 전압정격이 출력전압의 1/3로 작고 인터리빙이 가능하여 입출력 수동소자의 정격도 작다. 다이오드도 ZCS 턴오프 동작으로 인해 역방향 회복에 의한 서지가 거의 없다. 제안하는 컨버터의 동작원리를 설명하였고 이론적 해석과 시뮬레이션 및 실험을 통해 타당성을 검증하였다.

• 한국의류산업학회지
• /
• 제22권2호
• /
• pp.250-260
• /
• 2020

The purpose of the present study was to explore the most effective body region and cooling temperature to alleviate heat strain of workers in hot environments. We developed liquid cooling hood, vest, sleeves and socks and applied the water temperatures of 10, 15, 20, and 25℃ through the liquid cooling garments in a hot and humid environment (33℃ air temperature and 70% RH air humidity). A healthy young male participated in a total of 16 experimental trials (four cooling garments × four cooling temperatures) with the following protocol: 10-min rest, 40-min exercise on a treadmill and 10-min recovery. The results showed that rectal temperature, mean skin temperature, and ratings of perceived exertion during exercise; heart rate and diastolic blood pressure during recovery; and total sweat rate were lower for the vest condition than other garment conditions(p < .05). However, there was no differences in mean skin temperature among the four cooling garments when we compared the values converted by covering area(%BSA). When we classified the results by cooling temperature, there were no consistent differences in thermoregulatory and cardiovascular responses among the four temperatures, but 25℃ water temperature was evaluated as being the most ineffective cooling temperature in terms of subjective responses. In conclusion, the results indicated that wearing cooling vest with < 20℃ cooling temperature can alleviate heat strain of workers in hot and humid environments. If the peripheral body regions are cooled with liquid cooling garments, larger cooling area with lower cooling temperature than 10℃ would be effective to reduce heat strain of workers. Further studies with a vaild number of subjects are required.

• 한국양식학회지
• /
• 제16권1호
• /
• pp.31-36
• /
• 2003

사육 염분의 급성교환 실험에서, 해수의 담수화가 1시간 이내에 이루어졌을 경우 농어, 유어들은 다소의 스트레스 반응과 이온의 변화가 있었으며. 24시간 뒤에도 정상 회복이 더딘 것으로 나타났다. 그러나 5시간에 걸친 담수화 과정 중에 스트레스 반응은 담수화 직후 높게 나타났지만, 24시간 후 빠르게 정상으로 회복되는 것을 알 수 있다. 장기간 염분별 사육실험 결과, 20 ppt가 가장 높은 사료섭식량을 나타내었고, 2 ppt구가 가장 낮았다. 사료효율 또한 2 ppt구이 가장 낮게 나타났고, 10 ppt구가 가장 높았으며, 실험구별 유어의 성장은 실험 종료시 10, 20 및 30 ppt구가 2 ppt보다 유의하게 높은 길이 성장을 보였다. 무게 성장은 실험 종료시 20 ppt가 가장 빠른 무게 성장을 나타내었고, 다음으로 30 ppt, 10 ppt. 2 ppt순으로 나타났다. 염분별 사육유어의 혈액 성상은 2 ppt~30 ppt 사육수에 있어 농어 유어들의 혈액 조성은 큰 차이가 없는 것으로 나타났다.

• 한국수산과학회지
• /
• 제51권4호
• /
• pp.411-419
• /
• 2018

This study investigated the survival rates and physiological responses of Korean rockfish, Sebastes schlegeli, in live fish containers ($8^{\circ}C$, 33 psu) for 18 days. The survival rate was 99% and 97% in the control and experimental groups, respectively. Hematocrit and hemoglobin did not differ significantly between the control and experimental groups. Glucose and cortisol rose immediately on the first day of containment, but both gradually normalized. Aspartate aminotransferase and alanine aminotransferase did not differ significantly between the two groups after recovery. $NH_3$ continued to rise after the first day, but decreased to a level not significantly different from that of the control group during the recovery period. Plasma ions and osmolality did not change abnormally. The hemocyte population was not significantly different from that of the control. The ratios of apoptotic and necrotic cells indicated no specific variation in hemocyte viability. The histological changes in the skin and gills were not significantly different from those seen in the control. The experimental data obtained in this study suggest that live fish containers may be used to transport Korean rockfish without significantly affecting their physiology or survival.

• KEPCO Journal on Electric Power and Energy
• /
• 제6권4호
• /
• pp.393-397
• /
• 2020

무효전력 보상설비인 분로리액터는 전력계통의 부하 패턴에 따라서 하루에도 수 회 정도 차단기에 의해 운전되거나 정지된다. 분로리액터개폐 시 몇 가지 요인에 의해 발생하는 과전압은 차단기의 절연 성능을 저하시키며, 계통을 구성하는 전력기기에 심각한 전압 스트레스를 유발한다. 분로리액터 개폐 과정에서 발생하는 과도현상을 측정하는 것은 계통을 모의하여 차단기 성능을 검증하는 시험소 수준에서는 가능하나, 실제 계통 운전 중에 발생하는 과도현상을 측정하는 것은 여러 가지 제약으로 어려움이 있다. 따라서 본 논문에서는 실 계통에서 지상 소전류 차단과정에서 가혹한 과도회복전압(TRV: Transient Recovery Voltage)을 유발하는 재발호(reignition)나 전류재단(current chopping) 현상에 대한 해석을 위해 전자계과도해석프로그램(EMTP: Electro-magnetic Transients Program)을 활용한 모델링 과정과 이를 토대로 분로리액터 개폐 과정에서 차단기의 고장을 유발하는 주된 현상에 대해 해석하고자 한다.

• Geomechanics and Engineering
• /
• 제18권2호
• /
• pp.205-213
• /
• 2019

A calculation model of reservoir pressure field distribution around multiple production wells in a heavy oil reservoir is established, which can overcome the unreasonable uniform-pressure value calculated by the traditional mathematical model in the multiwell mining areas. A calculating program is developed based on the deduced equations by using Visual Basic computer language. Based on the proposed mathematical model, the effects of drainage rate and formation permeability on the distribution of reservoir pressure are studied. Results show that the reservoir pressure drops most at the wellbore. The farther the distance away from the borehole, the sparser the isobaric lines distribute. Increasing drainage rate results in decreasing reservoir pressure and bottom-hole pressure, especially the latter. The permeability has a significant effect on bottom hole pressure. The study provides a reference basis for studying the dynamic pressure field distribution before thermal recovery technology in heavy oilfield and optimizing construction parameters.

• Fisheries and Aquatic Sciences
• /
• 제26권2호
• /
• pp.117-132
• /
• 2023

Chum salmon (Oncorhynchus keta) is a species of anadromous salmonid inhabiting coastal rivers in the North Pacific and the Arctic in the Bering and is the most widely distributed among Pacific salmon species. It is an important fish species in Korea as the salmon releasing project is being actively carried out. This study was conducted to investigate changes in the physiological activity of O. keta according to water temperature. Three experiments were conducted according to the water temperature and period, and the plasma concentrations of cortisol and glucose were analyzed from the blood samples of the experimental groups. Experiment I is a short-term water temperature experiment, in which water temperature stimulation was given for 4 hours at water temperatures of 12℃, 16℃ (control), 20℃, and 24℃, and a recovery period was given for 4 hours. Experiment II is an experiment in which water temperature stimulation was given for 24 hours, 48 hours, and 72 hours at a high temperature of 24℃, and a recovery period was given for 12 hours, respectively. Experiment III is a long-term water temperature experiment, in which the water temperature was 12℃, 16℃ (control), 20℃, and 24℃ for 8 weeks. As a result of the experiment, in Experiment I, there was no significant difference in the survival rate between the experimental groups, but the concentration of cortisol and glucose in the plasma according to the set water temperature showed a significant difference. In Experiment II, there was no significant trend according to the maintenance time of the high-temperature state, but as the temperature increased, the plasma cortisol and glucose levels significantly increased compared to the control group. In Experiment III, all of the experimental group C (24℃) died in the 1st week, and there was no significant difference in the plasma glucose at the 1st and 8th weeks among the remaining experimental groups.

• 분석과학
• /
• 제36권1호
• /
• pp.32-43
• /
• 2023

This study reports for the first time about a stability indicating RP-HPLC method for qualitative and quantitative determination of acalabrutinib in bulk and dosage form and in presence its impurities 1, 2 and 3. The chromatographic separation was carried on Zorbax XDB-C18 (250×4.6 mm; 5 µ id) as stationary phase, Phosphate buffer pH 6.4 and methanol 80:20 (v/v) as mobile phase at a flow rate of 1.0 mL/min, UV detection was carried at wavelength of 238 nm and the analysis was completed with a run time of 15 min. In these conditions the retention time of acalabrutinib and its impurities 1, 2 and 3 was observed to be 3.50, 4.83, 8.40 and 9.93 min respectively. The method was validated for system suitability, range of analysis, precision, specificity, stability and robustness. Spiked recovery at 50 %, 100 % and 150 % was carried for both standard and impurities and the acceptable % recovery of 98-102 was observed for acalabrutinib and both impurities studied and the % RSD in each spiked level was found to be less than 2. Stability tests were done through exposure of the analyte solution to five different stress conditions i.e expose to 1N hydrochloric acid, 1 N sodium hydroxide, 3 % peroxide, 80 ℃ temperature and UV radiation at 254 nm. In all the degradation condition, standard drug acalabrutinib was detected along with both the impurities studied and the degradation products were successfully separated. In the formulation analysis there is no other chromatographic detection of other impurities and formulation excipients. Hence the developed method was found to be suitable for the quantification of acalabrutinib and can separate and analyse impurities 1 and 2.

• 한국잡초학회지
• /
• 제32권1호
• /
• pp.35-43
• /
• 2012

본 연구는 Protox 저해형 제초제 저항성인 형질전환벼 라인(MX, PX, AP37)과 비형질전환벼(WT)에서 저온, 고온, NaCl 및 chemical(paraquat) 스트레스에 대한 생리적 반응차이를 파악하기 위해 수행되었다. 형질전환벼와 비형질전환벼는 저온실험의 경우 $5^{\circ}C$에 1일 그리고 회복을 위해 $25^{\circ}C$에 6일 두었고, 고온 실험은 $45^{\circ}C$에 4일 그리고 회복을 위해 $25^{\circ}C$에 8일 두었다. 또한 0.5%와 1% NaCl 처리 후 6일간 그리고 ${0{\sim}300\mu}M$ paraquat 처리 후 5일간 형질전환벼와 비형질전환벼의 잎의 피해율, 지상부 생체중 및 생리적 반응(porphyrin 생합성 중간물질, 엽록소 함량)을 조사하였다. 형질전환벼 라인과 WT간에 잎 피해율 및 생제중은 저온처리와 저온처리 후 회복기간에는 유의적인 차이가 없었다. 한편 고온과 고온처리 후 회복 5일까지는 형질전환 라인과 WT간에 초장과 생체중에서 유의적인 차이가 없었으나 회복 6일째에 MX와 PX는 WT에 비해 초장 및 생체중의 감소가 컸다. NaCl 처리 후 잎의 피해율, 엽록소 함량 및 Mg-Proto IX ME 함량은 형질전환벼와 비형질전환벼간에 유의적인 차이가 없었으나 AP37의 Proto IX 함량과 PX와 AP37의 지상부 생체중은 0.5% NaCl 처리에서 WT에 비해 유의적으로 감소하였다. 그러나 paraquat 처리 후 잎의 피해율과 지상부 생체중의 변화는 형질전환벼와 비형질전환벼간에 유의적인 차이를 보이지 않았다. 비록 일부 환경스트레스의 일부 조사기간에서 형질전환벼와 비형질전환벼간에 다른 반응차이를 보였지만 일반적으로 형질전환벼와 비형질전환벼간에 환경스트레스에 유사한 반응차이를 보였다.

• The Korean Journal of Physiology and Pharmacology
• /
• 제1권6호
• /
• pp.749-758
• /
• 1997

Myocardial ischemia-reperfusion injury is known to be mediated by reactive oxygen species. The myocardial cell is equipped with endogenous antioxidant defensive system which can be adaptively stimulated by various oxidative stress. It is postulated that an increased oxygen partial pressure induced by hyperbaric oxygenation impose an oxidative stress on the cells, resulting alterations in the endogenous antioxidant system. In this study we investigated the effect of hyperbaric oxygenation on the activities of myocardial antioxidant enzymes and observed whether the hyperbaric oxygenation could protect the ischemia-reperfusion injury of heart. Rats or rabbits were pretreated with hyperbaric $oxygenation(2{\sim}3\;atm\;O_2/1{\sim}3\;hrs/1{\sim}10\;days)$. The changes in activities of major antioxidant enzymes(superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose-6-phasphate dehydrogenase), functional recovery and infarct size were observed in the experimentally induced ischemia-reperfused hearts. In the hearts isolated from rats pretreated with $2\;atm\;O_2/1{\sim}2\;hrs$ for 5 days, the functional recovery after reperfusion(20 min) following global ischemia(25 min) was significantly increased without any observable oxygen toxicity. Lactate dehydrogenase release was also significantly reduced in this hyperbaric oxygenated rat hearts. In in vivo regional ischemia(30 min) model of rabbit hearts, pretreatrment with $2\;atm\;O_2/1\;hr$ for 5 days significantly limited the infarct size. Among the myocardial antioxidant enzymes of rat hearts pretreated with the hyperbaric oxygenation, the activities of catalase, superoxide dismutase and glucose-6-phosphatase dehydrogenase were increased, while those of glutathione peroxidase and reductase were not changed. There were lethal cases in the groups of rats exposed to 3 atm $3\;atm\;O_2/2{\sim}3\;hrs$ for 5 days. A lipid-peroxidation product, rnnlondialdehyde was increased in brains and livers of the rats exposed to$2\;atm\;O_2/2{\sim}3\;hrs/5\;days\;and\;3\;atm\;O_2/1\;hr/5days$. The present results suggest that the pretreatment of hyperbaric oxygenation can protect the post-ischemic rererfused hearts in association with a stimulation of the activities of myocardial antioxidant defensive enzymes, and that the hyperbaric oxygenation of $2\;atm\;O_2/1\;hr$for 5 days would be a safe condition which does not produce any oxygen toxicity.